Estimation of Knee Joint Forces in Sport Movements Using Wearable Sensors and Machine Learning.

Knee joint forces (KJF) are biomechanical measures used to infer the load on knee joint structures. The purpose of this study is to develop an artificial neural network (ANN) that estimates KJF during sport movements, based on data obtained by wearable sensors. Thirteen participants were equipped with two inertial measurement units (IMUs) located on the right leg. Participants performed a variety of movements, including linear motions, changes of direction, and jumps. Biomechanical modelling was carried out to determine KJF. An ANN was trained to model the association between the IMU signals and the KJF time series. The ANN-predicted KJF yielded correlation coefficients that ranged from 0.60 to 0.94 (vertical KJF), 0.64 to 0.90 (anterior-posterior KJF) and 0.25 to 0.60 (medial-lateral KJF). The vertical KJF for moderate running showed the highest correlation (0.94 ± 0.33). The summed vertical KJF and peak vertical KJF differed between calculated and predicted KJF across all movements by an average of 5.7% ± 5.9% and 17.0% ± 13.6%, respectively. The vertical and anterior-posterior KJF values showed good agreement between ANN-predicted outcomes and reference KJF across most movements. This study supports the use of wearable sensors in combination with ANN for estimating joint reactions in sports applications.

Impact of a Semi-Rigid Knee Orthotic Intervention on Pain, Physical Activity, and Functional Capacity in Patients with Medial Knee Osteoarthritis.

Background: The effectiveness of knee orthoses as part of conservative treatment for patients with medial knee osteoarthritis has not been fully explored. The purpose of this study was to evaluate the effects of a novel semi-rigid knee orthosis on pain, physical activity, and functional capacity. Methods: Pain levels, physical activity, and functional capacity were assessed in 24 participants experiencing symptomatic medial knee osteoarthritis one week before (i.e., pretest) initiating a six-week orthosis intervention and again during the final week of the intervention (i.e., post-test). Results: Night pain, pain during walking, pain during stair climbing, and pain during sitting consistently decreased by 41% to 48% while wearing the knee orthosis. Device-based measured physical activity showed a 20.2-min increase in vigorous physical activity during the post-test, while light and moderate physical activity did not show significant changes. After six weeks of orthosis application, there was a 5% increased distance for the six-minute walk test, and participants reported fewer limitations both in everyday and athletic activities, as well as an enhanced quality of life. Conclusions: These findings highlight the potential effectiveness of a semi-rigid knee orthosis to enhancing functional capacity and quality of life. More extensive and longer clinical trials are needed to improve confidence in these findings and understand their impact on disease progression.

Effects of hip osteoarthritis on lower body joint kinematics during locomotion tasks: a systematic review and meta-analysis.

Introduction: Motion analysis can be used to gain information needed for disease diagnosis as well as for the design and evaluation of intervention strategies in patients with hip osteoarthritis (HOA). Thereby, joint kinematics might be of great interest due to their discriminative capacity and accessibility, especially with regard to the growing usage of wearable sensors for motion analysis. So far, no comprehensive literature review on lower limb joint kinematics of patients with HOA exists. Thus, the aim of this systematic review and meta-analysis was to synthesise existing literature on lower body joint kinematics of persons with HOA compared to those of healthy controls during locomotion tasks. Methods: Three databases were searched for studies on pelvis, hip, knee and ankle kinematics in subjects with HOA compared to healthy controls during locomotion tasks. Standardised mean differences were calculated and pooled using a random-effects model. Where possible, subgroup analyses were conducted. Risk of bias was assessed with the Downs and Black checklist. Results and Discussion: A total of 47 reports from 35 individual studies were included in this review. Most studies analysed walking and only a few studies analysed stair walking or turning while walking. Most group differences were found in ipsi- and contralateral three-dimensional hip and sagittal knee angles with reduced ranges of motion in HOA subjects. Differences between subjects with mild to moderate and severe HOA were found, with larger effects in severe HOA subjects. Additionally, stair walking and turning while walking might be promising extensions in clinical gait analysis due to their elevated requirements for joint mobility. Large between-study heterogeneity was observed, and future studies have to clarify the effects of OA severity, laterality, age, gender, study design and movement execution on lower limb joint kinematics. Systematic Review Registration: PROSPERO (CRD42021238237).

