RESUMEN
Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the drug-induced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. The aim of this work is to emphasize the need to include this differential diagnosis in cases of epidermal detachment and to review the literature on the subject and this specific clinical presentation.
Asunto(s)
Antibacterianos/efectos adversos , Dermatosis Bullosa IgA Lineal/inducido químicamente , Dermatosis Bullosa IgA Lineal/patología , Síndrome de Stevens-Johnson/patología , Vancomicina/efectos adversos , Anciano , Biopsia , Diagnóstico Diferencial , Epidermis/patología , Técnica del Anticuerpo Fluorescente Directa , Humanos , Masculino , Enfermedades Cutáneas Vesiculoampollosas/inducido químicamente , Enfermedades Cutáneas Vesiculoampollosas/patologíaAsunto(s)
Anticuerpos Monoclonales/efectos adversos , Terapia Biológica/efectos adversos , Erupciones por Medicamentos/etiología , Pénfigo/inducido químicamente , Adulto , Anticuerpos Monoclonales Humanizados , Artritis Reumatoide/tratamiento farmacológico , Erupciones por Medicamentos/patología , Eritema/inducido químicamente , Eritema/patología , Femenino , Humanos , Inmunohistoquímica , Pénfigo/patología , Piel/patologíaRESUMEN
Abstract Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the drug-induced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. The aim of this work is to emphasize the need to include this differential diagnosis in cases of epidermal detachment and to review the literature on the subject and this specific clinical presentation.