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1.
J Urban Health ; 2024 Nov 06.
Artículo en Inglés | MEDLINE | ID: mdl-39503836

RESUMEN

To date, there have been no peer-reviewed studies in the United States estimating the impact of gun-free zone policies in alcohol-serving establishments on rates of firearm violence in and around such establishments. In this study, we utilized a cross-sectional design to estimate the impact of Texas's 51% alcohol law, which prohibits the carrying of firearms in establishments that generate over half of their revenue from alcohol sales. The analysis focused on the difference in shooting incidents in and around establishments with and without firearm carrying prohibitions in 2021 and 2022. After adjusting for establishment type (bar/restaurant), alcohol sales volume, census tract level demographic factors, and the number of nearby restaurants and bars, results indicated that gun-prohibiting bars experienced significantly fewer shootings compared to those that allowed guns. Specifically, establishments that were gun-prohibited had 37% fewer shootings within 50 m than those that were gun-allowing, with a 95% confidence interval ranging from 60% fewer to 0.2% fewer. This association was more prominent in bars than in restaurants. The protective association with gun-prohibited status diminished with increased distance from the establishments; results were not significant at 100 m. Our study findings align with research suggesting that gun-free zones can reduce firearm violence. However, future studies using quasi-experimental designs that can better support causal inference are needed to support such a conclusion, as are studies exploring the efficacy of such policies in various settings and over longer periods.

2.
Am J Epidemiol ; 192(7): 1059-1063, 2023 07 07.
Artículo en Inglés | MEDLINE | ID: mdl-36896587

RESUMEN

In the last 30 years, 25 US states have relaxed laws regulating the concealed carrying of firearms (concealed-carry weapons (CCW) laws). These changes may have substantial impacts on violent crime. In a recent study, Doucette et al. (Am J Epidemiol. 2023;192(3):342-355) used a synthetic control approach to assess the effects of shifting from more restrictive "may/no-issue" CCW laws to less restrictive "shall-issue" CCW laws on homicides, aggravated assaults, and robberies involving a gun or committed by other means. The study adds to the evidence that more permissive CCW laws have probably increased rates of firearm assault in states adopting these laws. Importantly, this study is the first to identify that specific provisions of shall-issue CCW laws-including denying permits to persons with violent misdemeanor convictions, a history of dangerous behavior, or "questionable character" and live-fire training requirements-may help mitigate harms associated with shall-issue CCW laws. These findings are timely and salient given the recent Supreme Court ruling striking down a defining element of may-issue laws. This thorough study offers actionable results and provides a methodological model for state firearm policy evaluations. Its limitations reflect the needs of the field more broadly: greater focus on racial/ethnic equity and within-state variation, plus strengthening the data infrastructure on firearm violence and crime.


Asunto(s)
Armas de Fuego , Humanos , Estados Unidos/epidemiología , Homicidio/prevención & control , Violencia/prevención & control , Política Pública
3.
Am J Epidemiol ; 191(3): 516-525, 2022 02 19.
Artículo en Inglés | MEDLINE | ID: mdl-34788362

RESUMEN

Researchers often face the problem of how to address missing data. Multiple imputation is a popular approach, with multiple imputation by chained equations (MICE) being among the most common and flexible methods for execution. MICE iteratively fits a predictive model for each variable with missing values, conditional on other variables in the data. In theory, any imputation model can be used to predict the missing values. However, if the predictive models are incorrectly specified, they may produce biased estimates of the imputed data, yielding inconsistent parameter estimates and invalid inference. Given the set of modeling choices that must be made in conducting multiple imputation, in this paper we propose a data-adaptive approach to model selection. Specifically, we adapt MICE to incorporate an ensemble algorithm, Super Learner, to predict the conditional mean for each missing value, and we also incorporate a local kernel-based estimate of variance. We present a set of simulations indicating that this approach produces final parameter estimates with lower bias and better coverage than other commonly used imputation methods. These results suggest that using a flexible machine learning imputation approach can be useful in settings where data are missing at random, especially when the relationships among the variables are complex.


