Anti-Leishmania antibodies in blood donors from the Midwest region of Brazil.

The aim of the study was to detect asymptomatic infection by Leishmania sp. in blood donors. Serum samples (430) were tested by Immunofluorescent Antibody Test, and an interview with the blood donors was carried out. Antibodies were detected in 15.6% of samples. The variables associated with the infection were: origin of the donor, presence of builds, parks or squares, sick dog in the neighborhood, and neighboring with leishmaniasis. It was observed association between origin of donors and the presence of sick dog. It is important a careful screening of donors, due to the risk of infection through blood transfusion.

[Factors associated with birthweight of Terena indigenous children living in the urban area of Campo Grande, Mato Grosso do Sul State, Brazil]. / Fatores associados ao peso ao nascer de crianças indígenas Terena, residentes na área urbana de Campo Grande, Mato Grosso do Sul, Brasil.

The study aimed to verify the association between birthweight of Terena children living in the urban area of Campo Grande, Mato Grosso do Sul State, Brazil, and demographic, socioeconomic, and health variables and to describe the prevalence of low birthweight. Data were collective through home visits with a form completed with the mothers and based on records from the prenatal and neonatal cards. The sample included all the Terena women who gave birth to liveborn children from June 1, 2017, to July 31, 2018, and living in the Água Bonita, Darcy Ribeiro, Marçal de Souza, and Tarsila do Amaral villages. Birthweight was the outcome, and demographic, socioeconomic, and health characteristics were the exposure variables. A total of 43 mothers participated with their children. Low birthweight prevalence was 2.3%. In the final model, children living in households with makeshift cesspools showed lower birthweight when compared to those living in households connected to the public sewage disposal system, and daughters of mothers who were obese prior to the pregnancy presented higher birthweight than those born to normal weight mothers, according to pregestational body mass index. The data seek to contribute to discussions on the health and nutrition of this important share of the indigenous population that lives in urban areas.

O objetivo do estudo foi verificar a associação do peso ao nascer de crianças Terena, residentes na área urbana de Campo Grande, Mato Grosso do Sul, Brasil, com variáveis demográficas, socioeconômicas e de saúde, e descrever a frequência de baixo peso ao nascer. Os dados foram coletados em visitas domiciliares com formulários aplicados às mães e baseando-se em informações contidas nas Cadernetas da Gestante e da Criança. Foram incluídas todas as mulheres Terena que tiveram filhos nascidos vivos no período de 1º de junho de 2017 a 31 de julho de 2018 e residentes nas aldeias Água Bonita, Darcy Ribeiro, Marçal de Souza e Tarsila do Amaral. O peso ao nascer foi considerado desfecho e as variáveis demográficas, socioeconômicas e de saúde foram consideradas exposição. Participaram do estudo 43 mães e crianças. A frequência de baixo peso ao nascer foi de 2,3%. No modelo final, as crianças que residiam em domicílios com fossa séptica ou rudimentar apresentaram peso ao nascer menor quando comparadas às que residiam em domicílios com rede coletora de esgoto; e aquelas filhas de mães obesas antes da gestação apresentaram maior peso ao nascer quando comparadas às que nasceram de mães eutróficas segundo o índice de massa corporal pré-gestacional. Os dados buscam trazer à tona discussões sobre as condições de saúde e nutrição dessa importante parcela da população indígena que vive em áreas urbanas.

El objetivo del estudio fue verificar la asociación del peso al nacer de niños Terena, residentes en el área urbana de Campo Grande, Mato Grosso do Sul, Brasil, con variables demográficas, socioeconómicas y de salud, así como describir la frecuencia de bajo peso al nacer. Los datos se recogieron en visitas domiciliarias con formularios aplicados a las madres, y a partir de información que contenían los Cuadernillos de la Gestante y del Niño. Se incluyeron a todas las mujeres Terena que tuvieron hijos nacidos vivos, durante el período del 1 de junio de 2017 a 31 de julio de 2018, y residentes en las aldeas Água Bonita, Darcy Ribeiro, Marçal de Souza y Tarsila do Amaral. El peso al nacer se consideró un resultado y las variables demográficas, socioeconómicas y de salud se consideraron exposición. Participaron en el estudio 43 madres y niños. La frecuencia de bajo peso al nacer fue de un 2,3%. En el modelo final, los niños que residían en domicilios con fosa séptica o rudimentaria presentaron un peso al nacer menor, cuando se comparan con los que residían en domicilios con una red de alcantarillado; y aquellos hijos de madres obesas antes de la gestación presentaron un mayor peso al nacer, cuando se comparan con los que nacieron de madres eutróficas, según el índice de masa corporal pregestacional. Los datos pretenden plantear discusiones sobre condiciones de salud y nutrición de esta importante parte de la población indígena que vive en áreas urbanas.

