RESUMEN
The morphologic distinction between benign and malignant thyroid lesions can be difficult. Immunostaining for the Leu-7 antigen has been reported to be useful in the diagnosis of thyroid carcinoma. To test the specificity of immunostaining for Leu-7 in the diagnosis of thyroid carcinoma, we studied formalin-fixed, paraffin-embedded tissue specimens obtained from 66 thyroid lesions using the HNK-1 monoclonal antibody to Leu-7 and an avidin-biotin-complex technique. Positive reactivity for Leu-7 was seen in 11 (33%) of 33 benign thyroid conditions and in 27 (82%) of 33 thyroid carcinomas. We conclude that immunostaining for Leu-7 is not specific in the diagnosis of thyroid carcinoma.
Asunto(s)
Antígenos CD/metabolismo , Antígenos de Diferenciación de Linfocitos T/metabolismo , Carcinoma/patología , Neoplasias de la Tiroides/patología , Anticuerpos Monoclonales , Avidina , Biotina , Antígenos CD57 , Carcinoma/metabolismo , Humanos , Técnicas Inmunológicas , Coloración y Etiquetado , Neoplasias de la Tiroides/metabolismoRESUMEN
Hereditary neuropathy with liability to pressure palsy (HNPP) is characterised by recurrent mononeuropathies following minor trauma. We describe a case of fulminant HNPP beginning on the first day of military physical training. Protracted weakness, muscle atrophy, hand contractures, and multifocal sensory loss developed during a further three weeks of basic training. Nerve conduction changes were typical of HNPP, but without segmental slowing. Electromyographically, there was prominent acute denervation in muscles of the hands and right shoulder. Sural nerve biopsy demonstrated tomaculae and remyelination. Genetic testing revealed PMP-22 gene deletion. This case report demonstrates that HNPP can present with rapidly progressive peripheral nerve dysfunction and electrophysiological evidence of focal axonal loss.
Asunto(s)
Lesión Axonal Difusa/diagnóstico , Trastornos Heredodegenerativos del Sistema Nervioso/diagnóstico , Personal Militar , Síndromes de Compresión Nerviosa/diagnóstico , Parálisis/diagnóstico , Enfermedades del Sistema Nervioso Periférico/diagnóstico , Educación y Entrenamiento Físico , Adulto , Axones/patología , Biopsia , Diagnóstico Diferencial , Lesión Axonal Difusa/genética , Femenino , Trastornos Heredodegenerativos del Sistema Nervioso/genética , Humanos , Músculo Esquelético/inervación , Músculo Esquelético/patología , Proteínas de la Mielina/genética , Vaina de Mielina/patología , Síndromes de Compresión Nerviosa/genética , Examen Neurológico , Parálisis/genética , Enfermedades del Sistema Nervioso Periférico/genética , Degeneración Retrógrada/diagnóstico , Degeneración Retrógrada/genética , Nervio Sural/patologíaRESUMEN
Systemic lupus erythematosus presents various clinical manifestations. The coexistence of systemic lupus erythematosus and celiac sprue has been rarely reported. We present a patient who had systemic lupus erythematosus with malabsorption demonstrating characteristic clinical and pathologic findings of celiac sprue (gluten enteropathy).
Asunto(s)
Enfermedad Celíaca/complicaciones , Lupus Eritematoso Sistémico/complicaciones , Enfermedad Celíaca/dietoterapia , Enfermedad Celíaca/patología , Dieta con Restricción de Proteínas , Femenino , Estudios de Seguimiento , Glútenes/administración & dosificación , Humanos , Lupus Eritematoso Sistémico/patología , Persona de Mediana EdadRESUMEN
We describe a 45-year-old man who developed a painful mass about his knee. Magnetic resonance imaging demonstrated a well defined lesion, and biopsy confirmed a diagnosis of pigmented villonodular synovitis. Our case exemplifies a primary synovial process presenting as a subcutaneous tumor. Such diagnostic possibilities, although rare, should be more widely known.
Asunto(s)
Neoplasias de los Tejidos Blandos/diagnóstico , Sinovitis Pigmentada Vellonodular/diagnóstico , Diagnóstico Diferencial , Humanos , Rodilla/patología , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Neoplasias de los Tejidos Blandos/patología , Sinovitis Pigmentada Vellonodular/patologíaRESUMEN
We report the case of a 61-year-old man with an unusual intrasellar vascular malformation, who presented with symptoms of hypopituitarism and whose neuroradiologic evaluation mimicked a pituitary macroadenoma. The histopathologic and radiologic findings are discussed. This rare lesion should be considered in the diagnosis of a sellar mass lesion.