RESUMEN
AIM: The aim of our study was to compare serum levels of RBP4 in women with PCOS to the control group and to understand the relationship among RBP4 and biochemical and hormonal parameters related to disease process, especially gonadal steroids and markers of inflammation. METHODS: Twenty-eight women with PCOS (18 normal weight and 10 obese) and 27 normally menstruating healthy women (20 normal weight and 7 obese) were included. RESULTS: Women with PCOS had higher RBP4 concentrations. RBP4 levels correlated negatively with LDL, hsCRP and LH in women with PCOS and positively with BMI in the control group. When obese PCOS were compared to normal weight PCOS, increased CRP levels correlated negatively with RBP4 only in the normal weight PCOS group (normal PCOS r=-0.465, P=0.042; obese PCOS r=-0.505, P=0.137). Regression analysis of the effects of CRP and BMI on RBP4 levels revealed a statistically significant relationship between CRP and RBP4 independent of BMI. CONCLUSION: Serum RBP4 levels increased in women with PCOS and correlated negatively with CRP, LH and LDL. RBP4 probably acts as a negative acute phase reactant in normal weight PCOS. It cannot be used as a marker of chronic low grade inflammation in women with PCOS.
Asunto(s)
Proteínas de Fase Aguda/análisis , Inflamación/sangre , Síndrome del Ovario Poliquístico/sangre , Proteínas Plasmáticas de Unión al Retinol/análisis , Antropometría , Biomarcadores , Glucemia/análisis , Índice de Masa Corporal , Proteína C-Reactiva/análisis , Femenino , Hormonas/sangre , Humanos , Inflamación/complicaciones , Resistencia a la Insulina , Lípidos/sangre , Lipoproteínas/sangre , Hormona Luteinizante/sangre , Obesidad/sangre , Obesidad/complicaciones , Síndrome del Ovario Poliquístico/complicaciones , Estudios RetrospectivosRESUMEN
AIMS: Our aim was to understand the relationship between endogenous sex hormones and cardiovascular disease (CVD) risk factors in post-menopausal women. MATERIALS AND METHODS: Eighty-three post-menopausal women from a previous prospectively designed study were included. We analyzed endogenous sex hormones and biochemical parameters. RESULTS: Levels of estradiol and free testosterone were higher in patients with metabolic syndrome. Estradiol correlated positively with interleukin-6 (IL-6), weight, body mass index (BMI), insulin, homocysteine, and homeostasis model assessment of insulin resistance (HOMA-IR). Free testosterone correlated positively with weight, waist circumference (WC), BMI, insulin, HOMA-IR and negatively with HDL and SHBG. DHEAS correlated only with HDL. FSH correlated negatively with age, weight, WC, hip circumference, BMI, systolic blood pressure, diastolic blood pressure, duration of menopause, fasting glucose, HDL, C-reactive protein, and insulin. LH correlated negatively with IL-6, age, WC, duration of menopause and SHBG. CONCLUSIONS: We identified endogenous estradiol and free testosterone as the strongest links to CVD risk. They can be used as biomarkers for CVD risk estimation.
Asunto(s)
Enfermedades Cardiovasculares/etiología , Estradiol/sangre , Hormonas Esteroides Gonadales/sangre , Interleucina-6/sangre , Posmenopausia/sangre , Testosterona/sangre , Anciano , Índice de Masa Corporal , Peso Corporal , Estudios Transversales , Femenino , Homeostasis , Humanos , Insulina/sangre , Resistencia a la Insulina/fisiología , Síndrome Metabólico/sangre , Persona de Mediana Edad , Modelos Biológicos , Estudios Retrospectivos , Factores de Riesgo , Globulina de Unión a Hormona Sexual/metabolismo , Circunferencia de la CinturaRESUMEN
OBJECTIVE: The aim of this study was to investigate the incidence of low back pain in the postmenopausal period and the relationship between low back pain and emotional state, sleep and quality of life. METHODS: This cross-sectional study was conducted with 368 postmenopausal women between 40 and 65 years old. The frequency and severity of low back pain were recorded for all participants, as well as depressive symptoms and anxiety, quality of life and sleep quality. RESULTS: 90.2% of the participants reported low back pain. As low back pain severity increased, it was found that depression, anxiety levels, NHP and PSQI total scores increased as well (p= 0.0001). Significant positive correlations were found between pain intensity and outcome measures, except for sleep duration and habitual sleep efficiency (p< 0.01). CONCLUSION: A great majority of women experience postmenopausal low back pain, which causes significant problems that negatively affect their quality of life, emotional state and sleep quality.
Asunto(s)
Emociones/fisiología , Dolor de la Región Lumbar/psicología , Posmenopausia/psicología , Calidad de Vida/psicología , Sueño/fisiología , Adulto , Anciano , Ansiedad/psicología , Estudios Transversales , Depresión/psicología , Femenino , Humanos , Dolor de la Región Lumbar/diagnóstico , Dolor de la Región Lumbar/fisiopatología , Persona de Mediana Edad , Índice de Severidad de la EnfermedadRESUMEN
To determine regional percentile values and compare them with currently used national and international curves, we determined the birth weight, height and head and chest circumference of 3688 term neonates born in a state hospital in the Anatolian part of Istanbul, Turkey. Mean birth weight, height and head and chest circumference were 3334 (SD 494) g, 48.3 (SD 2.2) cm, 34.4 (SD 1.3) cm and 32.8 (1.9) cm respectively. For both boys and girls, the current Turkish national percentile curves overestimate the birth weight, height and head circumference at the 10th percentile. For boys, the national curves and those from the USA underestimate birth weight of neonates above the 90th percentile.
Asunto(s)
Antropometría/métodos , Peso al Nacer , Estatura , Cefalometría/métodos , Tórax/anatomía & histología , Sesgo , Estudios Transversales , Femenino , Hospitales Provinciales , Humanos , Recién Nacido , Masculino , Valores de Referencia , Caracteres Sexuales , Factores Socioeconómicos , Turquía , Población UrbanaRESUMEN
Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced tissue responsiveness to thyroid hormones. The main defects are due to mutations in thyroid hormone receptor beta (TRbeta). A male, term neonate was admitted because of indirect hyperbilirubinemia and polycythemia. Physical examination revealed ophtalmopathy. High serum T4 with unsupressed thyroid stimulating hormone (TSH) levels suggested RTH. In this presented case, A317T mutation was detected on exon 9 of the TRb-1 gene and precise diagnosis had been confirmed with genetic testing. In neonates and infants exhibiting hypo or hyperthyroidism features with increased circulating levels of thyroid hormones with a normal or increased serum TSH concentration should raise the suspicion of RTH.
Asunto(s)
Mutación , Receptores beta de Hormona Tiroidea/genética , Síndrome de Resistencia a Hormonas Tiroideas/genética , Exones/genética , Oftalmopatías/genética , Humanos , Hiperbilirrubinemia/genética , Recién Nacido , Masculino , Linaje , Policitemia/genética , Síndrome de Resistencia a Hormonas Tiroideas/diagnósticoRESUMEN
To determine regional percentile values and compare them with currently used national and international curves, we determined the birth weight, height and head and chest circumference of 3688 term neonates born in a state hospital in the Anatolian part of Istanbul, Turkey. Mean birth weight, height and head and chest circumference were 3334 [SD 494] g, 48.3 [SD 2.2] cm, 34.4 [SD 1.3] cm and 32.8 [1.9] cm respectively. For both boys and girls, the current Turkish national percentile curves overestimate the birth weight, height and head circumference at the 10th percentile. For boys, the national curves and those from the USA underestimate birth weight of neonates above the 90th percentile