Asunto(s)
Algoritmos , Aprendizaje Automático , Sesgo , Simulación por Computador , Humanos
4.
Prev Med ; 145: 106414, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33400939

RESUMEN

Background checks are designed to prevent firearm acquisition by people prohibited from purchasing or possessing firearms. There is limited information about background checks, particularly on a state by state basis. We conducted a state-representative, probability-based, Internet survey of California adults in 2018 (n=2558; completion rate 49%) to describe where, when, and how firearms are acquired and to estimate the proportion of current firearm owners who purchased their most recent firearm without a background check. An estimated 17.2% (95% CI: 9.6-28.8) of firearm owners who purchased their most recent firearm within California in 1991 or later, following implementation of the state's comprehensive background check law, reported doing so without a background check. This percentage was 44.6% (95% CI: 27.1-63.5) among owners who purchased their most recent firearm before 1991 and 27.1% (95% CI: 13.1-47.7) among those who purchased their most recent firearm outside California. Firearm purchases without background checks occurred more often for firearms purchased from private sellers (72.3%; 95% CI: 35.5-92.5) than retailers (8.5%; 95% CI: 3.4-19.7). Overall, firearm purchases without background checks are considerably less common in California than in states without regulations on private sales. However, gaps in implementation and proper enforcement remain. Future research could investigate reasons for such lapses, as well as complementary state policy approaches that require background checks prior to point of purchase.


Asunto(s)
Armas de Fuego , Adulto , California , Comercio , Humanos , Propiedad , Estados Unidos , Violencia
5.
Prev Med ; 153: 106821, 2021 12.
Artículo en Inglés | MEDLINE | ID: mdl-34599927

RESUMEN

Firearm access is a risk factor for firearm suicide; substance use may confer additional risk. In this retrospective cohort study, we estimated the associations between prior alcohol and drug charges at the time of handgun purchase and subsequent suicide among men in California. The sample comprised all men who legally purchased a handgun in California in 2001 and who were age ≥ 21 at the time of acquisition (N = 101,377), identified in the California Department of Justice (CA DOJ) Dealer's Record of Sale database. Exposures included alcohol and drug criminal charges and convictions accrued January 1, 1990 until the first ('index') handgun acquisition in 2001, recorded in the CA DOJ Criminal History Information System. Outcomes included suicide and firearm suicide occurring after the index purchase and before January 1, 2016. A total of 1907 purchasers had alcohol charges, 1248 had drug charges, and 304 had both; 594 purchasers died by suicide (516 by firearm suicide). Compared with those with neither alcohol nor drug charges, those with alcohol charges had 2.20 times the hazard of suicide (95% confidence interval [CI], 1.39-3.46) and 2.22 times the hazard of firearm suicide (95% CI, 1.36-3.62). Risk was most elevated among those with more recent charges and those with 2 or more charges, and in the time period closest to the purchase. The associations for drug charges and the combination of alcohol and drug charges were not distinguishable from the null. Firearm owners with alcohol offenses may benefit from intervention to reduce firearm access and alcohol use.


Asunto(s)
Armas de Fuego , Suicidio , California/epidemiología , Estudios de Cohortes , Humanos , Masculino , Estudios Retrospectivos , Violencia
6.
Am J Public Health ; 110(10): 1546-1552, 2020 10.
Artículo en Inglés | MEDLINE | ID: mdl-32816544

RESUMEN

Objectives. To estimate and compare the effects of state background check policies on firearm-related mortality in 4 US states.Methods. Annual data from 1985 to 2017 were used to examine Maryland and Pennsylvania, which implemented point-of-sale comprehensive background check (CBC) laws for handgun purchasers; Connecticut, which adopted a handgun purchaser licensing law; and Missouri, which repealed a similar law. Using synthetic control methods, we estimated the effects of these laws on homicide and suicide rates stratified by firearm involvement.Results. There was no consistent relationship between CBC laws and mortality rates. There were estimated decreases in firearm homicide (27.8%) and firearm suicide (23.2%-40.5%) rates associated with Connecticut's law. There were estimated increases in firearm homicide (47.3%), nonfirearm homicide (18.1%), and firearm suicide (23.5%) rates associated with Missouri's repeal.Conclusions. Purchaser licensing laws coupled with CBC requirements were consistently associated with lower firearm homicide and suicide rates, but CBC laws alone were not.Public Health Implications. Our results contribute to a body of research showing that CBC laws are not associated with reductions in firearm-related deaths unless they are coupled with handgun purchaser licensing laws.


