[Effect of semi-synthetic penicillins and cephaloridine on indices of immunologic reactivity and protein metabolism during treatment of puerperal infection]. / Izuchenie vliianiia polusinteticheskikh penitsillinov i tsefaloridina na pokazateli immunologicheskoi reaktivnosti i belkovogo obmena pri lechenii poslerodovykh infektsionnykh zabolevanii.

The effect of semisynthetic penicillins, such as methicillin and oxacillin and cephalosporins, such as cephaloridin of immunity and protein metabolism was studied on 63 patients with postnatal mastitis and endomyometritis. It was shown that the above antibiotics had no significant effect on the immunological reactivity and protein metabolism. However, lower titers of alpha-antitoxin, lysine levels and C-reactive protein content were registered in the mastitis patients treated with cephaloridin. Therefore, while recomending antibacterial drugs their effect on the immunity and protein metabolism should be taken into account and from this point of view semisynthetic penicillins are preferable in treatment of mastitis patients and semisynthetic penicillins and cephaloridin are preferable in treatment of endomyometritis patients.

[State of the blood coagulating system in the treatment of puerperal infections using semisynthetic penicillins and cephaloridine]. / Sostoianie svertyvaiushchei sistemy krovi pri lechenii poslerodovykh infektsionnykh zabolevanii polusinteticheskimi penitsillinami i tsefaloridinom.

The effect of some semi-synthetic penicillins, such as methicillin and oxacillin and cephalosporings, such as cephaloridin on the condition of the blood coagulation system in 85 patients with postnatal mastitis and endomyometritis was studied. It was shown that the above antibiotics had no significant effect on the parameters of the blood coagulating system. A decrease in the fibrinogen level was found in the mastitis patients treated with semi-synthetic penicillins and cephaloridin. An increase in the prothrombins index in the patients treated with methicillin oxacillin was shown. The use of the semi-synthetic penicillins and cephaloridin for the therapy of the puerpera with endomyometritis resulted in prolongation of the recalcification period. A decrease in the fibrinolytic activity most pronounced in therapy with cephaloridin was also found. Therefore, the above changes in the blood coagulating system of the puerpera with postnatal infections subjected to short-term treatment courses were insignificant and required no special correction.

[Phamacokinetics of methicillin, oxacillin and cephalosporin in the body of puerperae]. / Farmakokinetika metitsillina, oksatsillina i tsefalosporina v organizme rodil'nits.

Features of absorption, distribution and excretion of methicillin, oxacillin and cephaloridine in 58 puerpera were studied. No complications were observed in the postnatal period of the puerpera. The results of the study of the antibiotic pharmacokinetics provided elaboration of the optimal regimen for the use of methicillin, oxacillin and cephaloridine in puerpera, i. e. I g intramuscularly every 6 hours.

[Body pharmacokinetics of methicillin, oxacillin and cephaloridine in puerperal mastitis]. / Farmakokinetika metitsillina, oksatsillina i tsefaloridina v organizme bol'nykh poslerodovym mastitom.

Mechanisms of absorption, distribution and excretion of methicillin, oxacillin and cephaloridin were studied in 46 women with postnatal mastitis (serous and infiltrative forms). The results obtained allow one to document different clinical efficiency of antibiotics in treatment of patients with postnatal mastitis. Poor efficiency of cephaloridin in therapy of mastitis was shown.