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1.
J Int Med Res ; 20(2): 99-105, 1992 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-1521676

RESUMEN

In the present double-blind investigation, the effects of a new formulation of natural cartilage polysaccharides on sundamaged skin were studied in women aged 40-60 years. A group of 15 women were treated orally with 500 mg/day active substance (Vivida) for 90 days and a second group of 15 women received 500 mg/day placebo for 90 days. Clinical examinations after 45 and 90 days' treatment showed significant improvements in skin condition in the actively treated group but not in the placebo group (P less than 0.001). In the Vivida-treated patients, the epidermal thickness increased after 90 days from 0.11 mm to 0.29 mm, dermal thickness from 0.74 mm to 1.39 mm, skin elasticity index from 44% to 73% and the erythemal index decreased from 0.301 to 0.205. No changes were observed in the placebo group and no adverse effects were reported by either treatment group.


Asunto(s)
Polisacáridos/uso terapéutico , Envejecimiento de la Piel/efectos de los fármacos , Luz Solar/efectos adversos , Administración Oral , Adulto , Método Doble Ciego , Femenino , Humanos , Persona de Mediana Edad , Polisacáridos/administración & dosificación , Piel/efectos de los fármacos , Piel/patología
2.
J Int Med Res ; 20(3): 227-33, 1992 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-1397667

RESUMEN

Evidence is accumulating that cartilage polysaccharides derived from marine fish have a repairing effect on solar elastosis. In a double-blind trial, the efficacy and safety of two commercial preparations, Vivida and Imedeen, were compared in the treatment of sun-damaged skin in women aged 40-60 years. A group of 15 women received 500 mg/day Vivida and another 15 women received 380 mg/day Imedeen orally for 90 days. Subjective assessment revealed statistically significant improvements in skin condition in both treatment groups but Vivida was significantly (P less than 0.01) more effective than Imedeen for all parameters. In the Vivida group, mean epidermal thickness increased from 0.14 to 0.26 mm, dermal thickness from 0.90 to 1.51 mm and the elasticity index from 47% to 71%. In the Imedeen group, epidermal thickness increased from 0.13 to 0.18 mm, dermal thickness from 0.80 to 0.97 mm and the elasticity index from 48% to 56%. After 90 days, the differences between the two groups for all three parameters were statistically significant (P less than 0.001). The mean erythemal index decreased from 0.24 to 0.20 in the Vidida group, but increased from 0.23 to 0.25 in the Imedeen group. In the Vivida group, five patients developed transient, mild pimples during the first weeks of treatment, but no other adverse effects occurred.


Asunto(s)
Enfermedades del Tejido Conjuntivo/tratamiento farmacológico , Glicosaminoglicanos/uso terapéutico , Polisacáridos/uso terapéutico , Proteínas/uso terapéutico , Traumatismos por Radiación/tratamiento farmacológico , Envejecimiento de la Piel/efectos de los fármacos , Enfermedades de la Piel/tratamiento farmacológico , Luz Solar , Anciano , Cartílago , Enfermedades del Tejido Conjuntivo/etiología , Método Doble Ciego , Femenino , Humanos , Persona de Mediana Edad , Traumatismos por Radiación/etiología , Enfermedades de la Piel/etiología
3.
J Int Med Res ; 20(5): 381-91, 1992 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-1451921

RESUMEN

Vivida when used orally has been previously shown to be effective in treating degenerated skin of women. In the present study, 30 women with moderate to severe sun-damaged facial skin applied Vivida cream twice daily for 120 days on one side of the face and placebo to the other. Vivida was significantly (P < 0.001) more effective than placebo in improving wrinkles. The effects of Vivida cream on mottles and telangiectasis were also significantly (P < 0.01) greater than those of placebo. Scanner measurement showed that epidermal thickness increased from 0.13 mm to 0.29 mm and dermal thickness from 0.91 mm to 1.29 mm on the Vivida-treated side; only minimal changes were observed on the placebo-treated side. The elasticity index increased from about 50% to 69% on the Vivida-treated side and from 49% to 50% on the placebo-treated side.


Asunto(s)
Dermatosis Facial/tratamiento farmacológico , Polisacáridos/uso terapéutico , Envejecimiento de la Piel/efectos de los fármacos , Quemadura Solar/complicaciones , Administración Oral , Método Doble Ciego , Dermatosis Facial/etiología , Femenino , Humanos , Pomadas , Polisacáridos/administración & dosificación
4.
J Int Med Res ; 19(2): 147-52, 1991.
Artículo en Inglés | MEDLINE | ID: mdl-1864451

RESUMEN

Imedeen, a new compound for oral administration consisting of special protein fractions and some glucosaminoglycans extracted from marine fish, has been shown in previous pilot studies to have a repairing effect on sun-damaged skin. In an open study, 10 females with sun-damaged skin, aged 39-61 years, were treated with 0.5 g/day Imedeen for 90 days. At baseline and after 30, 60 and 90 days, the following parameters were clinically evaluated: wrinkles; mottles; dryness of skin; and brittleness of hair and nails. After 90 days' treatment all signs of sun-damage had improved and brittleness of hair and nails was normalized in all cases. These clinical observations were confirmed by changes in skin thickness and elasticity. In a second double-blind study, 30 females in the same age range and with similar signs of sun-damage were treated with 0.5 g/day Imedeen or placebo for 90 days. The results in the Imedeen-treated group corresponded to those in the first study whereas no response to treatment was observed in the placebo treatment group.


