RESUMEN
We report a case of cutaneous angiosarcoma occurring on the leg of a 97-year-old Japanese woman. Considering the patient's age and general condition, she was treated with electron beam irradiation, which led to the almost complete disappearance of the tumour. Because cutaneous angiosarcoma is an aggressive tumour with a high propensity for local recurrence and distant metastases, therapy preferably involves a multimodal approach. However, monotherapy with radiation may be effective in some cases of cutaneous angiosarcoma.
Asunto(s)
Hemangiosarcoma/radioterapia , Neoplasias Cutáneas/radioterapia , Anciano de 80 o más Años , Quemaduras/complicaciones , Femenino , Hemangiosarcoma/etiología , Hemangiosarcoma/patología , Humanos , Pierna/patología , Neoplasias Cutáneas/etiología , Neoplasias Cutáneas/patologíaRESUMEN
We report a male infant with Down syndrome who had a transient myeloproliferative disorder associated with skin lesions. He was transferred to a neonatal intensive care unit because of low body weight, fetal edema, disseminated intravascular coagulation, and 10% blast cells in the peripheral blood. On postnatal day (PD) 1, erythema with small papules, vesicles, and pustules appeared on the entire body. A smear preparation from the pustules on PD 2 showed 10% blast cells. A biopsy specimen taken on PD 5 revealed subcorneal pustules containing neutrophils and eosinophils. Genetic analyses detected a somatic mutation (197G>T, Glu295Stop) in exon 2 of GATA-1. On PD 10, the eruptions resolved spontaneously and the population of blast cells in peripheral blood decreased to 1%. The number of blast cells in pustules decreased markedly after three days. Therefore, we recommend that cytologic examination should be performed as early as possible.
Asunto(s)
Trastornos Mieloproliferativos/patología , Enfermedades Cutáneas Vesiculoampollosas/patología , Síndrome de Down/complicaciones , Factor de Transcripción GATA1/genética , Humanos , Recién Nacido , Masculino , Trastornos Mieloproliferativos/diagnósticoRESUMEN
Twelve cases of eccrine porocarcinoma have been reported at our facility in the past 10 years. All of them were Japanese; half had lymph node metastases; and one-third died of this disease. Lymph node metastasis was correlated with pathological lymphovascular invasion. Death was correlated with a pathological growth pattern and clinical lymph node metastasis. Sentinel lymph node biopsy was performed usefully in two patients.
Asunto(s)
Carcinoma/patología , Neoplasias de las Glándulas Sudoríparas/patología , Anciano , Anciano de 80 o más Años , Antineoplásicos/uso terapéutico , Carcinoma/secundario , Carcinoma/terapia , Femenino , Humanos , Escisión del Ganglio Linfático , Metástasis Linfática , Masculino , Persona de Mediana Edad , Invasividad Neoplásica/patología , Pronóstico , Biopsia del Ganglio Linfático Centinela/métodos , Neoplasias de las Glándulas Sudoríparas/terapiaRESUMEN
Pemphigus and pemphigoid are different types of autoimmune bullous disease and can occur in the same patient. We report a female patient with this condition. At first, we diagnosed her with bullous pemphigoid, and we treated her with tetracycline, niacinamide and a topical steroid. Tense bullas disappeared shortly after that, but crusted erythemas mainly on her head and trunk persisted. We examined BP180 and desmoglein 1 enzyme-linked immunosorbent assays, and also histological features, which showed coexistence of bullous pemphigoid and pemphigus foliaceus concurrently. Therefore, we tried prednisolone, which could control both conditions. This case showed that tetracycline and niacinamide could control bullous pemphigoid, but could not control pemphigus foliaceus, and that prednisolone was effective for both conditions.