Asunto(s)
Armas de Fuego/legislación & jurisprudencia , Homicidio/estadística & datos numéricos , Concesión de Licencias/legislación & jurisprudencia , Suicidio/estadística & datos numéricos , Adulto , Comportamiento del Consumidor , Ambiente , Humanos , Persona de Mediana Edad , Mortalidad/tendencias , Estados Unidos
7.
J Urban Health ; 97(1): 78-87, 2020 02.
Artículo en Inglés | MEDLINE | ID: mdl-31907705

RESUMEN

Women who experience housing instability are at high risk for violence and have disproportionately high rates of emergency department (ED) use. However, little has been done to characterize the violence they experience, or to understand how it may be related to ED use. We recruited homeless and unstably housed women from San Francisco shelters, free meal programs, and single room occupancy (SRO) hotels. We used generalized estimating equations to examine associations between violence and any ED use (i.e., an ED visit for any stated reason) every 6 months for 3 years. Among 300 participants, 44% were African-American, and the mean age was 48 years. The prevalence of violence experienced in the prior 6 months included psychological violence (87%), physical violence without a weapon (48%), physical violence with a weapon (18%), and sexual violence (18%). While most participants (85%) who experienced physical violence with a weapon or sexual violence in the prior 6 months had not visited an ED, these were the only two violence types significantly associated with ED use when all violence types were included in the same model (ORphysical/weapon = 1.83, 95% CI 1.02-3.28; ORsexual = 2.15, 95% CI 1.30-3.53). Only violence perpetrated by someone who was not a primary intimate partner was significantly associated with ED use when violence was categorized by perpetrator. The need to reduce violence in this population is urgent. In the context of health care delivery, policies to facilitate trauma-informed ED care and strategies that increase access to non-ED care, such as street-based medicine, could have substantial impact on the health of women who experience homelessness and housing instability.


Asunto(s)
Servicio de Urgencia en Hospital/estadística & datos numéricos , Personas con Mala Vivienda/estadística & datos numéricos , Violencia/estadística & datos numéricos , Adulto , Femenino , Personas con Mala Vivienda/psicología , Vivienda , Humanos , Drogas Ilícitas , Persona de Mediana Edad , Prevalencia , San Francisco/epidemiología , Delitos Sexuales/estadística & datos numéricos
8.
J Pediatr ; 209: 198-203, 2019 06.
Artículo en Inglés | MEDLINE | ID: mdl-30850086

RESUMEN

OBJECTIVES: To estimate associations between psychiatric disorders and gun carrying among adolescents and to estimate the total number of adolescents in the US who have psychiatric disorders and report carrying guns. STUDY DESIGN: We used cross-sectional data from the National Comorbidity Survey - Adolescent Supplement, a nationally representative sample of adolescents age 13-18 years (N = 10 123; response rate = 75.6%). Psychiatric disorders were assessed using the Composite International Diagnostic Interview. Gun carrying in the 30 days prior to the interview was assessed by self-report. We used multivariable Poisson regression to test for associations. RESULTS: The analytic sample included 10 112 adolescents, 2.4% of whom reported carrying a gun in the prior 30 days. The prevalence of gun carrying was greater among adolescents with conduct disorder (adjusted prevalence ratio [APR] = 1.88, 95% CI 1.38, 2.57), drug use disorders (APR = 1.91, 95% CI 1.05, 3.45), and specific phobias (APR = 1.54, 95% CI 1.07, 2.22) compared with adolescents without these disorders. We estimated that 1.1% (95% CI 0.77, 1.48) of adolescents with a disorder associated with self- or other-directed violence also carry guns. Nationally, that is approximately 272 000 adolescents with both risk factors. CONCLUSIONS: Specific psychiatric disorders are associated with an increased risk of gun carrying among adolescents, but the vast majority of adolescents with psychiatric disorders did not report gun carrying. Targeted efforts to assess access to and use of firearms in mental healthcare and other clinical settings are important, as are efforts to identify population approaches to prevention.


