Reduction in excitability of the auditory nerve following acute electrical stimulation at high stimulus rates: III. Capacitive versus non-capacitive coupling of the stimulating electrodes.

Safe electrical stimulation of neural tissue is typically achieved using charge-balanced biphasic current pulses, which are designed to minimize the generation of direct current (DC) and the production of harmful electrochemical products. However, due to the kinetics of the charge injection process, neural stimulators must also use capacitive coupling or electrode shorting techniques, to ensure DC levels are minimal. Previous studies have reported a reduction in excitability of the auditory nerve following acute simulation at high rates and intensities. Elevated levels of DC were reported in these studies despite using charge-balanced biphasic pulses and electrode shorting. The present study was designed to investigate the extent to which DC contributed to these stimulus induced reductions in auditory nerve excitability. Adult guinea pigs were bilaterally implanted and unilaterally stimulated for two hours using charge-balanced biphasic current pulses and stimulus rates of 200, 400 or 1000 pulses/s (pps) at a stimulus intensity well above clinical levels (0.34 microC/phase). DC levels were controlled using either electrode shorting, or electrode shorting with capacitive coupling. Electrically evoked auditory brainstem responses (EABRs) were recorded before and periodically following the acute stimulation. It was found that the extent of reduction in the EABR amplitude was a function of stimulus rate. While there was little change in the EABR following stimulation at 200 pps, significant post-stimulus reductions in the EABR amplitude were observed at stimulus rates of 400 and 1000 pps during the three hour post-stimulus monitoring period. Stimulation using capacitively coupled electrodes, which eliminated all DCs, showed reductions in EABR amplitudes similar to those observed following stimulation using electrode shorting alone. While there was no significant difference in the extent of reduction in EABR amplitudes for capacitive coupling versus electrode shorting at stimulus rates of 200 pps (P > 0.05) and 400 pps (P > 0.05), there was a significant difference at 1000 pps (P< 0.001). The present findings indicate that the major component of the stimulus induced reductions observed in auditory nerve excitability appear to be associated with stimulus induced neuronal activity, although elevated levels of DC ( > 2.5 microA) can also contribute to these changes. However, although statistically significant, the effects of DC are very small compared to the effects of high rate, high intensity stimulation per se.

Combined electrical and acoustical stimulation using a bimodal prosthesis.

A new device incorporating a cochlear implant speech processor and a speech-processing hearing aid for the unimplanted ear has been designed and tested with four severely hearing-impaired patients. The aim of the device is to provide a more acceptable and effective combination of electrical and acoustic signals to the two ears. When used monaurally, and binaurally in conjunction with the cochlear implant, the speech-processing hearing aid mean scores for open-set sentences, words, and consonants were as good as or better than the mean scores for the patients' own conventional hearing aids. Some patients improved much more than did others. Although not conclusive, these results are encouraging, especially as they were achieved with a laboratory prototype that did not allow the patients to become accustomed to the processor in everyday situations.

Electrical stimulation of the auditory nerve: direct current measurement in vivo.

Neural prostheses use charge recovery mechanisms to ensure the electrical stimulus is charge balanced. Nucleus cochlear implants short all stimulating electrodes between pulses in order to achieve charge balance, resulting in a small residual direct current (DC). In the present study we sought to characterize the variation of this residual DC with different charge recovery mechanisms, stimulation modes, and stimulation parameters, and by modeling, to gain insight into the underlying mechanisms. In an acute study with anaesthetised guinea pigs, DC was measured in four platinum intracochlear electrodes stimulated using a Nucleus C124M cochlear implant at moderate to high pulse rates (1200-14,500 pulses/s) and stimulus intensities (0.2-1.75 mA at 26-200 microseconds/phase). Both monopolar and bipolar stimulation modes were used, and the effects of shorting or combining a capacitor with shorting for charge recovery were investigated. Residual DC increased as a function of stimulus rate, stimulus intensity, and pulse width. DC was lower for monopolar than bipolar stimulation, and lower still with capacitively coupled monopolar stimulation. Our model suggests that residual DC is a consequence of Faradaic reactions which allow charge to leak through the electrode tissue interface. Such reactions and charge leakage are still present when capacitors are used to achieve charge recovery, but anodic and cathodic reactions are balanced in such a way that the net charge leakage is zero.