Sepsis survivors and caregivers perspectives on post-acute rehabilitation and aftercare in the first year after sepsis in Germany.

Background: Sepsis survivors often suffer from new morbidities. Current rehabilitation therapies are not tailored to their specific needs. The perspective of sepsis survivors and their caregivers on rehabilitation and aftercare is insufficiently understood. We aimed to assess how sepsis survivors in Germany rated the suitability, extent and satisfaction with rehabilitation therapies that they underwent in the year following the acute sepsis episode. Methods: Prospective mixed-methods, multicenter study among a cohort of adult ICU-treated sepsis survivors and their caregivers. Interviews were conducted 6 and 12 months after ICU discharge by telephone and comprised closed as well as open-ended questions. Primary outcomes were the utilization and patient satisfaction with inpatient and outpatient rehabilitation and post-sepsis aftercare in general. Open-ended questions were analyzed according to the principles of content analysis. Results: Foun hundred interviews were performed with 287 patients and/or relatives. At 6 months after sepsis, 85.0% of survivors had applied for and 70.0% had undergone rehabilitation. Among these, 97% received physical therapy, but only a minority reported therapies for specific ailments including pain, weaning from mechanical ventilation, cognitive deficits of fatigue. Survivors were moderately satisfied with the suitability, extent, and overall results of received therapies and perceived deficits in the timeliness, accessibility, and specificity of therapies as well as deficits in the structural support frameworks and patient education. Conclusion: From the perspective of survivors who undergo rehabilitation, therapies should already begin in hospital, be more appropriate for their specific ailments and include better patient and caregiver education. The general aftercare and structural support framework should be improved.

Effects of Hip Bracing on Gait Biomechanics, Pain and Function in Subjects With Mild to Moderate Hip Osteoarthritis.

Hip Osteoarthritis (HOA) is a common joint disease with serious impact on the quality of life of the affected persons. Additionally, persons with HOA often show alterations in gait biomechanics. Developing effective conservative treatment strategies is of paramount importance, as joint replacement is only indicated for end-stage HOA. In contrast to knee osteoarthritis, little is known about the effectiveness of hip bracing for the management of HOA. Studies analysing mechanically unloading hip braces partly showed beneficial results. However, methodological limitations of these studies, such as small sample sizes or lack of control groups, limit the applicability of the results. Additionally, mechanically unloading braces might impose restrictions on motion and comfort and thus, might not be suitable for people with only mild or moderate symptoms. The aim of this study was to comprehensively quantify the effects of unilateral HOA as well as functional hip bracing on gait biomechanics, pain, proprioception and functional capacity in people with mild to moderate HOA. Hip and pelvis biomechanics during walking were analysed in 21 subjects with mild to moderate HOA under three bracing conditions: unbraced, immediately after brace application and after 1 week of brace usage. Additionally, pain, hip proprioception and functional capacity were assessed. A matched group of 21 healthy subjects was included as reference. Kinematic and kinetic data were collected using a 16-camera infrared motion capturing system and two force plates. Visual analogue scales, an angle reproduction test and a 6-min walking test were applied to measure pain, hip proprioception and functional capacity, respectively. Subjects with HOA walked slower, with reduced step length, sagittal hip range of motion and peak extension angle and had a reduced functional capacity. After 1 week of brace application step length, walking speed and functional capacity were significantly increased. Additionally, pain perception was significantly lower in the intervention period. These results encourage the application of functional hip braces in the management of mild to moderate HOA. However, as key parameters of HOA gait such as a reduced peak extension angle remained unchanged, the underlying mechanisms remain partly unclear and have to be considered in the future.

