A quick guide for using Microsoft OneNote as an electronic laboratory notebook.

Scientific data recording and reporting systems are of a great interest for endorsing reproducibility and transparency practices among the scientific community. Current research generates large datasets that can no longer be documented using paper lab notebooks (PLNs). In this regard, electronic laboratory notebooks (ELNs) could be a promising solution to replace PLNs and promote scientific reproducibility and transparency. We previously analyzed five ELNs and performed two survey-based studies to implement an ELN in a biomedical research institute. Among the ELNs tested, we found that Microsoft OneNote presents numerous features related to ELN best functionalities. In addition, both surveyed groups preferred OneNote over a scientifically designed ELN (PerkinElmer Elements). However, OneNote remains a general note-taking application and has not been designed for scientific purposes. We therefore provide a quick guide to adapt OneNote to an ELN workflow that can also be adjusted to other nonscientific ELNs.

Postencephalitic amnesia with long term-working memory impairment: A case report.

Herpes simplex virus encephalitis (HSVE) is an inflammation of the brain parenchyma caused by virus, leading to focal necrosis in medial temporal lobes, hippocampal complex and basal forebrain. Cognitively, HSVE is associated to many dysfunctions which vary according to the extent of the lesion. Episodic memory impairment is the most common sequelae following HSVE episodes, although others can occur. The aim of this case report was to describe the cognitive profile of a 42 year-old man who had extensive bilateral damage to the medial temporal lobe, insular bilateral and orbitofrontal cortices due to HSVE. Severe anterograde and retrograde amnesia, naming deficits, perseverative behaviors and confabulations were observed on neuropsychological assessment. We discussed the concept of long term-working memory based on this evaluation. These cognitive impairments corroborated HSVE previous findings in the literature.

Encefalite herpética (EH) é uma inflamação do parênquima cerebral causada pelo vírus herpes e associada à necrose focal nos lobos temporais mesiais, formação hipocampal e nas partes basais do córtex pré-frontal. Cognitivamente, a EH é relacionada a diversos prejuízos que variam de acordo com a extensão da lesão. Prejuízo na memória episódica é a seqüela mais freqüente, embora outros possam ocorrer. O objetivo deste relato de caso é descrever o perfil cognitivo de um homem de 42 anos que teve extensa lesão nos lobos temporais mesiais, nas ínsulas e nas regiões orbitofrontais em decorrência de um episódio de EH. Amnésias do tipo anterógrada e retrógrada, prejuízos na nomeação, comportamentos perseverativos e confabulações foram observadas pela avaliação neuropsicológica. Nós discutimos o conceito de memória operacional de longo prazo com vistas aos resultados obtidos. Os prejuízos cognitivos observados corroboram a literatura sobre EH.