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1.
Br J Surg ; 108(6): 727-734, 2021 06 22.
Artículo en Inglés | MEDLINE | ID: mdl-34157086

RESUMEN

BACKGROUND: Clean Cut is an adaptive, multimodal programme to identify improvement opportunities and safety changes in surgery by enhancing outcomes surveillance, closing gaps in surgical infection prevention standards, and strengthening underlying processes of care. Surgical-site infections (SSIs) are common in low-income countries, so this study assessed a simple intervention to improve perioperative infection prevention practices in one. METHODS: Clean Cut was implemented in five hospitals in Ethiopia from August 2016 to October 2018. Compliance data were collected from the operating room focused on six key perioperative infection prevention standards. Process-mapping exercises were employed to understand barriers to compliance and identify locally driven improvement opportunities. Thirty-day outcomes were recorded on patients for whom intraoperative compliance information had been collected. RESULTS: Compliance data were collected from 2213 operations (374 at baseline and 1839 following process improvements) in 2202 patients. Follow-up was completed in 2159 patients (98·0 per cent). At baseline, perioperative teams complied with a mean of only 2·9 of the six critical perioperative infection prevention standards; following process improvement changes, compliance rose to a mean of 4·5 (P < 0·001). The relative risk of surgical infections after Clean Cut implementation was 0·65 (95 per cent c.i. 0·43 to 0·99; P = 0·043). Improved compliance with standards reduced the risk of postoperative infection by 46 per cent (relative risk 0·54, 95 per cent c.i. 0·30 to 0·97, for adherence score 3-6 versus 0-2; P = 0·038). CONCLUSION: The Clean Cut programme improved infection prevention standards to reduce SSI without infrastructure expenses or resource investments.


Asunto(s)
Mejoramiento de la Calidad , Infección de la Herida Quirúrgica/prevención & control , Adulto , Lista de Verificación , Países en Desarrollo , Etiopía , Femenino , Humanos , Periodo Intraoperatorio , Masculino , Estudios Prospectivos , Factores de Riesgo , Procedimientos Quirúrgicos Operativos/efectos adversos , Procedimientos Quirúrgicos Operativos/métodos , Procedimientos Quirúrgicos Operativos/normas , Infección de la Herida Quirúrgica/etiología , Resultado del Tratamiento , Adulto Joven
2.
Br J Surg ; 107(13): 1751-1761, 2020 12.
Artículo en Inglés | MEDLINE | ID: mdl-32592513

RESUMEN

BACKGROUND: Poor surgical lighting represents a major patient safety issue in low-income countries. This study evaluated device performance and undertook field assessment of high-quality headlights in Ethiopia to identify critical attributes that might improve safety and encourage local use. METHODS: Following an open call for submissions (December 2018 to January 2019), medical and technical (non-medical) headlights were identified for controlled specification testing on 14 prespecified parameters related to light quality/intensity, mounting and battery performance, including standardized illuminance measurements over time. The five highest-performing devices (differential illumination, colour rendering, spot size, mounting and battery duration) were distributed to eight Ethiopian surgeons working in resource-constrained facilities. Surgeons evaluated the devices in operating rooms, and in a comparative session rated each headlight in terms of performance and willingness to purchase. RESULTS: Of 25 submissions, eight headlights (6 surgical and 2 technical) met the criteria for full specification testing. Scores ranged from 8 to 12 (of 14), with differential performance in lighting, mounting and battery domains. Only two headlights met the illuminance parameters of more than 35 000 lux during initial testing, and no headlight satisfied all minimum specifications. Of the five headlights evaluated in Ethiopia, daily operation logbooks noted variability in surgeons' opinions of lighting quality (6-92 per cent) and spot size (0-92 per cent). Qualitative interviews also yielded important feedback, including preference for easy transport. Surgeons sought high quality with price sensitivity (using out-of-pocket funds) and identified the least expensive but high-functioning device as their first choice. CONCLUSION: No device satisfied all the predetermined specifications, and large price discrepancies were critical factors leading surgeons' choices. The favoured device is undergoing modification by the manufacturer based on design feedback so an affordable, high-quality surgical headlight crafted specifically for the needs of resource-constrained settings can be used to improve surgical safety.


