Temporal changes of the apparent diffusion coefficients of water and metabolites in rats with hemispheric infarction: experimental study of transhemispheric diaschisis in the contralateral hemisphere at 7 tesla.

The purpose of the present study was to clarify the temporal changes of the apparent diffusion coefficients (ADCs) of cerebral metabolites during early focal ischemia using stimulated echo acquisition mode with short echo time at a 7 T magnet to assess the pathophysiology of the reduction in diffusion properties observed both in the ischemic cerebral hemisphere and in the contralateral hemisphere. The ADCs of metabolites in the infarcted hemisphere 1 hour and 3 hours after the onset of ischemia decreased with 25% and 29% for choline containing compounds (Cho), 16% and 26% for creatine and phosphocreatine (Cre), and 19% and 19% for N-acetylaspartate (NAA), respectively, compared with the ADC values 2 hours later in the contralateral hemisphere. There were decreases in the ADC of Cho, Cre, and NAA with 21%, 7%, and 18% 8 hours later, respectively, in the noninfarcted hemisphere, which suggested transhemispheric diaschisis in rats with focal cerebral ischemia. The present study proposed that the diffusion characteristics of the brain metabolites might offer new insights into circulatory and metabolic alteration in the cerebral intracellular circumstance.

Dental bur fragments causing metal artifacts on MR images.

PURPOSE: Our purpose was to define the role of dental bur fragments in producing metal artifacts on MR images. METHODS: Dental prosthetic reconstructions were made for two dogs. The two lower second premolars were prepared for full-cast crowns by using a diamond bur. The crown margin was placed subgingivally on the right side (1 mm below the free gingival margin) and at the same level as the free gingival margin on the left side. After 1 week, full-cast crowns were cemented in place. MR imaging was performed 7 days later. RESULTS: Metal artifacts appeared in both second premolar regions of the mandible on MR images, with the right side, in which the crown margin was positioned subgingivally, displaying a larger signal distortion than the left side. After removal of the crown, the artifact remained on the right. On histopathologic examination, bur fragments were detected in the gingiva, more on the right than on the left. X-ray fluorescent element analysis showed iron in the gingival tissue containing bur fragments. CONCLUSION: Distortion of MR images was considered to be attributable in part to the damage of the gingiva and in part to the presence of dental bur fragments.

Physiological analyses of a patient with extreme widening of Virchow-Robin spaces.

We report on a 60-year-old woman with extreme widening of Virchow-Robin spaces who showed neither neurological symptoms nor signs. Magnetic resonance imagings (MRIs) of her brain disclosed multiple abnormalities located along the perforating medullary arteries in the white matter. Central sensory and motor conduction studies (sensory evoked potentials (SEPs) and magnetic stimulation) showed no conduction delays and several modulatory inputs normally influenced the motor and sensory cortical excitability, as expected from clinical features. These physiological analyses confirmed the functional integrity of the central sensory and motor systems, even though imaging studies showed seemingly serious abnormalities.

Hemiparkinsonism associated with a mesencephalic tumor.

A 66-year-old woman presented with a 3-year history of progressive right-sided hemiparkinsonism manifested by a right-hand resting tremor and right-sided bradykinesia. Magnetic resonance imaging (MRI) of the brain revealed a non-enhanced polycystic mass in the left midbrain. (11)C-methylspiperone ((11)C-NMSP) and (18)F-fluorodopa ((18)F-DOPA) positron emission tomography (PET) revealed a striatal hypometabolism that was restricted to the left side. These findings are consistent with a dysfunction in the left nigrostriatal dopaminergic pathway that is presumably induced by the cystic mass in the left midbrain. This case is significant due to the paucity of reports regarding the occurrence of a relatively pure parkinsonism that is associated with a mesencephalic space-occupying lesion.

Physical characteristics of low and medium energy collimators for 123I imaging and simultaneous dual-isotope imaging.

