[Immunology of non-Hodgkin lymphomas]. / Immunologia dei linfomi non Hodgkin.

Cytological and kinetic immunological homogeneity is typical of such lymphomas. Their cytogenesis is broadly connected to the development and differentiation of lymphocytes. It is mainly a question of proliferating B lymphocytes of which the monoclonal membrane receptors are tumoral markers. The final stage of B lymphocyte differentiation is the lymphoplasmacellular proliferation involving monoclonal Ig secretion and consequently the rarefaction and finally disappearance of surface receptors.

[Unusual clinical aspects of 3 cases of primary humoral immunodeficiency]. / Aspetti clinici peculiari di tre casi di immunodeficienze primitive umorali.

The clinical behaviour of three patients with primary antibody deficiencies was studied. Two of three were affected by X-linked agammaglobulinemia and one by common variable hypogammaglobulinemia that, besides clinical features common to most of the immunodeficiencies, showed pre-existent physiopathologic conditions completely different from the features traditionally found in primary antibody deficiencies. Moreover, the development of some immunologic parameters (monoclonal antibody analysis, surface markers and electrophoretic mobility of lymphocytes) has been carefully checked in these patients after immunotherapy by intravenous infusion of immunoglobulins. The lymphocyte electrophoretic mobility underlines how peripheral blood lymphocytes, faster than those normally controlled before therapy, normalized their velocity after immunotherapy.