Support Vector Machine as a Supervised Learning for the Prioritization of Novel Potential SARS-CoV-2 Main Protease Inhibitors.

In the last year, the COVID-19 pandemic has highly affected the lifestyle of the world population, encouraging the scientific community towards a great effort on studying the infection molecular mechanisms. Several vaccine formulations are nowadays available and helping to reach immunity. Nevertheless, there is a growing interest towards the development of novel anti-covid drugs. In this scenario, the main protease (Mpro) represents an appealing target, being the enzyme responsible for the cleavage of polypeptides during the viral genome transcription. With the aim of sharing new insights for the design of novel Mpro inhibitors, our research group developed a machine learning approach using the support vector machine (SVM) classification. Starting from a dataset of two million commercially available compounds, the model was able to classify two hundred novel chemo-types as potentially active against the viral protease. The compounds labelled as actives by SVM were next evaluated through consensus docking studies on two PDB structures and their binding mode was compared to well-known protease inhibitors. The best five compounds selected by consensus docking were then submitted to molecular dynamics to deepen binding interactions stability. Of note, the compounds selected via SVM retrieved all the most important interactions known in the literature.

[Effects of human disturbance on the population dynamics of Ocypode quadrata (Decapoda: Ocypodidae) in beaches of the Mexican Caribbean]. / Efectos del disturbio humano sobre la dinámica poblacional de Ocypode quadrata (Decapoda: Ocypodidae) en playas del Caribe mexicano.

The ghost crab Ocypode quadrata is a relevant species in the Western Atlantic beaches, and has been proposed as an indicator of human impact in these ecosystems. Eventhough some studies have covered various aspects of its natural history, no evaluations on the effects of human disturbance on its population dynamics have been made. This work compared the abundance, growth, and mortality of O. quadrata in two disturbed beaches (Aventuras and Majahual) and two preserved beaches (Xcacel and Puerto Angel) from the Mexican Caribbean. For this, nine samplings were made on each beach (every two to three months) between March 2013 and November 2014. Crabs were collected manually by three people, during the night first hours and for one hour, and a total area of 9 000 m2 per beach. The crabs were measured, weighed, and separated into three groups: juvenile, male and female; while abundance was estimated by the number of collected crabs, and growth parameters were estimated using length frequencies. A total of 1 047 crabs were sampled in the four beaches; a higher crab abundance was found in the preserved beaches, but significant differences were only found between Puerto Angel and Majahual (Tukey, p<0.05). The adult-juvenile ratio was 1:1 in Xcacel and Aventuras, while in Majahual, more juveniles than adults were collected; and Puerto Angel had more adults than the juveniles. The size structure at Xcacel ranged from 4-32 mm, but in the rest of the beaches the minimum size was 5 mm. The maximum size at Aventuras, Majahual and Puerto Angel were 27 mm, 25 mm and 30 mm, respectively. The modal progression analysis of length's pooled data, revealed the presence of at least two groups of ages in all beaches. For all beaches, individuals smaller than 10 mm length were collected in almost all sampling months, indicating a continuous recruitment throughout the year. The length-weight relationship of the ghost crab was found isometric in the two preserved beaches, and negative allometric at the two impacted beaches. Crabs from Puerto Angel showed the highest body condition (Tukey, p<0.05). K-values ranged from 0.6-0.97/year and L∞ from 29.0 mm to 33.6 mm with higher values for the two preserved beaches. The highest mortality values were found in Xcacel and Aventuras. In the disturbed beaches, the destruction of the dunes, the mechanical cleaning and the removal of organic matter, seem to be the main causes that lead to a low abundance of crabs, their slower growth and higher mortalities. However, in the best preserved beaches, biological interactions appear to be the most important aspects in regulating the population dynamics of this species. These results supported the information that the ghost crab is a good indicator of human disturbance, and its population changes were clearly measurable and comparable among protected and impacted beaches; these results are also relevant for the management of sandy beaches in the Mexican Caribbean.

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA).

DOCUMENT REVIEWERS: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis (Greece), Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine (Turkey), Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering (Poland), Sang Hyun Ihm (South Korea), Uday Jadhav (India), Manolis Kallistratos (Greece), Kazuomi Kario (Japan), Vasilios Kotsis (Greece), Adi Leiba (Israel), Patricio López-Jaramillo (Colombia), Hans-Peter Marti (Norway), Terry McCormack (UK), Paolo Mulatero (Italy), Dike B. Ojji (Nigeria), Sungha Park (South Korea), Priit Pauklin (Estonia), Sabine Perl (Austria), Arman Postadzhian (Bulgaria), Aleksander Prejbisz (Poland), Venkata Ram (India), Ramiro Sanchez (Argentina), Markus Schlaich (Australia), Alta Schutte (Australia), Cristina Sierra (Spain), Sekib Sokolovic (Bosnia and Herzegovina), Jonas Spaak (Sweden), Dimitrios Terentes-Printzios (Greece), Bruno Trimarco (Italy), Thomas Unger (The Netherlands), Bert-Jan van den Born (The Netherlands), Anna Vachulova (Slovak Republic), Agostino Virdis (Italy), Jiguang Wang (China), Ulrich Wenzel (Germany), Paul Whelton (USA), Jiri Widimsky (Czech Republic), Jacek Wolf (Poland), Grégoire Wuerzner (Switzerland), Eugene Yang (USA), Yuqing Zhang (China).