Septal penetration of high energy photons may degrade 123I images obtained with a low energy collimator. We evaluated the physical characteristics of a low energy, high resolution (LEHR) collimator, special LEHR (SLEHR) collimator, and medium energy collimator for 123I studies. The cross-talk of 99mTc and 123I into the 201Tl window was also examined. Sensitivity and spatial resolution were measured with each collimator. Point sources of 99mTc and 123I were imaged at various source-collimator distances using multiple energy windows, and the effects of collimator choice on energy spectrum and spatial distribution of photopeak counts were assessed. For 99mTc, both sensitivity and resolution were similar with the low energy collimators, and higher sensitivity and lower resolution were observed with the medium energy collimator. For 123I, the full width at tenth maximum was larger for 123I than for 99mTc when using the LEHR collimator. Acquisitions with multiple energy windows revealed severe degradation due to septal penetration in imaging 123I with the LEHR collimator, especially at short distances. The degradation was reduced with the SLEHR collimator and further with the medium energy collimator. In both 99mTc and 123I imaging, cross-talk into the 201Tl window was larger at shorter distances and the largest with the LEHR collimator. In conclusion, variation in collimator geometry causes differences in the effect of septal penetration on 123I images and in cross-talk into the 201Tl window. The SLEHR collimator may be suitable for use in high resolution 123I imaging and simultaneous 99mTc/201Tl imaging. Use of the medium energy collimator appears to be preferable in quantitative 123I studies.

Early diagnosis of central nervous system aspergillosis with combination use of cerebral diffusion-weighted echo-planar magnetic resonance image and polymerase chain reaction of cerebrospinal fluid.

We treated a patient diagnosed as central nervous system (CNS) aspergillosis with the combined use of cerebral diffusion-weighted echo-planar magnetic resonance imaging (DWI) and polymerase chain reaction of the cerebrospinal fluid (CSF-PCR). DWI, a cutting-edge imaging modality to reveal the earliest changes of cerebral infarction, detected cerebral fungal embolization when the conventional computed tomographic scan and magnetic resonance imaging failed to reveal it. CSF-PCR demonstrated the presence of Aspergillus-specific DNA in the specimen, when the conventional examination and culture of CSF were nonspecific or negative. These diagnostic methods could be useful in the early diagnosis of CNS aspergillosis.

Hypertensive encephalopathy: reversible CT and MR appearance.

The authors present a case of hypertensive encephalopathy in which CT and MR were performed. The brain stem and cerebellum were revealed as low density areas on CT and high intensity areas on T2-weighted MR images with mass effect. Slight abnormality was also noticed in the deep cerebral white matter. This distribution pattern is contrary to that described in previous reports in which cerebral white matter was mainly involved. The lesions showed definite improvement when the blood pressure was normalized. MR is more sensitive than CT, and is useful for early detection of the abnormality and follow-up study.

Detection of brain metastasis: comparison of Turbo-FLAIR imaging, T2-weighted imaging and double-dose gadolinium-enhanced MR imaging.

The purpose of this study was to compare Turbo-FLAIR imaging, T2-weighted imaging, and double-dose gadolinium-enhanced MR imaging in the detection of brain metastasis. Using the three sequences, 20 consecutive patients with brain metastases were prospectively studied with a 1.5-Tesla system. Three independent, blinded readers assessed the images for the presence, size, number, and location of metastatic lesions. In the detection of large lesions (> 0.5 cm), Turbo-FLAIR imaging (38/48, 79%) was not significantly different from gadolinium-enhanced imaging (42/48, 88%) (p = 0.273). T2-weighted imaging (31/48, 65%), however, was inferior to gadolinium-enhanced imaging (p < 0.05). There was no difference between Turbo-FLAIR imaging and gadolinium-enhanced imaging in the accuracy of detecting solitary brain metastasis (4/4, 100%). In conclusion, Turbo-FLAIR imaging is a useful, noninvasive screening modality for brain metastasis. Its use may lead to cost savings in the diagnosis of brain metastases and may impact positively the cost-effectiveness of treatment.

Direct cavernous sinus sampling.

To evaluate the potential of superselective cavernous sinus (CS) sampling in patients with functioning pituitary adenomas, we performed direct CS sampling in 18 patients with Cushing syndrome and other functioning adenomas using a mini-catheter. Samples from the inferior petrosal sinuses (IPS) were also obtained. All of the samples from 20 CS of 10 patients with Cushing syndrome and 13 of 16 samples from CS of eight patients with other adenomas were successfully obtained. No complication occurred. In three patients, the mini-catheter was introduced to the contralateral CS through intercavernous communication, and bilateral sampling could be performed via the unilateral jugular vein. The CS/peripheral (CS/P) ratio of ACTH (mean = 66.1) was significantly greater than the IPS/peripheral (IPS/P) ratio (mean = 14.9) in Cushing disease. In other functioning adenomas, the CS/P ratio (15.8) was not significantly higher than the IPS/P ratio (4.8). Direct CS sampling offers a much higher CS/P ratio than IPS/P ratio in Cushing disease, and may provide sufficient diagnostic accuracy without CRH stimulation or bilateral simultaneous sampling.