ANTECEDENTES: Una iluminación quirúrgica deficiente conlleva importantes problemas de seguridad para los pacientes en países de bajos ingresos. En Etiopía, se evaluó el rendimiento y la capacidad de iluminar el campo quirúrgico de varias lámparas de alta calidad para identificar aspectos esenciales que podrían mejorar la seguridad y fomentar su uso local. MÉTODOS: Tras una convocatoria abierta (diciembre de 2018-enero de 2019), se identificaron lamparás médicas y técnicas (no médicas) para realizar un análisis de 14 variables previamente definidas en relación con la calidad/intensidad de la luz, montaje y rendimiento de la batería, además de mediciones estandarizadas de iluminancia a largo plazo. Los cinco dispositivos de mayor rendimiento (iluminación diferencial, reproducción del color, tamaño del foco, montaje y duración de la batería) se distribuyeron entre 8 cirujanos etíopes que trabajaban en instalaciones con recursos limitados. Los cirujanos evaluaron los dispositivos en quirófano y en sesiones comparativas calificaron el rendimiento de cada lámpara y la disposición para su compra. RESULTADOS: De las 25 propuestas presentadas, 8 lámparas (6 quirúrgicas y 2 técnicas) cumplieron los criterios para realizar las pruebas de especificación completas. Las puntuaciones oscilaron entre 8 y 12 (de un total de 14), con diferencias en los ámbitos de iluminación, montaje y batería. Solo 2 lámparas proporcionaron > 35000 lux de iluminancia durante la prueba inicial, y ninguna lámpara cumplió con todas las especificaciones mínimas. De las cinco lámparas evaluadas en Etiopía, hubo una gran variabilidad en las opiniones de los cirujanos anotadas en los registros realizados, tanto sobre la calidad de la iluminación (21-92%), como del tamaño del foco (0-92%). En las entrevistas cualitativas surgieron comentarios importantes como la preferencia por un transporte fácil. Los cirujanos buscaban la mejor calidad al precio más razonable (dado que se utilizaban fondos propios para su adquisición) e identificaron el dispositivo menos costoso pero con alto funcionamiento como primera opción. CONCLUSIÓN: El hecho de que ningún dispositivo satisfizo todas las especificaciones predeterminadas y la gran variabilidad de precios fueron los aspectos esenciales que determinaron la elección de los cirujanos. El dispositivo mejor valorado está siendo modificado por el fabricante en función de los comentarios de diseño, para lograr una lámpara quirúrgica asequible y de alta calidad diseñada específicamente para satisfacer las necesidades de entornos con recursos limitados en la mejora la seguridad quirúrgica.


Asunto(s)
Diseño de Equipo , Iluminación/instrumentación , Seguridad del Paciente , Instrumentos Quirúrgicos , Actitud del Personal de Salud , Países en Desarrollo , Etiopía , Humanos , Entrevistas como Asunto , Quirófanos , Investigación Cualitativa , Calidad de la Atención de Salud , Cirujanos
3.
Pediatrics ; 89(6 Pt 2): 1226-9, 1992 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-1594380

RESUMEN

Extracorporeal piezoelectric lithotripsy is an effective method for treating renal pelvic stones in children. Treatment with the Wolf lithotriptor is essentially painless and can be performed without anesthesia on an outpatient basis. Real-time ultrasound is used to localize stones. In a 1-year period at the University of Utah, extracorporeal piezoelectric lithotripsy was administered to eight children with nine renal units. Of the eight children, aged 5 to 17 1/2 years, only two required sedation and only one received retreatment. No stents were placed. At 1 month posttreatment, all children were stone-free, and no significant complications occurred.


Asunto(s)
Cálculos Renales/terapia , Litotricia/instrumentación , Adolescente , Analgesia , Niño , Preescolar , Femenino , Humanos , Litotricia/métodos , Masculino
4.
Chest ; 112(4): 1035-42, 1997 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-9377914

RESUMEN

OBJECTIVE: To determine the predictors of outcome in cardiac surgical patients with prolonged ICU stay. DESIGN: Inception cohort with retrospective chart review. SETTING: Adult cardiovascular ICU. PATIENTS: All patients admitted after cardiac surgery who stayed in ICU for at least 14 consecutive days. INTERVENTIONS: Collection of data, including preoperative demographics, comorbidity, routine laboratory testing, surgical procedure, duration of cardiopulmonary bypass and aortic cross-clamping, postoperative requirement for transfusion and intra-aortic balloon counterpulsation, and postoperative indexes of organ dysfunction 14 and 28 days after surgery. An organ failure score (OFS) was calculated for days 1, 14, and 28. OUTCOME MEASURES: Hospital mortality. RESULTS: One hundred forty-one of 324 (43.5%) ICU admissions lasting at least 14 days resulted in hospital mortality. Seventy-four of 166 (45%) ICU admissions lasting at least 28 days resulted in hospital mortality. Preoperative demographics, morbidity, and indexes of organ failure in the first 24 h after surgery were not predictive of hospital mortality. Indexes of organ failure predictive of hospital death at 14 days included requirement for epinephrine infusion, diminished Glasgow coma scale, requirement for dialysis, greater value of BUN, lower value of creatinine, greater value of bilirubin, greater value of arterial PCO2, lower platelet count, and lower value of serum albumin. After a 28-day stay in ICU, the indexes of organ failure predictive of hospital mortality included requirement for dopamine or norepinephrine infusions, diminished Glasgow coma score, greater value of bilirubin, greater value of arterial PCO2, lower value of serum albumin, and advanced age. The area under the receiver operating characteristic curve for the OFS on day 1 was 0.55+/-0.04 (p=0.12), on day 14 it was 0.75+/-0.03 (p<0.0001), and on day 28 it was 0.76+/-0.04 (p<0.0001). CONCLUSION: Preoperative health status and early organ failure were not predictive of late hospital mortality. The pattern of late organ failure associated with hospital mortality changed with time.


