High-security 3D CAP modulation scheme based on a pyramid constellation design for 7-core fiber.

This paper proposes a 3-dimensional (3D) carrier-less amplitude and phase modulation (CAP) based on a pyramid constellation design encryption scheme for 7-core fiber in passive optical network (PON). The chaos sequences generated by the 4D hyperchaotic system are applied to produce the masking factor, and the pyramid Rubik's cube rotation rules are used to flip and rotate the constellation points. To verify the performance of the proposed 3D CAP-PON system, 25.5Gb/s encrypted Pyraminx-3D-CAP-16 signal transmission over 2 km 7-core fiber is experimentally demonstrated. Compared with the traditional 3D-CAP-16 signal, the proposed Pyraminx-3D-CAP-16 signal achieves a sensitivity gain of 0.5 dB under the limit of hard decision forward error correction (HD-FEC) 3.8 × 10-3. Compared with the Pyraminx-3D-CAP-16 signal, the encrypted Pyraminx-3D-CAP-16 signal has little difference from that before encryption, which has a great application prospect in the physical layer security enhancement of the 3D-CAP-PON system.

Performance improvement of non-orthogonal multiple access with a 3D constellation and a 2D IFFT modulator.

In this paper, we propose a performance improvement of non-orthogonal multiple access (NOMA) with a three-dimensional (3D) constellation and a two-dimensional Inverse Fast Fourier Transform IFFT modulator (2D-IFFT) for the passive optical network (PON). Two kinds of 3D constellation mapping are designed for the generation of a three-dimensional NOMA (3D-NOMA) signal. Higher-order 3D modulation signals can be obtained by superimposing signals of different power levels by pair mapping. Successive interference cancellation (SIC) algorithm is implemented at the receiver to remove interference from different users. Compared with the traditional two-dimensional NOMA (2D-NOMA), the proposed 3D-NOMA can increase the minimum Euclidean distance (MED) of constellation points by 15.48%, which enhances the bit error rate (BER) performance of the NOMA. The peak-to-average power ratio (PAPR) of NOMA can be reduced by 2 dB. A 12.17 Gb/s 3D-NOMA transmission over 25 km single-mode fiber (SMF) is experimentally demonstrated. The results show that at the bit error rate (BER) of 3.8 × 10-3, the sensitivity gain of the high-power signals of the two proposed 3D-NOMA schemes is 0.7 dB and 1 dB compared with that of 2D-NOMA under the condition of the same rate. Low-power level signal also has 0.3 dB and 1 dB performance improvement. Compared with 3D orthogonal frequency-division multiplexing (3D-OFDM), the proposed 3D-NOMA scheme could potentially expand the number of users without obvious performance degradation. Due to its good performance, 3D-NOMA is a potential method for future optical access systems.

Three-dimensional power sparse code division non-orthogonal multiple access scheme with constellation pair mapping.

This paper proposes a three-dimensional power sparse code division non-orthogonal multiple access (3D-PSCD-NOMA) scheme with 3D constellation pair mapping. The proposed sparse code is based on a balanced incomplete block design (BIBD). Its correlation matrix performs the overall signal mapping of multi-user information. Power multiplexing is realized by overlaying multi-level power signals with different path losses through pair mapping. Compared with the conventional 2D standard square 32 Quadrature Amplitude Modulation (QAM), the proposed 3D constellation pair mapping can improve the constellation points' minimum Euclidean distance (MED) by 17.7%, which is beneficial for the performance of the system. Based on obtaining the optimal power distribution ratio (PDR) for different schemes, a 3D-PSCD-NOMA signal with a rate of 15.22 Gb/s over a 25 km single-mode fiber (SMF) is experimentally performed. The experimental results show that 3D-PSCD-NOMA has a clear superiority. At the same rate, 3D-PSCD-NOMA2 can obtain a sensitivity gain of about 1.6 dB and 1.9 dB over the conventional 2D constellation. Moreover, 3D-PSCD-NOMA reduces the system's peak-to-average power ratio (PAPR) by 1.3 dB. The difference in sensitivity of the system before and after sparse code is about 0.15 dB, and no significant degradation occurred. Due to its advantages in transmission performance, 3D-PSCD-NOMA is a potential solution for future optical access systems.

