[Experimental development of immunity to pertussis]. / Osobennosti formirovaniia protivokokliushnogo immuniteta v éksperimente.

Experiments on animals inoculated intracerebrally with B. pertussis culture No 18-323, serovar 1.2.3, revealed that among sera against B. pertussis strains of different serovars sera against the strains of serovar 1 showed the highest protective potency, and sera against the strains of serovar 1.2 showed the lowest protective potency. In active immunization experiments vaccines from the strains of serovar 1 proved to be least effective, while the immunogenic properties of vaccines from the strains of serovar 1.2 were found to be most pronounced. Since this discrepancy in the above results is due to the fact that the strains of serovar 1 in small doses were unable to create a stable focus of antigenic stimulation, it is not expedient to include strains belonging to serovars other than 1.2 into vaccinal preparations.

[Changes in the immunologic status of myocardial infarct patients at various times in its course]. / Izmeneniia immunologicheskogo statusa bol'nykh infarktom miokarda v raznye sroki zabolevaniia.

Cell-mediated and humoral immunity parameters were investigated at different dates of myocardial infarction and compared with the blood tests. A diagram is proposed correlating changes of immune status to blood test results, as an instrument for the assessment of changes in immune status on the basis of blood composition. Immunologic changes (defense immunodeficiency and developing cytotoxic component) associated with acute myocardial infarction, and disorders of immunologic control persisting to the time of discharge were demonstrated. Immunologic tests with specific antigens help to decipher the nature of immunity disorders detectable on the basis of blood test results.

[Vaccine from the cell fragments of Bordetella pertussis. I. Protective, sensitizing properties and morphological characteristics of the vaccine]. / Vaktsina iz kletochnykh fragmentov Bordetella pertussis. Soobshchenie I. Zashchitnye, sensibiliziruiushche svoistva i morfologicheskaia kharacteristika vaktsiny

The authors present the results of studying the protective and sensitizing properties of a new preparation made of a ultrasonic disintegrate of pertussis microbes treated by ethyl ether. As shown by electron microscopy, the preparation consisted of the cell wall elements (the membrane), remnants of the cytoplasm and protectosome, i.e. it represented a vaccine consisting of cell fragments. In crude and sorbed condition it possessed marked protective properties (a test on mice). The content of protective units in the adsorbed preparation increased 1.5-3 times. The vaccine produced no sensitizing action, and its histamine-sensitizing activity was 3-5 times lower by protein and 5-10 times--by IOU than that of the whole-cell vaccine prepared form the same microbial suspension.