Asunto(s)
Procedimientos Quirúrgicos Cardíacos , Cuidados Críticos , Tiempo de Internación , Agonistas alfa-Adrenérgicos/uso terapéutico , Adulto , Factores de Edad , Anciano , Bilirrubina/sangre , Transfusión Sanguínea , Nitrógeno de la Urea Sanguínea , Dióxido de Carbono/sangre , Puente Cardiopulmonar , Estudios de Cohortes , Creatinina/sangre , Dopamina/uso terapéutico , Epinefrina/uso terapéutico , Femenino , Estudios de Seguimiento , Predicción , Escala de Coma de Glasgow , Mortalidad Hospitalaria , Humanos , Contrapulsador Intraaórtico , Masculino , Insuficiencia Multiorgánica/etiología , Norepinefrina/uso terapéutico , Oxígeno/sangre , Admisión del Paciente , Recuento de Plaquetas , Diálisis Renal , Estudios Retrospectivos , Albúmina Sérica/análisis , Tasa de Supervivencia , Factores de Tiempo , Resultado del Tratamiento
5.
Ann Thorac Surg ; 70(1): 175-81, 2000 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-10921704

RESUMEN

BACKGROUND: We examined the effect on outcome of mild hypothermia (< 36 degrees C) upon intensive care unit (ICU) admission on patient outcome after coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). METHODS: We performed a retrospective database analysis of 5,701 isolated CABG patients requiring CPB, operated upon from January 1995 to June 1997. Patients were classified as either hypo- (< 36 degrees C) or normothermic (> or = 36 degrees C) upon ICU admission. ICU admission bladder core temperature (BCT) versus outcome was evaluated. Outcome measures included mortality, resource utilization (mechanical ventilation time, ICU and hospital length of stay, and postoperative packed red blood cell transfusion), and major morbidity (cardiac, renal, neurologic, or major infection). RESULTS: Overall, patients admitted to the ICU with BCT < 36 degrees C had a significantly greater mortality (p = 0.02), prolonged mechanical ventilation (p = 0.007), packed red blood cell transfusion (p = 0.001), ICU (p = 0.01), and hospital (p = 0.005) length of stay. CONCLUSIONS: BCT of less than 36 degrees C, upon ICU admission, has a significant association with adverse outcome after CABG with CPB. M An __ Tl QA_7_t-0


Asunto(s)
Puente de Arteria Coronaria/efectos adversos , Hipotermia/complicaciones , Hipotermia/etiología , Anciano , Femenino , Humanos , Unidades de Cuidados Intensivos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Admisión del Paciente , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Resultado del Tratamiento
6.
Ann Thorac Surg ; 69(5): 1420-4, 2000 May.
Artículo en Inglés | MEDLINE | ID: mdl-10881816

RESUMEN

BACKGROUND: Corticosteroids have been recommended to facilitate rapid recovery after cardiac surgery. We previously reported that dexamethasone given after induction of anesthesia decreases the incidence of postoperative shivering. We performed a post hoc analysis of the data obtained during that study, focusing on secondary outcomes. METHODS: A total of 235 adult patients undergoing elective coronary or valvular heart surgery were randomized to receive dexamethasone 0.6 mg/kg or placebo after induction of anesthesia. Patients who had pharmacologically treated diabetes mellitus, had hypersensitivity to dexamethasone, or were receiving treatment with corticosteroids were excluded. RESULTS: We found that, compared with placebo, patients receiving dexamethasone were more likely to remain tracheally intubated for 6 hours or less (26.4% vs 10.0%, p = 0.020) and had a lower incidence of early postoperative fever (20.2% vs 36.8%, p = 0.009) and new-onset atrial fibrillation during the first 3 days postoperatively (18.9% vs 32.3%, p = 0.027). However, we could not demonstrate a statistical difference in the intensive care unit or hospital length of stay, or in overall morbidity and mortality. The dexamethasone-treated patients were also more likely to have a higher blood glucose on admission to the intensive care unit (186 mg/dL vs 143 mg/dL, p = 0.012). CONCLUSIONS: Dexamethasone facilitates early tracheal extubation and is associated with a lower incidence of early postoperative fever and new-onset atrial fibrillation. Apart from a treatable decreased glucose tolerance, dexamethasone treatment was not shown to affect morbidity or mortality significantly.


