Hybrid Nanofluids Flows Determined by a Permeable Power-Law Stretching/Shrinking Sheet Modulated by Orthogonal Surface Shear.

The present paper studies the flow and heat transfer of the hybrid nanofluids flows induced by a permeable power-law stretching/shrinking surface modulated orthogonal surface shear. The governing partial differential equations were converted into non-linear ordinary differential equations by using proper similarity transformations. These equations were then solved applying a numerical technique, namely bvp4c solver in MATLAB. Results of the flow field, temperature distribution, reduced skin friction coefficient and reduced Nusselt number were deduced. It was found that increasing mass flux parameter slows down the velocity and, hence, decreases the temperature. Furthermore, on enlarging the stretching parameter, the velocity and temperature increases and decreases, respectively. In addition, that the radiation parameter can effectively control the thermal boundary layer. Finally, the temperature decreases when the values of the temperature parameter increases. We apply similarity transformation in order to transform the governing model into a system of ODEs (ordinary differential equations). Numerical solutions for particular values of involved parameters are in very good agreement with previous calculations. The most important and interesting result of this paper is that for both the cases of shrinking and stretching sheet flows exhibit dual solutions in some intervals of the shrinking and stretching parameter. In spite of numerous published papers on the flow and heat transfer over a permeable stretching/shrinking surface in nanofluids and hybrid nanofluids, none of the researchers studied the present problem. Therefore, we believe that the results of the present paper are new, and have many industrial applications.

Granular aluminium as a superconducting material for high-impedance quantum circuits.

Superconducting quantum information processing machines are predominantly based on microwave circuits with relatively low characteristic impedance, about 100 Ω, and small anharmonicity, which can limit their coherence and logic gate fidelity1,2. A promising alternative is circuits based on so-called superinductors3-6, with characteristic impedances exceeding the resistance quantum RQ = 6.4 kΩ. However, previous implementations of superinductors, consisting of mesoscopic Josephson junction arrays7,8, can introduce unintended nonlinearity or parasitic resonant modes in the qubit vicinity, degrading its coherence. Here, we present a fluxonium qubit design based on a granular aluminium superinductor strip9-11. We show that granular aluminium can form an effective junction array with high kinetic inductance and be in situ integrated with standard aluminium circuit processing. The measured qubit coherence time [Formula: see text] illustrates the potential of granular aluminium for applications ranging from protected qubit designs to quantum-limited amplifiers and detectors.

Coherent suppression of electromagnetic dissipation due to superconducting quasiparticles.

Owing to the low-loss propagation of electromagnetic signals in superconductors, Josephson junctions constitute ideal building blocks for quantum memories, amplifiers, detectors and high-speed processing units, operating over a wide band of microwave frequencies. Nevertheless, although transport in superconducting wires is perfectly lossless for direct current, transport of radio-frequency signals can be dissipative in the presence of quasiparticle excitations above the superconducting gap. Moreover, the exact mechanism of this dissipation in Josephson junctions has never been fully resolved experimentally. In particular, Josephson's key theoretical prediction that quasiparticle dissipation should vanish in transport through a junction when the phase difference across the junction is π (ref. 2) has never been observed. This subtle effect can be understood as resulting from the destructive interference of two separate dissipative channels involving electron-like and hole-like quasiparticles. Here we report the experimental observation of this quantum coherent suppression of quasiparticle dissipation across a Josephson junction. As the average phase bias across the junction is swept through π, we measure an increase of more than one order of magnitude in the energy relaxation time of a superconducting artificial atom. This striking suppression of dissipation, despite the presence of lossy quasiparticle excitations above the superconducting gap, provides a powerful tool for minimizing decoherence in quantum electronic systems and could be directly exploited in quantum information experiments with superconducting quantum bits.

Loss Mechanisms and Quasiparticle Dynamics in Superconducting Microwave Resonators Made of Thin-Film Granular Aluminum.

