RESUMEN
A 51-year-old man presented with acute respiratory failure and myoglobinuria precipitated by an infection. Carnitine palmityltransferase (CPT) deficiency was documented in muscle, leukocytes, and liver. The enzyme defect in liver, previously suspected and now documented, explained the decreased production of ketone bodies during fasting observed in this patient as well as others with muscle CPT deficiency. Decreased utilization of long-chain fatty acids and decreased availability of ketone bodies can deprive the muscle of crucial sources of energy and, in certain conditions, may precipitate myoglobinuria.
Asunto(s)
Aciltransferasas/deficiencia , Carnitina O-Palmitoiltransferasa/deficiencia , Mioglobinuria/enzimología , Insuficiencia Respiratoria/enzimología , Biopsia , Carnitina/metabolismo , Carnitina O-Acetiltransferasa/metabolismo , Creatina Quinasa/metabolismo , Humanos , Cuerpos Cetónicos/sangre , Lípidos/sangre , Hígado/enzimología , Hígado/patología , Masculino , Persona de Mediana Edad , Músculos/enzimología , Músculos/patología , Atrofia Muscular/enzimología , Mioglobinuria/patología , Insuficiencia Respiratoria/patologíaRESUMEN
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.
Asunto(s)
Enfermedad de Alzheimer/diagnóstico , Enfermedad de Alzheimer/diagnóstico por imagen , Enfermedad de Alzheimer/psicología , Humanos , Pruebas Psicológicas , Tomografía Computarizada de Emisión , Tomografía Computarizada por Rayos X , Estados Unidos , United States Dept. of Health and Human ServicesRESUMEN
Experimental cerebral aneurysms were induced in rats in which the left carotid artery was ligated. The rats were rendered hypertensive by the Goldblatt procedure, and fed a diet containing beta-aminopropionitrile. These intracranial aneurysms have significant gross and microscopic similarities to human berry aneurysms. The procedures and microscopic observations indicate that this experimental model could be useful for studying the development, pathophysiology, and therapy of saccular aneurysms.