Asunto(s)
Antiinflamatorios/administración & dosificación , Procedimientos Quirúrgicos Cardíacos , Dexametasona/administración & dosificación , Anestesia , Fibrilación Atrial/prevención & control , Glucemia/análisis , Procedimientos Quirúrgicos Electivos , Femenino , Humanos , Unidades de Cuidados Intensivos , Intubación Intratraqueal , Tiempo de Internación , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/prevención & control , Resultado del Tratamiento
7.
Ann Thorac Surg ; 64(4): 1050-8, 1997 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-9354526

RESUMEN

BACKGROUND: This study was performed to develop an intensive care unit (ICU) admission risk score based on preoperative condition and intraoperative events. This score provides a tool with which to judge the effects of ICU quality of care on outcome. METHODS: Data were collected prospectively on 4,918 patients (study group n = 2,793 and a validation data set n = 2,125) undergoing coronary artery bypass grafting alone or combined with a valve or carotid procedure between January 1, 1993, and March 31, 1995. Data were analyzed by univariate and multiple logistic regression with the end points of hospital mortality and serious ICU morbidity (stroke, low cardiac output, myocardial infarction, prolonged ventilation, serious infection, renal failure, or death). RESULTS: Eight risk factors predicted hospital mortality at ICU admission, and these factors and five others predicted morbidity. A clinical score, weighted equally for morbidity and mortality, was developed. All models fit according to the Hosmer-Lemeshow goodness-of-fit test. This score applies equally well to patients undergoing isolated coronary artery bypass grafting. CONCLUSIONS: This model is complementary to our previously reported preoperative model, allowing the process of ICU care to be measured independent of the operative care. Sequential scoring also allows updated prognoses at different points in the continuum of care.


Asunto(s)
Puente de Arteria Coronaria/mortalidad , Unidades de Cuidados Coronarios , Complicaciones Posoperatorias/epidemiología , Femenino , Mortalidad Hospitalaria , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Medición de Riesgo , Factores de Riesgo , Índice de Severidad de la Enfermedad
8.
Ann Thorac Surg ; 64(2): 368-73; discussion 373-4, 1997 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-9262577

RESUMEN

BACKGROUND: Intraoperative echocardiography is a valuable monitoring and diagnostic technology used in cardiac surgery. This reports our clinical study of the usefulness of intraoperative echocardiography to both surgeons and anesthesiologists for high-risk coronary artery bypass grafting. METHODS: From March to November 1995, 82 consecutive high-risk patients undergoing coronary artery bypass grafting were studied in a four-stage protocol to determine the efficacy of intraoperative echocardiography in management planning. Alterations in surgical and anesthetic/hemodynamic management initiated by intraoperative echocardiography findings were documented in addition to perioperative morbidity and mortality. RESULTS: Intraoperative echocardiography initiated at least one major surgical management alteration in 27 patients (33%) and at least one major anesthetic/hemodynamic change in 42 (51%). Mortality and the rate of myocardial infarction in this consecutive high-risk study population using intraoperative echocardiography and in a similar group of patients without the use of intraoperative echocardiography was 1.2% versus 3.8% (not significant) and 1.2% versus 3.5% (not significant), respectively. CONCLUSIONS: We conclude that when all of the isolated diagnostic and monitoring applications of perioperative echocardiography are routinely and systematically performed together, it is a safe and viable tool that significantly affects the decision-making process in the intraoperative care of high-risk patients undergoing primary isolated coronary artery bypass grafting and may contribute to the optimal care of these patients.