Sickness absence among employees of the State Court of Campo Grande, Mato Grosso do Sul, Brazil.

BACKGROUND: The state of health of civil servants is a focus of much interest to public organizations. Within this context, health promotion, protection and recovery pose a challenge to nursing professionals engaged in occupational health surveillance. OBJECTIVE: To identify the main reasons of sickness absence among employees of the State Court of Campo Grande, Mato Grosso do Sul, Brazil, in the period from 2014 through 2016. METHODS: Documentary, exploratory and quantitative study in which variables of interest were sex, age, position, department, leave type, International Classification of Diseases (ICD-10) codes and duration of sick leave spells. The significance level was set to p=0.05 and the corresponding 95% confidence interval. RESULTS: Diseases of the musculoskeletal system and connective tissue (17.8%), mental and behavioral disorders (14.5%) and factors influencing health status and contact with health services (6.2%) were the main reasons for sickness absence. The absenteeism rate along the analyzed period was higher for women (74.7%), employees aged 41 to 60 (63.5%) and judicial analysists (71.8%). CONCLUSION: Musculoskeletal and mental disorders were the leading causes of sickness absence among employees of the State Court of Campo Grande. The results of the present study might help health managers improve the working conditions of this population of workers.

INTRODUÇÃO: A saúde dos servidores públicos tem sido um tema de suma importância no âmbito das empresas públicas. Sendo assim, a enfermagem, inserida no campo da vigilância em saúde do trabalhador, enfrenta o desafio da promoção, proteção e recuperação da saúde desse grupo. OBJETIVO: Identificar os principais motivos que levaram ao absenteísmo por doença dos servidores do Fórum da Justiça Estadual de Campo Grande (MS), entre 2014 e 2016. MÉTODO: Pesquisa de caráter documental e exploratória de análise quantitativa, utilizando as variáveis sexo, faixa etária, idade, cargo, unidade de trabalho, tipo de licença, Classificação Estatística Internacional de Doenças e Problemas Relacionados com a Saúde (CID) e número de dias de afastamento. Foram considerados nas análises p=0,05 e o intervalo de confiança de 95% (IC95%). RESULTADOS: As doenças do sistema osteomuscular e do tecido conjuntivo (17,8%), os transtornos mentais e comportamentais (14,5%) e os fatores que influenciam o estado de saúde e o contato com os serviços de saúde (6,2%) foram as principais causas de afastamento. O absenteísmo por doença de 2014 a 2016 foi maior em mulheres (74,7%) com faixa etária de 41-60 (63,5%), bem como entre o cargo de analista judiciário (71,8%). CONCLUSÕES: O estudo demonstrou que as doenças osteomusculares e os transtornos mentais foram as principais causas de absenteísmo por doença no Fórum Judicial Estadual do município de Campo Grande (MS) e poderá contribuir no futuro para a tomada de decisões dos gestores para que possam melhorar as condições de trabalho dos servidores.

Apoptotic effects of inositol hexaphosphate on biomarker Itpr3 in induced colon rat carcinogenesis.

PURPOSE: To study the effect of the modulation of inositol hexaphosphate (IP6) in the biological immunohistochemistry expression of cellular signaling marker apoptosis, in model of carcinogenesis of colon induced by azoxymethane (AOM). METHODS: Wistar rats (N=112) distributed in 4 groups (n=28): Control; B, AOM (5 mg kg-1, 2x, to break week 3); C, IP6 (in water 1%, six weeks); D, IP6+AOM. Weekly euthanasia (n=7), from week three. Immunohistochemistry of ascendant colon with biological marker inositol 1,4,5 triphosphate receptor type III (Itpr3). Quantification of the immune-expression with use of computer-assisted image processing. Analysis statistics of the means between groups, weeks in groups, groups in weeks, and established significance when p

Non-viral microbial keratitis in adults: clinical and laboratory aspects.