Asunto(s)
Conducta del Adolescente , Armas de Fuego , Trastornos Mentales/epidemiología , Trastornos Relacionados con Sustancias/epidemiología , Adolescente , Estudios Transversales , Femenino , Humanos , Masculino , Trastornos Mentales/complicaciones , Trastornos Relacionados con Sustancias/complicaciones , Estados Unidos/epidemiología
9.
Epidemiology ; 29(4): 494-502, 2018 07.
Artículo en Inglés | MEDLINE | ID: mdl-29613872

RESUMEN

BACKGROUND: In 2016, firearms killed 38,658 people in the United States. Federal law requires licensed gun dealers, but not private parties, to conduct background checks on prospective firearm purchasers with the goal of preventing prohibited persons from obtaining firearms. Our objective was to estimate the effect of the repeal of comprehensive background check laws-requiring a background check for all handgun sales, not just sales by licensed dealers-on firearm homicide and suicide rates in Indiana and Tennessee. METHODS: We compared age-adjusted firearm homicide and suicide rates, measured annually from 1981 to 2008 and 1994 to 2008 in Indiana and Tennessee, respectively, to rates in control groups constructed using the synthetic control method. RESULTS: The average rates of firearm homicide and suicide in Indiana and Tennessee following repeal were within the range of what could be expected, given natural variation (differences = 0.7 firearm homicides and 0.5 firearm suicides per 100,000 residents in Indiana and 0.4 firearm homicides and 0.3 firearm suicides per 100,000 residents in Tennessee). Sensitivity analyses resulted in similar findings. CONCLUSION: We found no evidence of an association between the repeal of comprehensive background check policies and firearm homicide and suicide rates in Indiana and Tennessee. In order to understand whether comprehensive background check policies reduce firearm deaths in the United States generally, more evidence on the impact of such policies from other states is needed. See video abstract at, http://links.lww.com/EDE/B353.


Asunto(s)
Disentimientos y Disputas/legislación & jurisprudencia , Armas de Fuego/legislación & jurisprudencia , Homicidio/tendencias , Suicidio/tendencias , Femenino , Homicidio/prevención & control , Humanos , Indiana/epidemiología , Aplicación de la Ley , Masculino , Estudios Prospectivos , Tennessee/epidemiología , Prevención del Suicidio
10.
Inj Prev ; 24(6): 431-436, 2018 12.
Artículo en Inglés | MEDLINE | ID: mdl-28986427

RESUMEN

BACKGROUND: Comprehensive background check (CBC) policies are hypothesised to reduce firearm-related violence because they extend background checks to private party firearm sales, but no study has determined whether these policies actually increase background checks, an expected intermediary outcome. We evaluate the association between CBC policies and the rates of firearm background checks in three states that recently implemented these policies: Delaware (July 2013), Colorado (July 2013) and Washington (December 2014). METHODS: We used the synthetic control group method to estimate the difference from estimated counterfactual postintervention trends in the monthly rate of background checks per 1 00 000 people for handguns, long guns and both types combined, using data for January 1999 through December 2016. Inference was based on results from permutation tests. We conducted multiple sensitivity analyses to assess the robustness of our results. RESULTS: Background check rates increased in Delaware, by 22%-34% depending on the type of firearm, following enactment of its CBC law. No overall changes were observed in Washington and Colorado. Our results were robust to changes in the comparison group and statistical methods. CONCLUSIONS: The enactment of CBC policies was associated with an overall increase in firearm background checks only in Delaware. Data external to the study suggest that Washington experienced a modest, but consistent, increase in background checks for private party sales, and Colorado experienced a similar increase in checks for sales not at gun shows. Non-compliance may explain the lack of an overall increase in background checks in Washington and Colorado.