Asunto(s)
Puente de Arteria Coronaria , Ecocardiografía , Anciano , Puente Cardiopulmonar , Puente de Arteria Coronaria/efectos adversos , Enfermedad Coronaria/complicaciones , Enfermedad Coronaria/cirugía , Humanos , Complicaciones Intraoperatorias/diagnóstico por imagen , Periodo Intraoperatorio , Persona de Mediana Edad , Infarto del Miocardio/diagnóstico por imagen , Infarto del Miocardio/etiología , Factores de Riesgo
9.
Ann Thorac Surg ; 65(2): 383-9, 1998 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-9485233

RESUMEN

BACKGROUND: The collective impact of advances in medical, surgical, and anesthetic care on the characteristics and outcomes of patients who undergo coronary artery bypass grafting was assessed. METHODS: We compared the demographic and clinical characteristics, preoperative risk factors, morbidity, and mortality of two groups of patients who underwent coronary artery bypass grafting in isolation or in combination with other procedures between July 1, 1986, and June 30,1988 (group 1, n = 5,051), and between January 1, 1993, and March 31, 1994 (group 2, n = 2,793). The patients were stratified according to their preoperative risk level. Outcome measures consisted of changes in preoperative risk categories; hospital mortality rates; overall and risk-adjusted major cardiac, neurologic, pulmonary, renal, and septic morbidity rates; and intensive care unit length of stay. RESULTS: Changes in the distribution of risk categories, from a median of 2 to 4 on a 9-point scale (p < 0.001), indicated that patients in group 2 were at significantly higher risk than those in group 1. The risk-adjusted mortality rate did not change (2.8% to 2.9%; p = 0.15), but the risk-adjusted morbidity rate decreased significantly (14.5% to 8.8%; p < 0.001). CONCLUSIONS: At our institution, patients who undergo coronary artery bypass grafting are now at greater preoperative risk at the time of hospital admission. However, their morbidity rate is significantly lower and their mortality rate is unchanged, results that we attribute to the collective impact of changes in our medical and surgical procedures.


Asunto(s)
Puente de Arteria Coronaria/efectos adversos , Anciano , Puente de Arteria Coronaria/mortalidad , Tratamiento de Urgencia , Mortalidad Hospitalaria , Humanos , Unidades de Cuidados Intensivos , Tiempo de Internación , Reoperación , Estudios Retrospectivos , Factores de Riesgo
10.
Semin Thorac Cardiovasc Surg ; 3(1): 88-94, 1991 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-2015323

RESUMEN

Comparisons between institutions are already occurring, and comparisons between individual providers may also become a reality. In spite of the negative views of such comparisons, they are likely to be mandated because of pressure from health care regulators, insurers, and patients. Despite awareness of the importance of demographic variables and concurrent medical problems in influencing outcome, valid comparisons are presently difficult to conduct in the open heart surgical population. Current methods of risk stratification each have limitations. A method for risk assessment based on multivariate analysis from a large group of patients that can be prospectively validated at multiple institutions would be valuable, not only for mortality rate comparisons, but also for patient counseling, research, and hospital management uses. Caution must be applied when using risk assessment in individual patients. Physicians need to be involved in the development of such severity stratifying systems, since inclusion of inappropriate or medically irrelevant data can influence the outcome of multivariate analyses. Ongoing research and evolution of scoring systems also need to occur since therapy changes over time. It is likely that models will need to be developed for application preoperatively, at ICU admission, and for the complex, long-term patient at 7 days or beyond, in order to fully inform medical decision-making.


Asunto(s)
Procedimientos Quirúrgicos Cardíacos/mortalidad , Evaluación de Procesos y Resultados en Atención de Salud , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Unidades de Cuidados Intensivos , Masculino , Análisis Multivariante , Oportunidad Relativa , Factores de Riesgo
11.
Vet Microbiol ; 66(2): 125-34, 1999 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-10227474

RESUMEN

Haemolysin is one type of virulence factor that assists in the pathogenesis of Escherichia coli. Currently, hemolytic activity in E. coli has been attributed to haemolysin genes found in either uropathogenic or enterohemorrhagic E. coli. Both haemolysins are classified as RTX toxins because they both have repeats in toxin domains and share similar operon organization, sequence homology, and mechanisms of action. Haemolytic avian E. coli isolates, however, lack either E. coli haemolysin gene. To investigate the avian E. coli haemolysin, a genomic library was made from an avian pathogenic E. coli. A haemolytic clone that was isolated was shown to contain homology with sheA, an E. coli K- 12 gene which causes haemolysis when present in high copy number. The cloned haemolysin gene, hlyE, lacked the conserved amino acid sequence and accessory genes common to all RTX toxins. DNA hybridizations and polymerase chain reaction amplifications showed that the nucleotide sequences homologous to hlyE were not present in a collection of three O157: H7 E. coli, five haemolytic canine uropathogenic E. coli, one haemolytic O26 E. coli, and three haemolytic avian pathogenic E. coli. Thus we have identified a new E. coli haemolysin distinct from the RTX haemolysins and have shown that some avian pathogenic E. coli possess a haemolysin with no apparent homology to hlyE or RTX haemolysins.


