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1.
Photochem Photobiol Sci ; 20(8): 1033-1051, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34297334

RESUMEN

Cordia verbenacea DC (Boraginaceae) is a flowering shrub found along the Brazilian Atlantic Forest, Brazilian coast, and low areas of the Amazon. The crude extract of its leaves is widely used in Brazilian folk medicine as an anti-inflammatory, both topically and orally. The aim of this study is to evaluate the activity of C. verbenacea ethanolic leaves extract (CVE) against UVB-triggered cutaneous inflammation and oxidative damage in hairless mice. CVE treatment recovered cutaneous antioxidant capacity demonstrated by scavenging ABTS+ free radical and iron-reducing antioxidant potential evaluated by FRAP. CVE also controlled the following UV-triggered events in the skin: reduced glutathione (GSH) depletion, catalase activity decrease, and superoxide anion (O⋅-) build-up. Furthermore, mice treated with CVE exhibited less inflammation, shown by the reduction in COX-2 expression, TNF-α, IL-1ß, IL-6, edema, and neutrophil infiltration. CVE also regulated epidermal thickening and sunburn cells, reduced dermal mast cells, and preserved collagen integrity. The best results were obtained using 5% CVE-added emulsion. The present data demonstrate that topical administration of CVE presents photochemoprotective activity in a mouse model of UVB inflammation and oxidative stress. Because of the intricate network linking inflammation, oxidative stress, and skin cancer, these results also indicate the importance of further studies elucidating a possible role of C. verbenacea in the prevention of UVB-induced skin cancer and evaluating a potential synergy between CVE and sunscreens in topical products against UVB damaging effects to the skin.


Asunto(s)
Cordia/química , Extractos Vegetales/química , Extractos Vegetales/farmacología , Piel/efectos de los fármacos , Piel/efectos de la radiación , Rayos Ultravioleta/efectos adversos , Administración Tópica , Animales , Emulsiones , Ratones , Estrés Oxidativo/efectos de los fármacos , Extractos Vegetales/administración & dosificación , Hojas de la Planta/química , Piel/metabolismo , Protectores Solares/administración & dosificación , Protectores Solares/química , Protectores Solares/farmacología
2.
Mediators Inflamm ; 2021: 9330596, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34764817

RESUMEN

UVB radiation is certainly one of the most important environmental threats to which we are subjected to. This fact highlights the crucial protective role of the skin. However, the skin itself may not be capable of protecting against UVB depending on irradiation intensity and time of exposition. Sun blockers are used to protect our skin, but they fail to fully protect it against oxidative and inflammatory injuries initiated by UVB. To solve this issue, topical administration of active molecules is an option. 15-Deoxy-Δ 12,14-prostaglandin J2 (15d-PGJ2) is an arachidonic acid-derived lipid with proresolution and anti-inflammatory actions. However, as far as we are aware, there is no evidence of its therapeutic use in a topical formulation to treat the deleterious events initiated by UVB, which was the aim of the present study. We used a nonionic cream to vehiculate 15d-PGJ2 (30, 90, and 300 ng/mouse) (TFcPGJ2) in the skin of hairless mice. UVB increased skin edema, myeloperoxidase activity, metalloproteinase-9 activity, lipid peroxidation, superoxide anion production, gp91phox and COX-2 mRNA expression, cytokine production, sunburn and mast cells, thickening of the epidermis, and collagen degradation. UVB also diminished skin ability to reduce iron and scavenge free radicals, reduced glutathione (GSH), sulfhydryl proteins, and catalase activity. TFcPGJ2 inhibited all these pathological alterations in the skin caused by UVB. No activity was observed with the unloaded topical formulation. The protective outcome of TFcPGJ2 indicates it is a promising therapeutic approach against cutaneous inflammatory and oxidative pathological alterations.