Asunto(s)
Armas de Fuego/legislación & jurisprudencia , Aplicación de la Ley , Concesión de Licencias/legislación & jurisprudencia , Propiedad/legislación & jurisprudencia , Política Pública , Heridas por Arma de Fuego/prevención & control , Colorado , Delaware , Armas de Fuego/estadística & datos numéricos , Homicidio/prevención & control , Humanos , Propiedad/estadística & datos numéricos , Estados Unidos , Violencia/prevención & control , Washingtón , Prevención del Suicidio
11.
Pediatr Allergy Immunol ; 28(8): 810-817, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28981980

RESUMEN

BACKGROUND: Airway epithelial cells (AEC) are quite difficult to access in newborns and infants. It is critically important to develop robust life-extended models to conduct translational studies in this age group. We propose the use of a recently described cell culture technology (conditionally reprogrammed cells-CRC) to generate continuous primary cell cultures from nasal and bronchial AEC of young children. METHODS: We collected nasal and/or bronchial AEC from a total of 23 subjects of different ages including newborns/infants/toddlers (0-2 years; N = 9), school-age children (4-11 years; N = 6), and a group of adolescent/adult donors (N = 8). For CRC generation, we used conditioned medium from mitotically inactivated 3T3 fibroblasts and Rho-associated kinase (ROCK) inhibitor (Y-27632). Antiviral immune responses were studied using 25 key antiviral genes and protein production of type III epithelial interferon (IFN λ1) after double-stranded (ds) RNA exposure. RESULTS: CRC derived from primary AEC of neonates/infants and young children exhibited: (i) augmented proliferative capacity and life extension, (ii) preserved airway epithelial phenotype after multiple passages, (iii) robust immune responses characterized by the expression of innate antiviral genes and parallel nasal/bronchial production of IFN λ1 after exposure to dsRNA, and (iv) induction of airway epithelial inflammatory and remodeling responses to dsRNA (eg, CXCL8 and MMP9). CONCLUSION: Conditional reprogramming of AEC from young children is a feasible and powerful translational approach to investigate early-life airway epithelial immune responses in humans.


Asunto(s)
Células Epiteliales/inmunología , Cultivo Primario de Células/métodos , Mucosa Respiratoria/citología , Adolescente , Adulto , Biomarcadores/metabolismo , Proliferación Celular , Células Cultivadas , Niño , Preescolar , Citocinas/metabolismo , Células Epiteliales/fisiología , Células Epiteliales/virología , Estudios de Factibilidad , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Mucosa Respiratoria/inmunología , Mucosa Respiratoria/metabolismo , Mucosa Respiratoria/virología , Enfermedades Respiratorias/inmunología , Enfermedades Respiratorias/virología
12.
J Adv Nurs ; 73(11): 2566-2576, 2017 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-28475213

RESUMEN

AIM: To identify and better understand opportunities for and challenges in attaining the maternal role among women who began childbearing in adolescence in rural Mexico. BACKGROUND: Adolescent mothers often face challenges rising from their socioeconomic status and developmental stage that can strain the process of developing confidence and competence in the maternal role. In Mexico, 19% of births are to women under age 20. Little is known about these mothers' experiences with parenting. DESIGN: Mixed methods. METHODS: Quantitative data collected in 2008 from a cluster-random sample of mothers (n = 1,381) in rural, impoverished areas of three southern states provided objective measures of mothers' socioeconomic position, well-being, and parenting practices. Semi-structured interviews conducted in 2013 with mothers (n = 30) provided insight into perceptions of motherhood and opportunities for and challenges in attaining the maternal role. FINDINGS: Ever-adolescent mothers scored lower than never-adolescent mothers on the total HOME and the parental responsivity and learning materials subscales. They also occupied the most economically disadvantaged positions, showing the lowest levels of education and wealth and the most depressive symptoms compared with never-adolescent mothers. The qualitative analysis supported these challenges and highlighted areas of opportunity: (1) early-adolescent parents faced economic challenges; (2) adolescent childbearing was normative with some exceptions; (3) participants' mothers and mothers-in-law provided social support; and (4) mothers focused on learning to parent and helping their children "get ahead" in life. CONCLUSION: Findings have important implications for identifying how to support young women as they become mothers and continue in this role.