Barriers and Proposed Solutions to a Successful Implementation of Pediatric Sepsis Protocols.

The implementation of managed protocols contributes to a systematized approach to the patient and continuous evaluation of results, focusing on improving clinical practice, early diagnosis, treatment, and outcomes. Advantages to the adoption of a pediatric sepsis recognition and treatment protocol include: a reduction in time to start fluid and antibiotic administration, decreased kidney dysfunction and organ dysfunction, reduction in length of stay, and even a decrease on mortality. Barriers are: absence of a written protocol, parental knowledge, early diagnosis by healthcare professionals, venous access, availability of antimicrobials and vasoactive drugs, conditions of work, engagement of healthcare professionals. There are challenges in low-middle-income countries (LMIC). The causes of sepsis and resources differ from high-income countries. Viral agent such as dengue, malaria are common in LMIC and initial approach differ from bacterial infections. Some authors found increased or no impact in mortality or increased length of stay associated with the implementation of the SCC sepsis bundle which reinforces the importance of adapting it to most frequent diseases, disposable resources, and characteristics of healthcare professionals. Conclusions: (1) be simple; (2) be precise; (3) education; (5) improve communication; (5) work as a team; (6) share and celebrate results.

Agronomic assessment of 32 sour passionfruit genotypes in federal district

The production of passion fruit is important in Brazil. In order to contribute to the development of the most promising cultivars of passion fruit, this study aimed to evaluate the agronomic performance of 32 genotypes of passion fruit in Federal District of Brazil, and to estimate genetic parameters for use in breeding programs. Thirty-two genotypes were used in a randomized block design, with eight plants per plot and four replications. The experiment was conducted in field. Twenty-eight harvests were performed, and the variables analyzed were: productivity estimated, total number of fruits per hectare, average fruit weight and these characteristics following classification of fruits in five categories. The genotypes that presented the highest total yield estimated were MAR20 # 23, AR 01 and PLANTA 7. For industrial purposes, genotypes MAR 20 # 21 and BRS Gigante Amarelo were superior. For fresh consumption, the genotypes with the best performance were PLANT 7, AR 01 and MSC. Total productivity estimated and total number of fruits per hectare in the first-class classification showed high values of heritability and CVg/CVe ratio. These results indicate a favorable condition for selection.

Resistance to diseases of sour, sweet and wild passion fruit genotypes

The cultivation of passion fruit is important for Brazil, since the country is currently the largest producer and consumer of fruit in the world. However, the fields of passion fruit still face important problems due to the incidence and severity of diseases in the field. Thus, the present study aimed to assess resistance to bacterial and fungal diseases in 13 genotypes of sour, sweet and wild passion fruit, in field conditions in the Distrito Federal, Brazil. For this, a field experiment was installed in a randomized block design, with four replications and 13 treatments (genotypes). The characteristics of incidence, severity and degree of resistance for bacteriosis, septoriosis, scab and anthracnose diseases were evaluated in 5 fruits per plot of each genotype. Genetic parameters of the evaluated traits were also estimated. High heritability values and CVg/Cve ratio were observed for most of the evaluated characteristics. The genotypes presented mean values of incidence and severity of bacteriosis, septoriosis, scab and anthracnose different among them, and the one that presented the best results in the degree of resistance for all diseases was F1 (MAR20 # 24 x ECL7 P1 R4).

Taking a look to promoting health and complications' prevention: differences by context.

OBJECTIVES: to acknowledge and compare the health promotion and complications' prevention practices performed by nurses working in hospital and primary health care contexts. METHODS: descriptive, exploratory and crosscutting study, performed with 474 nurses selected by convenience sampling. It was used a form that encompassed two categories of descriptive statements about quality in the professional exercise of nurses. This study had ethical committee approval. RESULTS: the nurses' population was mainly women (87,3%) with an average age of 35,5 years. There was more practices of the hospital's nurses related to the identification of potential problems of the patient (p=0.001) and supervision of the activities that put in place the nursing interventions and the activities that they delegate (p=0.003). CONCLUSION: the nurses perform health promotion and complications' prevention activities, however not in a systematic fashion and professional practices differ by context. This study is relevant as it may promote the critical consciousness of the nurses about the need of stressing quality practices.