Asunto(s)
Estrés Oxidativo , Prostaglandinas , Administración Tópica , Animales , Ratones , Ratones Pelados , Prostaglandinas/metabolismo , Piel/metabolismo , Rayos Ultravioleta
3.
Int Urogynecol J ; 31(1): 139-147, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-31129689

RESUMEN

INTRODUCTION AND HYPOTHESIS: Polypropylene mesh (PPM) is often used for urogynecological repair; however, it can cause complications. An approach to reduce complications is to coat PPM with anti-inflammatory and wound-healing molecules. Platelet-rich plasma (PRP) is inexpensive and improves wound healing. Therefore, we evaluated whether covering PPM with PRP could reduce inflammation, adhesion, and oxidative stress (OS) in rabbits. METHODS: The primary objective was to evaluate OS, and the secondary objectives were to evaluate inflammation and adhesion. PRP-coated PPM was implanted on the right side of the abdominal cavity of 12 female New Zealand rabbits, in the interface between the hypodermis and peritoneum. An uncoverated PPM was implanted in the other side. Twelve rabbits served as the sham group; all animals were euthanized after 30 or 60 days. Inflammatory parameters were myeloperoxidase (MPO) and N-acetylglucosaminidase (NAG) activities. OS was evaluated by measuring the ferric-reducing antioxidant power, the free-radical-reducing ability of 3-ethylbenzothiazoline-6-sulfonic acid [2,2'-azino-bis (ABTS)], reduced glutathione levels, and superoxide anion production. Adhesion was measured using tenacity and Diamond scales (the latter of which grades adhesions according to their extent) Inflammation and OS were analyzed by analysis of variance (ANOVA), followed by Tukey's test. The Mann-Whitney test was used to evaluate adhesions, and analysis of the sham group was conducted using Kruskal-Wallis test. RESULTS: No significant differences were observed in parameters of adhesions. After 60 days, PRP-coverated PPM presented a decrease in MPO and NAG activities. Furthermore, decreased OS and increased antioxidant levels were observed in PRP-coverated PPM samples. CONCLUSIONS: The reduction of OS and inflammatory responses indicates that PRP-covered PPM is a promising therapeutic approach.


Asunto(s)
Inflamación/prevención & control , Plasma Rico en Plaquetas , Mallas Quirúrgicas , Adherencias Tisulares/prevención & control , Animales , Estrés Oxidativo , Polipropilenos , Conejos , Distribución Aleatoria
4.
Cureus ; 16(5): e60585, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38894806

RESUMEN

Muscle tears/strains are among the most common musculoskeletal injuries, posing a serious challenge for sports medicine. Aiming to reduce the time to return to play and the rate of reinjuries, apart from the traditional conservative treatments and rehabilitation protocols, new and innovative therapeutic options have emerged, particularly platelet-rich plasma (PRP). This study aims to present the available evidence regarding PRP injection for the treatment of muscle strains in athletes. Two databases were searched for articles published between January 2012 and December 2022 in Portuguese or English. The query used for the PubMed database was ("Muscles/injuries"[Mesh]) AND ("Athletes"[Mesh] OR "Athletic Injuries"[Mesh]) AND "Platelet-Rich Plasma"[Mesh], while for the Web of Science database the search was performed for "Platelet-rich plasma" AND "Muscle injuries" AND ("Athletes" OR "Athletic injuries"). Eleven studies involving athletes diagnosed with muscle injuries who received treatment with PRP injection alone, or in combination with traditional conservative treatment, compared to a control group, were included. Four randomized controlled trials, four systematic reviews/meta-analyses, two retrospective studies, and one comparative study were included. Current evidence from the highest-quality studies does not support the hypothesis of reduction of time to return to play and the rate of reinjuries after PRP injection, even though some studies reported positive results. However, the available evidence suggests that PRP might have a beneficial effect on the pain perceived by athletes following an acute muscle strain. It is challenging to arrive at definitive conclusions and translate these findings into a clinical context for treating muscle strains in athletes. The existing trials present several inconsistencies and limitations, with a heterogeneous set of patients and injuries, as well as the use of different and inconsistent methods for preparing, administering, and measuring the effects of PRP. To achieve consistent outcomes, standardizing PRP administration procedures is essential.