Superconducting high kinetic inductance elements constitute a valuable resource for quantum circuit design and millimeter-wave detection. Granular aluminum (grAl) in the superconducting regime is a particularly interesting material since it has already shown a kinetic inductance in the range of nH/□ and its deposition is compatible with conventional Al/AlOx/Al Josephson junction fabrication. We characterize microwave resonators fabricated from grAl with a room temperature resistivity of 4×10^{3} µΩ cm, which is a factor of 3 below the superconductor to insulator transition, showing a kinetic inductance fraction close to unity. The measured internal quality factors are on the order of Q_{i}=10^{5} in the single photon regime, and we demonstrate that nonequilibrium quasiparticles (QPs) constitute the dominant loss mechanism. We extract QP relaxation times in the range of 1 s and we observe QP bursts every ∼20 s. The current level of coherence of grAl resonators makes them attractive for integration in quantum devices, while it also evidences the need to reduce the density of nonequilibrium QPs.

Attitude, knowledge and informed choice towards prenatal screening for Down Syndrome: a cross-sectional study.

BACKGROUND: Down Syndrome screening test is a bridge between knowledge and uncertainty, safety and risk, unpredictability and desire to know in order to gain control. It may be accepted either not to have a baby with Down syndrome, or to prepare to have a baby with this condition. Every woman should understand that it is an option and should be encouraged to make their own decisions based on information and personal values. The implications and possible subsequent scenarios differentiate this type of test from the common biochemical tests performed during pregnancy, of paramount importance being the right to make informed choices. The aim of this study was to investigate the knowledge and attitude towards prenatal Down syndrome screening in order to asses to what extent the Romanian women make informed choices in this area. METHODS: A cross-sectional study was carried out that included 530 postpartum women, clients of Romania' south-east region maternities, during April-September 2016. The level of knowledge and the attitude concerning the Down syndrome screening were evaluated using a questionnaire. Data were analyzed using SPSS version 20.0. RESULTS: 48.1% of the women have never heard about any tests for Down Syndrome and from those 51.9% who have heard, only 14.2% made an informed choice, 78.9% had a positive attitude for screening, 88% were classified as having insufficient knowledge and 68.3% made a value-consistent decision to accept or decline prenatal screening. A higher knowledge level was associated with a higher education level and the urban residence. The information satisfaction and confidence in the overall value of screening were predictive factors of positive attitude. More informed choices were made by women monitored by an obstetrician in a private practice. CONCLUSIONS: The prenatal screening tests for Down Syndrome were mostly unknown and the women who accepted or not to perform a test were insufficiently knowledgeable that means that the ethical concept of the informed choice wasn't followed. In our opinion the Romanian Health System needs to improve the antenatal policy by developing an adequate information strategy at the reproductive population level based on a network of trained specialists.

The relationship between factor V Leiden, prothrombin G20210A, and MTHFR mutations and the first major thrombotic episode in polycythemia vera and essential thrombocythemia.

Arterial and venous thrombosis are the most frequent complications in patients with polycythemia vera and essential thrombocythemia. We sought to demonstrate a possible contribution of the factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) 677 C > T and 1298 A > C mutations to the thrombotic risk in patients with polycythemia vera and essential thrombocythemia along with other biological features of these patients. We included 86 patients with polycythemia vera, of which 34 (39.5 %) had major thrombosis and 95 patients with essential thrombocythemia, of which 22 (23.1 %) had major thrombosis. In the whole cohort of patients, only the factor V Leiden mutation was significantly associated with both arterial and venous thrombosis in univariate and multivariate analysis (odds ratio (OR) = 4.3; 95 % confidence interval (CI) = 1.5-12.5; p = 0.008 and OR = 4.3; 95 % CI = 1.2-15.9; p = 0.02, respectively). Other factors significantly associated with thrombosis in both univariate and multivariate analysis were male sex (OR = 2.8, 95 % CI = 1.4-5.4, p = 0.002 and OR = 3.5, 95 % CI = 1.6-7.6, p = 0.002, respectively) and the JAK2 V617F mutation (OR = 5.5, 95 % CI = 2.1-15, p = 0.0001 and OR = 6.9, 95 % CI = 2.2-21.2, p = 0.001, respectively). In conclusion, among the four mutations analyzed (factor V Leiden, prothrombin G20210A, and MTHFR 677 C > T and 1298 A > C), only factor V Leiden is a major contributor to thrombosis in polycythemia vera and essential thrombocythemia.