Fruit quality of wild, sweet and yellow passion fruit genotypes in Distrito Federal, Brazil

Despite the importance of passion fruit for the Brazilian fruit market, there are still many agronomic and fruit quality problems to be solved, in order to increase this crop performance. The objective of this study was to evaluate the quality of twelve genotypes of wild, sweet and yellow passion fruit, aiming to identify promising materials considering fruit quality, in Federal District, Brazil. An experiment was carried out at the Água Limpa Farm of the Universidade de Brasília (UnB) from 2016 to 2018, in a randomized block design, with 12 treatments, 4 replicates and 6 plants/plot. At the harvesting time, six fruits per plot were randomly collected for the following physicochemical analysis: fruit mass, pulp mass with and without seeds, length/longitudinal diameter, width/transverse diameter, length/width ratio, husk thickness, predominant color of the pulp (L*, C*, h*), number of seeds, seed size, total soluble solids content, total titratable acidity, total soluble solids/total titratable acidity ratio and pH. High heritability values ​​and relation of genetic/environment variation coefficients ratio were observed for most of the characteristics evaluated. The genotypes of yellow passion fruit MAR20#21 P2 x FB 200 P1 R2 and MAR20#19 ROXO R4 x ECRAM P3 R3 showed the best characteristics of fruit mass and pulp mass with seed. All the genotypes studied showed values ​​of total soluble solids above 11ºBrix. Positive and significant correlation was observed between fruit mass and length/width ratio, indicating that oblong fruits have higher fruit mass.

Práticas de cuidado de saúde de homens adolescentes em comunidade periférica: discurso do sujeito coletivo / Health care practices of adolescent men in a peripheral community: collective subject discourse / Prácticas asistenciales de los hombres adolescentes en una comunidad periférica: discurso del sujeto colectivo

Objetivo: apreender as práticas de cuidado de saúde exercitadas por homens adolescentes, que convivem em comunidades periféricas na zona urbana. Método: Estudo qualitativo realizado com homens adolescentes com idade entre 18 e 21 anos, que frequentavam uma escola pública no município de Feira de Santana, Bahia, Brasil. Realizou-se entrevista individual submetidas à análise metodológica pelo Discurso do Sujeito Coletivo e interpretadas pelo referencial de praxeologia do cuidado. Resultados: o cuidado de saúde masculino teve centralidade na compreensão do cuidado como dimensão da vida humana, das relações cotidianas, da preocupação com os bens materiais e da família, em que a saúde ocupa lugar de importância. As práticas de cuidado de saúde estiveram concentradas no corpo com o controle e manutenção da higiene, imagem corporal e aparência física, na alimentação balanceada, melhoria da condição imunológica, na hidratação e na prática de atividade física. Foram consideradas também a adoção de comportamentos de proteção dos fatores ambientais e voltados ao controle do consumo de álcool, e por fim, as relações de trabalho, a busca por atenção médica nos serviços de saúde, a realização de exames diagnósticos e a prevenção de doenças a partir da imunização. Os homens se valerem de recursos preventivos e aspiraram contribuições positivas no desempenho das práticas de cuidado centrado na saúde. Conclusão: O exercício das práticas de cuidado em saúde proporcionou a obtenção e manutenção da saúde, bem como influências positivas na qualidade de vida dos garotos, prevenindo possíveis complicações, evitando o adoecimento e promovendo um envelhecimento saudável.

Objetivo: aprehender las prácticas de atención a la salud que ejercen los adolescentes varones, que viven en comunidades periféricas del área urbana. Método: Estudio cualitativo realizado con hombres adolescentes de entre 18 y 21 años, que asistían a una escuela pública en el municipio de Feira de Santana, Bahía, Brasil. Se realizaron entrevistas individuales, sometidas a análisis metodológico por el Discurso del Sujeto Colectivo e interpretadas por la praxeología referente del cuidado. Resultados: la atención de la salud masculina fue fundamental para la comprensión del cuidado como una dimensión de la vida humana, las relaciones cotidianas, la preocupación por los bienes materiales y la familia, en la que la salud ocupa un lugar importante. Las prácticas de cuidado de la salud se concentraron en el cuerpo con el control y mantenimiento de la higiene, imagen corporal y apariencia física, nutrición balanceada, mejora del estado inmunológico, hidratación y actividad física. También se consideró la adopción de conductas de protección de factores ambientales y orientadas a controlar el consumo de alcohol, y finalmente, las relaciones laborales, la búsqueda de atención médica en los servicios de salud, la realización de pruebas diagnósticas y la prevención de enfermedades. de la inmunización. Los hombres utilizan recursos preventivos y aspiran a contribuciones positivas en el desempeño de prácticas de atención centradas en la salud. Conclusión: El ejercicio de las prácticas asistenciales brindó el logro y mantenimiento de la salud, así como influencias positivas en la calidad de vida de los niños, previniendo posibles complicaciones, previniendo enfermedades y promoviendo un envejecimiento saludable

Genetic parameters estimate for plant characters of a particular carrot population in two different agroecologic cultivation systems / Parâmetros genéticos estimados para caracteres de planta de uma população particular de cenoura em dois sistemas de cultivo agroecológico diferentes