This study compares patients with and without non-viral microbial keratitis in relation to sociodemographic variables, clinical aspects, and involved causative agent. Clinical aspects, etiology and therapeutic procedures were assessed in patients with and without keratitis that were diagnosed in an Eye Care Center in Campo Grande, MS, Brazil. Patients were divided into two groups: (a) cases: 64 patients with non-viral microbial keratitis diagnosed at biomicroscopy; and (b) controls: 47 patients with other eye disorders that were not keratitis. Labor activity related to agriculture, cattle raising, and contact lens use were all linked to keratitis occurrence (p<0.005). In patients with keratitis, the most common symptoms were pain and photophobia, and the most frequently used medicines were fourth-generation fluoroquinolones (34.4%), amphotericin B (31.3%), and natamycin (28.1%). Microbial keratitis evolved to corneal perforation in 15.6% of cases; transplant was indicated in 10.9% of cases. Regarding the etiology of this condition, 23 (42.2%) keratitis cases were caused by bacteria (Pseudomonas aeruginosa, 12.5%), 17 (39.1%) by fungi (Fusarium spp., 14.1% and Aspergillus spp., 4.7%), and 4 (6.3%) by Acanthamoeba. Patients with keratitis present with a poorer prognosis. Rapid identification of the etiologic agent is indispensable and depends on appropriate ophthalmological collection and microbiological techniques.

Resolution of control and monitoring instrument of nutritional therapy in the intensive care unit of a university hospital.

INTRODUCTION: Patients in intensive care status are in nutritional threat and frequently present innutrition, therefore monitoring the nutritional offer becomes indispensable. AIM: To purpose a control and monitoring form of enteral nutritional therapy and to evaluate its resoluteness. METHODS: Observational, analytical and retrospective study performed in intensive care patients receiving an enteral diet exclusively and/or associated with the oral/parenteral route, from January to April 2015 and from January to April 2016. An enteral nutritional therapy control form was purposed and applied in 2016 and the results were compared to those of the previous year. In both of these years, five quality indicators proposed by the task force of clinical nutrition from the International Life Sciences Institute (Brazil, 2008) were applied. RESULTS: Ninety-four patients, mostly aged, were included (47 per year) in the study. There was an increase in the number of patients that presented diarrhea (p = 0.007) and hyperglycemia (p = 0.013) as well as an increase in the occurrence of these episodes among patients (p = 0.018, p = 0.032, respectively). The frequency of diarrhea, fasting of more than 24 hours and hypoglycemia did not correspond to the goal established by the indicators. Energy and protein estimations were reported, as well as their compliance with the literature. CONCLUSION: After using the form, a greater report of clinical intercurrences and information on caloric and protein estimates was observed, thus demonstrating its effectiveness with respect to data recording.

INTRODUCCIÓN: los pacientes en terapia intensiva presentan riesgo nutricional y frecuentemente se encuentran en estado de malnutrición, por lo que es fundamental la monitorización de la oferta nutricional. OBJETIVO: proponer una forma de control y seguimiento de la terapia nutricional enteral y evaluar su efectividad. MÉTODOS: estudio de observación, analítico y retrospectivo, realizado en pacientes ingresados en una unidad de cuidados intensivos que reciben dieta por vía enteral exclusiva y/o asociada a vía oral/parenteral, en el periodo de enero a abril de 2015 y de enero a abril de 2016. En 2016 se propuso y aplicó un instrumento de control y monitorización de la terapia nutricional enteral en la unidad de cuidados intensivos y los resultados fueron comparados con los del año anterior. En ambos periodos se aplicaron cinco indicadores de calidad propuestos por el grupo especial de nutrición clínica del International Life Sciences Institute, de Brasil (2008). RESULTADOS: se incluyen 94 pacientes y se estudiaron 47 en cada año, la mayoría de ellos ancianos. Hubo un aumento del número de pacientes que desarrollaron diarrea (p = 0,007) e hiperglucemia (p = 0,013) y también de la cantidad de episodios de estas complicaciones (p = 0,018 y p = 0,032, respectivamente). La frecuencia de diarrea, ayuno superior a 24h e hipoglucemia no correspondía a la meta fijada por los indicadores. Se recogieron datos del aporte energético y proteico, así como su comparación con lo publicado. CONCLUSIÓN: después de la utilización del instrumento hubo un aumento en el registro de complicaciones clínicas y la información referente a la estimación calórica y proteica, lo que demuestra su efectividad en el registro de datos para el cual fue desarrollado.

Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal.