Pyoderma Gangrenosum Post-Breast Surgery: A Case Report and Comprehensive Review of Management Strategies.

Background/Objectives: Pyoderma gangrenosum (PG) is a rare, autoimmune skin condition characterized by painful, rapidly progressing ulcers, often associated with autoimmune dysregulation. Managing PG following breast surgery presents unique challenges due to its pathergy phenomenon, which complicates surgical interventions. This article outlines the case of PG in a 48-year-old female post-breast surgery and reviews management strategies through a systematic analysis of the literature. Methods: A systematic literature review from 2018 to 2023 identified 24 relevant articles on PG management post-breast surgery. The studies were analyzed to compare the efficacy and complications of conservative versus combined (conservative and surgical) treatment strategies. Results: Results indicate that while conservative management, primarily with corticosteroids, remains preferred, combined strategies, including systemic therapies, vacuum-assisted closure, and surgery, offer significant benefits in select cases. Conclusions: Our findings suggest that a personalized, multifaceted treatment plan is crucial for managing PG effectively, emphasizing the need for early detection, meticulous planning, and comprehensive care to optimize patient outcomes.

Effect of Dietary Incorporation of Hemp Seeds Alone or with Dried Fruit Pomace on Laying Hens' Performance and on Lipid Composition and Oxidation Status of Egg Yolks.

The present study was conducted to investigate the effects of introducing hemp seeds, as a source of PUFAs, into a standard diet with or without dried fruit pomace (dried blackcurrant (DB) or dried rosehip (DR)), as a source of natural antioxidants, on the laying performance of hens and the FA profile, cholesterol level, antioxidant content, and lipid oxidative status in the yolks of fresh eggs or eggs stored at 4 °C for 28 days. The experiment used 128 Tetra SL hens at 35 weeks of age, which were divided into four groups and randomly assigned to four dietary treatments: a standard corn-wheat-soybean meal diet (C), standard diet containing 8% ground hemp seed (H), hemp seed diet containing 3% dried blackcurrant pomace (HB), and hemp seed diet containing 3% dried rosehip pomace (HR). The laying rate, feed conversion ratio (FCR), egg weight, and yolk weight were improved by the use of hemp seeds. The yolks of the H, HB, and HR eggs had a lower cholesterol (p ˂ 0.01) and SFA content, while the concentration of total and individual PUFAs (n-6 and n-3 FAs) was significantly higher (p ˂ 0.01) compared to C. In addition, the introduction of hemp seeds into the diets alone or with dried fruit pomace (DB or DR) led to increased (p ˂ 0.001) content of α-linolenic acid (ALA, 18:3n-3), eicosapentaenoic acid (EPA, 20:5n-3), and docosahexaenoic acid (DHA, 22:6n-3) and hypo-/hypercholesterolemic FA ratio and decreased arachidonic acid (AA, 20:4n-6) content, n-6/n-3 ratio, and thrombogenicity index (TI) compared to the control eggs. The introduction of dried fruit pomace (DB or DR) into the diets had no effect on the laying performance of the hens or the cholesterol content and FA profile of the egg yolks, compared to the diet supplemented only with hemp seeds. The dried fruit pomace improved the color, accumulation of antioxidants, and oxidative stability of fats in the yolks of the fresh eggs and eggs stored at 4 °C for 28 days. The DR was found to have the most desirable effects, producing the most intense color of egg yolks, the highest content of natural antioxidants, and the best oxidative stability of yolk lipids.

Observation of Josephson harmonics in tunnel junctions.