Carrots are among the most planted vegetables in Brazil, which represents importance in the national market. This crop can be grown in conventional and agroecological systems, and studies to improve productivity, disease resistance and root quality in agroecological cropping systems are important. The aim of the present work was to estimate genetic parameters that provide a breeding strategy in the search for the development of new varieties of carrot adapted to the conditions of Distrito Federal's agroecology cultivation. Considering data from tests performed in areas of agroecology cultivation (Natural Agriculture-NA and Organic Agriculture-OA), the following characteristics were evaluated: incidence of leaf blight-LB, incidence of root cracking-CRACK, root length-COMP, format of root tip-TP, format of root shoulder-TO, measure of the color of the a* xylem parameter-a*X, measure of the color of the a* phloem parameter-a*F. Traits were evaluated in 100 half-sib progenies derived from Brasília cultivar, using a completely randomized block design. For the characters COMP, a*X, a*F, TP and TO, the treatment X environment interaction was significant according to the results from test F. The values of the individual variance analyses presented significant effect for the following characteristics: COMP, a*X, TP, TO, LB for NA system, and COMP, a*X, a*F, TP for OA system. In NA system, the values of heritability estimates-ha² for the plant characters fluctuated from 65.66 to 25.52% and, in the OA system, the ha² of the characters a*X, was 81.13%. Estimates of genetic gain per cycle for the characters a*X and a*F were lower in NA system than the estimates observed in OA system.

A cenoura está entre as hortaliças mais plantadas no Brasil, o que representa importância no mercado nacional. Essa cultura pode ser cultivada em sistemas convencionais e agroecológicos, sendo importante o desenvolvimento de estudos para melhorar características de produtividade, resistência a doenças e qualidade de raiz em sistemas com base agroecológica de cultivo. O objetivo do presente trabalho foi estimar parâmetros genéticos que fornecem uma estratégia de melhoramento na busca pelo desenvolvimento de novas variedades de cenoura adaptadas às condições do cultivo agroecológico do Distrito Federal. Considerando dados de testes realizados em áreas de cultivo agroecológico (Agricultura Natural - NA e Agricultura Orgânica - OA), foram avaliadas as seguintes características: incidência de queima das folhas - LB, incidência de rachadura radicular - RACH, comprimento de raiz - COMP, formato de raiz -TP, formato do ombro -TO, medida da cor do parâmetro a * do xilema ­ a*X, medida da cor do parâmetro a *do floema ­ a*F. As características foram avaliadas em 100 progênies de meios-irmãos derivadas da cultivar Brasília, usando um delineamento de blocos inteiramente casualizados. Para os caracteres COMP, a*X, a*F, TP e TO, a interação tratamento X ambiente foi significativa de acordo com os resultados do teste F. Os valores das análises de variância individuais apresentaram efeito significativo para as seguintes características: COMP, a*X, TP, TO, LB para o sistema NA e COMP, a*X, um a*F, TP para o sistema OA. No sistema NA, os valores de estimativa de herdabilidade - ha² para os caracteres da planta variaram de 65,66 a 25,52% e, no sistema OA, o ha² da característica a*X foi de 81,13%. As estimativas de ganho genético por ciclo para os caracteres a*X e a*F foram menores no sistema NA do que as estimativas observadas no sistema OA.

O cotidiano hospitalar de crianças com hospitalizações prolongadas: entre tramas dos cuidados com o corpo e as mediações possíveis / The hospital routine of children with prolonged hospitalizations: between body-care and possible mediations / El cotidiano hospitalario de niños con hospitalizaciones prolongadas: entre tramas de los cuidados con el cuerpo y las mediaciones posibles

Esta pesquisa de cunho etnográfico buscou refletir sobre o cotidiano de crianças com condições crônicas e complexas (CCC) com hospitalizações prolongadas. Foram realizadas: coleta de dados em prontuário, observações participantes do cotidiano hospitalar, e entrevistas com as mães de crianças internadas em duas unidades pediátricas. Os principais resultados mostraram que o cotidiano desses sujeitos era engendrado numa íntima relação do corpo com o ambiente e a importância da mediação das mães e dos profissionais de saúde nesse cenário. Como considerações, discute-se sobre as necessidades de saúde das crianças com CCC, que não contemplam apenas medicamentos e técnicas. É fundamental entender que o hospital constitui um espaço de vida cotidiana para essa população, o que implica a valorização da inclusão das mães e a oferta de espaços e atividades que possam favorecer o dia a dia dessas crianças.(AU)

This ethnographic study reflected upon the experiences of prolonged hospitalization among children with chronic and complex conditions (CCC). Data was collected from the patients' medical records, participant observation, and interviews conducted with the parents of children hospitalized in two pediatric units. The findings reveal that the patients' daily lives were engendered by an intimate relationship between the body and environment and the importance of the mediation of parents and health professionals in this setting. A number of considerations are suggested, including the fact that the health needs of children with CCC extend beyond medication and techniques. It is vital to understand that the daily life of these children is played out temporarily in the hospital and therefore theses settings require the active presence of mothers and the provision of spaces and activities to optimize the daily lives of these children.(AU)

