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1.
Eur J Clin Microbiol Infect Dis ; 43(6): 1205-1212, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38557925

RESUMEN

Acute encephalitis syndrome (AES) outbreaks in children of Eastern Uttar Pradesh (E-UP) region of India have been a longstanding public health issue, with a significant case fatality rate of 20-25%. Since past decade, a rise in chikungunya (CHIK) cases has been occurring, which is a reported etiology of AES. However, the burden of chikungunya virus (CHIKV) among pediatric AES (pAES) is unknown from E-UP. We included 238 hospitalized pAES cases. The presence of IgM antibodies for CHIKV, and Dengue virus (DENV) was tested, and RT-PCR was performed for CHIKV and DENV in serologically confirmed CHIKV and DENV pAES cases. Positive samples were sequenced using Sangers sequencing. Further, to check for co-infection, IgM antibodies for other AES etiologies including Japanese encephalitis virus (JEV), Leptospira and Orientia tsutsugamushi (OT) in serum were also investigated. IgM ELISA demonstrated 5.04% (12) positivity for CHIKV. Among CHIKV IgM positive, 3 (25%, 3/12) pAES patients died. CHIKV genome was detected in 3 pAES specimens. Among which, 2 CHIKV cases were also positive for OT DNA. Partially sequenced CHIKV were genotyped as ECSA. The overall finding indicates evidence of CHIKV infection with high case fatality among pAES patients from E-UP. This study advocates constant serological and molecular surveillance of CHIKV in AES endemic regions of India.


Asunto(s)
Encefalopatía Aguda Febril , Anticuerpos Antivirales , Fiebre Chikungunya , Virus Chikungunya , Inmunoglobulina M , Humanos , India/epidemiología , Fiebre Chikungunya/mortalidad , Fiebre Chikungunya/epidemiología , Niño , Masculino , Femenino , Preescolar , Virus Chikungunya/genética , Virus Chikungunya/inmunología , Anticuerpos Antivirales/sangre , Inmunoglobulina M/sangre , Encefalopatía Aguda Febril/epidemiología , Lactante , Adolescente , Coinfección/mortalidad , Coinfección/virología , Coinfección/epidemiología , Virus del Dengue/genética , Virus del Dengue/inmunología , Filogenia , Brotes de Enfermedades
2.
J Assoc Physicians India ; 72(1): 96-98, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-38736081

RESUMEN

Acute pancreatitis is seen in patients with human immunodeficiency virus (HIV) as a result of antiretroviral drug therapy and hypertriglyceridemia. Thrombotic complications are known in patients of HIV as a result of endothelial dysfunction, and right-sided infective endocarditis (IE) is seen in HIV patients mostly due to intravenous (IV) drug abuse. However, the occurrence of acute pancreatitis with sepsis, IE, and bilateral thromboembolism in the same patient is rare. Here, we report this case of a treatment-naive nondrug abuser HIV patient with acute pancreatitis in sepsis, IE, and bilateral pulmonary thromboembolism who recovered completely with treatment.


Asunto(s)
Infecciones por VIH , Embolia Pulmonar , Sepsis , Humanos , Enfermedad Aguda , Anticoagulantes/uso terapéutico , Endocarditis/complicaciones , Endocarditis/diagnóstico , Infecciones por VIH/complicaciones , Infecciones por VIH/tratamiento farmacológico , Pancreatitis/diagnóstico , Pancreatitis/complicaciones , Pancreatitis/etiología , Embolia Pulmonar/etiología , Embolia Pulmonar/diagnóstico , Sepsis/complicaciones , Sepsis/diagnóstico
3.
Indian J Crit Care Med ; 23(8): 352-355, 2019 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-31485103