Approaches to developing large-scale superconducting quantum processors must cope with the numerous microscopic degrees of freedom that are ubiquitous in solid-state devices. State-of-the-art superconducting qubits employ aluminium oxide (AlOx) tunnel Josephson junctions as the sources of nonlinearity necessary to perform quantum operations. Analyses of these junctions typically assume an idealized, purely sinusoidal current-phase relation. However, this relation is expected to hold only in the limit of vanishingly low-transparency channels in the AlOx barrier. Here we show that the standard current-phase relation fails to accurately describe the energy spectra of transmon artificial atoms across various samples and laboratories. Instead, a mesoscopic model of tunnelling through an inhomogeneous AlOx barrier predicts percent-level contributions from higher Josephson harmonics. By including these in the transmon Hamiltonian, we obtain orders of magnitude better agreement between the computed and measured energy spectra. The presence and impact of Josephson harmonics has important implications for developing AlOx-based quantum technologies including quantum computers and parametric amplifiers. As an example, we show that engineered Josephson harmonics can reduce the charge dispersion and associated errors in transmon qubits by an order of magnitude while preserving their anharmonicity.

Relationship between VKORC1 single nucleotide polymorphism 1173C>T, bone mineral density & carotid intima-media thickness.

BACKGROUND & OBJECTIVES: The effects of vitamin K-dependent proteins in bone mineralization and vascular calcification and the implication of vitamin K epoxide reductase gene (VKORC1) 1173C>T polymorphism in warfarin sensitivity are well known. The main objective of the study was to investigate the relationship between VKORC1 1173C>T polymorphism, bone mineral density (BMD), and atherosclerosis (evaluated by intima-media thickness of the carotid artery and the presence of calcified plaques) in patients suspected to have osteoporosis or osteopenia and referred for BMD determination. METHODS: VKORC1 1173C>T polymorphism was evaluated in 239 consecutive patients referred by their physicians for BMD measurement (dual energy X-ray absorptiometry at L2-L4 lumbar spine, femoral neck and total hip). Ultrasonography of the carotid arteries was performed, intima-media thickness (IMT) was measured and the presence of atherosclerotic calcified plaques was recorded. RESULTS: In the patients with osteoporosis and osteopenia there was a higher frequency of TT genotype of VKORC1 1173C>T (P=0.04). The TT genotype was significantly more frequent in the osteoporotic group compared to the osteopenic group (P=0.01). The mean age and body mass index were lower in the patients with normal BMD and TT genotype (P=0.02, P=0.03). There was no correlation between the IMT and VKORC1 1173C>T genotype but the TT genotype had a significant association with the presence of calcified atherosclerotic plaques (P=0.05). This finding was not correlated with normal or pathologic BMD. INTERPRETATION & CONCLUSIONS: VKORC1 1173C>T polymorphism (TT genotype) was associated with osteoporosis and calcified plaques in the carotid artery in patients referred for BMD measurement. Different mechanisms are probably involved in these associations. TT genotype may serve as a potential genetic marker for the risk of OP and ATS.

Heat transfer characteristics of magnetized hybrid ferrofluid flow over a permeable moving surface with viscous dissipation effect.

Hybrid ferrofluid is a unique heat transfer fluid because it can be magnetically controlled and ideal in various applications. Further exploration to unleash its potential through studying heat transfer and boundary layer flow is crucial, especially in solving the thermal efficiency problem. Hence, this research focuses on the numerical examination of flow behaviour and heat transfer attributes of magnetized hybrid ferrofluid Fe3O4-CoFe2O4/water across a permeable moving surface considering the mutual effects of magnetohydrodynamic (MHD), viscous dissipation, and suction/injection. The problem was represented by the Tiwari and Das model with duo magnetic nanoparticle hybridization; magnetite Fe3O4 and cobalt ferrite CoFe2O4 immersed in water. The governing equations were transformed into ordinary differential equations using appropriate similarity variables and solved with bvp4c MATLAB. A dual solution is obtained, and via stability analysis, the first solution is stable and physically reliable. The significant influence of governing effects on the temperature and velocity profiles, the local skin friction coefficient and the local Nusselt number are analyzed and visually shown. The surge-up value of suction and CoFe2O4 ferroparticle volume concentration enhances the local skin friction coefficient and heat transfer rate. Additionally, the magnetic parameter and Eckert number reduced the heat transfer. Using a 1% volume fraction of Fe3O4 and CoFe2O4; the hybrid ferrofluid's convective heat transfer rate was shown to be superior to mono-ferrofluid and water by enhancing 2.75% and 6.91%, respectively. This present study also suggests implying a greater volume concentration of CoFe2O4 and lessening the magnetic intensity to maintain the laminar flow phase.

