Asunto(s)
Alérgenos/inmunología , Venenos de Abeja/inmunología , Hipersensibilidad/diagnóstico , Inmunoglobulina E/sangre , Pruebas Inmunológicas , Mordeduras y Picaduras de Insectos/diagnóstico , Proteínas de Insectos/inmunología , Fosfolipasas A/inmunología , Venenos de Avispas/inmunología , Adolescente , Adulto , Anciano , Alérgenos/administración & dosificación , Biomarcadores/sangre , Niño , República Checa , Femenino , Humanos , Hipersensibilidad/inmunología , Mordeduras y Picaduras de Insectos/inmunología , Proteínas de Insectos/administración & dosificación , Masculino , Persona de Mediana Edad , Fosfolipasas A/administración & dosificación , Valor Predictivo de las Pruebas , Proteínas Recombinantes/administración & dosificación , Proteínas Recombinantes/inmunología , Estudios Retrospectivos , Eslovenia , Adulto JovenRESUMEN
OBJECTIVES: To determine whether exocrine pancreatic function is impaired in patients with coeliac disease (CD) in our population and to evaluate its clinical importance. METHODS: Pancreatic exocrine function was determined by measuring faecal elastase-1 (FE) concentration. CD was diagnosed by serological testing using IgA anti-tissue transglutaminase antibody (IgAtTg) and small bowel biopsy using the Marsh classification. MRI of the pancreas was performed to evaluate any morphological changes. The study took place from January 2012 to December 2013. RESULTS: 90 patients (73 women and 17 men) of mean age 43.8±17.7â years (range 20-80) were included in the study. Mean time from CD confirmation was 5.8±0.7â years (range 1-25). Exocrine pancreatic insufficiency (EPI) was diagnosed in four (4.4%) patients (one with mild EPI and three with severe EPI). MRI showed no morphological changes in any of the four patients. In all patients with EPI at least one serological nutritional marker was below the lower limit of normal. CONCLUSIONS: EPI is present in a small number of patients with CD. EPI should be excluded in all patients with CD in the presence of overt malnutrition or in cases of persistent gastrointestinal symptoms despite a gluten-free diet. Measurement of a serum nutritional panel, regardless of the presence of clinical symptoms of EPI, can be of clinical importance. MRI should be performed to exclude any morphological change in the pancreas.