RESUMEN

BACKGROUND AND AIMS: Acute kidney injury (AKI) became an important cause of mortality and morbidity in critically ill children, despite advancement in its management. In developing countries etiology of AKI are different from that of developed countries. MATERIALS AND METHODS: This observational study was carried out in pediatric intensive care unit (PICU) in 2 months to18 years of critically ill children. Kidney injury was defined and categorized by the pRIFLE criteria. RESULTS: Out of 361children, 86 children (23.8%) developed AKI at some point during admission, 275 children (age and sex matched) who did not develop kidney injury during hospitalization served as non-AKI children. Maximum cases of AKI were seen in 1-5 years of age. Maximum children of AKI were of viral encephalitis (n = 43, 50.0%) followed by scrub typhus (n = 14, 16.3%). Risk factors for the development of AKI were shock, PRISM score and longer hospital stay. In our study the mortality in AKI children (n = 30, 34.8%) was significantly higher (p = 0.005) as compared to non-AKI children (n = 56, 20.3%)). Duration on mechanical ventilation, PICU stay and hospital stay were also significantly (p = 0.001) higher in AKI children. CONCLUSION: AKI is common in critically ill children and associated with high mortality and morbidity. HOW TO CITE THIS ARTICLE: Bharat A, Mehta A, Tiwari HC, Sharma B, Singh A, Singh V. Spectrum and Immediate Outcome of Acute Kidney Injury in a Pediatric Intensive Care Unit: A Snapshot Study from Indian Subcontinent. Indian J Crit Care Med 2019;23(8):352-355.

4.
Waste Manag Res ; 35(1): 79-91, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-27872406

RESUMEN

Dumping of municipal solid waste into uncontrolled dumpsites is the most common method of waste disposal in most cities of India. These dumpsites are posing a serious challenge to environmental quality and sustainable development. Mumbai, which generates over 9000 t of municipal solid waste daily, also disposes of most of its waste in open dumps. It is important to analyse the impact of municipal solid waste disposal today and what would be the impact under integrated waste management schemes. In this study, life cycle assessment methodology was used to determine the impact of municipal solid waste management under different scenarios. Six different scenarios were developed as alternatives to the current practice of open dumping and partially bioreactor landfilling. The scenarios include landfill with biogas collection, incineration and different combinations of recycling, landfill, composting, anaerobic digestion and incineration. Global warming, acidification, eutrophication and human toxicity were assessed as environmental impact categories. The sensitivity analysis shows that if the recycling rate is increased from 10% to 90%, the environmental impacts as compared with present scenario would reduce from 998.43 kg CO2 eq t-1 of municipal solid waste, 0.124 kg SO2 eq t-1, 0.46 kg PO4-3 eq t-1, 0.44 kg 1,4-DB eq t-1 to 892.34 kg CO2 eq t-1, 0.121 kg SO2 eq t-1, 0.36 kg PO4-3 eq t-1, 0.40 kg 1,4-DB eq t-1, respectively. An integrated municipal solid waste management approach with a mix of recycling, composting, anaerobic digestion and landfill had the lowest overall environmental impact. The technologies, such as incineration, would reduce the global warming emission because of the highest avoided emissions, however, human toxicity would increase.


Asunto(s)
Ambiente , Eliminación de Residuos/métodos , Biocombustibles , Ciudades , Eutrofización , Humanos , Incineración , India , Reciclaje , Suelo , Residuos Sólidos/análisis , Pruebas de Toxicidad , Instalaciones de Eliminación de Residuos
5.
Nanotechnology ; 25(1): 014002, 2014 Jan 10.
Artículo en Inglés | MEDLINE | ID: mdl-24334373

RESUMEN

We demonstrate photo-patternable ion gel-gated graphene transistors and inverters on plastic substrates. The photo-patternable ion gel can be used as a negative photoresist for the patterning of underlying graphene as well as gate dielectrics. As a result, an extra graphene-patterning step is not required, which simplifies the device fabrication and avoids a side effect arising from the photoresist residue. The high capacitance of ion gel gate dielectrics yielded a low voltage operation (~2 V) of the graphene transistor and inverter. The graphene transistors on plastic showed an on/off-current ratio of ~11.5, along with hole and electron mobilities of 852 ± 124 and 452 ± 98 cm(2) V(-1) s(-1), respectively. In addition, the flexible graphene inverter was successfully fabricated on plastic through the potential superposition effect from the drain bias. These devices show excellent mechanical flexibility and fatigue stability.