5.
J Biomech ; 131: 110900, 2022 01.
Artículo en Inglés | MEDLINE | ID: mdl-34954526

RESUMEN

Establishing the underlying biomechanics of acute ischemic stroke (AIS) and its treatment is fundamental to developing more effective clinical treatments for one of society's most impactful diseases. Recent changes in AIS management, driven by clinical evidence of improved treatments, has already led to a rapid rate of innovation, which is likely to be sustained for many years to come. These unprecedented AIS triage and treatment innovations provide a great opportunity to better understand the disease. In this article we provide a perspective on the recreation of AIS in the laboratory to inform contemporary device design and procedural techniques in mechanical thrombectomy. Presentation of these findings, which have been used to solve the applied problem of designing mechanical thrombectomy devices, is intended to help inform the development of basic biomechanics solutions for AIS.


Asunto(s)
Isquemia Encefálica , Accidente Cerebrovascular Isquémico , Accidente Cerebrovascular , Fenómenos Biomecánicos , Isquemia Encefálica/terapia , Humanos , Accidente Cerebrovascular/terapia , Trombectomía , Resultado del Tratamiento
6.
Lancet Glob Health ; 10(6): e907-e918, 2022 06.
Artículo en Inglés | MEDLINE | ID: mdl-35561725

RESUMEN

Benchmarking and monitoring of urban design and transport features is crucial to achieving local and international health and sustainability goals. However, most urban indicator frameworks use coarse spatial scales that either only allow between-city comparisons, or require expensive, technical, local spatial analyses for within-city comparisons. This study developed a reusable, open-source urban indicator computational framework using open data to enable consistent local and global comparative analyses. We show this framework by calculating spatial indicators-for 25 diverse cities in 19 countries-of urban design and transport features that support health and sustainability. We link these indicators to cities' policy contexts, and identify populations living above and below critical thresholds for physical activity through walking. Efforts to broaden participation in crowdsourcing data and to calculate globally consistent indicators are essential for planning evidence-informed urban interventions, monitoring policy effects, and learning lessons from peer cities to achieve health, equity, and sustainability goals.


Asunto(s)
Salud Global , Estado de Salud , Ciudades , Humanos , Programas Informáticos , Análisis Espacial
7.
J Drug Target ; 29(9): 983-997, 2021 11.
Artículo en Inglés | MEDLINE | ID: mdl-33685319

RESUMEN

Ultraviolet B (UVB) irradiation causes free radical production, increase inflammation and oxidative stress, thus, supporting the use of antioxidants by topical administration as therapeutic approaches. Quercetin (QC) is a flavonoid with antioxidant activity, however, high liposolubility makes it difficult to remain in the viable skin layer. Thus, this study evaluated whether microencapsulation of QC would enhance its activity in comparison with the same dose of free QC (non-active dose) and unloaded-microcapsules added in formulation for topical administration in a mouse model of UVB irradiation targeting the skin. Topical formulation containing Quercetin-loaded microcapsules (TFcQCMC) presents physico-chemical (colour, consistence, phase separation and pH) and functional antioxidant stability at 4 °C, room temperature and 40 °C for 6 months. TFcQCMC inhibited the UVB-triggered depletion of antioxidants observed by GSH (reduced glutathione), ability to reduce iron, ability to scavenge 2,2'-azinobis radical and catalase activity. TFcQCMC also inhibited markers of oxidation (lipid hydroperoxides and superoxide anion production). Concerning inflammation, TFcQCMC reduced the production of inflammatory cytokines, matrix metalloproteinase-9 activity, skin edoema, collagen fibre damage, myeloperoxidase activity/neutrophil recruitment, mast cell and sunburn cell counts. The pharmacological activity of TFcQCMC was not shared by the same pharmaceutical form containing the same dose of free QC or unloaded control microcapsules.


Asunto(s)
Antioxidantes/farmacología , Inflamación/tratamiento farmacológico , Estrés Oxidativo/efectos de los fármacos , Quercetina/farmacología , Piel/efectos de los fármacos , Administración Cutánea , Animales , Antioxidantes/administración & dosificación , Antioxidantes/metabolismo , Cápsulas , Modelos Animales de Enfermedad , Femenino , Inflamación/etiología , Masculino , Ratones , Ratones Pelados , Quercetina/administración & dosificación , Piel/patología , Rayos Ultravioleta/efectos adversos
8.
J Photochem Photobiol B ; 216: 112151, 2021 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-33581679

