[Influence of the characteristics of lipids on the regulation of biochemical processes in animal liver and blood].

It has been established experimentally that the character and the scale of interrelations between various parameters of the phospholipid composition and their group-average values depend significantly on the characteristics of lipids (the antioxidative activity, quantity of peroxides, and antiperoxide activity) of animal liver and blood erythrocytes. It was shown that a single injection of low-toxicity Tween 80 and acetone at low doses modifies the intensity of lipid peroxidation in the liver and changes the physicochemical properties of lipids, and the interrelations between the parameters that are coordinated in norm, thereby causing the disturbance of biochemical functions of the liver.

[Analysis of parameters of the lipid peroxidation regulatory system in mouse organs at a later time after acute irradiation]. / Analiz parametrov sistemy reguliatsii perikisnoga okisleniia lipidov v organakh myshei v otdalennye sroki posle ostrogo oblucheniia.

The antioxidant activity (AOA) and lipid fraction composition in organs from CBA and SHK mice were determined a month after acute irradiation with doses 4.5 and 5.0 Gy, correspondingly. More high radiosensitivity of these parameters in CBA mice in comparison with SHK mice was found. The decrease in antioxidant status of liver was shown. Pro-oxidant activity of spleen lipids was found. The direct correlation (r = 0.99 +/- 0.01) between survival and AOA of lipids for SHK mice was found. The changes in lipid fraction composition, more pronounced in spleen, were revealed. Thus, prolonged disturbance of lipid peroxidation regulatory system in two murine strains was established.

[Effect of a constant magnetic field on the respiration of human skin during reparative and destructive processes]. / Vliianie postoiannogo magnitnogo polia na dykhanie kozhi cheloveka pri reparativnykh i destruktivnykh protsessakh.

Effect of magnetophore applicators constant magnetic field (MACMF) on the functional state of human skin at reparative and destructive processes. It has been found in the investigations carried out during epidermatoplasty under the magnetic field effect on the reparation zone for 10--12 days that MACMF effect is of antihypoxic character and is manifested locally and only on a regenerating tissue. In the experiments on skin grafts exposed to magnetic field for 22--26 hours there was also found antihypoxic direction of MACMF effect expressed in the stabilization of tissue respiration, which points to the weakening of destruction.

[Effect of 6-methyluracil on various indicators of the lipid peroxidation regulation system in the body]. / Vliianie 6-metiluratsila na nekotorye pokazateli sistemy reguliatsii perekisnogo okisleniia lipidov v organizme.

Single intraperitoneal administration of 6-methyluracil in a dose of 50 mg/kg was shown to affect some patterns of the physico-chemical system regulating lipid peroxidation in mice liver tissue and erythrocytes: antioxidative activity of lipids (AOA), composition of phospholipids; the drug altered also activities of superoxide dismutase and catalase in liver tissue and blood serum of rats. These alterations observed had phase expressed dynamics and their rate was dissimilar in various tissues and depended on the interval after drug administration. 6-Methyluracil exhibited the highest effect on the rate of AOA in liver tissue and on phospholipid composition in erythrocytes. The biological activity of the drug appears related to its effects on the system regulating lipid peroxidation.

[The effect of 6-methyluracil on oxidative reactions in model systems of varying degrees of complexity]. / Vliianie 6-metiluratsila na okislitel'nye reaktsii v model'nykh sistemakh razlichnoi stepeni slozhnosti.

Effect of 6-methyluracyl (MU) on oxidative processes was studied on model systems of different degrees of complexity (methyloleate model, mitochondria isolated from rat liver, surviving slices of mammalian muscle tissues). On two former models it was shown that MU exerted antioxidant (AO) properties inferior to those of such antioxidants as ionol and K(+)-phenosan. The AO efficiency depended on the intensity of peroxide processes. The AO activity of MU was most fully realized on the model of isolated surviving slices of muscle tissue. The totality of data obtained suggests that participation of the substance in regulation of lipid peroxidation in the organism underlies its therapeutic activity in pathological states.

[Effect of 6-methyluracil on regulatory parameters of lipid peroxidation in thermal burn]. / Vliianie 6-metiluratsila na parametry sistemy reguliatsii peroksidnogo okisleniia lipidov pri termicheskom ozhoge.

The effects of 6-methyluracil given in single intraperitoneal doses of 50 and 2.7 mg/kg on the healing of burn wounds and some physicochemical parameters of lipid peroxidation regulation were studied in the liver and erythrocytes of noninbred albino rats with thermal burns. 6-Methyluracil was shown to alter the time course of a wound process and to accelerate the healing of burn wounds. The drug doses under study were found to exert a great effect on the level of lipid antioxidative activity and the composition of phospholipids of the liver and erythrocytes, which remained for a long time after burn. The findings suggest the hypothesis that the capacity of 6-methyluracil to be involved in the regulation of lipid peroxidation processes underlies its therapeutic effect.

[The antiradiation action of 6-methyluracil]. / Issledovanie protivoluchevogo deistviia 6-metiluratsila.

A single dose of 6-methyluracil (50 mg/kg) administered intraperitoneally to BALB and SHK mice prior to X irradiation (5.0 Gy) produced a pronounced radioprotective effect which was dependent upon the initial antioxidant status of the body, but independent of the effect of the agent on postirradiation leukopenia dynamics. The radioprotective effect of 6-methyluracil was conditioned by its influence on lipid peroxidation regulation and was displayed by the normalization of the antioxidant activity of lipids of radiosensitive organs and tissues and by high activity of superoxide dismutase in the liver and erythrocytes.

[Changes in the lipid peroxidation activity and intensity of tissue respiration during healing of aseptic and infected wounds in animal experiments]. / Dinamika izmenenii aktivnosti perekisnogo okisleniia lipidov i intensivnosti tkanevogo dykhaniia pri zazhivlenii asepticheskikh i infitsirovannykh ran v éksperimente.

The variance of lipid peroxidation (LPO) was studied by the concentrations of malonic dialdehyde (MDA) in the tissue of wound bed and blood serum on the model of surface musculocutaneous aseptic and infected wounds simulated in 250 rats. The speed of oxygen consumption by isolated wound tissue was determined simultaneously. It was stated that the time course of MDA concentration in wounds and sera as well as tissue respiration in animals with infected wounds differed from those in animals with aseptic wounds. In a whole, MDA levels were found to be higher in cases with infected wounds and of changeable character. The latter animals demonstrated less intensive respiration of granulation tissue. Correlation between the variance of tissue respiration and MDA levels was established as was that of LPO and respiration with the phases of wound process. The findings could be used for the development of pathogenetic therapy and evaluation of its efficacy.