[Pathologic anatomy of experimental listeriosis]. / Patologicheskaia anatomiia éksperimental'nogo listerioza

The authors present a survey of the Soviet and foreign literature and findings of their own experimental studies. On the basis of these data the pathologo-anatomic picture of listerosis in laboratory animals (white mice, guinea-pigs and rabbits) is given in dynamics and histogenesis of focal changes in this disease in elucidated. The most typical feature of listerosis in animals is lesions of the kidney where focal changes in the form of granulems could be detected macroscopically at an early period and with great consistency. Several stages in its histogenesis may be discerned: I. focal necroses of hepatic cells associated with their invasion with lister Listeria; 2. appearance of cellular elements around the foci of necroses with subsequent formation of granulemas consisting mainly of leucocytes and lymphoid cells; 3. development of necrobiotic changes in the central areas of granulemas with concomitance of exudative processes; 4. organization of necrotic foci with subsequent scarring.

[Morphological characteristics and various theories on the mechanism of biological effect of magnetic fields]. / Morfologicheskie osobennosti i nekotorye predstavleniia o mekhanizme biologicheskogo deistviia magnitnykh polei.

High sensitivity of biological objects to magnetic fields is shown on the basis of an analysis of the literature data and the authors' own studies. The intensity of the biological action of magnetic fields depends on the biotropic parameters of the field, while the pattern of the response depends upon the functional status of the living system. The morphofunctional changes developing in response to the effect of the magnetic field are initially adaptive. The development of pathological changes indicates a failure of the adaptive mechanisms. The authors distinguish the following components in the mechanism of biological action of magnetic fields: (1) quantum-biochemical interaction of the magnetic field with the biological substrate, (2) reception by the living system of the results of the magnetic field effect, (3) response of the system to the magnetic field.

[Pathomorphological reactions of the cerebral cortex nerve elements during treatment with an alternating magnetic field]. / Patomorfologicheskie reaktsii nervnykh élementov kory bol'shogo mozga v usloviiakh primeneniia peremennogo magnitnogo polia.

The results of investigations of certain aspects of the effect of magnetic fields on the nervous tissue are presented. The time course of pathomorphological reactions of the nerve cells and neuropile of the parietal cerebral cortex of rats receiving a single 61/2-hour treatment with alternating magnetic field (induction 20 mT, frequency 50 Hz) was studied. Changes in the microcirculatory bed of the cortex were observed manifested mainly by hydropic disorders in the cellular and fibrous components of the vessel wall. The effect of magnetic fields may be probably characterized by various hydropic changes in the cells, glial elements, and dendritic apparatus realized through disorders in the water-salt balance in cells.

[Damaging action of dithizone on insulin-releasing cells]. / Povrezhdaiushchee deistvie ditizona na insulinvyrabatyvaiushchie kletki.

Alterative action of dithizone was investigated in the experiments on various species of animals (fish, frogs, pigeons, mice, guinea pigs, golden hamsters, rats, rabbits, cats and dogs). The data received support the previously advanced suggestion that unsaturated (electrophilic) zinc complex formation is the basic mechanism of the alterative chelant's action.

[Comparative histochemical study of insulinocytes and Paneth cells]. / Sravnitel'noe gistokhimicheskoe issledovanie insulinotsitov i panetovskikh kletok.

Histochemical reactions of insulocytes and Paneth cells of rabbits and rats were investigated following the injection of the agents selectively affecting the above cells, as well as of glucose, a specific stimulant of insulin secretion. The data obtained suggest a functional relation between the pancreatic islet cells and the intestinal cryptic basal regions, which is mediated by the mechanisms, involved in regulation of the glycemic level.

[Toxic action of chelating agents on the animal hippocampus]. / Issledovanie toksicheskogo deistviia khelantov na gippokamp u zhivotnykh.

Injection of chelants into the animal body induces the development of the biphasic behavioral reaction. The first phase is marked by intensification of motor activity because of the direct chelant action on hippocampal synapses. The second phase is characterized by reduced motor activity due to the indirect chelant action on hippocampal synapses (via formation of toxic complexes with loosely bound zinc).

[Mechanism of the harmful action of chelating agents on pancreatic islet cells]. / Mekhanizm povrezhdaiushchego deistviia khelantov na kletki pankreaticheskikh ostrovkov.

Injection of chelants into the body induces the development of intravital zinc histochemical reaction in the pancreatic islet cells. The relationship was noted between this reaction intensity, duration of zinc chelate sojourn in the cells and the degree of cell injury. It is concluded that basic to the mechanism of alterative action of chelants on the insulocytes is the formation in them of toxic complexes with zinc.