RESUMEN

Photochemoprotection of the skin can be achieved by inhibiting inflammation and oxidative stress, which we tested using Cordia verbenacea extract, a medicinal plant known for its rich content of antioxidant molecules and anti-inflammatory activity. In vitro antioxidant evaluation of Cordia verbenacea leaves ethanolic extract (CVE) presented the following results: ferric reducing antioxidant power (886.32 µM equivalent of Trolox/g extract); IC50 of 19.128 µg/ml for scavenging 2,2-diphenyl-1-picrylhydrazyl; IC50 of 12.48 µg/mL for scavenging 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); decrease of hydroperoxides from linoleic acid (IC50 of 10.20 µg/mL); inhibition of thiobarbituric acid reactive substances (IC50 8.90 µg/mL); iron-chelating ability in bathophenanthroline iron assay (IC50 47.35 µg/mL); chemiluminescence triggered by free radicals in the H2O2/horseradish peroxidase/luminol (IC50 0.286 µg/mL) and xanthine/xanthine oxidase/luminol (IC50 0.42 µg/mL) methods. CVE (10-100 mg per kg, 30 min before and immediately after UVB exposure) treatment was performed by gavage in hairless mice. CVE inhibited skin edema, neutrophil infiltration, and overproduction of MMP-9; reduced levels of TNF-α, IL-1ß, and IL- 6; numbers of skin mast cells, epidermal thickening, number of epidermal apoptotic keratinocytes, and collagen degradation. CVE increased the skin's natural antioxidant defenses as observed by Nrf-2, NAD(P)H quinone oxidoreductase 1, and heme oxygenase 1 mRNA expression enhancement. Furthermore, CVE inhibited lipid peroxidation and superoxide anion production and recovered antioxidant reduced glutathione, catalase activity, and ROS scavenging capacity of the skin. Concluding, CVE downregulates the skin inflammatory and oxidative damages triggered by UVB, demonstrating its potentialities as a therapeutic approach.


Asunto(s)
Antiinflamatorios/química , Antioxidantes/química , Cordia/química , Extractos Vegetales/química , Hojas de la Planta/química , Sustancias Protectoras/química , Animales , Antiinflamatorios/farmacología , Antioxidantes/farmacología , Citocinas/metabolismo , Edema/metabolismo , Femenino , Hemo-Oxigenasa 1/metabolismo , Humanos , Peróxido de Hidrógeno/química , Ácido Linoleico/química , Peroxidación de Lípido , Ratones Pelados , Factor 2 Relacionado con NF-E2/metabolismo , Estrés Oxidativo/efectos de los fármacos , Estrés Oxidativo/efectos de la radiación , Extractos Vegetales/farmacología , Sustancias Protectoras/farmacología , Quinona Reductasas/metabolismo , Piel/efectos de la radiación , Superóxidos/metabolismo , Rayos Ultravioleta
9.
Sci Rep ; 9(1): 3062, 2019 02 28.
Artículo en Inglés | MEDLINE | ID: mdl-30816324

RESUMEN

Acute exposure to UVB irradiation causes skin inflammation and oxidative stress, and long-term exposure to UVB irradiation may lead to carcinogenesis. Our organism has endogenous mechanisms to actively limit inflammation. Maresin 1 (MaR1; 7R,14S-dihydroxy-docosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid) is a pro-resolution lipid mediator derived from the docosahexaenoic acid, which presents anti-inflammatory and pro-resolution effects. However, it remains to be determined if treatment with MaR1 can inhibit inflammatory and oxidative alterations in the skin triggered by UVB. The treatment with MaR1 (0.1-10 ng/mice at -10 min relative to the UVB irradiation protocol) reduced UVB-induced skin edema, neutrophil recruitment (MPO; myeloperoxidase activity, and migration of LysM-eGFP+ cells), cytokine production, matrix metalloproteinase-9 activity, keratinocyte apoptosis, epidermal thickening, mast cells counts and degradation of skin collagen in hairless mice. UVB irradiation caused a decrease of GSH (reduced glutathione) levels, activity of the enzyme catalase, ferric reducing ability (FRAP), and ABTS radical scavenging capacity as well as induced lipid hydroperoxide, superoxide anion production, and gp91phox mRNA expression. These parameters that indicate oxidative stress were inhibited by MaR1 treatment. Therefore, these data suggest MaR1 as a promising pharmacological tool in controlling the deleterious effects related to UVB irradiation.


