[The blood rheological properties in patients with amputation stumps and concomitant ischemic heart disease]. / Reologicheskie svoistva krovi u bol'nykh s kul'tiami konechnostei i soputstvuiushchei ishemicheskoi bolezn'iu serdtsa.

Blood rheology was compared in two groups of patients with ischemic heart disease (IHD). In group 1 patients low limbs were amputated. It is in them that rheological properties of blood were changed to the most extent. This is attributed to the effect of plasmic factors in the form of hypertriglyceridemia and hyperfibrinogenemia, sharp reduction of the total cross sectional vascular area (especially in high amputation) leading to blood cell damage associated with intensive platelet aggregation and red cell microhemolysis. Reduced muscular mass and resultant reduced capillary bed and deficiency of endothelial surface may stimulate accumulation of triglyceride-enriched very low density lipoproteins.

[Characteristics of disturbances in the hemostasis system in patients with insulin-dependent diabetes mellitus with angiopathies of the vessels of the lower extremities]. / Osobennosti narushenii v sisteme gemostaza u bol'nykh insulinnezavisimym tipom sakharnogo diabeta s angiopatiiami sosudov nizhnikh konechnostei.

Indices of the system of hemostasis, the levels of glycolysated hemoglobin were studied in 67 patients suffering from non-insulin-dependent diabetes mellitus with lower limb angiopathies (aged 40 to 60). Rheovasography of the lower limbs was performed. The patients were treated with antidiabetic drugs per os (with the exception of hydroxydione sodium succinate), platelet aggregation inhibitors (pentoxifylline, acetylsalicylic acid) and vasodilators (xanthinol nicotinate, solcoseryl and cinnarizine). The use of pentoxifylline after therapy increased the rate of platelet aggregation inhibition and decreased the prothrombin index, not influencing the other indices of the system of hemostasis. Pentoxifylline combined with acetylsalicylic acid at small doses normalized not only platelet indices but also the other indices of the system of hemostasis. Positive changes in the system of hemostasis were accompanied by a rise of the rheographic index in patients with vascular functional changes. In obliterating atherosclerosis the rheographic index was not on an increase indicating the necessity of corrective therapy of vascular lesions, first of all in the system of hemostasis, in the early period of diabetes mellitus.