Hybrid dispersion laser scanner.

Laser scanning technology is one of the most integral parts of today's scientific research, manufacturing, defense, and biomedicine. In many applications, high-speed scanning capability is essential for scanning a large area in a short time and multi-dimensional sensing of moving objects and dynamical processes with fine temporal resolution. Unfortunately, conventional laser scanners are often too slow, resulting in limited precision and utility. Here we present a new type of laser scanner that offers ∼1,000 times higher scan rates than conventional state-of-the-art scanners. This method employs spatial dispersion of temporally stretched broadband optical pulses onto the target, enabling inertia-free laser scans at unprecedented scan rates of nearly 100 MHz at 800 nm. To show our scanner's broad utility, we use it to demonstrate unique and previously difficult-to-achieve capabilities in imaging, surface vibrometry, and flow cytometry at a record 2D raster scan rate of more than 100 kHz with 27,000 resolvable points.

A passive microfluidic device for plasma extraction from whole human blood.

Promising microfluidic devices are proposed herein to continuously and passively extract plasma from whole human blood. These designs are based on the red cells lateral migration and the resulting cell-free layer locally expanded by geometric singularities, such as an abrupt enlargement of the channel or a cavity adjacent to the channel. After an explanation of flow patterns, devices are experimentally and biologically validated for plasma extraction. They are also successively optimized with extraction yields up to 17.8% for a 1:20 blood injected at 100 microL/min.