Asunto(s)
Antiinflamatorios/uso terapéutico , Antioxidantes/uso terapéutico , Ácidos Docosahexaenoicos/uso terapéutico , Inflamación/prevención & control , Estrés Oxidativo/efectos de los fármacos , Rayos Ultravioleta/efectos adversos , Animales , Ratones , Ratones Pelados , Ratones Endogámicos C57BL , Estrés Oxidativo/efectos de la radiación , Piel/efectos de los fármacos , Piel/efectos de la radiación
10.
J Pharm Pharmacol ; 70(11): 1461-1473, 2018 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-30132896

RESUMEN

OBJECTIVES: To evaluate the effects of a topical emulsion containing pyrrolidine dithiocarbamate (PDTC) (EcPDTC) in skin oxidative stress and inflammation triggered by ultraviolet B (UVB) irradiation (dose of 4.14 J/cm2 ). METHODS: Hairless mouse received treatment with 0.5 g of EcPDTC or control emulsion (CTRLE) on the dorsal surface skin 12 h, 6 h and 5 min before and 6 h after the irradiation. Oxidative stress was evaluated by ferric reducing antioxidant power (FRAP), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS) scavenging capacity, reduced glutathione quantitation, catalase activity, superoxide anion production and lipid peroxidation products. Inflammation parameters were as follows: skin oedema, myeloperoxidase activity (neutrophil marker), matrix metalloproteinase-9 activity, collagen fibre damage, mast cell and sunburn cell counts, and cytokine production. KEY FINDINGS: Topical treatment with EcPDTC protected from UVB-induced skin injury by maintaining the antioxidant capacity levels similar to non-irradiated control group. Furthermore, EcPDTC inhibited UVB irradiation-induced superoxide anion production, lipid peroxidation and reduced skin inflammation by inhibiting skin oedema, neutrophil recruitment, metalloproteinase-9 activity, collagen fibre damage, mast cell and sunburn cell counts, and cytokine (TNF-α and IL-1ß) production. CONCLUSIONS: Topical treatment with EcPDTC improves antioxidant systems and inhibits inflammation, protecting the skin from the damaging effects of UVB irradiation.


Asunto(s)
Antiinflamatorios/administración & dosificación , Antioxidantes/administración & dosificación , Pirrolidinas/administración & dosificación , Piel/efectos de los fármacos , Quemadura Solar/prevención & control , Tiocarbamatos/administración & dosificación , Rayos Ultravioleta , Administración Cutánea , Animales , Antiinflamatorios/química , Antioxidantes/química , Citocinas/metabolismo , Modelos Animales de Enfermedad , Composición de Medicamentos , Emulsiones , Mediadores de Inflamación/metabolismo , Peroxidación de Lípido/efectos de los fármacos , Ratones Pelados , Estrés Oxidativo/efectos de los fármacos , Pirrolidinas/química , Piel/metabolismo , Piel/patología , Quemadura Solar/metabolismo , Quemadura Solar/patología , Tiocarbamatos/química
11.
J Neurointerv Surg ; 9(5): 486-491, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-27127231

RESUMEN

BACKGROUND: Translational research on clot composition may be advanced by the use of clot analogs for the preclinical evaluation of mechanical thrombectomy devices. This work describes a novel set of clot analogs to represent a diverse range of fibrin and red blood cell (RBC) compositions for use in acute ischemic stroke (AIS) occlusion models. METHOD: Fresh whole blood obtained from ovine species was used to create seven different clot analog types. Five replicates were formed for each clot type. Varying amounts of whole blood constituents were mixed with thrombotic factors to create clots of varying compositions. Following histological processing, five sections from each clot were stained with H&E and Martius Scarlet Blue. Fibrin, RBC and white blood cell compositions were quantified. RESULTS: Histological examination demonstrated that the clot types had a distinct RBC and fibrin composition. No significant difference in composition was shown between replicates (p>0.05), indicating that the method of clot formation was reproducible. Percentage fibrin composition of the clot types was 1%, 8%, 31%, 38%, 64%, 79%, and 100%. A significant difference in fibrin and RBC composition between clot types was observed (p<0.05). CONCLUSIONS: Seven different clot types were developed to replicate common AIS thrombi. These clot analogs may be beneficial for the preclinical evaluation of endovascular therapies, and may be applied to interventional technique training.