Este estudio de cuño etnográfico buscó reflexionar sobre el cotidiano de niños con condiciones crónicas y complejas (CCC) con hospitalizaciones prolongadas. Se realizaron colecta de datos en historial, observaciones participantes del cotidiano hospitalario y entrevistas con las madres de niños internados en dos unidades pediátricas. Los principales resultados mostraron que el cotidiano de esos sujetos se engendraba en una íntima relación del cuerpo con el ambiente y la importancia de la mediación de las madres y de los profesionales de la salud en ese escenario. Como consideraciones, se discute sobre las necesidades de salud de los niños con CCC que no incluyen tan solo medicamentos y técnicas. Es fundamental entender que el hospital se constituye como espacio de vida cotidiana para esta población, lo que implica la valorización de la inclusión de las madres y la oferta de espacios y actividades que puedan favorecer el el dia a dia de estos ninõs.(AU)

Morphoagronomic characterization of sweet potato accessions from the germplasm bank of Embrapa hortaliças / Caracterização morfológica de acessos de batata-doce mantidos no banco de germoplasma da Embrapa Hortaliças

Studies on the determination of genetic divergence among genotypes are important tools in breeding programs, contributing to the identification of parents with considerable productive potential. However, little is known about the combinatorial capacity of sweet potato (Ipomoea batatas) accessions and its adaptation to the different regions of Brazil. The objective of this study was to evaluate the morpho-agronomic traits from 102 sweet potato accessions from the Germplasm Bank of Embrapa Hortaliças. The experiment was laid out as an augmented block design comprised of 102 treatments. Nineteen above ground traits were measured using descriptors for the respective parts. Estimated values of broad sense heritability were high for the traits mean branch length (95.75%), immature leaf color (85.06%), and predominant branch color (90.57%). Coefficients of environmental variation were below 30.00% for all variables, except for branch weight (51.62%). The 102 clones analyzed presented broad genetic variability for the different traits evaluated, especially for branch weight, and branch length, and mature leaf color.

Estudos de determinação de divergência genética entre genótipos são ferramentas de grande importância em programas de melhoramento, auxiliando na identificação de genitores com considerável potencial produtivo. No entanto, pouco ainda se sabe sobre a capacidade combinatória de acessos de batata-doce (Ipomoea batatas) e sobre a adaptação a diferentes regiões do Brasil. O objetivo deste trabalho foi avaliar características agronômicas de 102 acessos de batata-doce mantidos no Banco de Germoplasma da Embrapa Hortaliças. O experimento foi instalado utilizando o delineamento em blocos aumentados, com 102 tratamentos. Foram mensuradas 19 características da parte aérea utilizando-se descritores das respectivas partes. Os valores das estimativas de herdabilidade no sentido amplo foram altos para as características comprimento médio das ramas (95,75%), cor da folha imatura (85,06%) e cor predominante da rama (90,57%). Os coeficientes de variação foram inferiores a 30 % para todas as variáveis, exceto para peso das ramas (51.62%). Os 102 clones analisados apresentaram ampla variabilidade genética para as diferentes características avaliadas, principalmente para peso das ramas, comprimento das ramas e cor da folha madura

[Difficult news: meanings attributed by family members of children with cystic fibrosis]. / Notícias difíceis: sentidos atribuídos por familiares de crianças com fibrose cística.

This article studied some of the meanings that difficult news assumes when transmitted by health professionals to relatives of young cystic fibrosis patients undergoing treatment at a public hospital located in the south zone of the city of Rio de Janeiro, Brazil. It is the result of qualitative research and analysis of ten narratives collected during two months in 2010. These meanings are not understood by professionals and interfere with the evolution of the illness, the coping process and the care given to the children. It has been observed that the content of the news is perceived differently depending on: The clarity with which it is transmitted to each family member; The forthright way it is conveyed without the preparation of the listener; The consideration of the context in which people live and the consequences involved; The presence of a family member when the news is delivered; and the fragmentation of information. Results indicate the need to make professionals aware of the importance of communication aspects in clinical meetings and the inclusion of this training process in the medical curriculum as well as during physicians' professional lives. It seems that in delivery of the news the family expects a balance between technical efficiency and conversational tact from professionals.

Concepção do direito à saúde na perspectiva do profissional técnico de nível médio do Sistema Único de Saúde / Conception of the right to health of mid-level technical professionals of the mid-level of the Unified Health System in Brazil

INTRODUCTION: The right to health, one of the achievements guaranteed by the Citizen Constitution promulgated in 1988, came in response to the citizens' struggle for health reform in 1986. The guarantee of this right is established in the Unified Health System. OBJECTIVE: To analyze the conception of the right to health of middle level proffesionals of Unified Health System. METHODS: Qualitative approach research, through 2 focus groups involving 9 graduates of a Health Technical School of the SUS in the north of Brazil, from the courses of clinical analysis, dental hygiene and nursing, working in the Unified Health System. RESULTS: Three categories show the results obtained concluding concepts of health, the right to health and health conceptions; Health practices and access to care; and topics of training, health care and humanization. CONCLUSION: The participants of this study have a conception of the right to health directed to the legislation, their concepts of health approach elements of Unified Health System policy, among others, promotion, prevention, humanization; their conceptions of health are strongly focused on the biomedical model centered on disease and medicine.