Asunto(s)
Madres/psicología , Adolescente , Adulto , Femenino , Humanos , México , Responsabilidad Parental , Embarazo , Embarazo en Adolescencia , Población Rural , Clase Social , Adulto Joven
14.
Inj Epidemiol ; 11(1): 53, 2024 Sep 27.
Artículo en Inglés | MEDLINE | ID: mdl-39334284

RESUMEN

BACKGROUND: Suicide is a leading cause of death in the United States with rates increasing over the past two decades. The rate of suicide is higher in rural areas, but a greater number of people in urban areas die by suicide; understanding risk factors for suicide in this context is critically important to public health. Additionally, while many studies have focused on individual-level risk factors, few studies have identified social or structural features associated with suicide or firearm suicide, especially among young people. METHODS: Study outcomes included total firearm suicide, total youth (age 10-29) firearm suicide, total suicide, and total youth suicide in Detroit, Michigan from 2012 through 2019. The predictors in this study included 58 census-tract level variables characterizing the physical features, residential stability, socioeconomic status, and demographics of neighborhoods in Detroit over the study period. We used random forest, extreme gradient boosting (XGBoost), and generalized linear mixed models to predict the four outcomes. RESULTS: We found that the tract-level variables used in all three modeling approaches performed poorly at predicting the suicide outcomes, with area under the curve values at times exceeding 0.60 but with extremely low sensitivity (ranging from 0.05 to 0.45). However, the percentage of parcels sold in arms-length transfers in the previous 5 years, the count of vacant lots per square mile, and the percentage of children aged three and older who were enrolled in preschool each demonstrated associations with at least two of the outcomes studied. CONCLUSIONS: Our findings suggest place-based factors at the tract level do not provide meaningful insight into the risk of suicide or firearm suicide among youth or the general population in Detroit, Michigan. Future practice and study should consider focusing on both larger and smaller areas, including city and individual-level factors. For example, studies might benefit from the use of both neighborhood and individual-level measures and their interactions to improve our understanding of place-based risk factors and suicide risk.

15.
Int J Drug Policy ; 127: 104413, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38640707

RESUMEN

BACKGROUND: There is evidence linking use of controlled substances with perpetration of interpersonal violence. While the United States constitution protects the right to own a firearm, federal law prohibits firearm purchase and possession by persons believed to be at high risk for violence, including those who use controlled substances unlawfully. METHODS: We report here the results of a 13-year prospective observational study on the risk of violent crime associated with a history of criminal drug charges in a cohort of 79,678 legal purchasers of handguns in California in 2001. The main outcomes were post-purchase charges for any violent crime, violent Crime Index crimes (murder, rape, robbery, aggravated assault), and firearm-related violent crimes. The main exposure of interest was a history of pre-purchase charge(s) for drug-related offenses; we examined as a secondary exposure a history of marijuana-related charges. We estimated adjusted hazard ratios (aHR) with 95 % confidence intervals (CI) using Cox proportional hazards multiple events models. RESULTS: We found that legal handgun purchasers in California with a history of drug-related charges, even those with marijuana charges only, had triple the risk of a post-purchase violent crime charge compared to purchasers with no criminal charges (drug charges only: aHR=2.9, 95 % CI 2.2-3.8; marijuana charges only: aHR=3.3, 95 % CI 1.8-6.0). In addition, a criminal history of drug charges only vs. no criminal history was associated with increased risk of one or more violent crime charges after the first post-purchase arrest event (aHR=1.6, 95 % CI 1.2-2.3). CONCLUSION: It is incumbent on researchers and policy makers to understand the nature and causes of this risk in order to take effective steps towards mitigation.


Asunto(s)
Crimen , Armas de Fuego , Violencia , Humanos , California/epidemiología , Violencia/estadística & datos numéricos , Masculino , Crimen/estadística & datos numéricos , Armas de Fuego/legislación & jurisprudencia , Armas de Fuego/estadística & datos numéricos , Femenino , Adulto , Estudios Prospectivos , Adulto Joven , Adolescente , Persona de Mediana Edad
16.
An Acad Bras Cienc ; 85(1): 337-47, 2013 03.
Artículo en Inglés | MEDLINE | ID: mdl-23460440