Viscous dissipation effects on hybrid nanofluid flow over a non-linearly shrinking sheet with power-law velocity.

This research intends to investigate the effect of the nonlinearity of the surface velocity on the hybrid nanofluid flow behavior. Here, the total composition of Al2O3 (alumina) as well as Cu (copper) volume fractions, are implemented in a one-to-one ratio and then dispersed in water. The similarity equations are gained employing a similarity transformation, which is programmed in MATLAB software. The dual solutions are attainable for certain ranges with respect to the mass flux parameter S and the power-law index n. Also, the turning point occurs in the region of S<0 and n>1. Besides, the rise of n led to reduce the skin friction as well as the heat transfer coefficients with 39.44 % and 11.71 % reduction, respectively. Moreover, 14.39 % reduction of the heat transfer rate is observed in the presence of viscous dissipation (Eckert number). It is found that only the first solution is stable as time progresses. Generally, this study gives scientists and engineers a starting point for predicting how to control the parameters to achieve the best results for relevant practical applications.

Heat transfer analysis of buoyancy opposing radiated flow of alumina nanoparticles scattered in water-based fluid past a vertical cylinder.

Cooling and heating are two critical processes in the transportation and manufacturing industries. Fluid solutions containing metal nanoparticles have higher thermal conductivity than conventional fluids, allowing for more effective cooling. Thus, the current paper is a comparative exploration of the time-independent buoyancy opposing and heat transfer flow of alumina nanoparticles scattered in water as a regular fluid induced via a vertical cylinder with mutual effect of stagnation-point and radiation. Based on some reasonable assumptions, the model of nonlinear equations is developed and then tackled numerically employing the built-in bvp4c MATLAB solver. The impacts of assorted control parameters on gradients are investigated. The outcomes divulge that the aspect of friction factor and heat transport upsurge by incorporating alumina nanoparticles. The involvement of the radiation parameter shows an increasing tendency in the heat transfer rate, resulting in an enhancement in thermal flow efficacy. In addition, the temperature distribution uplifts due to radiation and curvature parameters. It is discerned that the branch of dual outcomes exists in the opposing flow case. Moreover, for higher values of the nanoparticle volume fraction, the reduced shear stress and the reduced heat transfer rate increased respectively by almost 1.30% and 0.0031% for the solution of the first branch, while nearly 1.24%, and 3.13% for the lower branch solution.

Stability analysis for heat transfer flow in micropolar hybrid nanofluids.

Objective: hybrid nanofluids have superior thermal efficiency and physical durability in contrast to regular nanofluids. The stagnation point flow of MHD micropolar hybrid nanofluids over a deformable sheet with viscous dissipation is investigated. Methodology: the controlling partial differential equations are converted to nonlinear ordinary differential equations using the transmuted similarity, and are subsequently solved using the bvp4c solver in MATLAB. The hybrid nanofluids consist of aluminum and copper nanoparticles, dispersed in a base fluid of water. Results: multiple solutions are obtained in the given problem for the case of shrinking as well as for the stretching sheet due to the variation in several influential parameters. Non-unique solutions, generally, exist for the case of shrinking sheets. In addition, the first branch solution is physically stable and acceptable according to the stability analysis. The friction factor is higher for the branch of the first solution and lower in the second branch due to the higher magnetic parameters, while the opposite behavior is seen in the case of the local heat transfer rate. Originality: the novelty of this model is that it finds multiple solutions in the presence of Cu and Al2O3 nanoparticles and also performs the stability analysis. In general, non-unique solutions exist for the phenomenon of shrinking sheets.