Asunto(s)
Infecciones por Escherichia coli/microbiología , Infecciones por Escherichia coli/veterinaria , Escherichia coli/genética , Proteínas Hemolisinas/genética , Enfermedades de las Aves de Corral/microbiología , Secuencia de Aminoácidos , Animales , Proteínas Bacterianas , Secuencia de Bases , Pollos , Clonación Molecular , Cartilla de ADN , Enfermedades de los Perros/microbiología , Perros , Escherichia coli/aislamiento & purificación , Proteínas Hemolisinas/química , Proteínas Hemolisinas/aislamiento & purificación , Humanos , Datos de Secuencia Molecular , Reacción en Cadena de la Polimerasa , Alineación de Secuencia , Homología de Secuencia de Aminoácido , Homología de Secuencia de Ácido Nucleico , Porcinos , Enfermedades de los Porcinos/microbiología
12.
JPEN J Parenter Enteral Nutr ; 21(2): 81-90, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9084010

RESUMEN

OBJECTIVE: To define the clinical characteristics and outcome of preoperative hypoalbuminemia in adult cardiovascular surgery. STUDY: Inception cohort. SETTING: Adult cardiovascular intensive care unit (CVICU). PATIENTS: Admissions to CVICU between January 1 and December 31, 1993. INTERVENTION: Preoperative hypoalbuminemia (serum albumin < or = 3.5 g/dL) was classified by the presence of malnutrition cachexia (body mass index of < or = 20 kg/m2), liver insufficiency (serum bilirubin > or = 2.0 mg/dL), history of congestive heart failure, or hypoalbuminemia alone. Demographics, chronic diseases, systemic hemodynamics, and laboratory data were obtained at preoperative and later on admission and during the stay in the CVICU. OUTCOME MEASURES: Postoperative organ dysfunction, nosocomial infections, length of mechanical ventilation, hospitalization and death. RESULTS: A total of 2,743 patients (91%) of 3,025 patients who were admitted to the CVICU were enrolled in the study. Preoperative hypoalbuminemia was found in 325 patients (12%): hypoalbuminemia and cachexia in 21 patients (6%), hypoalbuminemia and liver insufficiency in 26 patients (8%), hypoalbuminemia and history of congestive heart failure in 102 patients (31%), and hypoalbuminemia alone in 176 patients (54%). Clinical features of preoperative hypoalbuminemia were age > or = 75 years, female gender, left ventricular ejection fraction < or = 35%, hematocrit < or = 34%, serum creatinine > or = 1.9 mg/dL, systemic oxygen delivery < or = 350 mL/min.m2, acute stressful conditions (eg, infective endocarditis, acute myocardial infarction, or emergency surgery) and chronic obstructive pulmonary airway disease. Redo operations, combined valve and coronary artery bypass graft, mitral valve replacement, and thoracic aortic surgery were the commonest types of surgery performed in these patients. All types of hypoalbuminemia except for malnutrition cachexia increased the likelihood of postoperative organ dysfunction (cardiac, pulmonary, renal, hepatic, and neurologic), gastrointestinal bleeding, nosocomial infections, length of mechanical ventilation, stay in the CVICU, and hospital death. Cachectic hypoalbuminemia increased the requirement for postoperative parenteral nutrition and prolonged the length of stay in hospital. CONCLUSION: Preoperative hypoalbuminemia was attributed to malnutrition cachexia, liver insufficiency or congestive heart failure in < 50% of cardiac patients undergoing cardiovascular surgery. All types of hypoalbuminemia except for malnutrition cachexia increased the likelihood of postoperative organ dysfunction, nosocomial infections, prolonged mechanical ventilation, and death. The morbidity and mortality attributed to hypoalbuminemia could be explained by the underlying clinical characteristics rather than malnutrition cachexia in cardiac patients.


Asunto(s)
Enfermedades Cardiovasculares/cirugía , Cuidados Preoperatorios/normas , Albúmina Sérica/análisis , Anciano , Anciano de 80 o más Años , Bilirrubina/sangre , Enfermedades Cardiovasculares/sangre , Enfermedades Cardiovasculares/complicaciones , Estudios de Cohortes , Femenino , Insuficiencia Cardíaca/sangre , Insuficiencia Cardíaca/complicaciones , Humanos , Incidencia , Fallo Hepático/sangre , Fallo Hepático/complicaciones , Masculino , Persona de Mediana Edad , Trastornos Nutricionales/sangre , Trastornos Nutricionales/complicaciones , Nutrición Parenteral/normas , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Valor Predictivo de las Pruebas , Factores de Riesgo , Albúmina Sérica/metabolismo , Resultado del Tratamiento
13.
Pediatr Neurol ; 29(1): 34-41, 2003 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-13679119