Asunto(s)
Isquemia Encefálica/patología , Eritrocitos/química , Fibrina/química , Accidente Cerebrovascular/patología , Investigación Biomédica Traslacional/métodos , Animales , Femenino , Humanos , Trombosis Intracraneal/patología , Masculino , Ovinos
12.
J Photochem Photobiol B ; 171: 139-146, 2017 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28501692

RESUMEN

Trans-chalcone (TC) is a common precursor of flavonoids. However, the pharmacological properties of TC remain to be fully understood. The present study investigated whether topical formulation containing TC (TFcTC) presents therapeutic effect in UVB radiation-induced skin damage using disease, enzyme activity, antioxidant activity, protein and mRNA parameters. Control topical formulation (CTF) and TFcTC were applied in hairless mice before and after exposure to UVB radiation. Dorsal skin samples were collected after UVB exposure to evaluate: i) skin edema (weight) was measured by punch biopsy; ii) spectrophotometric assays were used to measure myeloperoxidase (MPO) and catalase activities, ferric (FRAP) and ABTS cation reducing antioxidant power, superoxide anion production and levels of reduced glutathione (GSH); iii) enzymography was used to measure matrix metalloproteinase-9 (MMP-9) activity; iv) chemiluminescence was used to measure the lipid peroxidation (LPO); v) enzyme-linked immunosorbent assay (ELISA) was used to measure tumor necrosis factor alpha (TNF-α) levels; vi) reverse transcription quantitative PCR (RT-qPCR) was used to measure cyclooxygenase-2 (COX-2), gp91phox (NADPH oxidase sub-unity), glutathione peroxidase-1 (Gpx1), glutathione reductase (Gr), nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) mRNA expression. TFcTC inhibited UVB-induced skin edema, MPO activity, MMP-9 activity, TNF-α production, and COX-2 mRNA expression. TFcTC inhibited UVB-induced LPO, down-regulated superoxide anion levels and gp91phox mRNA expression, and improved antioxidant potential and GSH skin levels. The mRNA expression of detoxification systems such as Nrf2, HO-1, Gpx1 and Gr, and catalase activity were also enhanced by treatment with TFcTC. In conclusion, TFcTC protects mice skin from UVB radiation by inhibiting inflammation, and improving antioxidant and detoxification systems. Therefore, topical treatment with TC is a novel therapeutic approach for the treatment of UVB radiation skin damages, which merits further pre-clinical and clinical investigation.


Asunto(s)
Chalcona/farmacología , Estrés Oxidativo/efectos de los fármacos , Piel/efectos de los fármacos , Rayos Ultravioleta , Administración Tópica , Animales , Catalasa/metabolismo , Chalcona/química , Ciclooxigenasa 2/genética , Ciclooxigenasa 2/metabolismo , Modelos Animales de Enfermedad , Glutatión Peroxidasa/genética , Glutatión Peroxidasa/metabolismo , Glutatión Reductasa/genética , Glutatión Reductasa/metabolismo , Hemo-Oxigenasa 1/genética , Hemo-Oxigenasa 1/metabolismo , Inflamación/prevención & control , Isomerismo , Peroxidación de Lípido/efectos de los fármacos , Metaloproteinasa 9 de la Matriz/metabolismo , Ratones , Ratones Pelados , Factor 2 Relacionado con NF-E2/genética , Factor 2 Relacionado con NF-E2/metabolismo , Estrés Oxidativo/efectos de la radiación , Peroxidasa/genética , Peroxidasa/metabolismo , Piel/metabolismo , Piel/efectos de la radiación , Factor de Necrosis Tumoral alfa/análisis , Glutatión Peroxidasa GPX1
13.
Int J Stroke ; 12(6): 606-614, 2017 08.
Artículo en Inglés | MEDLINE | ID: mdl-28534706