Asunto(s)
Glicosaminoglicanos/uso terapéutico , Proteínas/uso terapéutico , Enfermedades de la Piel/tratamiento farmacológico , Piel/efectos de la radiación , Luz Solar/efectos adversos , Administración Oral , Adulto , Método Doble Ciego , Tejido Elástico/efectos de la radiación , Femenino , Glicosaminoglicanos/administración & dosificación , Enfermedades del Cabello/tratamiento farmacológico , Humanos , Persona de Mediana Edad , Enfermedades de la Uña/tratamiento farmacológico , Proyectos Piloto , Proteínas/administración & dosificación , Piel/lesiones , Envejecimiento de la Piel/efectos de los fármacos
5.
J Int Med Res ; 18(1): 68-73, 1990.
Artículo en Inglés | MEDLINE | ID: mdl-2139859

RESUMEN

A total of 80 patients with chronic, stable psoriasis, 34 of whom also had psoriatic arthritis, were treated with 1122 mg/day eicosapentaenoic acid ethyl ester and 756 mg/day docosahexaenoic acid ethyl ester. Before the study and after 4 and 8 weeks of treatment a Psoriatic Association scoring index (PASI) score was assessed. Before treatment the mean PASI score was 3.56, after 4 weeks 1.98 and after 8 weeks 1.24; the decrease in the score was highly significant (P less than 0.001). The degree of pruritus decreased most rapidly, followed by scaling and induration of the plaques, and erythema was most persistent. At the end of the trial, seven patients were completely healed and in 13 other patients more than 75% healing was observed but in 14 patients the result was poor. The majority of patients with psoriatic arthritis reported a subjective improvement in joint pain during the study. It is concluded that polyunsaturated ethyl ester lipids may be useful for the treatment of psoriasis and psoriatic arthritis and may provide an important adjuvant to standard therapy of both conditions.


Asunto(s)
Artritis Psoriásica/dietoterapia , Ácidos Docosahexaenoicos/uso terapéutico , Ácido Eicosapentaenoico/análogos & derivados , Psoriasis/dietoterapia , Adulto , Anciano , Ensayos Clínicos como Asunto , Combinación de Medicamentos/uso terapéutico , Ácido Eicosapentaenoico/uso terapéutico , Femenino , Humanos , Lípidos/sangre , Masculino , Persona de Mediana Edad , Dolor/dietoterapia
6.
Genitourin Med ; 66(4): 254-6, 1990 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-2202655

RESUMEN

Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% idoxuridine cream and five patients treated with 0.25% idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.


Asunto(s)
Condiloma Acuminado/tratamiento farmacológico , Idoxuridina/administración & dosificación , Neoplasias del Pene/tratamiento farmacológico , Administración Tópica , Adulto , Método Doble Ciego , Humanos , Masculino , Pomadas , Ensayos Clínicos Controlados Aleatorios como Asunto
7.
Sex Transm Dis ; 17(3): 127-9, 1990.
Artículo en Inglés | MEDLINE | ID: mdl-2174190

RESUMEN

Forty heterosexual male patients with therapy resistant penile warts of long duration (mean 12.9 months) were treated with carbon dioxide laser, immediately followed by topical application of 0.5% idoxuridine cream twice daily for 14 days. In case of incomplete or no response to the initial treatment, the treatment procedure was repeated once. All patients had previously been repeatedly treated with podophyllotoxin 0.5% solution and/or carbon dioxide laser surgery. After two weeks of treatment, 32 patients (80%) were completely healed. The remaining eight patients were retreated and four weeks after the start of the study 35 patients (87.5%) showed complete response. Three months after the study had been initiated 34 patients (85%) were still completely healed. No adverse reactions were observed. It was concluded that laser surgery followed by topical application of 0.5% idoxuridine cream for two to four weeks seems to be highly effective in the treatment of longstanding, therapy-resistant genital warts in men. Because of the uncontrolled nature of the present study and the relatively small number of patients treated, it would be important to carry out controlled studies in larger study populations and to carry out a follow-up examination of at least six months after treatment.


Asunto(s)
Condiloma Acuminado/cirugía , Idoxuridina/administración & dosificación , Terapia por Láser , Neoplasias del Pene/cirugía , Adulto , Terapia Combinada , Condiloma Acuminado/tratamiento farmacológico , Humanos , Idoxuridina/uso terapéutico , Masculino , Pomadas , Papillomaviridae , Neoplasias del Pene/tratamiento farmacológico , Infecciones Tumorales por Virus/tratamiento farmacológico , Infecciones Tumorales por Virus/cirugía
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