Crisis responses, opportunity, and public authority during Covid-19's first wave in Uganda, the Democratic Republic of Congo, and South Sudan.

Discussions on African responses to Covid-19 have focused on the state and its international backers. Far less is known about a wider range of public authorities, including chiefs, humanitarians, criminal gangs, and armed groups. This paper investigates how the pandemic provided opportunities for claims to and contests over power in Uganda, the Democratic Republic of the Congo, and South Sudan. Ethnographic research is used to contend that local forms of public authority can be akin to miniature sovereigns, able to interpret dictates, policies, and advice as required. Alongside coping with existing complex protracted emergencies, many try to advance their own agendas and secure benefits. Those they seek to govern, though, do not passively accept the new normal, instead often challenging those in positions of influence. This paper assesses which of these actions and reactions will have lasting effects on local notions of statehood and argues for a public authorities lens in times of crisis.

Resilient patriarchy: public authority and women's (in)security in Karamoja, Uganda.

This paper draws on fieldwork conducted in 2011 and 2016 to explore the differing experiences of Karamojong women following the Government of Uganda's most recent disarmament programme. Besides being deprived of their guns, Karamojong communities have lost most of the cattle on which their livelihoods and way of life were centred. The study assesses whether or not women's experience of patriarchy has changed in these new circumstances, and, if so, how this impacts on their security and control of resources, or the absence of them. It maps, using information primarily supplied by women, public authorities from below, and evaluates if and how they respond to women's protection and survival needs, as well as if current development/humanitarian interventions are of sustainable benefit to Karamojong women. The paper concludes that apparent shifts in gender relations are probably superficial, contingent on continuing food aid, and that economic development and positive social change for women remain elusive.

Gender, sexuality, and violence in humanitarian crises.

Gender, sexuality, and violence have attracted significant attention in the sphere of humanitarianism in recent years. While this shift builds on the earlier 'Gender and Development' approach and the 'Women, Peace, and Security Agenda', analytical depth is lacking in practice. Notably, 'gender' often means a singular concern for women, neglecting questions of agency and the dynamic and changing realities of gendered power relations. This introductory paper examines why this neglect occurs and proposes a more relational approach to gender. It explores how the contributions to this special issue of Disasters revisit classic gender issues pertaining to violence, livelihoods, and institutions in different settings of humanitarian emergencies, while expanding one's vision beyond them. It draws from the seven papers a number of lessons for humanitarianism, concerning the entangled nature of gender relations, the risks of the unintended effects of gender programming, and the importance of paying sustained attention to how gender relations unfold in a time of crisis.

Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death.

The adapters IRS1 and IRS2 link growth factor receptors to downstream signaling pathways that regulate proliferation and survival. Both suppress factor-withdrawal-induced apoptosis and have been implicated in cancer progression. However, recent studies suggest IRS1 and IRS2 mediate differential functions in cancer pathogenesis. IRS1 promoted breast cancer proliferation, while IRS2 promoted metastasis. The role of IRS1 and IRS2 in controlling cell responses to chemotherapy is unknown. To determine the role of IRS1 and IRS2 in the sensitivity of cells to chemotherapy, we treated 32D cells lacking or expressing IRS proteins with various concentrations of chemotherapeutic agents. We found that expression of IRS1, in contrast to IRS2, enhanced the sensitivity of 32D cells to chemotherapy-induced apoptosis. When IRS2 was expressed with IRS1, the cells no longer showed enhanced sensitivity. Expression of IRS1 did not alter the expression of pro- and anti-apoptotic proteins; however, 32D-IRS1 cells expressed higher levels of Annexin A2. In 32D-IRS1 cells, IRS1 and Annexin A2 were both located in cytoplasmic and membrane fractions. We also found that IRS1 coprecipitated with Annexin A2, while IRS2 did not. Decreasing Annexin A2 levels reduced 32D-IRS1 cell sensitivity to chemotherapy. These results suggest IRS1 enhances sensitivity to chemotherapy in part through Annexin A2.

The Partner Relay Communication Network: Sharing Information During Emergencies with Limited English Proficient Populations.

Sharing information with people with limited English proficiency is a universal challenge. The County of San Diego has a diverse population and, as a result, language and access barriers present serious risks when communicating disaster and public health emergency information. In support of the "Live Well San Diego" vision of a county that is healthy, safe, and thriving, the County of San Diego Office of Emergency Services and Health and Human Services Agency, Public Health Services, worked to design a community-based program to address this critical issue. Program development included a literature review of existing strategies as well as gathering community input. Documented promising practices included: (1) community engagement during planning, design, and implementation of communication plans to create buy-in and a sense of ownership; (2) dissemination of translated messages; and (3) communication through culturally appropriate and trusted channels, including individuals, community groups, and organizations. Using a systematic approach, the program engaged leaders and community representatives of the top 6 languages spoken in San Diego (following English)-Spanish, Tagalog, Chinese, Arabic, Korean, and Vietnamese-and 2 recently arrived refugee groups, Karen and Somali. Community input was gathered through focus groups, feedback sessions, training sessions, and drills. The community's recommendations mirrored the existing promising practices, and a program strategy was adopted.

IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors.

Insulin receptor substrate (IRS) proteins have been shown to play an important role in breast cancer by differentially regulating cancer cell survival, proliferation, and motility. Furthermore, the IL-4-induced tyrosine phosphorylation of the transcription factor STAT6 was shown to protect breast cancer cells from apoptosis. Here, we analyzed human breast cancer tissues for the expression of IRS1, IRS2, STAT6, and tyrosine phosphorylated STAT6 (pSTAT6). We found that IRS1 and pSTAT6 were both highly expressed in ductal carcinoma in situ (DCIS). On the other hand, IRS2 expression was low in DCIS, but increased significantly in relation to tumor invasiveness. We utilized cell lines with disparate IRS1 expression, MDA-MB-231, MCF7, and MCF7 cells with depleted IRS1 due to shRNA lentiviral infection, to examine the role of IRS1 and IRS2 in the responsiveness of breast cancer cells to chemotherapy. We report that high IRS1 sensitized MCF7 cells to specific chemotherapeutic agents. These results suggest that high IRS1 with low IRS2 expression may predict the effectiveness of specific types of chemotherapy in breast cancer.