RESUMEN
The purpose of this investigation was to determine whether increased endurance exercise capacity alters total hepatic cytochrome P-450 content and cytochrome P-450 (CYP1A and CYP2B) mediated hepatic microsomal mixed-function oxidase drug metabolism. Twenty adult male Sprague-Dawley rats were randomly assigned to either a control (C) or an endurance trained group (ET). ET rats were progressively trained 5 d.wk-1 for 11 wk. Both C and ET rats were administered in random order single posttraining doses of probe drugs theophylline (probe for CYP1A) and antipyrine (probe for CYP2B). Soleus muscle citrate synthase activity of ET rats was significantly greater (P < 0.01) than for C rats (mean +/- SD; C, 26.4 +/- 1.3 mumol.g-1.min-1; ET, 46.1 +/- 2.7). In contrast, total liver cytochrome P-450 content was not significantly different (P > 0.01) among C and ET rats (mean +/- SD; C, 0.554 +/- 0.055 nmol.mg-1 liver protein; ET, 0.604 +/- 0.080). Likewise, the posttraining C and ET single-sample plasma clearances of theophylline (mean +/- SD; C, 1.89 +/- 0.360 1.h-1.kg-1 total liver weight; ET, 2.08 +/- 0.49) and antipyrine (mean +/- SD; C, 6.44 +/- 1.56 1.h-1.kg-1 total liver weight; ET, 6.51 +/- 1.02) were not significantly different (P > 0.01). Therefore, it was concluded that strenuous endurance training of 11 wk duration did not alter total hepatic cytochrome P-450 content or CYP1A or CYP2B activity.
Asunto(s)
Sistema Enzimático del Citocromo P-450/análisis , Hígado/enzimología , Microsomas Hepáticos/enzimología , Oxigenasas de Función Mixta/metabolismo , Condicionamiento Físico Animal/fisiología , Animales , Antipirina/sangre , Antipirina/metabolismo , Citrato (si)-Sintasa/metabolismo , Sistema Enzimático del Citocromo P-450/metabolismo , Masculino , Tasa de Depuración Metabólica , Músculo Esquelético/enzimología , Resistencia Física , Ratas , Ratas Sprague-Dawley , Carrera/fisiología , Teofilina/sangre , Teofilina/metabolismoAsunto(s)
Antihipertensivos/farmacología , Circulación Cerebrovascular/efectos de los fármacos , Imidazoles/farmacología , Resistencia Vascular/efectos de los fármacos , Animales , Determinación de la Presión Sanguínea , Perros , Femenino , Masculino , Parabiosis , Perfusión , Sistema Nervioso Simpático/efectos de los fármacosAsunto(s)
Acetofenonas/farmacología , Antihipertensivos/farmacología , Músculo Liso/efectos de los fármacos , Acetofenonas/administración & dosificación , Angiotensina II/antagonistas & inhibidores , Animales , Antihipertensivos/administración & dosificación , Aorta Torácica/análisis , Aorta Torácica/efectos de los fármacos , Presión Sanguínea/efectos de los fármacos , Perros , Femenino , Técnicas In Vitro , Masculino , Contracción Muscular/efectos de los fármacos , Norepinefrina/antagonistas & inhibidores , Potasio/análisis , Potasio/sangre , Conejos , Ratas , Sodio/análisis , Sodio/sangreAsunto(s)
Educación en Salud , Trastornos Relacionados con Sustancias , Enseñanza , Adolescente , Niño , Curriculum , Docentes , Humanos , Métodos , Instituciones AcadémicasRESUMEN
A case is presented with a child with a desmoid tumor of the pterygopalatine fossa in which approximately a third of the mandible including the condyle was removed for exposure. The trimmed mandibular segment was then returned to position with a fascia cap over the condyle and intermaxillary fixation was instituted. The graft was followed by serial roentgenogram over five years. The graft took completely, grew with the patient, and resulted in normal dental occlusion and normal mandibular excursion.
Asunto(s)
Neoplasias Óseas/cirugía , Fibroma/cirugía , Mandíbula/cirugía , Osteotomía/métodos , Neoplasias Palatinas/cirugía , Hueso Esfenoides/cirugía , Niño , Humanos , Masculino , Desarrollo MaxilofacialRESUMEN
Potentially life-threatening massive supraglottic swelling is occasionally seen in patients presenting with neck swelling following carotid endarterectomy. This is considered to be a distinct clinical entity, and a theoretical mechanism based on a review of the relevant anatomy and physiology is postulated.