Asunto(s)
Agammaglobulinemia/genética , Deficiencia de alfa 1-Antitripsina , Agammaglobulinemia/complicaciones , Agammaglobulinemia/inmunología , Femenino , Humanos , Inmunoglobulina A/análisis , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Masculino , Fenotipo , alfa 1-Antitripsina/genéticaRESUMEN
Immunologic studies were done in a patient with common variable hypogammaglobulinemia, bronchiectasis and M. avium intracellulare pulmonary infection. Adherent cells from the patient were found to suppress the proliferative response of normal control cells to PPD antigen. The suppression seemed to be mediated by prostaglandin as it was reversed by indomethacin. Increased suppressor cell activity may play an important role in the pathogenesis of Mycobacterium avium-intracellulare infection by permitting the transformation of a status of colonization by the organism in pre-existing pulmonary conditions into an invasive, progressive disease.
Asunto(s)
Agammaglobulinemia/inmunología , Linfocitos T Reguladores/inmunología , Tuberculosis Pulmonar/inmunología , Agammaglobulinemia/complicaciones , Bronquiectasia/complicaciones , Bronquiectasia/inmunología , Adhesión Celular , Células Cultivadas , Femenino , Humanos , Prueba de Cultivo Mixto de Linfocitos , Persona de Mediana Edad , Pruebas Cutáneas , Tuberculosis Pulmonar/complicacionesRESUMEN
The study was designed to measure the effect of inhaled beclomethasone on patients with severe symptomatic rhinosinusitis and nasal polyposis following 12 weeks of therapy. Only one of eight patients had improved nasal symptoms and a reduction in the degree of nasal obstruction. Except for an occasional patient intranasal beclomethasone in the recommended dosage is not effective in the management of chronic severe symptomatic rhinosinusitis.