INTRODUÇÃO: O Direito à saúde, uma das conquistas garantidas pela Constituição Cidadã promulgada em 1988, veio em resposta aos movimentos de luta dos cidadãos pela Reforma Sanitária em 1986. Na proposta do Sistema Único de Saúde a garantia desse direito está estabelecida. OBJETIVO: Analisar a concepção de direito à saúde no contexto do profissional de nível médio do SUS. MÉTODO: Pesquisa de abordagem qualitativa, através de 2 grupos focais envolvendo 9 egressos de uma Escola Técnica em Saúde do Sistema Único de Saúde do norte do Brasil, dos cursos de análises clínicas, higiene dental e enfermagem, atuando no Sistema Único de Saúde. O tratamento dos dados foi por análise de conteúdo proposta por Bardin (2009), com a definição de 3 categorias RESULTADOS: Três categorias retratam os resultados obtidos congregando conceitos de saúde e de direito à saúde e concepções de saúde; práticas de saúde e acesso à atenção; e ainda, conteúdos da formação, cuidado sanitário e humanização. CONCLUSÃO: Os participantes desse estudo demonstram uma concepção de direito à saúde voltada ao legislado e seus conceitos de saúde abordam elementos da política do SUS, dentre outros, promoção, prevenção, humanização; suas concepções de saúde estão marcadamente voltadas ao modelo biologicista, focado na doença e no medicamento.

Ornamental potential of sweet potato accessions / Potencial ornamental de acessos de batata-doce

Sweet potato [Ipomoea batatas (L.) Lam.] is a multipurpose plant due to the different uses for its roots, leaves, and branches. The objective of this study was to evaluate the ornamental potential of sweet potato accessions from the Germplasm Bank of Embrapa Hortaliças, Brasilia, DF, Brazil. The morphological characterization and evaluation of the ornamental potential used five accessions with distinct leaf shape (CNPH 980, CNPH 1205, CNPH 895, CNPH 796, CNPH 1284) and 12 qualitative and quantitative descriptors [plant type (PT), leaf lobe type (LLT), immature leaf color (ILC), leaf lobe number (LLN), branch color (BC), shape of central leaf lobe (SCLL), petiole pigmentation (PP), mature leaf size (MLS), mature leaf color (MLC), leaf shape (LS), branch yield (BY), and root yield (RY)]. In the evaluation of the ornamental potential, each criterion was scored from 10 (minimum) to 100 (maximum). Leaf lobe number was the trait that pleased the evaluators the most, and the greater the number of lobes, the greater was the ornamental potential. CNPH 980, CNPH 1205, and CNPH 1284 stood out for this trait. CNPH 1284 (almost divided leaf type) had the greatest score and was considered, by the evaluators, as the accession with the most harmonious aesthetics, indicating a great ornamental potential for the consumer market. All accessions studied presented considerable ornamental potential and could be used in floral arrangements or garden beds.

A batata-doce [Ipomoea batatas (L.) Lam.] é uma planta com diferentes aptidões de uso das suas raízes, folhas e hastes. O objetivo deste trabalho foi avaliar o potencial ornamental de acessos de batata-doce oriundas do banco de germoplasma mantidos na Embrapa Hortaliças, Brasília, DF, Brasil. Para a caracterização morfológica e avaliação do potencial ornamental, foram escolhidos cinco acessos com formatos de folhas diferentes (CNPH 980, CNPH 1205, CNPH 895, CNPH 796, CNPH 1284) e utilizados doze descritores qualitativos e quantitativos [tipo de planta (TP), tipo de lóbulo da folha (TLF), cor da folha imatura (CFI), número de lóbulos por folha (NLF), cor das ramas (CR), formato do lóbulo central (FLC), pigmento no pecíolo (PP), tamanho da folha madura (TFM), cor da folha madura (CFM), formato da folha (FF), produção de ramas (BY) e produção de raízes (RY)]. Na avaliação do potencial ornamental, cada critério foi pontuado por meio de notas variando de 10 (mínimo) a 100 (máximo). A característica número de lóbulos da folha foi a que mais agradou os avaliadores. Observou-se que quanto mais lóbulos, maior o potencial ornamental, sendo que os acessos CNPH 980, CNPH 1205 e CNPH 1284 se destacaram para essa característica. CNPH 1284, com folhas no formato quase dividido, obteve a maior nota e foi considerado como o acesso com a estética mais harmoniosa, indicando grande potencial ornamental para o mercado consumidor, na opinião dos avaliadores. Os cinco acessos estudados apresentaram considerável potencial ornamental, podendo ser usados como forragem, complementos para arranjos florais ou como jardineiras.