Microwave characterization of Josephson junction arrays: implementing a low loss superinductance.

We have measured the plasma resonances of an array of Josephson junctions in the regime E(J)>>E(C), up to the ninth harmonic by incorporating it as part of a resonator capacitively coupled to a coplanar waveguide. From the characteristics of the resonances, we infer the successful implementation of a superinductance, an electrical element with a nondissipative impedance greater than the resistance quantum [R(Q)=h/(2e)(2) is approximately equal to 6.5 kΩ] at microwave frequencies. Such an element is crucial for preserving the quantum coherence in circuits exploiting large fluctuations of the superconducting phase. Our results show internal losses less than 20 ppm, self-resonant frequencies greater than 10 GHz, and phase-slip rates less than 1 mHz, enabling direct application of such arrays for quantum information and metrology. Arrays with a loop geometry also demonstrate a new manifestation of flux quantization in a dispersive analog of the Little-Parks effect.

Stability Analysis of Unsteady Hybrid Nanofluid Flow over the Falkner-Skan Wedge.

Numerous manufacturing processes, including the drawing of plastic films, have a major impact on mass transport. These functionalities necessitate the solution of the Falkner-Skan equation and some of its configurations when applied to various geometries and boundary conditions. Hence, the current paper discusses the impact of unsteady hybrid nanofluid flow on a moving Falkner-Skan wedge with a convective boundary condition. This problem is modeled by partial differential equations, which are then converted into ordinary (similar) differential equations using appropriate similarity transformations. The bvp4c technique in MATLAB solves these ordinary differential equations numerically. Since more than one solution is possible in this paper, stability analysis is conducted. Thus, it is found that only one stable solution is identified as reliable (physically realizable in practice). The skin friction coefficient and heat transfer rate, along with the velocity and temperature profile distributions, are examined to determine the values of several parameters. The findings reveal that dual-type nanoparticles and wedge angle parameters improve thermal efficiency. A lower value of the unsteadiness parameter reduces the efficiency of hybrid nanofluids in terms of heat transfer and skin friction coefficient, whereas increasing the Biot number of the working fluid does not affect the critical point in the current analysis.

The Impact of Thermal Radiation on Maxwell Hybrid Nanofluids in the Stagnation Region.

Previous research has recognised the study of stagnation point flow by focusing Maxwell nanofluid on a stretching sheet surface. Motivated by this research idea, our main objective is to formulate and analyse a new mathematical model of stagnation point flow in Maxwell fluid that highlights the dual types of fluid known as hybrid nanofluids. The effects of thermal radiation and heat transfer are also considered. The partial differential equations (PDEs) are converted into ordinary differential equations (ODEs) via similarity variables that generate similarity solutions. Following that, the bvp4c approach is employed to discover the approximate solutions of the reduced ODEs. The significance of various parameters is graphically presented and considers the physical quantities of interest. A remarkable observation found in this study is the enhancement of the heat transfer rate in Maxwell hybrid nanofluids, which is steadily amplified in contrast to traditional fluids. Indeed, the Maxwell parameter in hybrid nanofluids embarks on a substantial increment of the heat transfer rate. The current study succeeds in establishing more than one solution along the stretching/shrinking sheet. Thus, the stability analysis is conducted to confirm the sustainability of the solutions.

Prenatal screening for Down syndrome: popularity, perceptions and factors associated with acceptance or refusal of testing.

