Relationship between SARS-CoV-2 vaccination and cases, program breakthrough cases, and deaths in Dois Vizinhos, Paraná, Brazil.

Several vaccines have been produced in 2 years of the COVID-19 pandemic to control the infection outbreak. This study demonstrated the success of vaccination in controlling COVID-19 cases and deaths in a small city (41 424 people) with a low population density in Brazil. This study was based on a 1-year dataset since the application of the first dose in January 2021. The results show a reduction in positive cases and deaths as the vaccination coverage increased in the city, mainly after 15 000 inhabitants were vaccinated (35.21% of the population) in July 2021. At the time, 49.06% of administered vaccines were ChAdOx1-S recombinant, 39.80% inactivated SARS-CoV-2 virus (CZ02 strain), 9.70% Tozinameran, and 1.44% Ad26.COV2-S recombinant. From August 2021, a marked reduction in daily positive cases and deaths was observed, and incidence (≤2.49 per 1000 inhabitants) and mortality (≤0.02 per 1000 inhabitants) rates remained stabilized until January 2022, when a new outbreak occurred upon the emergence of the Omicron variant. However, the mortality rate (0.07 per 1000 inhabitants) remained low regardless of the Omicron high incidence rate (68.41 per 1000 inhabitants). These data demonstrate the COVID-19 vaccination effectiveness with a threshold of 35.21% of the population vaccinated in this city model.

From chaos to clarity: The scientometric breakthrough in COVID-19 research.

BACKGROUND: The COVID-19 pandemic paralyzed the world for over three years, generating unprecedented social changes in recent human history. AIMS: We aimed to scientometrically summarize a global and temporal overview of publications on COVID-19 in the two worst years of the pandemic and its progression in early 2022, after the start of vaccination. METHODS: Using the Web of Science database, this review covered the period from late 2019 to March 2022 and included all publications identified using the following terms: "SARS-CoV-2", "COVID-19", "Coronavirus Disease 19", and "2019-nCoV". We retrieved 268,904 publications, with evident global spreading, demonstrating that the pandemic triggered worldwide scientific research efforts. RESULTS: Within the dataset, 195 countries have published about Covid-19. In initial publications, a solid trend in genotyping, sequencing, and detection of the virus was evident; however, in the development of the pandemic, new knowledge and research focus gained relevance, with continental solid trends, revealed by the keywords sustainability (eastern Europe); material sciences (Asia); public and mental health (Africa); information sciences (western Europe); education (Latin America). It identified high-impact research, mainly on diagnosis and vaccines, but also equally essential topics for returning life to the new normal, such as mental health, education, and remote work. The world experienced a highly transmissible infection that proved how fragile we are regarding organization and society. CONCLUSIONS: It is necessary to learn from such an event and establish a protocol of actions and measures to be taken and avoided in a health emergency, aiming to act differently from the chaos experienced during the pandemic. Following the One Health approach, humanity must be aware of the need for more sustainable attitudes, given the inseparability of human beings from the environment.

Allium cepa test vs. insecticides: a scientometric and meta-analytical review.

Insecticides stand out as the most dangerous pesticides, and many of them can cause cytotoxic and genotoxic effects in organisms. For this reason, a systematic review was performed focusing on the effect of insecticides on Allium cepa system by two ways: (1) a scientometric study to identify trends and gaps in the literature on the evaluation of insecticides to guide future research efforts and (2) a meta-analytical approach compiling the information to obtain an overall result about insecticide effect on A. cepa. It was found that there is an increasing production of articles in this research area. The H-index of our data set was 11, with an average of 13.72 citations per item. The leader country in this research area was India, followed by Turkey and Brazil. The best cited research area was "Environmental Sciences" and "Environmental Sciences and Ecology," followed by "Cell Biology." The most used keywords were genotoxicity, pesticides, and insecticide. The meta-analytical test showed that the number of micronuclei found in onion cells treated with insecticides is higher than that in untreated ones, and the use of pesticides reduced the mitotic index. In conclusion, it is evident the need for more studies about biotechnology, nanotechnology, and biopesticides to develop safer pesticides.

Identifying global trends and gaps in research on pesticide fipronil: a scientometric review.

Fipronil is a broad potent insecticide that belongs to the phenylpyrazole chemical family. Its action mode acting in the presynaptic and postsynaptic blocking the chlorine ions by the neurotransmitters GABA. It is considered highly toxic, and in some countries, its use has been prohibited. The objective of this review is to perform a scientometric analysis for global measurement of the research on the insecticide fipronil. All information in this study was searched in the Web of Science (WoS) database in December 2021. The search was carried using the term "fipronil." Thus, 2362 studies were selected. Most selected articles showed toxicity effects of fipronil on non-target organisms, analytical methods to detect the insecticide, environmental degradation processes, and efficiency in reducing insects through its use. The H index for this dataset was 91. The cooperation network of the authors among countries showed the USA as the most notorious, with 30.6% of studies, followed by China (15.7%) and Brazil (10.9%). There are many studies on the toxicity of fipronil in bees, forms of degradation, and effectiveness of this insecticide. The present work presents suggestions pointed out in the articles for further research and highlights the importance of studies involving fipronil, as well as studies of alternative pest control.