3D-CT angiography of cerebral arteriovenous malformations.

We studied 76 patients with cerebral arteriovenous malformations (AVMs) using dynamic-CT with intravenous injection of contrast material and reconstructed three-dimensional images (3D-CT angiography). All patients received stereotactic radiotherapy (gamma-knife). We compared 3D-CT angiography with conventional angiography to determine the usefulness of this technique. 3D-CT angiography could be performed in conjunction with usual axial high-resolution CT without any additional scanning time and within 10-30 minutes for the overall study. Most niduses and drainers of AVMs were clearly visualized by 3D-CT angiography. 3D-reconstruction was very helpful in demonstrating the niduses, drainers, and three-dimensional structure of AVMs. Demonstrations of feeders were not remarkable. Dynamic CT was very helpful in dose planning for gamma-knife radiosurgery, because gamma-knife angiograms were limited in terms of angles, magnification, and establishing precise localizations using a head frame. 3D-CT added information on trails of drainers and was useful in reducing the volume of irradiation. 3D-CT angiography of cerebral AVMs could be performed routinely, and three-dimensional imaging was helpful in demonstrating the complex anatomy of cerebral AVMs. This technique was very helpful in planning gamma-knife radiosurgery.

[CT appearance of uterine adenomyosis].

CT findings in 37 cases with pathological diagnosis of uterine adenomyosis were reviewed retrospectively. The attenuation coefficient of adenomyosis is almost same as normal parenchyma on both plain and enhanced CT. The margin was obscure except for one case. In focal type, deviation of the endometrium and deformity of the uterus may be a clue to the detection of adenomyosis. But differential diagnosis of adenomyosis from leiomyoma with ill-defined margin was very difficult. In diffuse type, the uterine body is swollen without deviation of the endometrium. This type can be diagnosed if the endometrium identified clearly.

Neurinoma of the oculomotor nerve: CT and MR features.

The authors present a case of neurinoma of the oculomotor nerve without evidence of von Recklinghausen disease. The literature is reviewed and CT and magnetic resonance findings are discussed.

[Clinical usefulness of 67Ga-citrate scintigraphy combined early image in malignant lymphoma--detection of abdominal lesions].

In order to improve the diagnostic accuracy in detecting abdominal lesions of malignant lymphoma, we studied prospectively the usefulness of 67Ga-citrate scintigraphy combined 5 to 6-hour early image with conventional 72-hour delayed image after injection. During the period from July 1986 to September 1988, total 41 67Ga-citrate scintigrams performed on 28 patients with malignant lymphoma (3 Hodgkin's disease, 25 non-Hodgkin lymphoma) were evaluated between early and delayed image regarding to such points as follows; 1) the physiologic bowel uptake of 67Ga-citrate, 2) detection of abdominal lesions indicated by other diagnostic modalities involving computed tomography, lymphography and ultrasonography. Following results were obtained: 1) Prominent bowel uptake of 67Ga-citrate thought to be difficult to interpret the scintigram was observed in only 1 of 41 (2%) on early image versus 13 of 41 (32%) on delayed image. 2) Known lesion sites were detected in 24 of 31 (77%) on early image versus 21 of 31 (68%) on delayed image, resulting in 26 of 31 (84%) in combination with both images. 3) There were 2 false-positive and 5 false-negative lesions. Two false-positive lesions on early image were explained by physiologic hepatic uptake with ill-defined outline and bladder uptake. On the other hand, all of 5 lesions on delayed image were explained by prominent bowel uptake. 4) Two patients were revealed higher splenic uptake comparing with hepatic uptake on both images, later proved to be diffuse splenic involvement without evidence of lesions on other diagnostic modalities. 5) The lesions less than 2 cm in diameter could not be detected in both images.(ABSTRACT TRUNCATED AT 250 WORDS)

Acquired epidermoid tumour in the thoracic spinal canal.

Acquired spinal epidermoid tumours are rare, and probably caused by skin fragments that have been transplanted by trauma or lumbar puncture. They almost always occur in the region of the cauda equina. We present an acquired spinal epidermoid tumour at the T 10 level, with pathological confirmation. A skin fragment had migrated to a site where it developed into a tumour.