The Use of Compression Stockings to Reduce Water Retention in the Legs During Gaming and Esports: Randomized Controlled Field Study.

BACKGROUND: With the increasing digitalization of daily life, internet-based entertainment such as gaming and streaming has advanced to one of the megatrends of the 21st century. Besides offering a multitude of controversially discussed opportunities for entertainment and social interaction, there is reasonable concern about health issues caused by the absence of physical activity among activities linked to gaming and streaming. OBJECTIVE: The aim of this study is to compare the water balance of recreational gamers with and those without compression stockings during a gaming event. METHODS: We measured body composition and water balance with 8-electrode bioelectrical impedance analysis among 46 recreational gamers with an average age of 27.1 (SD 6.5) years (5/46, 11% women and 41/46, 89% men) before and after 24 hours at a gaming event. Of the 46 gamers, 23 (50%) gamers wore compression stockings for the duration of the study. RESULTS: Our study shows that prolonged gaming and associated behaviors during a 24-hour time frame lead to an increase in total body water (+0.76 L; P<.001) and a decrease of phase angle in the lower extremities (-0.47°; P<.001) but not in the upper extremities (+0.09°; P=.80), when no compression is used. Gamers using compression socks did not show any significant negative effects on their body composition. CONCLUSIONS: Prolonged gaming and streaming are serious risk factors for diseases associated with water retention in the legs, and these risks can be measured by bioelectrical impedance and reduced by wearing compression stockings. We conclude that these findings should be discussed and replicated in larger studies and that there is a considerably large market for compression stockings among gamers and live streamers.

Effect of Different Knee Braces in ACL-Deficient Patients.

Knee braces are often used during rehabilitation after ACL injury. There are two main concepts, rigid and soft braces, but studies comparing the two show conflicting results. Most studies used movement tasks with low translational or rotational loads and did not provide joint kinematics. Therefore, the purpose of this study was to investigate the influence of two different knee braces (rigid vs. soft) on knee joint kinematics in ACL-deficient patients compared to an unbraced control condition using two tasks (walking and 180° cutting) provoking knee movements in the frontal and transverse planes. 17 subjects with ACL-deficient knees participated in this study. 3D knee joint kinematics were recorded. To provoke frontal plane knee joint motion a laterally tilting plate was applied during a walking task. Both braces reduced the maximum valgus angle compared to the unbraced condition, stabilizing the knee joint against excessive valgus motion. Yet, no differences in peak abduction angle between the two braces were found. However, a significant extension deficit was observed with the rigid brace. Moreover, both braces increased transverse plane RoM and peak internal rotation angle, with the effects being significantly larger with the rigid brace. These effects have been associated with decreased knee stability and unphysiological cartilage loading. Therefore, the soft brace seems to be able to limit peak abduction with a lesser impact on physiological gait compared to the rigid brace. The cutting task was selected to provoke transverse plane knee movement and large external knee rotation was expected. However, none of the braces was able to reduce peak external knee rotation. Again, an increase in transverse plane RoM was observed with both braces. Based on these results, no brace outmatched the other in the second task. This study was the first attempt to clarify the effect of brace design for the stabilization of the knee joint during movements with frontal and transverse plane loading. However, to provide physicians and patients with a comprehensive guideline for brace usage, future studies will have to extent these findings to other daily or sportive movement tasks.

A Machine Learning and Wearable Sensor Based Approach to Estimate External Knee Flexion and Adduction Moments During Various Locomotion Tasks.