INTRODUCTION: This study aimed to describe cryptococcal meningitis (CM) cases and the associated demographic, clinical, and microbiological data obtained from cities in the State of Mato Grosso do Sul in the Midwestern region of Brazil. METHODS: The data from 129 patients with laboratory-confirmed CM admitted from 1997 to 2014 were retrospectively reviewed. The molecular types of Cryptococcus neoformans and Cryptococcus gattii isolated from cerebrospinal fluid were analyzed to determine their geographic distribution. RESULTS: The patients had a mean age of 37 years and consisted mostly of men (76.7%). Most of the Cryptococcus isolates were obtained from patients infected with human immunodeficiency virus (HIV) and included 105 (87.5%) and 5 (55.6%) isolates of C. neoformans and C. gattii complexes, respectively. A restriction fragment length polymorphism (RFLP) analysis of URA5 revealed that most of the isolates were C. neoformans molecular type VNI (89.1%), whereas the molecular types VGII (7%) and VNII (3.9%) were observed less frequently. Notably, 65% of the cases with a time from symptom onset to laboratory diagnosis of more than 60 days resulted in fatalities, and sequelae were observed among the patients who survived. CONCLUSIONS: The present study documents the occurrence of neurocryptococcosis, which is mainly caused by C. neoformans VNI, in Mato Grosso do Sul, Brazil, with probable autochthonous cases in the Brazilian Pantanal, the world's largest tropical wetland, and a biome where cryptococcosis has not yet been explored.

Effectiveness of a bioactive food compound in anthropometric measures of individuals with HIV/AIDS: A nonrandomized trial.

BACKGROUND: Highly Active Antiretroviral therapy (HAART) promotes anthropometric changes in lipid metabolism and glucose in patients with Human Immunodeficiency Virus (HIV). Functional foods play an important role on metabolism. Bioactive Food Compound (BFC) has shown effective results in changes arising from decompensated lipid metabolism due to the effects of HAART on HIV patients. From this perspective, the objective of this study is to evaluate anthropometric indicators and the body composition of patients undergoing HAART before and after consumption of BFC. METHODS: This is a prospective intervention with 180 individuals with HIV undergoing HAART. They formed two groups and were monitored for 3 months: the first group consisted of individuals who consumed BFC (n = 121) at the recommended daily intake of 40 g. The second group consisted of individuals who did not consume BFC (n = 59). We determined body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), conicity index (CI) and antiretroviral regimen used by the patients. RESULTS: The BMI among adults (p<0.001), the WC (p<0.001 and p<0.014 for men and women, respectively) and the CI (p = 0.001 and p<0.001 for men and women, respectively) increased at the end of the study in the group of individuals who did not consume BFC and remained stable in the BFC group. There were no changes in WHR in any of the groups evaluated. Regarding the antiretroviral regimens used, we observed that there was no difference between regimens as for BMI, WC, WHR and CI. CONCLUSIONS: The BFC consumed by HIV patients undergoing HAART allowed the maintenance of anthropometric measures without increasing the mean values of conicity index, suggesting that the consumption of this bioactive compound protects the individual against the development of metabolic syndrome (MeS) in patients infected with HIV undergoing antiretroviral therapy.

Enteroparasites in Riverside Settlements in the Pantanal Wetlands Ecosystem.

BACKGROUND: Intestinal parasites are a major source of health problems in developing countries, where socioeconomic, cultural, and environmental conditions contribute in maintaining the biological cycles of various parasites and facilitating their spread. The objective of this study, conducted in Corumbá, Mato Grosso do Sul state, Brazil, was to investigate the occurrence of intestinal parasites in riverside communities in the South Pantanal wetlands and conduct educational interventions focused on health and environmental preservation. METHOD: In total, 196 stool samples were tested for parasites using the merthiolate-iodine-formaldehyde concentration (MIFC) technique and spontaneous sedimentation and educational activities were carried out. RESULTS: Enteroparasite prevalence was 72% (65.6-78.2%; 95% CI). Of the 141 positive cases, monoparasitism was found in 34.7%, biparasitism in 23%, and polyparasitism in 14.3%. Entamoeba coli was the most frequent protozoan (70.2%). Among helminths, hookworms were the most prevalent. Enteroparasitosis prevalence did not differ for sex or place of abode but proved higher in individuals older than 10 years. CONCLUSION: The high positivity rate for enteroparasites found for the communities stems from lack of sanitation and poor personal and environmental hygiene habits, indicating that effective health policies and educational interventions are needed to reduce the current risk levels.

Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

Transfusion-transmitted leishmaniasis has been a concern in regions endemic for the disease. Whether immediate or delayed, the risks posed by this mode of transmission call for careful assessment. The purpose of this study was to detect Leishmania infection in blood donors living in an endemic area and to investigate progression to the disease in these individuals. Immunofluorescent antibody test, enzyme-linked immunosorbent assay, leishmaniasis rapid test, and the polymerase chain reaction were applied to 430 donors in an initial evaluation. Of those donors with at least one positive test, 50 were reevaluated four years later by the same methods, as were 25 controls who had been negative on the same tests. In the first evaluation, Leishmania infection was detected in 41.4% (95% CI: 36.7-46.1) of donors (n = 430). None of the 75 reevaluated individuals had developed the disease, but retesting revealed positivity in at least one test in 36.0% (95% CI: 25.1-46.9) of donors. Of the 50 initially testing positive, 50% remained so on retesting. Of the 25 initially negative controls, two tested positive in the subsequent evaluation. The severity of the parasitosis and the risk of transfusion transmission warrant investigation of the potential inclusion of methods for Leishmania detection into blood banks for effective screening of infected donors.