6.
Front Biosci (Landmark Ed) ; 29(3): 110, 2024 Mar 19.
Artículo en Inglés | MEDLINE | ID: mdl-38538264

RESUMEN

BACKGROUND: The purpose of this study is to investigate the electroosmotic flow of a hybrid nanofluid (Al2O3-Cu/Blood) with gyrotactic microorganisms through a bifurcated artery with mild stenosis in both parent and daughter arteries. The flow is subjected to a uniform magnetic field, viscous dissipation, and a heat source. METHODS: The governing equations undergo the non-dimensional transformation and coordinate conversion to regularize irregular boundaries, then solve the resulting system using the Crank-Nicolson method. RESULTS: In both sections of the bifurcated artery (parent and daughter artery), the wall shear stress (WSS) profile decreases with increasing stenotic depth. Nusselt profile increases with an increase in the heat source parameter. CONCLUSIONS: The present endeavour can be beneficial for designing better biomedical devices and gaining insight into the hemodynamic flow for therapeutic applications in the biomedical sciences.


Asunto(s)
Electroósmosis , Hemodinámica , Humanos , Constricción Patológica , Arterias , Calor
7.
Heliyon ; 10(3): e25102, 2024 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-38322951

RESUMEN

In this study, the computational analysis of entropy generation optimization for synthetic cilia regulated ternary hybrid Jeffery nanofluid (Ag-Au-TiO2/PVA) flow through a peristaltic vertical channel with swimming motile Gyrotactic microorganisms is investigated. Understanding the intricate interaction of multiple physical phenomena in biomedical applications is essential for optimizing entropy generation and advancing microfluidic systems. The characteristics of nanofluid are explored for the electroosmotic MHD fluid flow in the presence of thermophoresis and Brownian motion, viscous dissipation, Ohmic heating and chemical reaction. Using the appropriate transformations, a set of ordinary differential equations are created from the governing partial differential equations. The resulting ODEs are numerically solved using the shooting technique using BVP5C in MATLAB after applying the long-wavelength and low Reynolds number approximation. The velocity, temperature, concentration, electroosmosis, and microorganism density profiles are analyzed graphically for different emerging parameters. Graphical investigation of engineering interest quantities like heat transfer rate, mass transfer rate, skin friction coefficient, and entropy generation optimization are also presented. It is observed that the rate of mass transfer increases for increasing thermophoretic parameter, while reverse effect is noted for Brownian motion parameter, Schmidt number, and chemical reaction number. The outcomes of present study can be pertinent in studying Cilia properties of respiratory tract, reproductive system, and brain ventricles.

8.
Curr Pharm Des ; 29(26): 2050-2061, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37641985

RESUMEN

Allergies are a major health issue. Allergen avoidance, antihistamines, and corticosteroids do not treat the pathology's causes, therefore long-term therapy is essential. Long-term allergen-specific immunotherapy builds immune tolerance to the allergen. Unfortunately, immunotherapies for all allergens are not available, and adverse reactions during therapy, especially in severely allergic persons, remain a worry. In this regard, cell and bio- or nanomaterial-based allergy treatments are promising. This overview covers the most important tactics from these two strategies with examples. Nanotechnology encompasses science, engineering, and technology at 1-100 nm. Due to their one-of-a-kind characteristics, nanomaterials can be used in healthcare. Small molecules' chemical and physical properties are modified by the system's size, shape, content, and function. Toxicity and hypersensitivity reactions need to be evaluated. Regulating the physico-chemical properties of numerous accessible structures would make clinical diagnosis and therapy safer and more successful. Dendrimeric antigens, nanoallergens, and nanoparticles can mimic carrier proteins, boost specific IgE binding, and improve signal detection in allergy diagnosis. In immunotherapy, several allergenic structures like glycodendrimers, liposomes, polymers, and nanoparticles have been used as adjuvants, protectors, or depots for allergens. Nanotechnology has the potential to substantially improve both the diagnosis and treatment of allergies.


Asunto(s)
Hipersensibilidad , Humanos , Hipersensibilidad/diagnóstico , Hipersensibilidad/terapia , Hipersensibilidad/etiología , Alérgenos , Desensibilización Inmunológica/efectos adversos , Nanotecnología , Tolerancia Inmunológica
9.
Nanomaterials (Basel) ; 13(4)2023 Feb 07.
Artículo en Inglés | MEDLINE | ID: mdl-36839020