RESUMEN

Limited data exist on clot composition and detailed characteristics of arterial thrombi associated with large vessel occlusion in acute ischemic stroke. Advances in endovascular thrombectomy and related imaging modalities have created a unique opportunity to analyze thrombi removed from cerebral arteries. Insights into thrombus composition, etiology, physical properties and neurovascular interactions may lead to future advancements in acute ischemic stroke treatment and improved clinical outcomes. Advances in imaging techniques may enhance clot characterization and inform therapeutic decision-making prior to treatment and reveal stroke etiology to guide secondary prevention. Current imaging techniques can provide some information about thrombi, but there remains much to evaluate about relationships that may exist among thrombus composition, occlusion characteristics and treatment outcomes. Improved pathophysiological characterization of clot types, their properties and how these properties change over time, together with clinical correlates from ongoing studies, may facilitate revascularization with thrombolysis and thrombectomy. Interdisciplinary approaches covering clinical, engineering and scientific aspects of thrombus research will be key to advancing the understanding of thrombi and improving acute ischemic stroke therapy. This consensus statement integrates recent research on clots and thrombi retrieved from cerebral arteries and provides a rationale for further analyses, including current opportunities and limitations.


Asunto(s)
Isquemia Encefálica/patología , Consenso , Accidente Cerebrovascular/patología , Terapia Trombolítica , Trombosis/patología , Isquemia Encefálica/complicaciones , Humanos , Accidente Cerebrovascular/terapia , Terapia Trombolítica/métodos , Trombosis/complicaciones , Resultado del Tratamiento
14.
Interaçao psicol ; 24(3): 249-257, ago.-dez. 2020.
Artículo en Portugués | LILACS-Express | LILACS | ID: biblio-1511780

RESUMEN

Esse artigo tem como objetivo compreender as fontes de apoio social utilizadas pelos moradores de comunidades rurais nas regiões Nordeste, Norte e Sul do Brasil, analisadas como estratégias de enfrentamento às situações de opressão decorrentes da pobreza. Foram realizados 14 grupos focais, analisados em quatro dimensões: apoio familiar, apoio comunitário, apoio religioso e apoio institucional, com a utilização do software Atlas ti 5.2. Os resultados apontam que a família é o apoio diante de situações de angustia e privações decorrentes dos contextos de pobreza, reiterando a sua função no suporte emocional e na segurança material. O apoio comunitário se relaciona também ao apoio emocional e à partilha dos bens disponíveis, com poucas referências às lutas comunitárias. A espiritualidade, analisada como apoio religioso, é um campo de consolo existencial que se amplia a partir da precarização do apoio institucional. Esse apoio institucional, advindo das políticas públicas de saúde, educação e assistência social, apareceu na realidade dessas comunidades, no entanto com algumas dificuldades de funcionamento. Estudar o apoio social em comunidades rurais pobres busca superar os estudos que identificam a pobreza apenas como ausência, carência ou limitações, esquecendo a existência de espaços de potencialidades e enfrentamento.


This article aims to understand the sources of the social support used by residents of rural communities in the Northeast, North, and South regions of Brazil, analyzed as strategies to confront situations of oppression resulting from poverty. A total of 14 focus groups were analyzed in four dimensions: family support, community support, religious support, and institutional support using the Atlas software 5.2. The results indicate that the family is supportive of situations of distress and deprivation arising from the contexts of poverty, reiterating its role in emotional support and material security. Community support also relates to emotional support and the sharing of available assets, with few references to community struggles. Spirituality, analyzed as religious support, is a field of existential consolation that expands from the precariousness of institutional support. This institutional support, coming from the public policies of health, education, and social assistance, has appeared in the reality of these communities, but with some difficulties in functioning. Studying social support in poor rural communities seeks to overcome studies that identify poverty only as an absence, lack, or limitations, forgetting the existence of spaces of potentialities and coping

15.
Rev. psicol. (Fortaleza, Online) ; 7(1): 202-209, jul.-dez. 2016.
Artículo en Portugués | LILACS, Index Psi (psicología) | ID: biblio-879549