NOMA security scheme based on constellation camouflage and selective mapping.

This study aims to present a non-orthogonal multiple access (NOMA) security scheme based on constellation camouflage and selective mapping. To improve the security of the system, we use a four-dimensional chaos model to camouflage high-power signals at the transmitter. The constellation diagram of high power is disguised from binary phase-shift keying (BPSK) form to quadrature phase-shift keying (QPSK) form, and after power multiplexing, further camouflaged from 8 points to 16 points. To improve the transmission performance of the designed system as much as possible and not increase the computational complexity, we use the selective mapping method in the process of power multiplexing and use the region decision method for demodulation at the receiving end. The proposed scheme is verified by experiments on a 2-km 7-core optical fiber, and achieves the safety transmission of a power division multiplexing-orthogonal frequency-division multiplexing (PDM-OFDM) signal with a net rate of 97.38 Gb/s without signal damage. The maximum achievable key space of the proposed scheme is 10135. Hence, it is a feasible and secure non-orthogonal multiple access-passive optical network scheme.

NOMA security scheme based on constellation camouflage and selective mapping: publisher's note.

This publisher's note contains corrections to Opt. Lett.48, 4101 (2023)10.1364/OL.493540.

Intelligent dynamic data perturbation OCDM encryption scheme based on cellular neural network and biological genetic encoding.

In this paper, an intelligent dynamic perturbation orthogonal chirp division multiplexing (OCDM) encryption scheme based on cellular neural network and biological genetic encoding for seven-core optical fiber is proposed for the first time to our knowledge. In this scheme, chaotic sequences generated by cellular neural network are employed to construct six masking vectors to achieve six dimensions of ultra-high security encryption. The transmitted bit data is interleaved according to the DNA operation rules. The subcarrier frequency, symbol matrix, and time are scrambled. Because the selected encoding rule, decoding rule, key base sequence, subcarrier frequency, symbol matrix, and scrambling position of time all change dynamically, the robustness against malicious attack is enhanced. Simultaneously, OCDM technology is employed to optimize the system, which effectively improves the anti-interference ability and bit error performance of the system. A 70 Gb /s (7×10 Gb /s) encrypted OCDM signal transmission experiment is carried out on a 2 km 7-core fiber, and an orthogonal frequency division multiplexing (OFDM) signal is transmitted under the same conditions for comparison and verification. The results show that the key space of the newly proposed encryption scheme can reach 101170, and the receiver sensitivity of OCDM is 1.2 dB greater than that of OFDM when the bit error rate is 10-3. The scheme can improve the security of encrypted information and the performance of the system, which is very promising in the optical access network of the future.

Optical non-orthogonal multiple access based on amino acids and extended zigzag.

We propose a novel security-enhanced power division multiplexing (SPDM) optical non-orthogonal multiple access scheme in conjunction with seven-core optical fiber in this paper. This scheme could improve the security of data transmission at the physical layer and the split ratio of the access network, ensuring more users can be served at the same time. Additionally, multiple signals can be superimposed in the digital domain, leading to a significant improvement in spectral efficiency. We have further experimentally demonstrated the transmission of 47.25 Gb/s SPDM orthogonal frequency division multiplexing (OFDM) signals in a 2 km seven-core fiber system. The experimental results confirm that our scheme can increase the number of access users by 14 times without influencing the privacy of different users. It is worth mentioning the signal encryption method based on amino acids combine with extended zigzag is proposed for the first time as we know. Meanwhile, the key space reaches 10182, indicating that the data transmission process can be effectively protected from the attack of stealers. The proposed security-enhanced power division multiplexing space division multiplexing passive optical network (SPDM-SDM-PON) support multi-threading and multi-functions, showing a great potential to be applied in the future telecommunication systems.

