[Noninvasive impedance method of determining left ventricular filling pressure]. / Neinvazivnyi impedansnyi metod opredeleniia davleniia napolneniia levogo zheludochka serdtsa.

Impedance chest plethysmograms (IPG) were recorded simultaneously with intraventricular pressure curves before and after ventriculography in 36 patients with chronic coronary heart disease. Phono- and apex cardiograms were recorded simultaneously with the 1st IPG derivative. The analysis of the tracings established criteria for determining the duration of isometric relaxation phase (IRP) from the 1st IPG derivative. The comparison between the IRPIPG and left-ventricular filling pressure (LVFP) values obtained by direct measurement, demonstrated a close correlation (r = 0.896) and suggested a simple formula for non-invasive LVFP determination.

[Diagnostic possibilities of hand isometric exercise in the assessment of coronary and contractile reserve of the heart in patients with unstable angina pectoris]. / Diagnosticheskie vozmozhnosti kistevoi izometricheskoi nagruzki v otsenke koronarnogo i sokratitel'nogo rezerva serdtsa u bol'nykh s nestabil'noi stenokardiei.

The potentialities of hand isometric exercise (HIE) were studied in 84 patients with unstable angina pectoris and 25 with stable angina. With HIE, the coronary and contractile reserve was measured in the patients with angina. Lower exercise tolerance was revealed in the patients with unstable angina than in those with stable one. Among the patients with unstable angina, those at risk for myocardial infarction were predominant. Lower exercise tolerance appeared as decreased "threshold" double product values and diminished myocardial contractile reserve (higher left ventricular filling pressure). HIE applied in the study evaluates the efficacy of treatment and the prediction of the disease course more accurately.

[Use of the Complamin test for diagnosing stenosing atherosclerosis in the coronary arteries]. / Primenenie komplaminovoi proby dlia diagnostiki stenoziruiushchego ateroskleroza venechnykh arterii serdtsa.

A pharmacologic loading test with xanthinol nicotinate was used unprecedentedly to detect occlusion of coronary arteries. Complamine was administered intramuscularly in a dose of 7.5 mg per 1 kg of the patient's weight. Twenty-nine patients with coronarographically-confirmed coronary arterial stenosis and twenty patients with cardialgias of non-coronary origin were investigated. Clinical and electrocardiographic criteria were worked out for the assessment of the complamine test results. The sensitivity and specificity of the test were estimated at 93.1 and 98%, respectively. The complamine test is recommended as part of combined screening for stenosed coronary arteries in patients with coronary heart disease.

[Psychophysiological aspect of the therapeutic use of pyridinolcarbamate]. / Psikhofiziologicheskii aspekt lechebnogo deistviia piridinokarbamata.

The effect of prodectin was examined in 79 patients with coronary disease after a course of treatment, and in 16 normal subjects. A series of electrocardiographic and hemodynamic parameters were investigated at rest and during bicycle ergometric exercise. Resultant psycho-physiologic shifts were reviewed with the aid of the information test recording the time of response, errors and vegetative changes in response to colour and mathematical stimuli. Pyridinol carbamate was found to produce a psychostimulating effect, with information processing and vegetative control improved significantly. Therefore the drug appears to be advisable for patients with coronary disease exposed to increased information inflow which requires greater concentration of their attention in short time.

[Clinical use of arfonad and hygronium aerosols in emergency hypotensive therapy]. / Klinicheskoe primenenie aérozolei arfonada i gigroniia pri neotlozhnoi gipotenzivnoi terapii.

During clinical testing of the administration of ganglion-blocking agents by inhalation (175 persons) it was established that drug aerosols of arfonad and hygronium possess high effectiveness, act rapidly, and are relatively safe. The inhalation method of the management of hypertensive crises may find wide use in out-patient practice, under conditions of the admission room, cardiological and resuscitation departments, as well as in obstetrics when controlled hypotension is necessary.

[The microcirculatory bed and its functional reserves in patients with hypertension]. / Issledovanie mikrotsirkuliatornogo rusla i ego funktsional'nykh rezervov u bol'nykh gipertonicheskoi bolezn'iu.

In patients with hypertension disorders of the microcirculatory bed and oxygen supply of tissues progress with relation to disease stage. Clofelin therapy by courses resulted in a recovery of the functional properties of microvessels in patients with Stage I disease and their improvement in patients with Stage IIA-III disease. The use of trental in patients with Stage IIA and Stage IIB disease decreased pathological changes in microvessels, limited erythrocyte aggregation in them and enhanced potentialities of the microcirculatory bed in oxygen supply of tissues.

[Diagnostic potentials of a precordial mapping method in patients with acute and chronic forms of ischemic heart disease]. / Diagnosticheskie vozmozhnosti metoda prekordial'nogo kartirovaniia u bol'nykh s ostroi i khronicheskimi formami ishemicheskoi bolezni serdtsa.

Diagnostic potentialities of modified 27 and 30 precordial ECG-leads were defined for rapid assessment of the coronary blood flow in patients with acute myocardial infarction (AMI) and chronic coronary heart disease during an acute pharmacological test. ECG criterita of limiting AMI size and ECG criteria of the ischemic reaction during the pharmacological xantinol nicotinate test were defined. It was proved that the use of multiple ECG leads raised the sensitivity of the ECG method in the diagnosis of AMI by 13.6% and in the diagnosis of stenosing atherosclerosis of the coronary arteries by 12.9%.

[Antioxidant status and glutathione redox potential of erythrocytes in patients with acute coronary syndrome].

Indicators of oxidative stress (OS), systemic inflammation, metabolism and redox status of glutathione (GSH) were investigated and compared in patients with ST-segment elevation myocardial infarction on electrocardiograms (STEMI), and patients with unstable angina (UA). The elevated and decreased myeloperoxidase level, superoxide dismutase activity, and moderate increased plasma levels of interleukin-6, while maintaining the antioxidant potential, were found in Group 1. Disorders in pro-/antioxidant balance and systemic inflammatory response were manifested in UA. Increased GSH concentration (and total GSH) in erythrocytes has been established for STEMI patients and the decreased GSH for UA patients. Thus, a significant shift of erythrocytes redox to oxidization and increase (unlike STEMI patients) of glutathione peroxidase activity were recorded. Mechanisms of the pro- and antioxidant functions of red blood cells in acute coronary syndrome are considered. The role of red blood cell glutathione to provide more oxidized intravascular environment for S-glutathionylation and optimization of redox signaling in target cells is pronounced.