RESUMEN

Studies of children with stroke indicate remarkable recovery of language after some initial delay. However, complex language abilities as measured by discourse (connected language) may be required to detect the full impact of stroke on subsequent cognitive-linguistic development. This study examined discourse ability in children with stroke as compared with orthopedic controls, age-at-injury, and lesion effects. Discourse between two groups of children was compared [stroke (n = 17) vs orthopedic control (n = 17)]. The stroke group was subdivided into early age at stroke (<1 year) and late age at stroke (>1 year). The discourse samples were analyzed along two dimensions: language and information structure. Results revealed that the stroke group performed at significantly lower levels than the orthopedic control group across discourse measures. The most important finding was a poorer outcome for early age at stroke as compared with later age at stroke. These findings alter the widespread belief of optimistic language outcomes after childhood stroke. Interestingly, no site or size-of-lesion effects, common to adult stroke, were identified. These findings identify poor long-term outcome with early brain insults at stages far removed from the onset of injury. The implication is that childhood stroke management should be revised to provide protracted follow-up and treatment.


Asunto(s)
Encéfalo/patología , Trastornos del Desarrollo del Lenguaje/patología , Plasticidad Neuronal , Pruebas Neuropsicológicas/estadística & datos numéricos , Accidente Cerebrovascular/patología , Adolescente , Adulto , Factores de Edad , Niño , Humanos , Trastornos del Desarrollo del Lenguaje/etiología , Modelos Lineales , Plasticidad Neuronal/fisiología , Estadísticas no Paramétricas , Accidente Cerebrovascular/complicaciones
14.
Health Educ Behav ; 25(1): 79-98, 1998 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-9474501

RESUMEN

The Fresno Asthma Project targeted the entire low-income, inner-city, multiethnic population of Fresno, California. For 36 months following a 6-month planning phase, continuing education was provided to a high proportion of physicians, pharmacists, nurses/respiratory therapists, emergency medical technicians, school personnel, and allied health professionals involved in asthma care in Fresno, including virtually all those providing care/services to the target population. Small group patient education was made available and provided in age- and culturally appropriate formats to patients/families in clinics, hospitals, and schools. General and ethnic media and a Speakers Bureau were used to raise public awareness of asthma as a serious but controllable health problem. This community intervention model is particularly appropriate to multiethnic communities. It is relatively low cost (total direct costs were $140,000 per year), uses existing educational resources, and appears to have minimized counterproductive competition. Although morbidity and mortality trend data are not yet available to monitor program impact, penetration into the target community has been substantial: community physicians refer patients to asthma classes, asthma educator training is ongoing through the local American Lung Association chapter, hospitals and managed care systems serving low- income/MediCal patients offer asthma classes, and public schools and HeadStart are institutionalizing asthma awareness and self-management classes.


Asunto(s)
Asma/prevención & control , Educación en Salud/organización & administración , Servicios Urbanos de Salud/organización & administración , Adulto , Asma/epidemiología , California , Niño , Participación de la Comunidad , Educación Continua , Humanos , Modelos Organizacionales , Educación del Paciente como Asunto , Pobreza , Estados Unidos/epidemiología
15.
J Cardiovasc Surg (Torino) ; 26(1): 53-8, 1985.
Artículo en Inglés | MEDLINE | ID: mdl-3968161

RESUMEN

Changes in cardiac performance during coronary revascularization surgery were followed in 22 selected patients with normal or mildly impaired left ventricles; vasoactive or inotropic drugs were generally avoided. Arterial pressure, filling pressures, and cardiac output were measured; stroke volume and work were calculated before induction of anesthesia, following sternotomy, soon after discontinuation of extracorporeal circulation, and one hour postoperatively. Induction and sternotomy were associated with a depressant effect on cardiac performance. After extracorporeal circulation, however, cardiac performance recovered, cardiac output increased to 7 +/- 0.5 l/min from a preoperative control of 4.9 +/- 0.3 L/min (p less than 0.002) without an elevation of atrial pressures. This increase in cardiac output after bypass resulted from decreased afterload and increased preload secondary to hemodilution. Cardiac performance approached control values early in the postoperative period.