RESUMEN

A novel analysis of the electromagnetohydrodynamic (EMHD) non-Newtonian nanofluid blood flow incorporating CuO and Al2O3 nanoparticles through a permeable walled diseased artery having irregular stenosis and an aneurysm is analyzed in this paper. The non-Newtonian behavior of blood flow is addressed by the Casson fluid model. The effective viscosity and thermal conductivity of nanofluids are calculated using the Koo-Kleinstreuer-Li model, which takes into account the Brownian motion of nanoparticles. The mild stenosis approximation is employed to reduce the bi-directional flow of blood to uni-directional. The blood flow is influenced by an electric field along with a magnetic field perpendicular to the blood flow. The governing mathematical equations are solved using Crank-Nicolson finite difference approach. The model has been developed and validated by comparing the current results to previously published benchmarks that are peculiar to this study. The results are utilized to investigate the impact of physical factors on momentum diffusion and heat transfer. The Nusselt number escalates with increasing CuO nanoparticle diameter and diminishing the diameter of Al2O3 nanoparticles. The relative % variation in Nusselt number enhances with Magnetic number, whereas a declining trend is obtained for the electric field parameter. The present study's findings may be helpful in the diagnosis of hemodynamic abnormalities and the fields of nano-hemodynamics, nano-pharmacology, drug delivery, tissue regeneration, wound healing, and blood purification systems.

10.
Sci Rep ; 13(1): 15441, 2023 09 18.
Artículo en Inglés | MEDLINE | ID: mdl-37723188

RESUMEN

The present study deals with the entropy generation analysis on the flow of an electrically conductive fluid (Blood) with [Formula: see text]-suspended nanoparticles through the irregular stenosed artery with thrombosis on the catheter. The fluid flow can be actuated by the interactions of different physical phenomena like electroosmosis, radiation, Joule heating and a uniform radial magnetic field. The analysis of different shapes and sizes of the nanoparticle is considered by taking the Crocine model. The velocity, temperature, and concentration distributions are computed using the Crank-Nicholson method within the framework of the Debye-Huckel linearization approximation. In order to see how blood flow changes in response to different parameters, the velocity contour is calculated. The aluminium oxide nanoparticles employed in this research have several potential uses in biomedicine and biosensing. The surface's stability, biocompatibility, and reactivity may be enhanced by surface engineering, making the material effective for deoxyribonucleic acid sensing. It may be deduced that the velocity profile reduces as the nanoparticle's size grows while depicts the reverse trend for the shape size. In a region close to the walls, the entropy profile decreases, while in the region in the middle, it rises as the magnetic field parameter rises. The present endeavour can be beneficial in biomedical sciences in designing better biomedical devices and gaining insight into the hemodynamic flow for treatment modalities.


Asunto(s)
Electroósmosis , Trombosis , Humanos , Constricción Patológica , Entropía , Arterias
11.
Sci Rep ; 13(1): 14483, 2023 Sep 02.
Artículo en Inglés | MEDLINE | ID: mdl-37660186

RESUMEN

This study deals with the entropy generation analysis of synthetic cilia using a ternary hybrid nanofluid (Al-Cu-Fe2O3/Blood) flow through an inclined channel. The objective of the current study is to investigate the effects of entropy generation optimization, heat, and mass transfer on ternary hybrid nanofluid passing through an inclined channel in the proximity of the induced magnetic field. The novelty of the current study is present in studying the combined effect of viscous dissipation, thermophoresis, Brownian motion, exponential heat sink/source, porous medium, endothermic-exothermic chemical reactions, and activation energy in the proximity of induced magnetic field is examined. The governing partial differential equations (PDEs) are transformed into the ordinary differential equations (ODEs) using appropriate transformations. Applying the low Reynolds number and the long-wavelength approximation, resultant ODEs are numerically solved using shooting technique via BVP5C in MATLAB. The velocity, temperature, concentration, and induced magnetism profiles are visually discussed and graphically analyzed for various fluid flow parameters. Graphical analysis of physical interest quantities like mass transfer rate, heat transfer rate, entropy generation optimization, and skin friction coefficient are also graphically discussed. The entropy generation improves for enhancing values of Reynolds number, solutal Grashof number, heat sink/source parameter, Brinkman number, magnetic Prandtl number, and endothermic-exothermic reaction parameter while the reverse effect is noticed for chemical reaction and induced magnetic field parameter. The findings of this study can be applied to enhance heat transfer efficiency in biomedical devices, optimizing cooling systems, designing efficient energy conversion processes, and spanning from renewable energy technologies to aerospace propulsion systems.