Intestinal parasitism among waste pickers in Mato Grosso do Sul, Midwest Brazil.

The purpose of this study was to estimate the prevalence of intestinal parasites in both cooperative-affiliated and independent waste pickers operating at the municipal sanitary landfill in Campo Grande, Mato Grosso do Sul, Brazil, and associate these findings with hemoglobin, eosinophils, vitamin A and C levels and interleukin 5 and 10 (IL-5 and IL-10) production. Biological samples were collected, in addition to clinical, epidemiological, and sociodemographic data. Stool analyzes were based on sedimentation by centrifugation and on spontaneous sedimentation. High-performance liquid chromatography was used to determine vitamin A and C levels. ELISA was employed to quantify interleukins. Intestinal parasites were found in 29 of the 66 subjects assessed (43.9%). Endolimax nana (22.7%), Entamoeba coli (21.1%), Giardia lamblia (6.1%), Entamoeba histolytica/E. dispar (4.5%), and Ascaris lumbricoides (4.5%) were the most prevalent species. Pathogenic parasites were detected in 11 individuals (16.7%). Hypovitaminoses A and C were detected in 19.6% (13/66) and 98.4% (65/66) of subjects, respectively. IL-5 and IL-10 production was observed in 21 (31.8%) and 32 (48.4%) subjects, respectively. Infection with pathogenic intestinal parasites was not a cause of vitamin A and C deficiency or IL-5 and IL-10 production among these workers.

Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats.

PURPOSE: To evaluate modulation in the expression of Transforming growth factor beta2 (TGF-beta2) in short-term colon carcinogenesis. METHODS: 64 male rats was used, comprising 4 groups of 16 animals each: group 1 received Inositol hexaphosphate (IP6) and azoxymethane (AOM); group 2, AOM alone; group 3, IP6 alone; group 4 was used as control. Groups 1 and 3 were given 1% IP6 in drinking water for 6 weeks. AOM was administered subcutaneously at weeks 3 and 4 of the experiment at 20 mg/kg of body weight each week. Immunohistochemical processing was performed with the use of anti-TGF-beta2 primary antibodies in right colon samples and quantitation of TGF-beta2 as percentage of expression, through computer-assisted image processing. RESULTS: mean values of TGF-beta2 expression were 9.0 +/- 3.9% for group 4 (control), 12.7 +/- 4.0% for group 3 (IP6), 19.3 +/- 6.2% for group 2 (AOM), and 13.1 +/- 5.3% for group 1 (IP6+AOM). The value of p was calculated as 0.0001 for a 5% or lower significance level. CONCLUSION: the experiment revealed a significant increase in TGF-beta2 expression in right colon with the administration of AOM, and a significant decrease in TGF-beta2 expression when IP6 was administered with AOM.

Evaluation of epidural blockade as therapy for patients with sciatica secondary to lumbar disc herniation.

OBJECTIVE: Sciatic pain secondary to lumbar disc herniation is a complex condition that is often highly limiting. The causes of pain in disc herniation are multifactorial. Two physiopathological mechanisms are involved in discogenic pain: mechanical deformation of nerve roots and a biochemical inflammatory component resulting from contact between the intervertebral disc and neural tissue, by way of the nucleus pulposus. The aim of this study was to evaluate the efficacy and safety of epidural blockade as therapy for bulging lumbar disc herniation. METHODS: A clinical study was conducted based on a retrospective and prospective survey. The blockade consisted of interlaminar puncture and bolus drug delivery. The number of procedures varied according to the clinical response, as determined through weekly evaluations and then 30, 90, and 180 days after the final session. A total of 124 patients who received one to five blockades were evaluated. RESULTS: The success rate (defining success as a reduction in sciatic pain of at least 80%) was 75.8%. CONCLUSION: The results demonstrated the therapeutic action of epidural blockade over the short term, i.e. in cases of acute pain, thus showing that intense and excruciating sciatic pain can be relieved through this technique. Because of the multifactorial genesis of sciatica and the difficulties encountered by healthcare professionals in treating this condition, epidural blockade can become part of therapeutic arsenal available. This procedure is situated between conservative treatment with an eminently clinical focus and surgical approaches.