Asunto(s)
Gasto Cardíaco , Puente Cardiopulmonar , Adulto , Anciano , Presión Sanguínea , Viscosidad Sanguínea , Ventrículos Cardíacos/fisiopatología , Hematócrito , Humanos , Hipotermia Inducida , Masculino , Persona de Mediana Edad , Nitroprusiato/uso terapéutico , Resistencia Vascular
16.
Int J Periodontics Restorative Dent ; 21(1): 61-7, 2001 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-11829037

RESUMEN

A restorative design is introduced in preference to the implant-supported bar, clip, or ball-type removable prosthesis. It has been necessary to develop an alternative treatment approach to the placement and restoration of implants in the posterior mandible or maxilla. In an examination of the available therapeutic choices and their rationales, this treatment option offers greater function, esthetics, and comfort. Four maxillary and one mandibular arches were reconstructed with anterior implant-supported fixed bridges/splinted restorations and a precision partial denture design posteriorly, using an extracoronal universal ball attachment. These cases have demonstrated minimal maintenance up to 7 years in function.


Asunto(s)
Implantes Dentales , Prótesis Dental de Soporte Implantado , Diseño de Dentadura , Dentadura Parcial Fija , Adulto , Pilares Dentales , Ajuste de Precisión de Prótesis , Retención de Dentadura , Dentadura Parcial Removible , Femenino , Estudios de Seguimiento , Humanos , Arcada Parcialmente Edéntula/rehabilitación , Arcada Parcialmente Edéntula/cirugía , Mandíbula/cirugía , Maxilar/cirugía , Periodontitis/rehabilitación , Periodontitis/terapia
17.
J Health Law ; 32(1): 115-37, 1999.
Artículo en Inglés | MEDLINE | ID: mdl-10569845

RESUMEN

As more Blue Cross/Blue Shield Organizations employ various means to convert to for-profit status, myriad issues arise concerning the proper treatment of assets that were accumulated during the not-for-profit years of such organizations. Moreover, state officials face pressure from all sides to assure that the conversion process is "fair." In the following Article, the author examines the conversion of Blue Cross and Blue Shield of Georgia to demonstrate the various conversion issues that arise under traditional legal principles--as well as the means by which that Blue employed newly enacted legislation to avoid many of the requirements that otherwise would have attended its conversion.


Asunto(s)
Planes de Seguros y Protección Cruz Azul/legislación & jurisprudencia , Organizaciones sin Fines de Lucro/legislación & jurisprudencia , Planes de Seguros y Protección Cruz Azul/economía , Planes de Seguros y Protección Cruz Azul/organización & administración , Organizaciones de Beneficencia/legislación & jurisprudencia , Participación de la Comunidad , Georgia , Consejo Directivo , Propiedad/legislación & jurisprudencia , Planes Estatales de Salud/legislación & jurisprudencia , Exención de Impuesto/legislación & jurisprudencia , Estados Unidos
18.
Compend Contin Educ Dent ; 22(1): 13-6, 18, 20 passim; quiz 24, 2001 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-11911055

RESUMEN

A diagnostic and therapeutic approach is offered to enable the surgeon and restorative dentist to successfully install endosseous implants into the vertically enhanced ridge. The strategy involves the use of diagnostic and surgical templates to aid in the creation of positive osseous architecture followed by the vertical orientation of the endosseous implant(s). This effort provides optimal hard-tissue and soft-tissue form for the creation of the most favorable crown profiles for implant-supported prostheses.


Asunto(s)
Aumento de la Cresta Alveolar , Implantación Dental Endoósea/métodos , Pérdida de Hueso Alveolar/diagnóstico , Pérdida de Hueso Alveolar/cirugía , Aumento de la Cresta Alveolar/clasificación , Aumento de la Cresta Alveolar/instrumentación , Humanos , Modelos Anatómicos , Modelos Dentales , Planificación de Atención al Paciente , Grupo de Atención al Paciente
19.
Alpha Omegan ; 85(4): 29-32, 40, 1992.
Artículo en Inglés | MEDLINE | ID: mdl-1308339

RESUMEN

Periodontal prosthesis can be defined as "those restorative and prosthetic endeavors that are absolutely essential in the treatment of advanced periodontal disease". The sequence of therapy is planned so that the basic contributing factors of inflammation and trauma from occlusion are brought under control. Experimental and clinical research over the last decade has shifted the focus of periodontics towards increased use of guided tissue membrane techniques. Today, as a result of the longitudinal studies on the viability of endosseous implantology, implants used as an integral part of Periodontal Prosthesis now offer the patient and dentist a more stable and predictable restoration. These articles focus on the comprehensive treatment of the partially edentulous situation. The first two parts address diagnosis, treatment planning and treatment sequencing in the overall management of the compromised dentition.


Asunto(s)
Implantación Dental Endoósea , Enfermedades Periodontales/diagnóstico , Prótesis Periodontal , Proceso Alveolar/patología , Pilares Dentales , Análisis del Estrés Dental , Humanos , Planificación de Atención al Paciente , Enfermedades Periodontales/terapia
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