Mode division multiplexing chaotic encryption scheme based on key intertwining and accompanying transmission.

A mode division multiplexing (MDM) chaotic encryption scheme based on key intertwining and accompanying transmission is proposed in this paper. Based on the weakly coupled few-mode fiber (FMF), data and time-varying keys can be accompanied by transmission in two modes, LP01 and LP11, respectively. In order to generate a new key, the current key is XORed with all of the keys from all the preceding moments, one by one. To implement chaotic masking in the digital domain, the three chaotic sequences corresponding to the new key are adopted to encrypt the data at the constellation phase, data symbol block, and subcarrier levels. An 8.89 Gb/s encrypted 16QAM-OFDM signal transmission over 1 km weakly-coupled FMF is experimentally demonstrated. The receiver with the correct key can recover the data normally, while the BER of the illegal receiver remains around 0.5. In the case of the key transmission bit rate of 1 Gb/s, the cracking efficiency threshold of the time-varying key encryption scheme is 5.21 × 106 times that of the time-invariant key encryption scheme, which suggests that the proposed work is a promising candidate for future physical layer security.

Dual-physical layer high-security encryption scheme for seven-core fiber FPS-OFDM-PON.

This paper proposes an encryption scheme for floating probabilistic shaping orthogonal frequency division multiplexing passive optical networks (FPS-OFDM-PON). Four chaotic sequences are generated by the 4D hyperchaotic model for floating probabilistic shaping (FPS) and bubble sort encryption scheme. An experiment is conducted to demonstrate the transmission of a 70Gb/s (7×10Gb/s) FPS-OFDM-PON signal across a 2km weakly coupled 7-core fiber. The keyspace of the 4D hyperchaotic model reaches 10120. The results show that a 1.82 dB gain in receiver sensitivity compared with the conventional uniform 16QAM-OFDM due to the introduction of FPS. When the system is assaulted by an unlawful receiver, the bit error rate (BER) can still remain at 0.49, successfully assuring the system's security. Due to its good transmission and security performance, the scheme has important application prospects in the future optical access network.

Secure OFDM transmission scheme based on chaotic encryption and noise-masking key distribution.

In this Letter, we propose a secure orthogonal frequency division multiplexing (OFDM) transmission scheme based on chaotic encryption and noise-masking key distribution. With the implementation of a three-dimensional digital chaotic system, the security performance is effectively enhanced by scrambling the phase, symbol, and subcarrier frequency of the OFDM signal. The proposed noise-masking key distribution can mask the key information of the chaotic system into noise and transmit it with the chaotic encrypted signal simultaneously. By this mechanism, the legal receiver can realize uninterrupted authentication and decryption even if the key is constantly updated. Transmission of a 62.2-Gb/s quadrature phase shift keying (QPSK) and 124.4-Gb/s 16 quadrature amplitude modulation (16QAM) OFDM signal over a 2-km 7-core fiber using the proposed scheme is experimentally demonstrated. The results show that the proposed scheme can realize security enhancement and cost-effective key distribution without significant bit error ratio (BER) performance degradation.

Flexible non-linear physical security coding scheme combined with chaotic neural network for OFDM-WDM-PON.

In this paper, a flexible physical security coding scheme integrating chaotic neural network (CNN) and non-linear encryption is proposed for orthogonal frequency division multiplexing wavelength division multiplexing passive optical network (OFDM-WDM-PON). The scheme improved the flexibility, adjustability and the key space of chaotic encryption system by introducing chaos into neural networks. The system will encrypt the bit series, probability shaping points, and subcarriers position of the OFDM signal through linear encryption and non-linear encryption concurrently. Results show that a key sensitivity of 10-15 and a key space of more than 10279 can be achieved. The encrypted system's Lyapunov is 5.2631, along with 12 parameters can be dynamically changed in the range of 0∼5. Furthermore, when the bit error rate (BER) is less than 3.8×10-3, probabilistic shaping (PS) technology decreases power loss by around 0.5 dB. A 20.454 Gb/s data transmission experiment was successfully verified for a span of 25 Km single-mode fiber. According to the experimental results, the proposed encryption scheme is likely to be used in future OFDM-WDM-PON transmission systems.