12.
Nanomaterials (Basel) ; 13(3)2023 Jan 29.
Artículo en Inglés | MEDLINE | ID: mdl-36770505

RESUMEN

This article examines the effects of entropy generation, heat transmission, and mass transfer on the flow of Jeffrey fluid under the influence of solar radiation in the presence of copper nanoparticles and gyrotactic microorganisms, with polyvinyl alcohol-water serving as the base fluid. The impact of source terms such as Joule heating, viscous dissipation, and the exponential heat source is analyzed via a nonlinear elongating surface of nonuniform thickness. The development of an efficient numerical model describing the flow and thermal characteristics of a parabolic trough solar collector (PTSC) installed on a solar plate is underway as the use of solar plates in various devices continues to increase. Governing PDEs are first converted into ODEs using a suitable similarity transformation. The resulting higher-order coupled ODEs are converted into a system of first-order ODEs and then solved using the RK 4th-order method with shooting technique. The remarkable impacts of pertinent parameters such as Deborah number, magnetic field parameter, electric field parameter, Grashof number, solutal Grashof number, Prandtl number, Eckert number, exponential heat source parameter, Lewis number, chemical reaction parameter, bioconvection Lewis number, and Peclet number associated with the flow properties are discussed graphically. The increase in the radiation parameter and volume fraction of the nanoparticles enhances the temperature profile. The Bejan number and entropy generation rate increase with the rise in diffusion parameter and bioconvection diffusion parameter. The novelty of the present work is analyzing the entropy generation and solar radiation effects in the presence of motile gyrotactic microorganisms and copper nanoparticles with polyvinyl alcohol-water as the base fluid under the influence of the source terms, such as viscous dissipation, Ohmic heating, exponential heat source, and chemical reaction of the electromagnetohydrodynamic (EMHD) Jeffrey fluid flow. The non-Newtonian nanofluids have proven their great potential for heat transfer processes, which have various applications in cooling microchips, solar energy systems, and thermal energy technologies.

13.
Environ Monit Assess ; 184(10): 5945-56, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22033817

RESUMEN

Air samples for PM(10) (dp < 10 µm in aerodynamic diameter) were collected from March 2007 to February 2008 near Taj Mahal-a historically sensitive site in Agra. Each sample collected on 20.3 × 25.4-cm Whatman quartz microfiber filter using respirable dust sampler was analyzed gravimetrically for mass concentrations and chemically for elements such as Na, Mg, Al, Si, S, Ca, Sc, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Br, Rb, Cd, Ba, and Pb by inductively coupled plasma atomic emission spectroscopy and inorganic ions such as NH (4) (+) , K(+), SO (4) (2-) , NO (3) (-) , F(-), and Cl(-) by ion chromatograph. Annual average of PM(10) 155.47 ± 77.97 µg/m(3) was three times high the annual average NAAQ standard of 50 µg/m(3) for sensitive area. PM(10) as well as K(+), Cl(-), As, and Pb were higher in winter while crust elements and secondary aerosols were higher in summer. The average equivalent ratio of NH (4) (+) to sum up of SO (4) (2-) and NO (3) (-) was greater than unity which indicates high source strength of ammonia and alkaline nature of aerosols in Agra. Source apportionment of PM(10) was carried out by factor analysis using principal component analysis (varimax rotated factor matrix method) of SPSS. Five sources contributing to PM(10) were identified as crust material, vehicular emissions, industrial emissions, coal and biomass burning, and secondary aerosols.


Asunto(s)
Contaminantes Atmosféricos/análisis , Monitoreo del Ambiente , Material Particulado/análisis , Aerosoles/análisis , Contaminación del Aire/estadística & datos numéricos , Tamaño de la Partícula , Análisis de Componente Principal , Estaciones del Año , Espectrofotometría Atómica , Emisiones de Vehículos/análisis
14.
Materials (Basel) ; 15(23)2022 Dec 03.
Artículo en Inglés | MEDLINE | ID: mdl-36500124

