1.
Bull Exp Biol Med
; 159(5): 680-4, 2015 Sep.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26463059
RESUMEN
Long-term administration of pyridoxine to rats kept on a diabetogenic diet stimulating endogenous synthesis of xanthurenic acid resulted in minimal glycemia, less pronounced decrease in insulin content in ß-cells, and more intensive excretion of xanthurenic acid with urine. Histological changes were observed in 23% pancreatic islets, whereas in rats not treated with pyridoxine, destruction and necrosis of 40-45% ß-cells were found in 38% of studied islets.