BACKGROUND: Prenatal screening tests for aneuploidies have become increasingly used in maternal and fetal medicine. Given that all pregnancies associate a potential risk of Down syndrome, adequate knowledge of the tests, and their characteristics as well as facilitating decision-making autonomy are fundamental rights that must be respected. OBJECTIVES: Identification of the popularity of the tests, their perception and the factors associated with the acceptance or refusal to perform them. METHODS: A cross-sectional study was carried out in the South-East region of Romania, between April and September 2016. The data were collected from 275 postpartum women. The instrument used was a self-administered questionnaire and the data obtained were processed using the IBM SPSS 20.0 statistical software (IBM Corp., Armonk, NY, USA). The normality of the distribution was analyzed with Chi-square, Kolmogorov-Smirnov and Shapiro-Wilk tests. Factorial Analysis was carried out for the Principal Components of the scales for the reasons for performing and not performing. RESULTS: The 2nd Trimester Morphology had the popularity as well as the highest rate of accomplishment (98.2% respectively 67.6%) among the investigated women. It is also the preferred recommendation of the specialists (81.1%). The least popular test was the TPNI, only 13.1% of the participants heard about it, as it was recommended in only 2% of the situations. Most of the participants perceived the screening tests as essential and useful, but 43.3% considered that they become mandatory if the doctor recommends them. The acceptance of the child with DS and the misperception of the risk were the main factors associated with the refusal of the test and the compliance with the recommendation of the specialist (system confidence), and social influence (non-acceptance of the Down syndrome by the society) were the main factors associated with the acceptance. CONCLUSIONS: The number of women who made the decision to accept the test was greater than the ones who refused. The amendment is that acceptance was based on the custom of socio-economic-medical compliance and responsibility. For many women, the motivation of acceptance meant alignment with the normality directed by the society and the system. Even the popularity of the tests carries the imprint of the beliefs and values of the system and the specialists involved. For an adequate perception and an autonomous and informed choice of women, the screening program must include adequate information and communication services by involving specialists responsible for multidisciplinary competencies. The percentage of completion and the type of test performed almost perfectly align with the recommendations received.

Lateral sinus thrombosis in a young patient with sudden neurosensorial hearing loss and genetic thrombophilia: A case report.

Sensorineural hearing loss (SSHL) with a sudden onset is frequently encountered as a medical emergency in the ear, nose and throat (ENT) practice. The exact pathophysiology of the disease remains unknown, with the most likely etiologies being viral infection, inflammation, drug toxicity, trauma, or autoimmune response. Even though thrombophilia and cerebrovascular complications may lead, among others, to sudden neurosensorial hearing loss, its diagnosis is most often made following the onset of thrombotic complications. A case of a young female patient with unknown congenital hypercoagulation status complicated with lateral sinus thrombosis and unilateral drug-induced reversible hearing loss is presented. Molecular testing confirmed the diagnosis of genetic thrombophilia, due to the homozygous V Leiden, homozygous MTHFR A1298C, and heterozygous MTHFR C677T mutations. Although hereditary thrombophilia is a well-known topic in medical practice, current guidelines require continuous improvement, especially among patients treated in departments where this pathology is more difficult to recognize and manage.

Time-Dependent Flow of Water-Based CoFe2O4-Mn-ZnFe2O4 Nanoparticles over a Shrinking Sheet with Mass Transfer Effect in Porous Media.

The use of hybrid nanoparticles to increase heat transfer is a favorable area of research, and therefore, numerous scientists, researchers, and scholars have expressed their appreciation for and interest in this field. Determining the dynamic role of nanofluids in the cooling of microscopic electronic gadgets, such as microchips and related devices, is also one of the fundamental tasks. With such interesting and useful applications of hybrid nanofluids in mind, the main objective is to deal with the analysis of the unsteady flow towards a shrinking sheet in a water-based hybrid ferrite nanoparticle in porous media, with heat sink/source effects. Moreover, the impact of these parameters on heat and mass transfers is also reported. Numerical results are obtained using MATLAB software. Non-unique solutions are determined for a certain shrinking strength, in addition to the unsteadiness parameter. The mass transfer and friction factor increase for the first solution due to the hybrid nanoparticles, but the heat transfer rate shows the opposite effect.