OBJETIVO: A dor ciática secundária a hérnia discal lombar é condição complexa e, muitas vezes, intensamente limitante. As causas de dor na herniação discal são multifatoriais. Na dor discogênica há envolvimento de dois mecanismos fisiopatológicos: a deformação mecânica das raízes nervosas e o componente bioquímico inflamatório, que resulta do contato do disco intervertebral, através do núcleo pulposo, com o tecido neural. O objetivo desta investigação foi verificar a eficácia e a segurança do bloqueio epidural como terapêutica em hérnias discais lombares protrusas. MÉTODOS: Empreendeu-se um ensaio clínico com base em levantamento retrospectivo e prospectivo. O bloqueio foi feito por punção interlaminar com administração de fármacos em bolo. O número de procedimentos variou conforme a evolução clínica, com avaliações semanais e, finalmente, aos 30, 90 e 180 dias da última sessão. Foram avaliados 124 pacientes, que receberam de um a cinco bloqueios. RESULTADOS: A taxa de sucesso (considerado como redução de no mínimo 80% na dor ciática) foi de 75,8%. CONCLUSÃO: Os resultados revelaram a ação terapêutica do bloqueio epidural em curto prazo ­ ou seja, na dor aguda ­ e demonstraram que a dor ciática intensa e excruciante pode ser aliviada com essa técnica. A gênese multifatorial da ciatalgia e as dificuldades encontradas pelos profissionais em seu tratamento permitem que o bloqueio epidural integre o arsenal terapêutico disponível. O procedimento insere-se entre o tratamento conservador, eminentemente clínico, e o cirúrgico.

Antissaliva Antibodies of Lutzomyia Longipalpis in area of Visceral Leishmaniasis.

The aim of the present study was to assess the presence of antissaliva antibodies of Lutzomyia longipalpis in human hosts living in area of visceral leishmaniasis, located in the Center-West region of Brazil. The presence of antissaliva antibodies of L. longipalpis exhibited a strong correlation with the protection and development of antibodies against Leishmania sp. Of the 492 children studied, elevated antissaliva antibodies of L. longipalpis were detected in 38.4% of the participants. There was a higher percentage of positivity (64.7%) among children who exhibited anti-Leishmania sp. antibodies and among those who were positive in the delayed hypersensitivity test (34.8%).

Mortalidade infantil por causas evitáveis em municípios de fronteira e não fronteira / Infant mortality from preventable causes in border and non-border cities

Resumo Introdução É grande o desafio de reduzir a mortalidade infantil por causas evitáveis no Brasil, dadas as desigualdades existentes no território. Objetivo Estimar a taxa de mortalidade infantil por causas evitáveis e comparar os resultados entre os municípios de fronteira e de não fronteira, no estado de Mato Grosso do Sul. Método Trata-se de um estudo ecológico. Foram estudados três grupos de municípios: Grupo 1 - municípios de fronteira contígua com área urbana no país vizinho; Grupo 2 - municípios de fronteira não contígua com área urbana no país vizinho; e Grupo 3 - municípios de não fronteira. Os dados foram obtidos a partir do Sistema de Informações sobre Mortalidade e do Sistema de Informações sobre Nascidos Vivos. Resultados As taxas de mortalidade infantil por mil nascidos vivos, devido a causas evitáveis em 2004 e 2014, foram respectivamente: Grupo 1 (21,8/11,29), Grupo 2 (24,68/14,7) e Grupo 3 (14,3/7,23). A maior ocorrência dos óbitos ocorreu por causas relacionadas à inadequada atenção à mulher na gestação, parto, feto e ao recém-nascido. Conclusão O risco de óbito por causas evitáveis é maior nas crianças residentes nos municípios de fronteira, e isso deve ser considerado na elaboração das políticas e ações de saúde.

Abstract Introduction There is a great challenge to reduce infant mortality from preventable causes in Brazil, given the inequalities that exist in the territory. Objective To estimate the Infant Mortality Rate due to preventable causes and to compare the results between the border and non-border municipalities, in the State of Mato Grosso do Sul. Method This is an ecological study. Three groups from cities were analyzed: Group 1 - contiguous cities with urban border in a neighboring country; Group 2 - non-contiguous cities with urban border in a neighboring country; e Group 3 - non-border cities. The data were obtained from Living Born Information System and Mortality Information System. Results Infant mortality rates per 1,000 live births, by preventable causes in 2004 and 2014, were respectively: Group 1 (21.8 / 11.29), Group 2 (24.68 / 14.7) and Group 3 (14.3 / 7.23). The highest occurrence of deaths happened due to causes related to inadequate care to women during pregnancy, childbirth, fetus and the newborn. Conclusion The risk of death due to preventable causes is higher in children living in border cities, and this should be considered in the elaboration of future health policies and actions.