Perception of connected speech without lipreading, using a multi-channel hearing prosthesis.

Four of 13 totally deaf patients implanted with the Nucleus multi-channel hearing prosthesis at the University of Melbourne have demonstrated the ability to understand connected speech without lipreading or other visual cues. These patients were able to repeat verbatim unknown material read by a tester at rates of up to 35 words per minute. They were also able to understand an average of 78% of key words in everyday sentences in ideal acoustic conditions and 51% of equivalent material over the telephone. These results show that with a good proportion of postlingually deaf patients, the multi-channel hearing prosthesis can not only act as an aid to lipreading, but also restore effective speech understanding without lipreading.

Speech perception using a two-formant 22-electrode cochlear prosthesis in quiet and in noise.

A new speech-processing strategy has been developed for the Cochlear Pty. Ltd. 22-electrode cochlear prosthesis which codes an estimate of the first formant frequency in addition to the amplitude, voice pitch and second formant frequencies. Two groups of cochlear implant patients were tested 3 months after implant surgery, one group (n = 13) having used the old (F0F2) processing strategy and the other (n = 9) having used the new (F0F1F2) strategy. All patients underwent similar postoperative training programs. Results indicated significantly improved speech recognition for the F0F1F2 group, particularly on open set tests with audition alone. Additional testing with a smaller group of patients was carried out with competing noise (speech babble). Results for a closed set spondee test showed that patient performance was significantly degraded at a signal-to-noise ratio of 10 dB when using the F0F2 strategy, but was not significantly affected with the F0F1F2 strategy.

A multiple-channel cochlear implant and wearable speech-processor: an audiological evaluation.

Stand audiological tests were administered to a totally deaf multiple-channel cochlear implant patient with a wearable speech-processor in a monitored sound field under the following conditions: a wearable unit activated alone (WA), lipreading with the wearable unit off (LA), and wearable unit activated in combination with lipreading (WL). Thresholds obtained for narrow-band noise signals indicated that the wearable unit allowed the patient to detect a variety of sounds at different frequencies. The results obtained in closed-set word tests and open-set word and sentence tests showed significant improvements in word and sentence scores from LA to WL. In the open-set (C.I.D.) sentence test, the patient scored 22% for LA and 76% for WL. The WL score of 76% correlates with a satisfactory performance in understanding connected speech. The patient also scored 30% correct in a test involving the recognition of environmental sounds.

Evaluation of the Nucleus Spectra 22 processor and new speech processing strategy (SPEAK) in postlinguistically deafened adults.

A new speech processing strategy (SPEAK) has been compared with the previous Multipeak (MPEAK) strategy in a study with 24 postlinguistically deafened adults. The results show that performance with the SPEAK coding strategy was significantly better for 58.31% of subjects on closed-set consonant identification, for 33.3% of subjects on closed-set vowel identification and open-set monosyllabic word recognition, and for 81.8% of subjects on open-set sentence recognition in quiet and in competing noise (+ 10 dB signal-to-noise ratio). By far the largest improvement observed was for sentence recognition in noise, with the mean score across subjects for the SPEAK strategy twice that obtained with MPEAK.

Coding of voice source information in the Nucleus cochlear implant system.