Perfil sociodemográfico de idosos com a Síndrome da Imunodeficiência Adquirida no Brasil: revisão integrativa / Sociodemographic profile of elderly people with immunodeficiency syndrome Acquired in Brazil: integrative review / Perfil sociodemográfico de las personas mayores portadoras del Síndrome de Inmunodeficiencia Adquirida em Brasil: revisión integrativa

Este estudo objetiva determinar o perfil sociodemográfico dos idosos com HIV/AIDS, no Brasil, a partir de uma revisão bibliográfica na base de dados SciELO. Foram analisados 12 artigos publicados em português no período de 2012 a 2018. A infecção apresenta predominância de indivíduos do sexo masculino a partir de 60 anos, de cor branca e com menos de oito anos de escolaridade, sem diferenciação quanto ao estado civil, o que torna imprescindível o cuidado em saúde relacionado à vida sexual desses indivíduos.

This study, aims to determine the sociodemographic profile of elderly people living with HIV/AIDS in Brazil from a integrative review in the SciELO database. Analyzing 12 articles, published in Portuguese in the period from 2012 to 2018. The infection has a predominance of white men aged 60 years and older and less than 8 years of schooling, with no difference in marital status. Essential health care related to the sexual life of these individuals.

Este estudio tiene por objetivo, determinar el perfil sociodemográfico de las personas mayores con del VIH/Sida en el Brasil, desde una revisión integrativa en las bases de datos SciELO. Fueron analizados 12 artículos publicados en portugués en los años de 2012 a 2018. La infección presenta dominancia en las personas del sexo masculino a partir de los 60 años, blancos y con menos de 8 años de escolaridad, sin diferencia en el estado civil, lo que resulta imprescindible em el cuidado de la salud relacionada a la vida sexual de estos individuos.

Upregulation of innate antiviral restricting factor expression in the cord blood and decidual tissue of HIV-infected mothers.

Programs for the prevention of mother-to-child transmission of HIV have reduced the transmission rate of perinatal HIV infection and have thereby increased the number of HIV-exposed uninfected (HEU) infants. Natural immunity to HIV-1 infection in both mothers and newborns needs to be further explored. In this study, we compared the expression of antiviral restricting factors in HIV-infected pregnant mothers treated with antiretroviral therapy (ART) in pregnancy (n=23) and in cord blood (CB) (n=16), placental tissues (n=10-13) and colostrum (n=5-6) samples and compared them to expression in samples from uninfected (UN) pregnant mothers (n=21). Mononuclear cells (MNCs) were prepared from maternal and CB samples following deliveries by cesarean section. Maternal (decidua) and fetal (chorionic villus) placental tissues were obtained, and colostrum was collected 24 h after delivery. The mRNA and protein expression levels of antiviral factors were then evaluated. We observed a significant increase in the mRNA expression levels of antiviral factors in MNCs from HIV-infected mothers and CB, including the apolipoprotein B mRNA-editing enzyme 3G (A3G), A3F, tripartite motif family-5α (TRIM-5α), TRIM-22, myxovirus resistance protein A (MxA), stimulator of interferon (IFN) genes (STING) and IFN-ß, compared with the levels detected in uninfected (UN) mother-CB pairs. Moreover, A3G transcript and protein levels and α-defensin transcript levels were decreased in the decidua of HIV-infected mothers. Decreased TRIM-5α protein levels in the villi and increased STING mRNA expression in both placental tissues were also observed in HIV-infected mothers compared with uninfected (UN) mothers. Additionally, colostrum cells from infected mothers showed increased tetherin and IFN-ß mRNA levels and CXCL9 protein levels. The data presented here indicate that antiviral restricting factor expression can be induced in utero in HIV-infected mothers. Future studies are warranted to determine whether this upregulation of antiviral factors during the perinatal period has a protective effect against HIV-1 infection.

Sutilezas e tessituras do ambiente hospitalar: o cotidiano de uma enfermaria pediátrica de média e alta complexidade / Hospital subtleties and tessitura: daily routine of a pediatric ward of medium and high complexity

[{"text": "Objetivo: Este artigo procurou investigar o cotidiano de crianças e de adolescentes internados em uma\r\nenfermaria de alta e média complexidade. Método: Tratou-se de uma pesquisa exploratória cujo procedimento\r\ntécnico foi o estudo de campo. Dentro da abordagem qualitativa, optou-se por escolher a perspectiva etnográfica, com a observação participante e os registros em diários de campo. O material da coleta de dados de campo foi lido exaustivamente a fim de relacioná-lo ao referencial teórico, utilizando a análise de conteúdo na modalidade temática. Resultados: Ao estudar o cotidiano de uma enfermaria pediátrica de média e alta complexidade, foi possível constatar: que ele é permeado por intervenções da equipe de saúde; que as crianças e os adolescentes têm pouco espaço para exercer a autonomia nos cuidados em saúde; que os espaços para outras atividades são escassos; e que os objetos hospitalares estão presentes na quase totalidade das cadeias operatórias, extrapolando aquelas ligadas aos cuidados em saúde. Conclusão: Acredita-se que também é um papel da equipe de saúde problematizar a vida cotidiana hospitalar e, por meio de tecnologias relacionais, criar, facilitar e valorizar os espaços de liberdade possíveis e o exercício da autonomia para que as crianças e os adolescentes hospitalizados conduzam a vida cotidiana hospitalar com maior autonomia.", "_i": "pt"}, {"text": "Objective: This study aimed at investigating the daily lives of children and adolescents hospitalized\r\nin a nursing ward of high and medium complexity. Method: This was an exploratory research whose technical procedure consisted in a field study. In the qualitative approach, we decided to choose the ethnographic perspective. The material collected was thoroughly read and related to the theoretical framework by means of content analysis in the thematic modality. Results: The study of the daily routine of the medium and high complexity pediatric ward showed that this characterized by a high number of interventions carried out by the health team; the hospitalized children and adolescents have little room to exercise their autonomy in health care; there is little space for other activities; and the hospital equipment is present in almost all the operational chains, extrapolating those related to health care. Conclusion: Therefore, the health care must discuss the hospital daily routine and create, facilitate and enhance, through relational technologies, the room for freedom and autonomy so that hospitalized children and adolescents may experience their life at the hospital more autonomously.", "_i": "en"}]