RESUMEN

A severe plastic deformation process for the achievement of favorable mechanical properties for metallic powder is mechanical milling. However, to obtain the highest productivity while maintaining reasonable manufacturing costs, the process parameters must be optimized to achieve the best mechanical properties. This study involved the use of response surface methodology to optimize the mechanical milling process parameters of harmonic-structure pure Cu. Certain critical parameters that affect the properties and fracture mechanisms of harmonic-structure pure Cu were investigated and are discussed in detail. The Box-Behnken design was used to design the experiments to determine the correlation between the process parameters and mechanical properties. The results show that the parameters (rotation speed, mechanical milling time, and powder-to-ball ratio) affect the microstructure characteristics and influence the mechanical performance, including the fracture mechanisms of harmonic-structure pure Cu specimens. The best combination values of the ultimate tensile strength (UTS) and elongation were found to be 272 MPa and 46.85%, respectively. This combination of properties can be achieved by applying an optimum set of process parameters: a rotation speed of 200 rpm; mechanical milling time of 17.78 h; and powder-to-ball ratio of 0.065. The superior UTS and elongation of the harmonic-structure pure Cu were found to be related to the delay of void and crack initiation in the core and shell interface regions, which in turn were controlled by the degree of strength variation between these regions.

15.
Nat Commun ; 13(1): 6860, 2022 Nov 18.
Artículo en Inglés | MEDLINE | ID: mdl-36400773

RESUMEN

Hydrogen drastically embrittles high-strength aluminum alloys, which impedes efforts to develop ultrastrong components in the aerospace and transportation industries. Understanding and utilizing the interaction of hydrogen with core strengthening elements in aluminum alloys, particularly nanoprecipitates, are critical to break this bottleneck. Herein, we show that hydrogen embrittlement of aluminum alloys can be largely suppressed by switching nanoprecipitates from the η phase to the T phase without changing the overall chemical composition. The T phase strongly traps hydrogen and resists hydrogen-assisted crack growth, with a more than 60% reduction in the areal fractions of cracks. The T phase-induced reduction in the concentration of hydrogen at defects and interfaces, which facilitates crack growth, primarily contributes to the suppressed hydrogen embrittlement. Transforming precipitates into strong hydrogen traps is proven to be a potential mitigation strategy for hydrogen embrittlement in aluminum alloys.

16.
Waste Manag ; 124: 293-302, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33640669

RESUMEN

This study quantifies and compares the cost of municipal solid waste (MSW) management systems under different scenarios using life cycle cost (LCC) analysis approach. LCC analysis was performed for six integrated MSW management scenarios for Mumbai city, India which generates over 9000 metric tonnes of MSW daily and disposes most of it in open dumps. The scenarios are the combinations of recycling, composting, anaerobic digestion, incineration with electricity generation, and landfill with biogas recovery. To perform LCC analysis of scenarios, present worth method was used. The present worth of operations and maintenance (O&M) cost and revenue generated was estimated using a discount rate of 11.25% for a 20-year life span. Results show that the incineration based scenario is the most cost-intensive option with a net LCC of US$38 per tonne of MSW due to the high capital cost involved in case of incineration. While the scenario with a combination of recycling and sanitary landfill was the most economically viable option with a net LCC of US$19 per tonne of MSW due to comparative lower operating cost. The sensitivity analysis shows that the O&M cost was the most sensitive parameter and a change of ±10% and ±20% in O&M cost, the net LCC of scenarios changes in the range of 14-33% and 29-65%, respectively. This study provides an economic comparison of MSW treatment scenarios from a life cycle perspective, which facilitates the decision-making process for improvement in cost estimation and planning of waste management strategies in India.


Asunto(s)
Eliminación de Residuos , Administración de Residuos , Animales , Ciudades , Costos y Análisis de Costo , India , Estadios del Ciclo de Vida , Residuos Sólidos/análisis , Instalaciones de Eliminación de Residuos
17.
Urol Ann ; 13(1): 36-40, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33897162

RESUMEN

INTRODUCTION: Management of chyluria with initial conservative approach and then using endoscopic sclerotherapy is a mainstay approach. However, a wide range of sclerosants are available with differential success rates and complication rates. This study evaluated the safety and efficacy of a single-dose instillation of 1% povidone iodine for the treatment of chyluria. MATERIALS AND METHODS: This was a prospective, observational study conducted on patients with chyluria who did not respond to conservative management with dietary restriction and diethylcarbamazine. The site of chyle efflux was identified by cystoscopy. A 6 Fr ureteral stent was inserted into effluxing side, diluted contrast was injected to delineate the pelvicalyceal system and the pyelolymphatic connection (arborization of the pelvicalyceal system), and a single-dose of 1% povidone iodine was instilled. Patients were observed for loin pain, fever, and disappearance of milky urine postinstillation and followed up at intervals of 3 months for a total duration of 1 year. RESULTS: Of a total 50 patients included, 35 were men and 15 were women, with a mean age of 37 years. Pyelolymphatic connections were noted in 48% of the patients. All patients showed an immediate disappearance of milky urine. During 1-year follow-up, 92% of the patients were symptom-free till the last follow-up while only 8% of the patients experienced recurrence of chyluria which were treated with other treatment modalities. The mean duration of recurrence was 8 weeks. CONCLUSION: Single dose of 1% povidone iodine was effective in immediate clearance of milky urine and well tolerated in patients with chyluria during 1-year follow-up.