Two studies are reported in which the effectiveness of explicitly coding voicing and fundamental frequency information for the Nucleus cochlear implant was investigated. In the first study, the voicing perception of a group of three experienced Multipeak users was evaluated when they were using Multipeak and a modified Multipeak in which the explicit fundamental frequency and voicing cues were eliminated and replaced with a 250-Hz constant rate of stimulation. The results of consonant and monosyllabic word tests showed that there was no significant difference in the subjects' ability to discriminate voicing. In the second study, the ability of a group of five experienced users of the constant rate spectral maxima sound processor (SMSP) strategy to discriminate suprasegmental contrasts was evaluated when they were using the SMSP strategy and a modified SMSP strategy that included a rate-encoded representation of the fundamental frequency on the most apical stimulation channel. The results of intonation, roving stress, and question-statement tests showed that there was no significant difference between the scores recorded with these strategies. Since the temporal voicing cue is not a primary cue to voicing discrimination for Multipeak users, and the provision of an additional rate cue to the SMSP strategy does not improve SMSP users' ability to discriminate suprasegmental contrasts, the results of these studies indicate that in the cases investigated, the coding of voice source information by rate of stimulation does not significantly augment the cues present in the spatially distributed constant rate stimulation pattern.

Speech perception in children using the advanced Speak speech-processing strategy.

The Speak speech-processing strategy, developed by the University of Melbourne and commercialized by Cochlear Pty Limited for use in the new Spectra 22 speech processor, has been shown to provide improved speech perception for adults in both quiet and noisy situations. The present study evaluated the ability of children experienced in the use of the Multipeak (Mpeak) speech-processing strategy (implemented in the Nucleus Minisystem-22 cochlear implant) to adapt to and benefit from the advanced Speak speech-processing strategy (implemented in the Nucleus Spectra 22 speech processor). Twelve children were assessed using Mpeak and Speak over a period of 8 months. All of the children had over 1 year's previous experience with Mpeak, and all were able to score significantly on open-set word and sentence tests using the cochlear implant alone. Children were assessed with both live-voice and recorded speech materials, including Consonant-Nucleus-Consonant monosyllabic words and Speech Intelligibility Test sentences. Assessments were made in both quiet and in noise. Assessments were made at 3-week intervals to investigate the ability of the children to adapt to the new speech-processing strategy. For most of the children, a significant advantage was evident when using the Speak strategy as compared with Mpeak. For 4 of the children, there was no decrement in speech perception scores immediately following fitting with Speak. Eight of the children showed a small (10% to 20%) decrement in speech perception scores for between 3 and 6 weeks following the changeover to Speak. After 24 weeks' experience with Speak, 11 of the children had shown a steady increase in speech perception scores, with final Speak scores higher than for Mpeak. Only 1 child showed a significant decrement in speech perception with Speak, which did not recover to original Mpeak levels.

Telephone use by a multi-channel cochlear implant patient. An evaluation using open-set CID sentences.

A totally deaf person with a multiple-channel cochlear prosthesis obtained open-set speech discrimination using the telephone. CID Everyday Sentences were presented by telephone to the patient, who repeated an average of 21 per cent of key words correctly on the first presentation, and 47 per cent when a repeat of the sentences was permitted. This result is consistent with the patient's reports of telephone usage.

A multi-channel hearing prosthesis for profound-to-total hearing loss.

A multi-channel cochlear implant hearing prosthesis providing 22 separate channels of stimulation has been developed. The electronics for the implantable receiver-stimulator have been incorporated on a single chip, using digital circuits and employing CMOS technology. The chip is enclosed in a titanium capsule with platinum/ceramic electrode feed-throughs. A pocket-sized speech processor and directional microphone extract the following speech parameters: signal amplitude, fundamental frequency and formant frequency. The fundamental frequency is coded as electric pulse rate, and formant frequency by electrode position. The speech processor has been realized using hybrid circuits and CMOS gate arrays. The multi-channel prosthesis has undergone a clinical trial on four postlingually deaf patients with profound-total hearing losses. The speech perception results indicate that they were able to obtain open-set speech recognition scores for phonetically balanced words, CID sentences and spondees. In all cases the tests showed significant improvements when using the cochlear prosthesis combined with lipreading compared to lipreading alone.

