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Org Lett
; 15(6): 1266-9, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23461785
RESUMEN
An efficient synthesis of enantioenriched α-substituted γ-hydroxy esters via a kinetic resolution event is described. Bulky racemic esters in the presence of a chiral Brønsted acid selectively lactonize to yield a recoverable enantioenriched hydroxy ester and lactone. These esters are highly versatile building blocks that can readily be converted to synthetically useful materials.