Postaortic left innominate vein: radiological assessment and pathogenesis.

Postaortic left innominate vein (PALIV) is a rare venous anomaly and the findings on plain chest radiographs have not been well described. Plain chest radiographs, CT and MR of nine adults known to have PALIV were reviewed. They all showed a high aortic arch, including four with a right-sided aortic arch and one with a double aortic arch, in postero-anterior radiographs, and seven showed curved shadows in the left upper mediastinum. On all lateral chest radiographs (n = 5), the superior retrosternal region was opacified by the high aortic arch. CT or MR images confirmed the aortic arch and/or innominate artery to be in that part of the retrosternal space, normally occupied by the left innominate vein, in all cases. Association of a curved shadow in the superior mediastinum with a high aortic arch on plain chest radiographs is therefore suggestive of, though not diagnostic for, PALIV. This entity was well documented by CT or MR and the radiological findings were considered to imply that developmentally PALIV is secondary to a high position of the aortic arch.

Motor cortical reflex myoclonus: a case study with MEG.

Cortical reflex myoclonus usually depends for its generation on the hyperexcitability of sensory cortex, which manifests itself as an enhanced somatosensory evoked potential (SEP). A 25-year-old female, presenting with involuntary jerky dorsiflexion of the left foot, was found to have cortical reflex myoclonus which was aggravated during intended movements. The jerks were also elicited by electrical stimulation of the posterior tibial nerve, although the SEP evoked by the same stimulus was normal in latency and amplitude. Both the spontaneous spikes and the premyoclonus spike demonstrated by jerk-locked back averaging were localized to the superior frontal gyrus, just anterior to the paracentral sulcus. Paired-pulse magnetic stimulation disclosed lack of inhibition in the right hemisphere leg motor area, whereas the excitability of sensory cortex as studied by paired SEP testing was normal. This suggests that the myoclonus was caused mainly by enhanced excitability of the motor cortex and that this alone was enough for the production of long loop reflexes. We propose to designate this type of cortical myoclonus as motor cortical reflex myoclonus. It is generated in the motor cortex, but is at the same time stimulus-sensitive.

Posterior cranial fossa dural arteriovenous malformation with a varix mimicking a thrombosed aneurysm: case report.

Dural arteriovenous malformations (AVMs) in the posterior cranial fossa are relatively infrequent. Intradural haemorrhage is one of their specific complications. Angiographic demonstration of varices or aneurysmal structures is one of the hallmarks of severe cases. We report a patient with posterior cranial fossa dural AVM associated with a varix mimicking a thrombosed aneurysm on CT and MRI. Internal carotid and vertebral angiography failed to demonstrate an aneurysm, but external carotid injection revealed a dural AVM affecting the sigmoid sinus, and a varix. The AVM was completely eliminated by embolization. When a dural AVM is suspected clinically selective angiography should be performed to confirm the diagnosis even when CT or MRI do not show dilated vessels.

Avulsion injury of cervical nerve roots: enhanced intradural nerve roots at MR imaging.

PURPOSE: To study the magnetic resonance (MR) imaging features of intradural nerve roots in avulsion injury of the cervical nerve roots. MATERIALS AND METHODS: Presurgical gadolinium-enhanced MR imaging was performed in 27 consecutive patients. The images were evaluated for enhancement of the intradural nerve roots and enhancement of the spinal cord surface at the root entry zone ("root stump" enhancement) by two radiologists, who were blinded to the clinical information. Intradural nerve roots were classified as enhanced, normal, or not visible. Root stumps were classified as enhanced or normal. The results were compared with the results of nerve root continuity studies (exploratory surgery with intraoperative recording of somatosensory evoked potentials or neurologic examination). RESULTS: At the 250 nerve levels (500 nerve roots) studied, 12 enhanced nerve roots and 42 enhanced root stumps were found. Seven enhanced nerve roots and 38 enhanced root stumps were related to preganglionic injury. Results of the kappa test for interobserver concordance on findings of intradural nerve roots and root stumps were 0.55 and 0.93, respectively. CONCLUSION: Although visualization of nerve roots is a problem, enhanced MR imaging is a noninvasive means of obtaining anatomic information and unique physiologic information on injured intradural nerve roots.