Effects of risk factors on evoked pain patterns in rat models of experimental knee osteoarthritis.

Pain experiences in patients with knee osteoarthritis (OA) may be influenced differently by OA risk factors, reducing the translatability of preclinical research into the clinic. Our objective was to contrast evoked pain patterns after exposure to different OA risk factors including acute joint trauma, chronic instability, or obesity/metabolic syndrome using rat models of experimental knee OA. We tested longitudinal patterns of evoked pain behaviors (knee pressure pain threshold and hindpaw withdrawal threshold) in young male rats exposed to different OA-inducing risk factors including (1) nonsurgical joint trauma (impact-induced anterior cruciate ligament (ACL) rupture); (2) surgical joint destabilization (ACL + medial meniscotibial ligament transection); and (3) high fat/sucrose (HFS) diet-induced obesity. Histopathology for synovitis, cartilage damage, and subchondral bone morphology was performed. Pressure pain threshold was reduced (more pain) most, and earlier by joint trauma (Week 4-12) and HFS (Week 8-28) than by joint destabilization (Week 12). Hindpaw withdrawal threshold was reduced transiently after joint trauma (Week 4), with smaller and later reductions after joint destabilization (Week 12), but not with HFS. Synovial inflammation occurred at Week 4 after joint trauma and instability but only coincided with pain behaviors after joint trauma. Cartilage and bone histopathology were most severe after joint destabilization and least severe with HFS. The pattern, intensity, and timing of evoked pain behaviors varied due to OA risk factor exposure and were inconsistently associated with histopathological OA features. These findings may help to explain the challenges with translating preclinical OA pain research to multimorbid clinical OA contexts.

Many hours of watching medical TV shows is associated with greater medical knowledge.

Television (TV) is a popular and effective media in the formation of behaviours, beliefs and emotions. Watching TV is a main hobby in people's lives, and has become an increasingly more common hobby for children nowadays as opposed to several decades ago. However, while many studies have reported the negative effects, there have been little to no studies investigating whether a positive effect may exist. The aim of this study was to determine whether individuals who watch medical dramas are generally more knowledgeable about medicine than those who do not watch medical dramas. This was a cross-sectional survey of adolescents and young adults using an e-questionnaire. The questionnaire had four sections - a consent form, demographics of respondents, TV show(s) respondents watched and assessment of medical knowledge. Questionnaires were circulated to the international community, with a focus on respondents in Canada, the US and Nigeria. Responses were analysed using statistical analysis software. Between August and December 2017, a total of 746 consenting respondents completed the questionnaire. The average knowledge score of all respondents on medical terminologies was 6.80 out of 10. For respondents who had a history of watching medical TV shows, they were more knowledgeable than those without such a history (p = 0.0008). Additionally, those who watched more than one season of TV were more knowledgeable than those who had watched less than one season (p < 0.0001). The results suggest that people who have a history of watching TV shows are more knowledgeable than those without such a history, and also that those who watch more hours of medical TV shows are more knowledgeable than those who watch only a few hours. Future studies could investigate whether medical TV shows causes higher knowledge (as this study suggests association), and to ultimately determine whether it can be an essential component of increasing medical knowledge of the population, and in turn, patients.

Awareness of bicycle light use of young adults.

Helmet use amongst bicyclists has been well documented in recent literature. Helmet use is not the only measure cyclists can take to reduce their chance of crashes. Many places, in addition to mandating helmet use by law for youths, also require bicycle lights to be used under low-light conditions (i.e. during sunrise, during sunset and at night). The aim of this study was to investigate the awareness of bicycle light use amongst young adults, with respect to the legalities and also utility of lights while cycling. An anonymous survey was developed and circulated to young adults in Canada, Ireland and the United States of America. A total of 112 individuals completed the survey. Only 13% of individuals had an unsatisfactory knowledge of bicycle light use. As knowledge is the first step towards advocating for new measures, young adults seem well -versed with respect to bicycle light use and may be able to be targeted to increase bicycle light use. Frequency of commute was related to the knowledge of bicycle light use; those who commuted more regularly were more knowledgeable. This study, however, was composed primarily of young adults residing in Canada. Future studies could investigate knowledge among young adults who reside in a region that more regularly commutes using a bicycle, to see whether this trend holds.

Bicycle and helmet use of adolescents in Markham, Canada.

Bicycle crashes are the second most common sports- or recreation-associated cause of serious injury. While the literature suggests that wearing protective helmets can significantly decrease risks associated with bicycle-related injuries, overall helmet use remains sub-optimal. A recent study by Chow et al. suggested that helmet-wearing rates in adolescent boys are negatively correlated with age. The aim of this study was to determine if similar trends are observed in a co-educational high school setting. A questionnaire was circulated at Unionville High School, a co-ed public high school in Markham, Canada. Of the 144 participants, 27 of them were in Grade 9 or 10, and 117 of them were in Grade 11 or 12. While there was no statistical difference between helmet-wearing rates in Grade 9-10 and Grade 11-12 students, overall usage rates were low (41% and 38%, respectively, for recreational cyclists). This trend is interesting, considering that nearly 90% of all students were aware that wearing a helmet while cycling is required under Ontario law. Further studies should be conducted among the young adult population to determine whether the alarming trends discovered by this study and Chow et al. continue.