[The level of cyclic nucleotides and the activity of their phosphodiesterases in the peripheral blood lymphocytes in lung diseases during endolymphatic antibiotic therapy]. / Uroven' tsiklicheskikh nukleotidov i aktivnost' ikh fosfodiésteraz v limfotsitakh perifericheskoi krovi pri zabolevaniiakh legkikh na fone éndolimfaticheskoi antibiotikoterapii.

Fifty patients with chronic bronchitis, 30 with lingering pneumonias and 60 with lung abscesses were examined. The status of the system of cyclic nucleotides and functional properties of T lymphocytes depending on different administrations of antibiotics into the patients' body (endolymphatically or intravenously) were studied over time. The degree of the recovery to normal of the functional status of the T system immunity and cyclic nucleotides turned out significantly higher in patients receiving antibiotics endolymphatically than in those given intravenous injections. This attests to the high efficacy and advantages of endolymphatic antibiotic therapy in patients with inflammation in the lungs and bronchi.

[The prognostic importance of rheopulmonography in the diagnosis of thromboembolic complications]. / Prognosticheskoe znachenie reopul'monografii v diagnostike tromboémbolicheskikh oslozhnenii.

A possibility was analyzed of use of rheopulmonography in the diagnosis of thromboembolic complications. Studies were made as exemplified by examination of patients operated on for abdominal hemorrhages. As a result of multiparametric statistical processing of the analysis results two groups were identified of indices for the state of pulmonary bloodflow and ventilation, effectiveness of alveolar-arterial gas transfer. In the first group, the values were within the relatively normal range, the second group being patients with microthromboembolism of the pulmonary artery. The use of pharmacological methods for the prophylaxis administration was seen to result in lower probability of pneumonia origination in the examined patients. Zonal rheopulmonography is believed to allow some judgement about the probability of the thromboembolic complications development and control over the efficiency of methods for their prevention.

[The nonoliguric form of kidney failure in the posthemorrhagic period]. / Neolihurychna forma nyrkovoï nedostatnosti v pisliahemorahichnomu periodi.

At research of rules of deviations of the parameters homeostasis for patients with bleedings we pursued to find dependence of the parameters of homeostasis from function of kidneys. The researches were carried out in the early posthemorrhagic period on an example of inspection of the patients who were operated concerning gastrointestinal and intraabdominal hemorrhages. Is revealed, that the renal insufficiency, which arose at 23.21% surveyed, proceeded without oliguria--in the neoliguric form. It was characterized by normal speed diuresis, despite of the essential damages of the function of nephron: infringement of a primary filtration in glomerulus, reabsorption of water and electrolytes in tubules, restriction of excretion H+. Normal diuresis in such cases was explained by the early and duly beginning of the infusion therapy, owing to what, probably, the infringement of passableness tubules was prevented. Despite of it, the patients with the damaged function of kidneys require the careful control of spent therapy because of an opportunity of dangerous deviations of the parameters homeostasis of norm. Confirmation it became the reduction, fixed at such patients, clearance of electrolytes, infringement of the extraction of acid by kidneys.

[Experience with the use of endolymphatic antibacterial therapy]. / Opyt primeneniia éndolimfaticheskoi antibakteria'lnoi terapii.

In 98 patients with different purulent-inflammatory processes, the method of antegrad endolymphatic antibacterial therapy was used in the complex of treatment. One of the antibiotics (ampicillin, gentamycin, claforan), and metrogyl, dioxydin, contrical, heparin at the routine therapeutic doses 1 time at 24-48 h were introduced into the lymphatic vessel of the lower extremity via a catheter. The duration of treatment depended on the severity of the course of inflammatory process. In 74.4% of cases, the treatment was effective.

[The patterns of oxygen metabolism in the early posthemorrhagic period]. / Zakonomirnosti obminu kysniu v rann'omu pisliahemorahichnomu periodi.

Investigated all links of oxygen homeostasis of patients in early period afterwards surgical stoppage gastro-intestinal bleeding and urgent intravascular volume replacement. Macrodelivery of oxygen (DO2) was reduced in two and more time in comparison with norm predominant in connection with anemia. In spite of the infringement of transport of oxygen through alveolar-capillary membrane (especially in patients with complications and death in early postoperative period), little affected of degree of hemoglobin saturation by oxygen. Despite decrease of erythrocyte zeta-potential, largely expressed in cases of lethal outcome, considerable infringement of passage through microcirculation vessels is fixed was not. The increase of degree of morbidity and anaerobic metabolism in early postoperative period was accompanied of hyperdynamic hemodynamic reaction. The increase of degree of morbidity was accompanied of increase oxygen deficit owing to infringement of oxidoreduction in fabries also.