Intracutaneous cornifying epithelioma (keratoacanthoma) in the dog: a retrospective study of 25 cases.

The clinical, histopathologic, and behavioral features of 25 cases of intracutaneous cornifying epithelioma (ICE) in the dog were reviewed. A typical ICE consisted of a keratin-filled crypt in the dermis and subcutis that opened to the skin surface. Most of these tumors occurred on the back, neck, sides of the thorax, and the shoulders. Two distinct patterns existed-a solitary form (single growth) and a generalized form (up to 40 growths). The Norwegian Elkhound appeared to be a breed predisposed to the development of the generalized type. Breed predilection for the solitary form was not observed. The ICE was a benign neoplasm, and simple surgical excision was curative except in the generalized cases in which additional growths developed. Keratoacanthoma of man and ICE of the dog were compared, and it was concluded that although they are similar in many respects they are not identical entities.

Anatrichosoma infection in two white-handed gibbons.

Multiple nodular lesions of the nematode Anatrichosoma were observed on the ears, lips, nares, and eyelids of 2 adult gibbons (Hylobates lar). The lesions were 4 to 7 mm in diameter, gray to pink, and firm on palpation. Microscopically, the nodules consisted of thickened epidermis having intraepidermal cysts containing the nematode and eggs. Live female nematodes were recovered from fresh biopsy specimens. Because male specimens were not obtained, the species could not be identified.

Oral eosinophilic granuloma in Siberian husky dogs.

Oral eosinophilic granuloma in 6 young Siberian Husky dogs was characterized by involvement of lateral and ventral surfaces of the tongue. Histologically, the major change was degenerated (necrobiotic) collagen. Although the cause of the disease is unknown, hereditary and immunologic factors are implicated in the pathogenesis.

Detrusor myopathy in young beagle dogs.

Hematoxylin and eosin-stained sections of urinary bladder were examined microscopically from 449 male and female beagle dogs after 2- to 4-week toxicology studies. Degenerative lesions (detrusor myopathy) of the urinary bladder muscular tunic were present in 59 of 449 (13%) dogs. Myopathic lesions consisted of focal to multifocal areas of smooth muscle fiber atrophy with cytoplasmic basophilia and vacuolation, individual cell necrosis, enlarged smooth muscle nuclei and nucleoli, and occasional mitotic figures. Adjacent areas of arteritis and periarteritis were present in 10 of 59 (17%) beagles with detrusor myopathy suggesting a possible ischemic pathogenesis of the smooth muscle lesions. There was no significant difference in prevalence of myopathy in beagles administered vehicle or various test compounds. Prior urinary catheterization procedures appeared to augment the prevalence of myopathy; some lesions were adjacent to minor, iatrogenically traumatized urinary bladder mucosa. Muscle lesions were not observed in urinary bladders from mongrel dogs, monkeys, cats, rats, or microswine. When compared to crossbred dogs and other laboratory species, the beagle dog thus appears to be sensitive to development of detrusor myopathy.