Joint moment measurements represent an objective biomechanical parameter of knee joint load in knee osteoarthritis (KOA). Wearable sensors in combination with machine learning techniques may provide solutions to develop assistive devices in KOA patients to improve disease treatment and to minimize risk of non-functional overreaching (e.g., pain). The purpose of this study was to develop an artificial neural network (ANN) that estimates external knee flexion moments (KFM) and external knee adduction moments (KAM) during various locomotion tasks, based on data obtained by two wearable sensors. Thirteen participants were instrumented with two inertial measurement units (IMUs) located on the right thigh and shank. Participants performed six different locomotion tasks consisting of linear motions and motions with a change of direction, while IMU signals as well as full body kinematics and ground reaction forces were synchronously recorded. KFM and KAM were determined using a full body biomechanical model. An ANN was trained to estimate the KFM and KAM time series using the IMU signals as input. Evaluation of the ANN was done using a leave-one-subject-out cross-validation. Concordance of the ANN-estimated KFM and reference data was categorized for five tasks (walking straight, 90° walking turn, moderate running, 90° running turn and 45° cutting maneuver) as strong (r ≥ 0.69, rRMSE ≤ 23.1) and as moderate for fast running (r = 0.65 ± 0.43, rRMSE = 25.5 ± 7.0%). For all locomotion tasks, KAM yielded a lower concordance in comparison to the KFM, ranging from weak (r ≤ 0.21, rRMSE ≥ 33.8%) in cutting and fast running to strong (r = 0.71 ± 0.26, rRMSE = 22.3 ± 8.3%) for walking straight. Smallest mean difference of classical discrete load metrics was seen for KFM impulse, 10.6 ± 47.0%. The results demonstrate the feasibility of using only two IMUs to estimate KFM and KAM to a limited extent. This methodological step facilitates further work that should aim to improve the estimation accuracy to provide valuable biofeedback systems for KOA patients. Greater accuracy of effective implementation could be achieved by a participant- or task-specific ANN modeling.

Automated gait event detection for a variety of locomotion tasks using a novel gyroscope-based algorithm.

BACKGROUND: The robust identification of initial contact (IC) and toe-off (TO) events is a vital task in mobile sensor-based gait analysis. Shank attached gyroscopes in combination with suitable algorithms for data processing can robustly and accurately complete this task for gait event detection. However, little research has considered gait detection algorithms that are applicable to different locomotion tasks. RESEARCH QUESTION: Does a gait event detection algorithm for various locomotion tasks provide comparable estimation accuracies as existing task-specific algorithms? METHODS: Thirteen males, equipped with a gyroscope attached to the right shank, volunteered to perform nine different locomotion tasks consisting of linear movements and movements with a change of direction. A rule-based algorithm for IC and TO events was developed based on the shank sagittal plane angular velocity. The algorithm was evaluated against events determined by vertical ground reaction force. Absolute mean error (AME), relative absolute mean error (RAME) and Bland-Altman analysis was used to assess its accuracy. RESULTS: The average AME and RAME were 11 ±â€¯3 ms and 3.07 ±â€¯1.33 %, respectively, for IC and 29 ±â€¯11 ms and 7.27 ±â€¯2.92 %, respectively, for TO. Alterations of the walking movement, such as turns and types of running, slightly reduced the accuracy of IC and TO detection. In comparison to previous methods, increased or comparable accuracies for both IC and TO detection are shown. SIGNIFICANCE: The study shows that the proposed algorithm is capable of detecting gait events for a variety of locomotion tasks by means of a single gyroscope located on the shank. In consequence, the algorithm can be applied to activities, which consist of various movements (e.g., soccer). Ultimately, this extends the use of mobile sensor-based gait analysis.

Modularity in Motor Control: Similarities in Kinematic Synergies Across Varying Locomotion Tasks.

