RESUMEN
The sperm production of 25 patients with Hodgkin's disease treated with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) chemotherapy was studied retrospectively. All but two patients also received radiotherapy treatment to pelvic and/or non-pelvic fields. Sperm counts were obtained from patients treated either with three or fewer (MOPP-2 group) or with five or more (MOPP-6 group) chemotherapy cycles. Recovery of spermatogenesis following treatment-induced azoospermia was significantly higher among the MOPP-2 patients (Mann-Whitney rank sum test, p = 0.001). Patients in this group who did not receive pelvic irradiation appeared to have greater recovery rates (p = 0.06). The results suggest that three cycles of MOPP chemotherapy represent a maximum exposure compatible with the recovery of spermatogenesis.
Asunto(s)
Antineoplásicos/efectos adversos , Protocolos de Quimioterapia Combinada Antineoplásica , Enfermedad de Hodgkin/tratamiento farmacológico , Espermatogénesis/efectos de los fármacos , Adolescente , Adulto , Antineoplásicos/uso terapéutico , Terapia Combinada , Enfermedad de Hodgkin/fisiopatología , Enfermedad de Hodgkin/radioterapia , Humanos , Masculino , Mecloretamina/administración & dosificación , Mecloretamina/efectos adversos , Pelvis/efectos de la radiación , Prednisona/administración & dosificación , Prednisona/efectos adversos , Procarbazina/administración & dosificación , Procarbazina/efectos adversos , Recuento de Espermatozoides , Espermatogénesis/efectos de la radiación , Vincristina/administración & dosificación , Vincristina/efectos adversosRESUMEN
A patient is presented who developed ventricular fibrillation following AMSA treatment, in the setting of hypokalemia. Resuscitation was successful, chemotherapy treatment response was observed, and further treatment with AMSA was uncomplicated after correction of the hypokalemia. With careful attention to electrolyte balance, a prior history of AMSA-induced cardiac arrhythmia does not contraindicate further treatment with AMSA.
Asunto(s)
Aminoacridinas/efectos adversos , Antineoplásicos/efectos adversos , Hipocalcemia/complicaciones , Linfoma no Hodgkin/tratamiento farmacológico , Fibrilación Ventricular/inducido químicamente , Adulto , Amsacrina , Femenino , HumanosRESUMEN
The demonstration by computed tomography (CT) of enlarged nodes and/or masses in lymphoma patients has been interpreted as indicating that active disease is present. Four cases are presented in which either biopsy or laparotomy of a CT-detected mass after therapy revealed fibrous tissue with no evidence of viable neoplasm. These four cases demonstrate the possible pitfall of diagnosing viable lymphoma in masses detected by CT after therapy.