Late diagnosis: a factor associated with death from visceral leishmaniasis in elderly patients.

INTRODUCTION: Visceral leishmaniasis (VL) is among the seven global endemic diseases assigned a high priority by the World Health Organization. In Latin America, most cases occur in Brazil. Despite the availability of intensive treatment resources and protocols for specific treatment, lethality rates for VL have increased in several regions in the country over the past 10 years, particularly in patients under one and over 50 years of age. As the growth of the elderly population accelerates in Brazil, VL poses a greater challenge to public health. Given the scarcity of studies addressing the disease in this age group, the purpose of this study was to identify factors associated with VL lethality among the elderly. METHODS/KEY FINDINGS: This analytical, cross-sectional epidemiological study comprised 80 elderly patients who sought treatment at the teaching hospital of the Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil, in the period 2000-2013.Clinical, laboratory and treatment variables were investigated from records of elderly patients with VL diagnosis confirmed by at least one laboratory test positive (culture for parasite or direct parasitological examination; reactive immunofluorescence; immunochromatographic test with recombinant antigens) or patients without laboratory confirmation who lived in endemic areas and responded favorably to therapeutic trial, as defined by the Brazilian Ministry of Health. Of the 80 patients included, 78 tested positive to at least one exam; in two cases, diagnosis was based on clinical and epidemiological criteria. The lethality rate was 20%. Multivariate analysis revealed an association between death and time elapsed from symptom onset.

Melanoma inhibitory activity in Brazilian patients with cutaneous melanoma.

BACKGROUND: Melanoma inhibitory activity is a protein secreted by melanoma cells and has been used as a tumor marker. Increased Melanoma inhibitory activity serum levels are related to metastatic disease or tumor recurrence. Currently there are no studies on Melanoma inhibitory activity and cutaneous melanoma involving Brazilian patients. OBJECTIVE: To evaluate the performance and feasibility of measuring Melanoma inhibitory activity levels in Brazilian patients with cutaneous melanoma. METHODS: Blood was obtained from ten patients with proved metastatic cutaneous melanoma (Group 1), 15 patients resected for cutaneous melanoma without metastasis (Group 2) and 5 healthy donors (Group 3). Melanoma inhibitory activity was measured using a commercially available ELISA kit. RESULTS: There was a statistically significant difference of Melanoma inhibitory activity levels between patients with and without metastasis (p=0.002), and between patients with metastasis and healthy donors (p=0.002). There was no difference between patients without metastasis and healthy donors (p=0.443). CONCLUSION: Melanoma inhibitory activity is a tumor marker for cutaneous melanoma and the Melanoma inhibitory activity-ELISA test can be easily performed. Patients with metastasis have increased Melanoma inhibitory activity serum levels when compared to patients without metastasis and healthy donors.

Survival and mortality among users and non-users of hydroxyurea with sickle cell disease.

OBJECTIVE: to estimate survival, mortality and cause of death among users or not of hydroxyurea with sickle cell disease. METHOD: cohort study with retrospective data collection, from 1980 to 2010 of patients receiving inpatient treatment in two Brazilian public hospitals. The survival probability was determined using the Kaplan-Meier estimator, survival calculations (SPSS version 10.0), comparison between survival curves, using the log rank method. The level of significance was p=0.05. RESULTS: of 63 patients, 87% had sickle cell anemia, with 39 using hydroxyurea, with a mean time of use of the drug of 20.0±10.0 years and a mean dose of 17.37±5.4 to 20.94±7.2 mg/kg/day, raising the fetal hemoglobin. In the comparison between those using hydroxyurea and those not, the survival curve was greater among the users (p=0.014). A total of 10 deaths occurred, with a mean age of 28.1 years old, and with Acute Respiratory Failure as the main cause. CONCLUSION: the survival curve is greater among the users of hydroxyurea. The results indicate the importance of the nurse incorporating therapeutic advances of hydroxyurea in her care actions.