RESUMEN

During the ageing process the enteric nervous system undergoes morphofunctional changes, such as enteric neurodegeneration. Neuronal death can be attributed to increase radicals free, and ascorbic acid (AA), known antioxidant, could minimize damage cause by oxidative stress. The objective of this study is to analyse the behaviour of morphoquantative myenteric neurons in the duodenum of adult Wistar rats with aged 90 (C90), 345 (E345) and 428 (E428) days, as well as animals of the same age who received ascorbic acid supplementation for 120 days (EA345 and EA428). Whole-mount preparations of muscle layer from the duodenum of the animals were immunostained by the method myosin V. 80 microscopic fields were quantified (14.8 mm2/animal) and measured 100 neuronal cell bodies per animal. During the aging process, there was a reduction in neuronal density in all animals groups, indicating that the effects of age were not attenuated with AA supplementation. The increase in the neuronal area of the cell bodies in 428-day-old animals proved the influence of age on this parameter. There was no observed a neuroprotective effect of AA (1 mL/g body weight) on the neuronal population myenteric myosin V immunoreactive.


Asunto(s)
Envejecimiento , Antioxidantes/farmacología , Ácido Ascórbico/farmacología , Duodeno/inervación , Plexo Mientérico/efectos de los fármacos , Neuronas/efectos de los fármacos , Animales , Suplementos Dietéticos , Duodeno/efectos de los fármacos , Inmunohistoquímica , Masculino , Miosina Tipo V/análisis , Ratas , Ratas Wistar
17.
Inj Epidemiol ; 10(1): 26, 2023 Jun 16.
Artículo en Inglés | MEDLINE | ID: mdl-37328869

RESUMEN

BACKGROUND: Suicide is a pressing public health problem, and firearm owners are at especially elevated risk. Certain health conditions are markers of suicide risk, but more research is needed on clinical risk markers for suicide among firearm owners specifically. Our goal was to examine associations of emergency department and inpatient hospital visits for behavioral and physical health conditions with firearm suicide among handgun purchasers. METHODS: This was a case-control study of 5415 legal handgun purchasers in California who died between January 1, 2008, and December 31, 2013. Cases were firearm suicide decedents; controls were motor vehicle crash decedents. Exposures were emergency department and hospital visits for six categories of health diagnoses in the 3 years prior to death. To account for selection bias due to deceased controls, we used probabilistic quantitative bias analysis to generate bias-adjusted estimates. RESULTS: There were 3862 firearm suicide decedents and 1553 motor vehicle crash decedents. In multivariable models, suicidal ideation/attempt (OR 4.92; 95% CI 3.27-7.40), mental illness (OR 1.97; 95% CI 1.60-2.43), drug use disorder (OR 1.40; 95% CI 1.05-1.88), pain (OR 1.34; 95% CI 1.07-1.69), and alcohol use disorder (OR 1.29; 95% CI 1.01-1.65) were associated with higher odds of firearm suicide. When adjusting for all conditions simultaneously, only the associations for suicidal ideation/attempt and mental illness remained significant. Quantitative bias analysis indicated that observed associations were generally biased downward. For example, the bias-adjusted OR for suicidal ideation/attempt was 8.39 (95% simulation interval 5.46-13.04), almost twice that of the observed OR. CONCLUSIONS: Diagnoses for behavioral health conditions were markers for firearm suicide risk among handgun purchasers, even for conservative estimates that did not adjust for selection bias. Encounters with the healthcare system may provide opportunities to identify firearm owners at high risk of suicide.

