The controlling nutritional status score: A promising tool for nutritional screening and predicting severity in ulcerative colitis patients. / La escala control nutricional (CONUT): una herramienta prometedora para el cribado nutricional y como predictor de severidad en la colitis ulcerosa crónica idiopática.

INTRODUCTION AND AIMS: The controlling nutritional status (CONUT) score has previously been shown to be useful for nutritional assessment and the prediction of several inflammatory and neoplastic diseases. The aim of the present study was to evaluate the potential use of the CONUT score as a method for nutritional screening and predicting severity in ulcerative colitis (UC). MATERIALS AND METHODS: The study was conducted on 60 patients diagnosed with UC. Demographic, clinical, and biochemical patient characteristics were collected from their clinical records, and disease severity was assessed using the Truelove and Witts scale (TWS). The risks for malnutrition were evaluated through the nutritional risk index and the CONUT score. RESULTS: More than 90% of the UC patients presented with malnutrition risk, according to the scores analyzed. Patients with a high (>6points) CONUT score presented with moderate-to-severe activity on the TWS. A higher CONUT score was also associated with an increase in C-reactive protein (CRP) (P=.002) and erythrocyte sedimentation rate (ESR) (P=.009). The data analysis was performed utilizing the SPSS version 19 program. CONCLUSIONS: The CONUT score could be a promising tool for evaluating nutritional status in UC patients and predicting UC severity.

[Epidemiological characteristics of colorectal cancer in the General Hospital of Mexico. A 20 years analysis: 1988-2007]. / Comportamiento epidemiológico del cáncer de colon y recto en el Hospital General de México. Análisis de 20 años: 1988-2007.

INTRODUCTION: Distribution of colon and rectal tumors has been studied by many authors, which have considered that distal colon and rectum are more affected. However, its frequency and distribution have changed in recent years. OBJECTIVE: A descriptive analysis of colorectal cancer in the General Hospital of Mexico during the last 20 years (1988-2007). MATERIAL AND METHODS: This is a transversal comparative study between decades from the database of the Pathology Service of the General Hospital of Mexico, of cases of cancer diagnosed from January 1988 to December 2007. Variables included age, gender, anatomic site of the tumor,grade of differentiation, stadification and type of surgery. RESULTS: There were 222 cases from 1988 to 1997 and 400 cases from 1998 to 2007. 115 (52%) were female in the firs decade and 210 (53%) in the second. We found a prevalence of 71 cases (32%) for the proximal colon, 24 (11%) for the distal colon and 127 (57%) for the rectum in the first decade; in second decade there were 182 (45%) cases for the proximal colon, 50 (13%) for the distal colon and 168 (42%) for the rectum. CONCLUSIONS: The number of colorectal cancerduring the last decade almost doubled in our hospital (80%); we also found an increase in the number of proximal tumors and a decreasein the number of rectal tumors.

[Anal intraepithelial neoplasia (NIA) and infection with human papillomavirus (HPV) in anoreceptive patients]. / La neoplasia intraepitelial anal y la infección por virus del papiloma humano en pacientes anorreceptivos.

BACKGROUND: An association between human papilloma virus (HPV) infection and progression to anal intraepithelial neoplasia (AIN) and epidermoid cancer has been established. OBJECTIVE: To know the prevalence of low and high grade AIN, as well as HPV infection in an anoreceptive patients group, infected or not, by human immunodeficiency virus (HIV). MATERIAL AND METHODS: All patients with anoreceptive sexual relations were considered in this study. Patients who accepted anal citology and high definition anoscopy and biopsies with a follow-up not minor of 3 months were included. RESULTS: Forty-four patients were included: 40 male (90.9%) with average age of 31 years. Anal cytology showed inflammatory alterations in 21 patients (28%), low grade intraepithelial lesion in 23 (52%); there were not patients with high grade epithelial lesion. According to the high definition anoscopy, there were low grade intraepithelial lesion in 42 patients (95%) and high grade in 2 (5%). Biopsy showed low grade intraepithelial in 26 patients (59%), high grade in 4 (9%) and inflammatory alterations in 14 (32%). The prevalence of AIN and HPV infection was 68% in both diseases. The HIV infection was associated with the presence of high grade AIN (p=0.002, OR 47.7) CONCLUSIONS: There is a high prevalence of AIN and HPV infection between patients with anoreceptive sexual relations. The HIV infection is a risk factor for the development of high grade AIN.