1.
Bioorg Med Chem Lett
; 22(21): 6580-2, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23017884
RESUMEN
A new construct for imitating a natural peptide ligand using a modified retro-inverso sequence is described. It is demonstrated through the synthesis of a peptidomimetic derived from the endogenous sequence of leucine enkephalin. The product was active at 400 nM and selective for µ-opioid receptors.