18.
Inj Epidemiol ; 10(1): 57, 2023 Nov 09.
Artículo en Inglés | MEDLINE | ID: mdl-37941024

RESUMEN

BACKGROUND: Prohibiting the purchase and possession of firearms by those at risk of violence is an established approach to preventing firearm violence. Prior studies of legal purchasers have focused on convictions for specific crimes, such as violent misdemeanors and driving under the influence (DUI). We broaden that line of inquiry by investigating and comparing the associations between prior arrests for most categories of crime and subsequent arrest for violent offenses among legal handgun purchasers in California. METHODS: In this longitudinal cohort study of 79,678 legal handgun purchasers in California in 2001, we group arrest charges prior to their first purchases in 2001 according to categories defined by the Uniform Crime Report (UCR) Handbook. We use a gradient boosting machine to identify categories of offenses that are most important for predicting arrest for violent crime following firearm purchase. For each category identified, we then estimate the difference in risk of subsequent arrest for a violent offense using survival regression models. RESULTS: We identified eight crime categories with high predictive importance: simple assaults, aggravated assaults, vehicle violations, weapon, other crimes, theft, drug abuse, and DUI. Compared to purchasers with no prior arrests, those with a prior arrest for any one of the eight important categories and no other categories were found to be at increased risk of arrest for a Crime Index-listed violent crime (murder, rape, robbery, aggravated assault), with the greatest estimated risk corresponding to the simple assault UCR category (adjusted hazard ratio 4.0; 95% CI 2.8-5.9). Simple assault was also associated with the greatest risk for subsequent arrest for firearm violence (adjusted hazard ratio 4.6; 95% CI 2.4-9.0) and any violent offense (adjusted hazard ratio 3.7; 95% CI 2.7-5.0). CONCLUSION: The findings of this study suggest that prior arrests for a broad array of crimes, both violent and non-violent, are associated with risk of subsequent violent crimes, including Crime Index-listed violent crimes and firearm violence, among legal purchasers of firearms. Current policies aimed at restricting access to firearms for individuals at increased risk of violence should be re-examined considering these findings.

19.
Artículo en Inglés | MEDLINE | ID: mdl-36293646

RESUMEN

Thousands of buildings in Cleveland, Ohio were demolished or rehabilitated since the Great Recession in the 2000s. Recent evidence suggests removing vacant and decaying buildings reduces violent and firearm-involved crime. This study examines the dose-response relationship between demolitions, rehabilitations, and crime. We use Bayesian spatiotemporal models to estimate the association of interest for five types of crime outcomes: violent crimes, violent crimes involving a firearm, drug crimes, and crimes often associated with building vacancy. We estimate associations in quarterly time periods from 2012 through 2017 in 569 hexagons approximately the size of a neighborhood (2000 feet, approximately 610 m, in diameter), stratified by vacancy level. Across vacancy levels, the majority of our models do not identify statistically significant associations between demolition and rehabilitation dose and crime incidence. However, in some cases, we identify positive associations between demolition and crime. These associations generally appeared at higher levels of demolition (2 or 3 or more demolitions) in areas characterized by medium to high levels of vacancy. We also find that the presence of a property rehabilitation is associated with an increase in drug crimes in areas with medium levels of vacancy.


Asunto(s)
Armas de Fuego , Violencia , Teorema de Bayes , Crimen , Características de la Residencia
20.
J Interpers Violence ; 37(23-24): NP21447-NP21475, 2022 12.
Artículo en Inglés | MEDLINE | ID: mdl-34894835

RESUMEN

Perpetrators of intimate partner violence (IPV) often reoffend, and firearm access increases risk of severe injury or fatality. Prior research identifies an association between a history of violent misdemeanor convictions among handgun purchasers and increased risk of subsequent arrest for a violent crime; the risk associated specifically with an IPV criminal history remains largely unexplored. The current study examined a cohort of 76,311 California adults who legally purchased a handgun in 2001 and followed them through 2013. Compared with purchasers who had no criminal history at the time of purchase, those with a history of only IPV (n = 178) charges were at increased risk of subsequent arrest for a violent Crime Index crime (murder, rape, robbery, aggravated assault; adjusted hazard ratio [AHR], 2.6; 95% confidence interval [CI]: 1.4-5.1), any violent crime (AHR, 3.2; 95% CI: 2.0-5.1), and an IPV crime (AHR, 5.2; 95% CI: 3.0-9.0). Purchasers with both IPV and non-IPV charges demonstrated the greatest risk of re-arrest relative to those with no criminal history. Despite the strength of the relationship between IPV and subsequent arrest, a small proportion of handgun purchasers with an IPV criminal history were re-arrested for firearm violence crimes, limiting application for risk assessment purposes. Results affirm prior research identifying IPV as a risk factor for future offending.


Asunto(s)
Criminales , Armas de Fuego , Violencia de Pareja , Adulto , Humanos , Homicidio , Estudios de Cohortes
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