18.
J Nanosci Nanotechnol ; 10(12): 8424-31, 2010 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-21121349

RESUMEN

ZnO nanorods are grown on seedless and ZnO seeded glass substrates using chemical solution method and their structural, morphological, optical and valence band studies have been carried out. On seedless substrate horizontal nanorods are observed whereas for the seeded substrates vertically aligned hollow and solid nanorods grows. X-ray diffraction analysis revealed the presence of tensile stress in the vertical nanorods. Blue shift has been observed in the band gap of the vertical nanorods as compared to the horizontal nanorods which is attributed to the presence of tensile stress in the vertically aligned nanorods. Photoluminescence spectra revealed the dominance of Zinc vacancies (V(Zn)) related defects in the nanorods and oxygen defects are found to be higher in the vertically aligned nanorods as compared to the horizontal nanorods. The difference between the Fermi level and valence band maxima for horizontal, hollow vertical and solid vertical nanorods are found to be approximately 0.56 eV, approximately 0.70 eV and approximately 0.92 eV respectively indicating the possibility of p-type of conduction in the nanorods which has been attributed to presence of V(Zn) defects in the ZnO nanorods.

19.
ACS Nano ; 13(3): 3023-3030, 2019 03 26.
Artículo en Inglés | MEDLINE | ID: mdl-30768896

RESUMEN

Large-area, ultrathin flexible tactile sensors with conformal adherence are becoming crucial for advances in wearable electronics, electronic skins and biorobotics. However, normal passive tactile sensors suffer from high crosstalk, resulting in inaccurate sensing, which consequently limits their use in such advanced applications. Active-matrix-driven tactile sensors could potentially overcome such hurdles, but it demands the high performance and reliable operations of the thin-film-transistor array that could efficiently control integrated pressure gauges. Herein, we utilized the benefit of the semiconducting and mechanical excellence of MoS2 and placed it between high- k Al2O3 dielectric sandwich layers to achieve the high and reliable performance of MoS2-based back-plane circuitry and strain sensor. This strategical combination reduces the fabrication complexity and enables the demonstration of an all MoS2-based large area (8 × 8 array) active-matrix tactile sensor offering a wide sensing range (1-120 kPa), sensitivity value (Δ R/ R0: 0.011 kPa-1), and a response time (180 ms) with excellent linearity. In addition, it showed potential in sensing multitouch accurately, tracking a stylus trajectory, and detecting the shape of an external object by grasping it using the palm of the human hand.


Asunto(s)
Disulfuros/química , Molibdeno/química , Pruebas Cutáneas , Piel/química , Tacto , Disulfuros/síntesis química , Equipos y Suministros Eléctricos , Electrodos , Humanos , Semiconductores , Sensibilidad y Especificidad , Propiedades de Superficie
20.
ACS Appl Mater Interfaces ; 11(15): 14222-14228, 2019 Apr 17.
Artículo en Inglés | MEDLINE | ID: mdl-30912424

RESUMEN

Stretchable alternating-current electroluminescent (ACEL) devices are required due to their potential in wearable, biomedical, e-skin, robotic, lighting, and display applications; however, one of the main hurdles is to achieve uniform electroluminescence with an optimal combination of transparency, conductivity, and stretchability in electrodes. We therefore propose a fabrication scheme involving strategically combining two-dimensional graphene layers with a silver nanowire (Ag NW)-embedded PEDOT:PSS film. The developed hybrid electrode overcomes the limitations of commonly known metallic NWs and ionic conductor-based electrodes for ACEL applications. Furthermore, the potential of the hybrid electrode is realized in demonstrating large-area stretchable ACEL devices composed of an 8 × 8 passive array. The prototype ACEL passive array demonstrates efficient and uniform electroluminescence under high levels of mechanical deformation such as bending, rolling, twisting, and stretching.

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