Kinematic synergies (kSYN) provide an approach to quantify the covariation of joint motions and to explain the mechanisms underlying human motor behavior. A low-dimensional control strategy by means of the activation of a moderate number of kSYN would simplify the performance of complex motor tasks. The purpose of this study was to examine similarities between the kSYN of varying locomotion tasks: straight-line walking, walking a 90° spin turn and walking upstairs. Task-specific kSYN were extracted from full body kinematic recordings of 13 participants by principal component analysis. The first five kSYN accounting for most of the variance within each task were selected for further analysis following previous studies. The similarities between the kSYN of the three different locomotion tasks were quantified by calculating cosine similarities (SIM), as a vector-based similarity measure ranging from 0 (no similarity) to 1 (high similarity), between absolute principal component loading vectors. A SIM between two kSYN > 0.8 was interpreted as highly similar. Two to three highly similar kSYN were identified when comparing two individual tasks with each other. One kSYN, primarily characterized by anteversion and retroversion of the arms and legs, were found to be similar in all three tasks. Additional kSYN that occurred between individual tasks reflected mainly an upwards/downwards movement of the body or a countercyclical knee flexion/extension. The results demonstrate that the three investigated locomotion tasks are characterized by kSYN and that certain kSYN repeatedly occur across the three locomotion tasks. PCA yields kSYN which are in descent order according to their amount of total variance accounted for. Referring to the placing of a kSYN within the order as priorization, we found a change in priorization of repeatedly occurring kSYN across the individual tasks. The findings support the idea that movements can be efficiently performed through a flexible combination of a lower number of control-relevant variables.

Deficient knee joint biomechanics in bilateral jumping after anterior cruciate ligament reconstruction.

BACKGROUND: The purpose of this study was to analyze sagittal-plane knee biomechanics in individuals with ACL reconstructions in bilateral countermovement jumps. This aimed to determine potential knee compensation strategies during a high-demanding symmetrical movement task from pre to six months post-ACL reconstruction. METHODS: 20 ACL-reconstructed individuals were tested pre-operatively, and then seven weeks, three months, and six months after reconstruction. Additionally, a matched control group was analyzed. Data were sampled with 3D motion capture and two force plates. The following kinematic data were analyzed: peak knee flexion during countermovement, knee angle at toe-off, and knee flexion excursion during landing. The following kinetic data were analyzed: peak knee extension moments during countermovement and landing. FINDINGS: ACL-reconstructed individuals showed significant increases in knee flexion during countermovement and knee flexion excursion during landing from six weeks to six months after reconstruction but they remained significantly below the level of the controls. The reconstructed knee joint showed increased flexion at toe-off compared to the non-injured leg at all test sessions. Knee extension moments during countermovement increased up to six months after reconstruction, but remained deficient in ACL-reconstructed individuals during countermovement and landing compared to the controls. INTERPRETATION: Although ACL-reconstructed individuals showed increases in most kinematic and kinetic variables, they remained below the controls at six months post-ACL reconstruction. The deficits between contralateral legs and compared to the controls show that six months post-ACL reconstruction, knee joint functionality was still not equal between reconstructed and non-injured legs or in comparison to controls.

Towards a wearable monitoring tool for in-field ice hockey skating performance analysis.

The capturing of movements by means of wearable sensors has become increasingly popular in order to obtain sport performance measures during training or competition. The purpose of the current study was to investigate the feasibility of using body worn accelerometers to identify previous highlighted performance related biomechanical changes in terms of substantial differences across skill levels and skating phases. Twenty-two ice hockey players of different caliber were equipped with two 3D accelerometers, located on the skate and the waist, as they performed 30 m forward skating sprints on an ice rink. Two measures of the temporal stride characteristics (contact time and stride time) and one measure of the propulsive power (stride propulsion) of a skating stride were calculated and checked for discriminating effects across (i) skill levels and (ii) sprint phases as well as for their (iii) strength of association with the sprint performance (total sprint time). High caliber players showed an increased stride propulsion (+22%, P < 0.05) and shorter contact time (-5%, P < 0.05). All three analysed variables highlighted substantial biomechanical differences between the accelerative and constant velocity phases (P < 0.05). Stride propulsion of acceleration strides primarily correlated to total sprint time (r = -0.57, P < 0.05). The results demonstrate the potential of accelerometers to assess skating technique elements such as contact time or elements characterizing the propulsive power such as center of mass acceleration, to gauge skating performance. Thus, the findings of this study might contribute to establishing wearable sensors for in-field ice hockey skating performance analysis.

How does functionality proceed in ACL reconstructed subjects? Proceeding of functional performance from pre- to six months post-ACL reconstruction.

