RESUMEN
In quantum mechanics the Young-type double-slit experiment can be performed with electrons either traveling through a double slit or being coherently emitted from two inversion symmetric molecular sites. In the latter one the valence photoionization cross sections of homonuclear diatomic molecules were predicted to oscillate over kinetic energy almost 50 years ago. Beyond the direct proof of the oscillatory behavior of these photoionization cross sections σ, we show that the angular distribution of the emitted electrons reveals hitherto unexplored information on the relative phase shift between the corresponding partial waves through two-center interference patterns.
RESUMEN
BACKGROUND: Interleukin (IL)-33 is a member of the IL-1 family and has been implicated in Th2-driven allergic diseases such as atopic dermatitis (AD) and asthma. The principal Th2 cytokine IL-4, found highly expressed in acute allergic eczema, is known to downregulate human ß-defensin 2 (hBD2) expression in human keratinocytes and this is associated with superinfection in patients with AD. OBJECTIVES: To investigate the effect of IL-33 on the expression of hBD2 in human keratinocytes. METHODS: hBD2 production by stimulated keratinocytes was measured by enzyme-linked immunosorbent assay. RESULTS: Our results showed that serum is a very potent inducer of hBD2 and 2·5% human serum was much more potent in inducing hBD2 than 20 ng mL(-1) of tumour necrosis factor-α. Interestingly, serum from patients with AD showed an impaired ability to induce hBD2 in normal keratinocytes. IL-33 significantly downregulated serum-induced hBD2. The downregulatory capacity of IL-33 was found to be 1·5- to 2-fold weaker compared with IL-4. CONCLUSIONS: Our data suggest that IL-33 can significantly contribute to the decreased expression of hBD2 in acute eczematous reaction clinically characterized by spongiosis and oozing - thus indicative for contact of the epidermis with serum components.
Asunto(s)
Dermatitis Atópica/patología , Interleucina-1/metabolismo , Interleucinas/farmacología , Queratinocitos/efectos de los fármacos , Sobreinfección/metabolismo , beta-Defensinas/metabolismo , Células Cultivadas , Dermatitis Atópica/sangre , Ensayo de Inmunoadsorción Enzimática , Humanos , Interleucina-33 , Interleucina-4/farmacología , Queratinocitos/metabolismo , Suero/fisiología , Factor de Necrosis Tumoral alfa/metabolismo , Factor de Necrosis Tumoral alfa/farmacologíaRESUMEN
A transmission polarizer for producing elliptically polarized soft X-ray radiation from linearly polarized light is presented. The setup is intended for use at synchrotron and free-electron laser beamlines that do not directly offer circularly polarized light for, e.g., X-ray magnetic circular dichroism (XMCD) measurements or holographic imaging. Here, we investigate the degree of ellipticity upon transmission of linearly polarized radiation through a cobalt thin film. The experiment was performed at a photon energy resonant to the Co L3-edge, i.e., 778 eV, and the polarization of the transmitted radiation was determined using a polarization analyzer that measures the directional dependence of photo electrons emitted from a gas target. Elliptically polarized radiation can be created at any absorption edge showing the XMCD effect by using the respective magnetic element.
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Short wavelength free-electron lasers (FELs), providing pulses of ultrahigh photon intensity, have revolutionized spectroscopy on ionic targets. Their exceptional photon flux enables multiple photon absorptions within a single femtosecond pulse, which in turn allows for deep insights into the photoionization process itself as well as into evolving ionic states of a target. Here we employ ultraintense pulses from the FEL FERMI to spectroscopically investigate the sequential emission of electrons from gaseous, atomic argon in the neutral as well as the ionic ground state. A pronounced forward-backward symmetry breaking of the angularly resolved emission patterns with respect to the light propagation direction is experimentally observed and theoretically explained for the region of the Cooper minimum, where the asymmetry of electron emission is strongly enhanced. These findings aim to originate a better understanding of the fundamentals of photon momentum transfer in ionic matter.
RESUMEN
The effect of director pretilt on the twist magnetic Fréedericksz transition of nematics was investigated in a planar cell. The director configuration was calculated as a function of magnetic inductance. The dielectric and optical response of the nematic liquid crystal was numerically modeled. A dielectric measurement method for determining the elastic constant K_{22} is presented. The influence of the conditions for the Mauguin effect is discussed. The theoretical predictions were confirmed by our experiments. Experimental data for all elastic constants of a bent-core nematic material are presented and discussed.