Detalles de la búsqueda
1.
Novel 1-(1-Arylimiazolin-2-Yl)-3-Arylalkilurea Derivatives with Modulatory Activity on Opioid MOP Receptors.
Molecules
; 29(3)2024 Jan 24.
Artículo
Inglés
| MEDLINE | ID: mdl-38338317
2.
Anti-inflammatory effects of new human histamine H3 receptor ligands with flavonoid structure on BV-2 neuroinflammation.
Inflamm Res
; 72(2): 181-194, 2023 Feb.
Artículo
Inglés
| MEDLINE | ID: mdl-36370200
3.
Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold.
Bioorg Chem
; 139: 106737, 2023 10.
Artículo
Inglés
| MEDLINE | ID: mdl-37482048
4.
Synthesis and biological evaluation of novel 3-(5-substituted-1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT.
Bioorg Chem
; 141: 106903, 2023 12.
Artículo
Inglés
| MEDLINE | ID: mdl-37827015
5.
Evaluation of Some Safety Parameters of Dual Histamine H3 and Sigma-2 Receptor Ligands with Anti-Obesity Potential.
Int J Mol Sci
; 24(8)2023 Apr 19.
Artículo
Inglés
| MEDLINE | ID: mdl-37108661
6.
The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α1-Adrenoceptors Antagonists.
Int J Mol Sci
; 24(23)2023 Nov 22.
Artículo
Inglés
| MEDLINE | ID: mdl-38068933
7.
Potential of nafimidone derivatives against co-morbidities of epilepsy: In vitro, in vivo, and in silico investigations.
Drug Dev Res
; 83(1): 184-193, 2022 02.
Artículo
Inglés
| MEDLINE | ID: mdl-34291476
8.
The Antiarrhythmic and Hypotensive Effects of S-61 and S-73, the Pyrrolidin-2-one Derivatives with α1-Adrenolytic Properties.
Int J Mol Sci
; 23(18)2022 Sep 08.
Artículo
Inglés
| MEDLINE | ID: mdl-36142287
9.
Novel Arylpiperazine Derivatives of Salicylamide with α1-Adrenolytic Properties Showed Antiarrhythmic and Hypotensive Properties in Rats.
Int J Mol Sci
; 24(1)2022 Dec 24.
Artículo
Inglés
| MEDLINE | ID: mdl-36613736
10.
Serotonin 5-HT6 Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity-Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer's Disease.
Int J Mol Sci
; 23(16)2022 Aug 21.
Artículo
Inglés
| MEDLINE | ID: mdl-36012707
11.
Modulation of the MOP Receptor (µ Opioid Receptor) by Imidazo[1,2-a]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action.
Molecules
; 27(9)2022 May 04.
Artículo
Inglés
| MEDLINE | ID: mdl-35566280
12.
Synthesis of Novel Pyrido[1,2-c]pyrimidine Derivatives with 6-Fluoro-3-(4-piperidynyl)-1,2-benzisoxazole Moiety as Potential SSRI and 5-HT1A Receptor Ligands.
Int J Mol Sci
; 22(5)2021 Feb 26.
Artículo
Inglés
| MEDLINE | ID: mdl-33652672
13.
The Structural Determinants for α1-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives.
Molecules
; 26(22)2021 Nov 20.
Artículo
Inglés
| MEDLINE | ID: mdl-34834117
14.
Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties.
Molecules
; 26(13)2021 Jun 23.
Artículo
Inglés
| MEDLINE | ID: mdl-34201675
15.
Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs.
Bioorg Med Chem Lett
; 30(21): 127493, 2020 11 01.
Artículo
Inglés
| MEDLINE | ID: mdl-32798652
16.
Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives.
Bioorg Med Chem Lett
; 30(16): 127325, 2020 08 15.
Artículo
Inglés
| MEDLINE | ID: mdl-32631530
17.
Synthesis of new 4-butyl-arylpiperazine-3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives and evaluation for their 5-HT1A and D2 receptor affinity and serotonin transporter inhibition.
Bioorg Chem
; 97: 103662, 2020 04.
Artículo
Inglés
| MEDLINE | ID: mdl-32086055
18.
6-Acetyl-5-hydroxy-4,7-dimethylcoumarin derivatives: Design, synthesis, modeling studies, 5-HT1A, 5-HT2A and D2 receptors affinity.
Bioorg Chem
; 100: 103912, 2020 07.
Artículo
Inglés
| MEDLINE | ID: mdl-32388437
19.
Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltage-gated sodium channels (VGSCs) as promising anticonvulsant drug candidates.
Bioorg Chem
; 94: 103355, 2020 01.
Artículo
Inglés
| MEDLINE | ID: mdl-31662213
20.
Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.
Molecules
; 25(17)2020 Aug 25.
Artículo
Inglés
| MEDLINE | ID: mdl-32854402