This is the first study examining functionality of subjects with anterior cruciate ligament (ACL) tears and a subsequent reconstruction comprehensively by multiple test sessions from pre- to six months post-reconstruction. The purpose was to evaluate if a generally applied rehabilitation program restores functionality to levels of healthy controls. Subjects with unilateral tears of the ACL were compared to matched healthy controls throughout the rehabilitation. 20 recreational athletes were tested: T1 (preoperative), 6 weeks after tear; T2, 6 weeks, T3, 3 months, T4, 6 months post-reconstruction. At all test sessions, subjects self-evaluated their activity level with the Tegner activity score and their knee state with the Knee Injury and Osteoarthritis Outcome Score. Passive range of motion during knee flexion and extension and leg circumference were measured as functional clinical tests. Bilateral countermovement jumps, one-leg jumps for distance and isometric force tests in knee flexion and extension with 90° and 110° knee angle were conducted as functional performance tests. For determination of functionality, leg symmetry indices (LSIs) were calculated by dividing values of the injured by the uninjured leg. In the ACL group most LSIs decreased from T1 to T2, and increased from T2 and T3 to T4. LSIs of ACL subjects remained lower than LSIs of healthy controls at 6 months post-reconstruction in nearly all parameters. Self-evaluation of ACL subjects showed, additionally, that activity level was lower than the pre-injury level at 6 months post-reconstruction. Low LSIs and low self-evaluation indicate that knee joint functionality is not completely restored at 6 months post-reconstruction. The study shows that multiple comprehensive testing throughout the rehabilitation gives detailed images of the functional state. Therefore, the functional state of ACL reconstructed individuals should be evaluated comprehensively and continuously throughout the rehabilitation to detect persisting deficiencies detailed and adapt rehabilitation programs individually depending on the functionality.

No difference between two doses of diclofenac in prophylaxis of heterotopic ossifications after total hip arthroplasty.

BACKGROUND: In a monocentric, randomized, placebo-controlled double-blind study, we investigated the efficacy of two doses of diclofenac-cholestyramine for the prevention of heterotopic ossification (HO). PATIENTS: The study comprised 245 patients undergoing total hip arthroplasty (THA). RESULTS: With 150 mg cholestyramine-bound diclofenac (2 x 1 capsule Voltaren resinate) daily during a postoperative period of 14 days, 19% of patients showed slight HO (Brooker grade 1), and no patient had more severe ossifications (grades 2-4). In the group receiving 75 mg daily (1 x 1 capsule), 17% of patients showed grade 1 HO and 4% grade 2 HO. No patient had grades 3-4 HO. No differences in clinical results were seen between the two groups 6 months after THA. INTERPRETATION: Since the rate of adverse gastrointestinal events was lower (23% versus 38%, p = 0.02) in the group receiving the lower dose, we recommend it.

Dose-dependent efficacy of diclofenac-cholestyramine on pain and periarticular ossifications after total hip arthroplasty: a double-blind, prospective, randomised trial.

INTRODUCTION: To investigate the efficacy of treatment with diclofenac-cholestyramine on postoperative pain and functional outcome after total hip arthroplasty, a randomised double-blind study was conducted. MATERIALS AND METHODS: A total of 245 patients received postoperative treatment with 75 mg or 150 mg diclofenac p.o. daily for 14 days. RESULTS: Patients who received 75 mg diclofenac per day needed paracetamol as an additional analgesic significantly more often (p=0.0162) than patients who were treated with 150 mg diclofenac daily (75 mg twice a day). The incidence of adverse gastrointestinal events was significantly lower in the group receiving 75 mg diclofenac daily than in the group receiving the higher dose (23.1% vs 37.1%; p=0.025). Six months after the operation, no differences were observed between the two groups with regard to pain or functionality measured in terms of overall mobility of the hip. No patient of either group developed clinically relevant heterotopic ossifications. CONCLUSION: Treatment with a dose of 75 mg diclofenac once daily-if necessary with the additional use of paracetamol-is a favourable option for the postoperative care of THA.