Combined effects of avasimibe immunotherapy, doxorubicin chemotherapy, and metal-organic frameworks nanoparticles on breast cancer.

CD8+ T cells play a vital role in cancer immunotherapy and can be shaped by metabolism. Avasimibe is an acyl coenzyme A-cholesterol acyltransferase (ACAT) inhibitor, which has been clinically verified safe in other phase Ⅲ clinical trials. It can potentiate the killing function of CD8+ T cells by modulating cholesterol metabolism. Doxorubicin (DOX) is an anticancer drug widely used in many cancers to induce tumor cell apoptosis. Unfortunately, DOX also can induce toxic and side effects in many organs, compromising its usage and efficacy. Herein, we report the combinational usage of avasimibe and a safe pH sensitive nano-drug delivery system composing of DOX and metal-organic frameworks nanoparticles (MNPs). Our findings demonstrated that DOX-MNPs treatment inhibited tumor growth with good safety profile and avasimibe treatment combined DOX-MNPs treatment exhibited a better efficacy than monotherapies in 4T1 breast cancer therapy.

Crystal structures of rice hexokinase 6 with a series of substrates shed light on its enzymatic mechanism.

Hexokinases (HXKs) have determined to be multifaceted proteins, and they are the only ones able to phosphorylate glucose in plants. However, the binding mode for ATP to plant HXKs remains unclear. Here, we report the crystal structures of rice hexokinase 6 (OsHXK6) in four different forms: (i) apo-form, (ii) binary complex with D-Glc, (iii) quaternary complex with ADP, PO4 and Mg2+, and (iv) pentanary complex with D-Glc, ADP, PO4, and Mg2+. The apo form is in the open state conformation, and the three others are in the closed state, indicating that glucose and ADP-PO4 binding induces a large conformational change by domain rearrangement. The quaternary complex is a novel intermediate during the catalytic reaction we trapped for the first time, which provides a new evidence for the enzymatic mechanism of HXKs. In addition, the latter two complexes reveal the binding mode for ADP-PO4 to plant HXKs, which provide the structural explanation for the dual-function of OsHXK6. In addition, we identified that residues Gly112, Thr261, Gly262, and Gly450 are essential to the binding between ADP-PO4 and OsHXK6 by a series of single mutations and enzymatic assays. Our study provide structural basis for the other functional studies of OsHXK6 in rice.

A Cas12a ortholog with stringent PAM recognition followed by low off-target editing rates for genome editing.

BACKGROUND: AsCas12a and LbCas12a nucleases are reported to be promising tools for genome engineering with protospacer adjacent motif (PAM) TTTV as the optimal. However, the C-containing PAM (CTTV, TCTV, TTCV, etc.) recognition by Cas12a might induce extra off-target edits at these non-canonical PAM sites. RESULTS: Here, we identify a novel Cas12a nuclease CeCas12a from Coprococcus eutactus, which is a programmable nuclease with genome-editing efficiencies comparable to AsCas12a and LbCas12a in human cells. Moreover, CeCas12a is revealed to be more stringent for PAM recognition in vitro and in vivo followed by very low off-target editing rates in cells. Notably, CeCas12a renders less off-target edits located at C-containing PAM at multiple sites compared to LbCas12a and AsCas12a, as assessed by targeted sequencing methods. CONCLUSIONS: Our study shows that CeCas12a nuclease is active in human cells and the stringency of PAM recognition could be an important factor shaping off-target editing in gene editing. Thus, CeCas12a provides a promising candidate with distinctive characteristics for research and therapeutic applications.