Comparison among parameters of maximal respiratory pressures in healthy subjects.

OBJECTIVE: To investigate four parameters defining maximal respiratory pressures and to evaluate their correlations and agreements among those parameters for the determination of MIP and MEP. METHODS: This was a cross-sectional study involving 49 healthy, well-nourished males and females. The mean age was 23.08 ± 2.5 years. Measurements were carried out using a pressure transducer, and the estimated values for the parameters peak pressure (Ppeak), plateau pressure (Pplateau), mean maximal pressure (Pmean), and pressure according to the area (Parea) were determined with an algorithm developed for the study. To characterize the study sample, we used descriptive statistics, followed by repeated measures ANOVA and Bonferroni post hoc test or by the Friedman test and the Wilcoxon post hoc test, as well as by Pearson's or Spearman's correlation coefficients, depending on the normality of the data. The agreement between the variables was assessed with Bland & Altman plots. RESULTS: There were significant differences among all of the parameters studied for MIP (Ppeak = 95.69 ± 27.89 cmH2O; Parea = 88.53 ± 26.45 cmH2O⁻; Pplateau = 82.48 ± 25.11 cmH2O⁻; Pmean = 89.01 ± 26.41 cmH2O⁻; p < 0.05 for all) and for MEP (Ppeak = 109.98 ± 40.67 cmH2O; Parea = 103.85 ± 36.63 cmH2O; Pplateau = 98.93 ± 32.10 cmH2O; Pmean = 104.43 ± 36.74 cmH2O; p < 0.0083 for all). Poor agreement was found among almost all of the parameters. Higher pressure values resulted in larger differences between the variables. CONCLUSIONS: The maximal respiratory pressure parameters evaluated do not seem to be interchangeable, and higher pressure values result in larger differences among the parameters.

Exchanging knowledge within a community of practice: toward an epistemology of practice in Occupational Therapy paediatric hospital care / Compartilhando conhecimento em uma comunidade de prática: para uma epistemologia de prática da Terapia Ocupacional no cuidado hospitalar pediátrico

Objective: This research proposed the creation of a community of practice (CoP) with the objective of: (i) analysing the feasibility of a CoP as a means of generating knowledge among occupational therapists and (ii) investigating the practice of occupational therapy with hospitalized children and adolescents. This article privileges the results of one of the predominantly discussed themes - the use of assessments and strategies of evaluation in Occupational Therapy in the hospital context. Method: A participatory action research study was undertaken with nine occupational therapists in face-to-face meetings combined with virtual tasks on an on-line platform. A hermeneutic and dialectical method was used to interpret the results. Results: The CoP produced practical knowledge about the use of assessments with hospitalized children and adolescents and demonstrated to be a strategy of knowledge development through dialogue and collaborative reflection on practice. Conclusion: Research on the implementation of communities of practice offers a promising approach to the production of knowledge in occupational therapy. The generated knowledge is representative of occupational therapists' experiences and demonstrates an example of an epistemology of practice.

Objetivo: Esta pesquisa propôs a criação de uma comunidade de prática (CoP) com o objetivo de: (i) analisar a viabilidade de uma CoP como meio de gerar conhecimento entre terapeutas ocupacionais e (ii) investigar a prática da terapia ocupacional com crianças e adolescentes hospitalizados. Este artigo privilegia os resultados de um dos temas predominantemente discutidos - o uso de instrumentos e estratégias de avaliação em terapia ocupacional no contexto hospitalar pediátrico. Método: Foi realizada uma pesquisa-ação participativa com nove terapeutas ocupacionais em encontros face a face combinados com tarefas virtuais em uma plataforma online. Um método hermenêutico e dialético foi utilizado para interpretar os resultados. Resultados: A CoP produziu conhecimento prático sobre o uso de avaliações com crianças e adolescentes hospitalizados e demonstrou ser uma estratégia de desenvolvimento do conhecimento através do diálogo e da reflexão colaborativa sobre a prática. Conclusão: A pesquisa sobre a implementação de CoP oferece uma abordagem promissora para a produção de conhecimento em terapia ocupacional. O conhecimento gerado é representativo das experiências dos terapeutas ocupacionais e demonstra um exemplo de epistemologia da prática.