Preliminary evaluation of a formant enhancement algorithm on the perception of speech in noise for normally hearing listeners.

The effects on speech perception in noise of dynamic filtering with bandpass filters centred at the first formant (f1) and second formant (f2) frequencies were evaluated with four normally hearing listeners. Multitalker babble was added to the speech signal with signal-to-noise ratios of -5 to -15 dB, chosen to reduce intelligibility to about 50%. The combined signal was then filtered with two-pole programmable bandpass filters centred at f1 and f2 under the control of a real-time speech processor. The f1 and f2 frequencies were estimated from the speech signal before noise was added to avoid hardware processing errors. Closed set vowel and consonant tests (using 11 /h/vowel/d/ and 12 /a/consonant/a/ stimuli), the Consonant-Nucleus-Consonant Monosyllabic Word Test and the Bamford-Kowal-Bench Sentence Test were carried out for three filter bandwidths (3/4, 1/3 and 1/6 octave) and for unprocessed speech in noise. The processing produced a small significant improvement for vowels in all three processed speech conditions and for monosyllables at the broadest filter setting compared to the unprocessed speech condition. There was no significant effect on consonants. A small negative effect was observed for sentences at the narrowest filter setting.

Acoustic parameters measured by a formant-estimating speech processor for a multiple-channel cochlear implant.

In order to assess the limitations imposed on a cochlear implant system by a wearable speech processor, the parameters extracted from a set of 11 vowels and 24 consonants were examined. An estimate of the fundamental frequency EF 0 was derived from the zero crossings of the low-pass filtered envelope of the waveform. Estimates of the first and second formant frequencies EF 1 and EF 2 were derived from the zero crossings of the waveform, which was filtered in the ranges 300-1000 and 800-4000 Hz. Estimates of the formant amplitudes EA 1 and EA 2 were derived by peak detectors operating on the outputs of the same filters. For vowels, these parameters corresponded well to the first and second formants and gave sufficient information to identify each vowel. For consonants, the relative levels and onset times of EA 1 and EA 2 and the EF 0 values gave cues to voicing. The variation in time of EA 1, EA 2, EF 1, and EF 2 gave cues to the manner of articulation. Cues to the place of articulation were given by EF 1 and EF 2. When pink noise was added, the parameters were gradually degraded as the signal-to-noise ratio decreased. Consonants were affected more than vowels, and EF 2 was affected more than EF 1. Results for three good patients using a speech processor that coded EF 0 as an electric pulse rate, EF 1 and EF 2 as electrode positions, and EA 1 and EA 2 as electric current levels confirmed that the parameters were useful for recognition of vowels and consonants. Average scores were 76% for recognition of 11 vowels and 71% for 12 consonants in the hearing-alone condition. The error rates were 4% for voicing, 12% for manner, and 25% for place.

A 12-consonant confusion study on a multiple-channel cochlear implant patient.

A consonant confusion study was undertaken on a multiple-channel cochlear implant patient using a wearable speech processing device. This patient suffered from total bilateral deafness acquired postlingually. The consonants /b/, /p/, /m/, /v/, /f/, /d/, /t/, /n/, /z/, /s/, /g/, /k/ were presented in a VCV context with the vowel /a/ as in father by a male and female speaker under three conditions: lipreading alone; electrical stimulation alone using the wearable speech processor and multiple-channel cochlear implant; lipreading in conjunction with electrical stimulation. No significant difference was detected between the results for the male and female speakers. The percentage correct scores for the pooled results of both speakers were lipreading alone--30%; electrical stimulation alone--48%; lipreading with electrical stimulation--70%. Performance was significantly better for lipreading with electrical stimulation than for lipreading alone and for electrical stimulation alone than for lipreading alone. An information transmission analysis demonstrated the effective integration of visual and auditory information for lipreading with electrical stimulation. There was a significant improvement in performance for the electrical stimulation alone condition over the 2 months of the study in contrast to no such improvement for lipreading alone.

