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Objective To identify whether long-term hyperuricemia(HU)is able to induce arota pathological changes in rat.Methods 2%OA forage and 100 μmol/L uric acid plus OA lavage were used to copy a long-term hyperuricemia animal model,eNOS,ET-1,ICAM expression in arota was evaluated to find out the role of uric acid in cardiovascular diseases.Results The arotas of hyperuricemia rats had tiny damages whereas that of rats in con-trol group was totally normal; Hyperuricemia rat had less eNOS expression,more ET-1,ICAM expression in arota (P<0.05)and less NO,more ET-1,ICAM in serum.Conclusions Long-term hyperuricemia is able to induce im-pairment in endothelium in rat arota,but fails to cause atherosclerosis.
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Objective To observe the curative effects of Shuxuetong in treating patients with acute cerebral infarction and its effects on the level of serum C-reactive protein (CRP).Methods One hundred and twenty patients with acute cerebral infarction who had the onset within 48 h were equally randomized into treatment group and control group.Six ml Shuxuetong and Troxerutin for intravenous drip daily were given to the treatment group and the control group,respectively,for a consecutive 14 d.The concentrations of serum CRP in the 2 groups were measured by immunonephelometry before treatment and on the 5th,10th and 14th d of treatment.The scores of neurological functional deficit scale were compared before treatment and on the 14th d of treatment in the 2 groups.Results The concentration of serum CRP in the treatment group on the 5th,10th and 14th d of treatment was significantly lower than that in the control group (P<0.05).The scores of neurological functional deficit scale in the treatment group (14.57±7.88) were significantly lower than those in the control group (19.08±8.11) (P<0.05).The clinical efficacy between the 2 groups was obviously different (P<0.05).Conclusion Shuxuetoug can decrease the concentration of serum CRP and improve the nervous function in patients with acute cerebral infarction.