Detalles de la búsqueda
1.
Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates.
Chem Soc Rev
; 53(4): 2099-2210, 2024 Feb 19.
Artículo
Inglés
| MEDLINE | ID: mdl-38226865
2.
Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates.
Mol Pharm
; 20(1): 206-218, 2023 01 02.
Artículo
Inglés
| MEDLINE | ID: mdl-36394563
3.
Sweet Battle of the EpimersâContinued Exploration of Monosaccharide-Derived Delivery Agents for Boron Neutron Capture Therapy.
Mol Pharm
; 20(6): 3127-3139, 2023 06 05.
Artículo
Inglés
| MEDLINE | ID: mdl-37134022
4.
Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma.
Int J Mol Sci
; 23(15)2022 Jul 30.
Artículo
Inglés
| MEDLINE | ID: mdl-35955600
5.
Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates.
Mol Pharm
; 18(1): 285-304, 2021 01 04.
Artículo
Inglés
| MEDLINE | ID: mdl-33390018
6.
Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation.
Bioorg Chem
; 112: 104921, 2021 07.
Artículo
Inglés
| MEDLINE | ID: mdl-33933805
7.
Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing.
Mol Pharm
; 17(6): 1945-1953, 2020 06 01.
Artículo
Inglés
| MEDLINE | ID: mdl-32320251
8.
Addressing the Biochemical Foundations of a Glucose-Based "Trojan Horse"-Strategy to Boron Neutron Capture Therapy: From Chemical Synthesis to In Vitro Assessment.
Mol Pharm
; 17(10): 3885-3899, 2020 10 05.
Artículo
Inglés
| MEDLINE | ID: mdl-32787269
9.
Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7.
Int J Mol Sci
; 21(6)2020 Mar 20.
Artículo
Inglés
| MEDLINE | ID: mdl-32244913
10.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.
Molecules
; 25(13)2020 Jun 28.
Artículo
Inglés
| MEDLINE | ID: mdl-32605268
11.
Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells.
Molecules
; 24(21)2019 Oct 27.
Artículo
Inglés
| MEDLINE | ID: mdl-31717859
12.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.
Molecules
; 24(13)2019 Jun 30.
Artículo
Inglés
| MEDLINE | ID: mdl-31262039
13.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.
Molecules
; 25(1)2019 Dec 28.
Artículo
Inglés
| MEDLINE | ID: mdl-31905602
14.
Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug.
Bioorg Med Chem Lett
; 28(17): 2856-2860, 2018 09 15.
Artículo
Inglés
| MEDLINE | ID: mdl-30055889
15.
Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase.
Bioorg Chem
; 80: 655-667, 2018 10.
Artículo
Inglés
| MEDLINE | ID: mdl-30059891
16.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopesâ»4.
Molecules
; 24(1)2018 Dec 31.
Artículo
Inglés
| MEDLINE | ID: mdl-30602690
17.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.
Molecules
; 23(1)2017 Dec 28.
Artículo
Inglés
| MEDLINE | ID: mdl-29283400
18.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes.
Molecules
; 22(5)2017 May 05.
Artículo
Inglés
| MEDLINE | ID: mdl-28475136
19.
Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure.
Neurochem Res
; 41(10): 2797-2809, 2016 Oct.
Artículo
Inglés
| MEDLINE | ID: mdl-27412117
20.
Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.
Bioorg Med Chem
; 24(21): 5481-5494, 2016 11 01.
Artículo
Inglés
| MEDLINE | ID: mdl-27647366