Recent developments with the nucleus 22-electrode cochlear implant: a new two formant speech coding strategy and its performance in background noise.

A clinical evaluation of speech processing strategies for the Nucleus 22-electrode cochlear implant showed improvements in understanding speech using the new FOF1F2 speech coding strategy instead of the F0F2 strategy. Significant improvement in closed-set speech recognition in the presence of background noise was an additional advantage of the new speech processing strategy.

Vowel and consonant recognition of cochlear implant patients using formant-estimating speech processors.

Vowel and consonant confusion matrices were collected in the hearing alone (H), lipreading alone (L), and hearing plus lipreading (HL) conditions for 28 patients participating in the clinical trial of the multiple-channel cochlear implant. All patients were profound-to-totally deaf and "hearing" refers to the presentation of auditory information via the implant. The average scores were 49% for vowels and 37% for consonants in the H condition and the HL scores were significantly higher than the L scores. Information transmission and multidimensional scaling analyses showed that different speech features were conveyed at different levels in the H and L conditions. In the HL condition, the visual and auditory signals provided independent information sources for each feature. For vowels, the auditory signal was the major source of duration information, while the visual signal was the major source of first and second formant frequency information. The implant provided information about the amplitude envelope of the speech and the estimated frequency of the main spectral peak between 800 and 4000 Hz, which was useful for consonant recognition. A speech processor that coded the estimated frequency and amplitude of an additional peak between 300 and 1000 Hz was shown to increase the vowel and consonant recognition in the H condition by improving the transmission of first formant and voicing information.

A signal processor for a multiple-electrode hearing prosthesis.

A 22-electrode implantable hearing prosthesis uses a wearable speech processor which estimates three speech signal parameters. These are voice pitch, second formant frequency and flattened spectrum amplitude. The signal is monitored continuously for periodicity in the range 80-400 Hz and, if this is present, stimulation occurs at the same rate. Otherwise, as in the case of unvoiced sounds, it occurs at the random rate of fluctuation of the signal envelope. The second formant is obtained by filtering to extract the dominant peak in the midband region and by continuous measurement of the zero crossing rate. The amplitude measured is that of the whole speech spectrum, pre-emphasized by differentiation. The values that are presented to the patient are the parameter estimates immediately prior to the stimulation pulse. Second formant frequency is coded by selection of an appropriate electrode in the cochlea and amplitude by a suitably controlled current. Automatic gain control is used to keep the dynamic range of the amplitude estimate within the 30 dB range of the circuitry.

Performance of postlinguistically deaf adults with the Wearable Speech Processor (WSP III) and Mini Speech Processor (MSP) of the Nucleus Multi-Electrode Cochlear Implant.

Seven postlinguistically deaf adults implanted with the Nucleus Multi-Electrode Cochlear Implant participated in an evaluation of speech perception performance with three speech processors: the Wearable Speech Process (WSP III), a prototype of the Mini Speech Processor, and the Mini Speech Processor. The first experiment was performed with the prototype and Wearable Speech Processor both programmed using the F0F1F2 speech coding strategy. The second experiment compared performance with the Mini Speech Processor programmed with the Multi-Peak speech coding strategy and the Wearable Speech Processor programmed with the F0F1F2 speech coding strategy. Performance was evaluated in the sound-only condition using recorded speech tests presented in quiet and in noise. Questionnaires and informal reports provided information about use in everyday life. In experiment I, there was no significant difference in performance using the Wearable Speech Processor and prototype on any of the tests. Nevertheless, six out of seven subjects preferred the prototype for use in everyday life. In experiment II, performance on open-set tests in quiet and noise was significantly higher with the Mini Speech Processor (Multi-Peak speech coding strategy) than with the Wearable Speech Processor. Subjects reported an increase in their ability to communicate with other people using the Mini Speech Processor (Multi-Peak speech coding strategy) compared with the Wearable Speech Processor in everyday life.