Fatores associados ao peso ao nascer de crianças indígenas Terena, residentes na área urbana de Campo Grande, Mato Grosso do Sul, Brasil / Factors associated with birthweight of Terena indigenous children living in the urban area of Campo Grande, Mato Grosso do Sul State, Brazil / Factores asociados al peso al nacer de niños indígenas Terena, residentes en el área urbana de Campo Grande, Mato Grosso do Sul, Brasil

Resumo: O objetivo do estudo foi verificar a associação do peso ao nascer de crianças Terena, residentes na área urbana de Campo Grande, Mato Grosso do Sul, Brasil, com variáveis demográficas, socioeconômicas e de saúde, e descrever a frequência de baixo peso ao nascer. Os dados foram coletados em visitas domiciliares com formulários aplicados às mães e baseando-se em informações contidas nas Cadernetas da Gestante e da Criança. Foram incluídas todas as mulheres Terena que tiveram filhos nascidos vivos no período de 1º de junho de 2017 a 31 de julho de 2018 e residentes nas aldeias Água Bonita, Darcy Ribeiro, Marçal de Souza e Tarsila do Amaral. O peso ao nascer foi considerado desfecho e as variáveis demográficas, socioeconômicas e de saúde foram consideradas exposição. Participaram do estudo 43 mães e crianças. A frequência de baixo peso ao nascer foi de 2,3%. No modelo final, as crianças que residiam em domicílios com fossa séptica ou rudimentar apresentaram peso ao nascer menor quando comparadas às que residiam em domicílios com rede coletora de esgoto; e aquelas filhas de mães obesas antes da gestação apresentaram maior peso ao nascer quando comparadas às que nasceram de mães eutróficas segundo o índice de massa corporal pré-gestacional. Os dados buscam trazer à tona discussões sobre as condições de saúde e nutrição dessa importante parcela da população indígena que vive em áreas urbanas.

Abstract: The study aimed to verify the association between birthweight of Terena children living in the urban area of Campo Grande, Mato Grosso do Sul State, Brazil, and demographic, socioeconomic, and health variables and to describe the prevalence of low birthweight. Data were collective through home visits with a form completed with the mothers and based on records from the prenatal and neonatal cards. The sample included all the Terena women who gave birth to liveborn children from June 1, 2017, to July 31, 2018, and living in the Água Bonita, Darcy Ribeiro, Marçal de Souza, and Tarsila do Amaral villages. Birthweight was the outcome, and demographic, socioeconomic, and health characteristics were the exposure variables. A total of 43 mothers participated with their children. Low birthweight prevalence was 2.3%. In the final model, children living in households with makeshift cesspools showed lower birthweight when compared to those living in households connected to the public sewage disposal system, and daughters of mothers who were obese prior to the pregnancy presented higher birthweight than those born to normal weight mothers, according to pregestational body mass index. The data seek to contribute to discussions on the health and nutrition of this important share of the indigenous population that lives in urban areas.

Resumen: El objetivo del estudio fue verificar la asociación del peso al nacer de niños Terena, residentes en el área urbana de Campo Grande, Mato Grosso do Sul, Brasil, con variables demográficas, socioeconómicas y de salud, así como describir la frecuencia de bajo peso al nacer. Los datos se recogieron en visitas domiciliarias con formularios aplicados a las madres, y a partir de información que contenían los Cuadernillos de la Gestante y del Niño. Se incluyeron a todas las mujeres Terena que tuvieron hijos nacidos vivos, durante el período del 1 de junio de 2017 a 31 de julio de 2018, y residentes en las aldeas Água Bonita, Darcy Ribeiro, Marçal de Souza y Tarsila do Amaral. El peso al nacer se consideró un resultado y las variables demográficas, socioeconómicas y de salud se consideraron exposición. Participaron en el estudio 43 madres y niños. La frecuencia de bajo peso al nacer fue de un 2,3%. En el modelo final, los niños que residían en domicilios con fosa séptica o rudimentaria presentaron un peso al nacer menor, cuando se comparan con los que residían en domicilios con una red de alcantarillado; y aquellos hijos de madres obesas antes de la gestación presentaron un mayor peso al nacer, cuando se comparan con los que nacieron de madres eutróficas, según el índice de masa corporal pregestacional. Los datos pretenden plantear discusiones sobre condiciones de salud y nutrición de esta importante parte de la población indígena que vive en áreas urbanas.

[Incorporation of controlling dengue by community health agent]. / Incorporação do controle da dengue pelo agente comunitário de saúde.

The purpose of this study was to identify self-perceived differences in the work processes of community health agents (CHA) in two counties of Mato Grosso do Sul, regarding dengue control and Family Health Strategy (FHS) activities. Structured interviews were applied to 57 CHA. The subjects had similar sociodemographic characteristics. Agents in Rio Verde de Mato Grosso county, who performed only FHS tasks, failed to complete essential data of the Form A. In São Gabriel do Oeste county, CHA currently perform tasks pertaining to dengue fever control, previously conducted by Endemic Disease Control Agents (now abolished), while in Rio Verde de Mato Grosso county, dengue control remained assigned to the latter group. In São Gabriel do Oeste county, CHA did not view the double workload of two programs as affecting their professional productivity. The pooling of tasks from the two programs proved to be feasible, with no detrimental effects on performance.