RESUMEN

O Núcleo de Psicologia Comunitária (NUCOM), programa afiliado à Pró-Reitoria de Extensão da UFC, baseia-se no tripé ensino, pesquisa e extensão, tendo como objetivo contribuir com conhecimento metodológico, conceitual e instrumental para a realização de atividades em comunidades pobres, desenvolvendo e fortalecendo os sujeitos comunitários. Em 2015, o núcleo teve como foco de atuação o desenvolvimento de conhecimentos teóricos e práticas relacionadas às implicações psicossociais da pobreza. Atuando na comunidade do Bom Jardim e na comunidade de Canafístula (Apuiarés), o NUCOM tem buscado uma maior articulação com a pesquisa "Impactos da Pobreza no Desenvolvimento da Saúde Comunitária: avaliação psicossocial de comunidades rurais das regiões Nordeste, Norte e Sul". A construção de parcerias internacionais e de convênios com universidades no México, Barcelona e Peru configura uma ampliação dos intercâmbios e das pesquisas. Todas as atividades são desenvolvidas por estudantes extensionistas, mestrandos, doutorandas e uma professora. Os espaços conjuntos promovem um maior compartilhamento entre graduação e pós-graduação, quais sejam: supervisão dos projetos de extensão, planejamento de atividades do núcleo, publicações conjunta, grupos de estudo, participação em pesquisa e encontros de formação.


Community Psychology Nucleus (NUCOM), an affiliated to the Universidade Federal do Ceará's Dean of Extension program, operates based on the tripod Education, Research and Extension with the objective of contribuiting with methodological, conceptual and instrumental knowledge to the execution of activities in poor communities, developing and stengthening individuals of the community. In 2015, NUCOM has had as a scop of activity the development of theoretical knowledge and practices related to the psichossocial implications of poverty. Working within the communities of Bom Jardim and Canafístula (Apuiarés), NUCOM has been searching for a greater interaction with the research "Impacts of Poverty in Communitary Healthness Development: psychossocial avaliation of rural communities in Northeast, North and South Regions." Building international partnerships and agreements with universities in Mexico, Barcelona and Peru represents the growth of exchange arrangements and research. All activities are organized by graduation, master and doctor students, and a teacher. Common spaces, such as: supervisal of extension projects, planning of NUCOM's activities, collaborative publications, study groups, research engagement and education training, promote graduation and post-graduation sharing.


Asunto(s)
Servicios de Salud Comunitaria , Relaciones Comunidad-Institución , Psicología Social , Universidades , Pobreza , Capacitación Profesional
16.
Rev. psicol ; 7(1): 202-209, jan.-jun. 2016.
Artículo en Portugués | Index Psi (psicología) | ID: psi-71261

RESUMEN

O Núcleo de Psicologia Comunitária (NUCOM), programa afiliado à Pró-Reitoria de Extensão da UFC, baseia-se no tripé ensino, pesquisa e extensão, tendo como objetivo contribuir com conhecimento metodológico, conceitual e instrumental para a realização de atividades em comunidades pobres, desenvolvendo e fortalecendo os sujeitos comunitários. Em 2015, o núcleo teve como foco de atuação o desenvolvimento de conhecimentos teóricos e práticas relacionadas às implicações psicossociais da pobreza. Atuando na comunidade do Bom Jardim e na comunidade de Canafístula (Apuiarés), o NUCOM tem buscado uma maior articulação com a pesquisa “Impactos da Pobreza no Desenvolvimento da Saúde Comunitária: avaliação psicossocial de comunidades rurais das regiões Nordeste, Norte e Sul”. A construção de parcerias internacionais e de convênios com universidades no México, Barcelona e Peru configura uma ampliação dos intercâmbios e das pesquisas. Todas as atividades são desenvolvidas por estudantes extensionistas, mestrandos, doutorandas e uma professora. Os espaços conjuntos promovem um maior compartilhamento entre graduação e pós-graduação, quais sejam:supervisão dos projetos de extensão, planejamento de atividades do núcleo, publicações conjunta, grupos de estudo, participação em pesquisa e encontros de formação.(AU)


Asunto(s)
Humanos , Actuación (Psicología) , Pobreza
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