[Factors influencing glucose metabolism in young obese subjects with obstructive sleep apnea hypopnea syndrome].

OBJECTIVE: To explore the factors influencing glucose metabolism in young obese subjects with obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: A total of 106 young obese subjects[18-44 years old, body mass index (BMI) ≥30 kg/m(2)]were enrolled and divided into two groups based on full-night polysomnography (PSG), OSAHS group[apnea hypopnea index (AHI) ≥5 events/h]and non-OSAHS group (AHI<5 events/h). Oral glucose tolerance-insulin releasing test (OGTT-IRT) was performed and serum glycosylated hemoglobin A1 (HbA1c) levels were measured after an overnight fast. Homeostasis model assessment-IR (HOMA-IR), Matsuda insulin sensitivity index (MI), homeostasis model assessment-ß (HOMA-ß), the early phase insulinogenic index (ΔI(30)/ΔG(30)), total area under the curve of insulin in 180 minutes (AUC-I180) and oral disposition index (DIo) were calculated to evaluate insulin resistance and pancreatic ß cell function. Stepwise multiple linear regressions were conducted to determine the independent linear correlation of glucose measurements with PSG parameters. RESULTS: Prevalence of diabetes was higher in OSAHS than in non-OSAHS group (22.0% vs 4.3%, P=0.009). OGTT 0, 30, 60 min glucose and HbA1c levels were higher in OSAHS group than those in non-OASHS group (all P<0.05). DIo were lower in OSAHS group than those in non-OASHS group (P=0.024), HOMA-IR, MI, HOMA-ß, ΔI(30)/ΔG(30), and AUC-I(180) were similar between two groups (all P>0.05). In stepwise multiple linear regressions, OGTT 0, 30 and 60 min glucose were positively correlated with oxygen desaturation index (ODI) (ß=0.243, 0.273 and 0.371 respectively, all P<0.05). HOMA-ß was negatively correlated with AHI (ß=-0.243, P=0.011). DIo was negatively correlated with ODI (ß=-0.234, P=0.031). CONCLUSION: OSAHS worsens glucose metabolism and compensatory pancreatic ß-cell function in young obese subjects, which could probably be attributed to sleep apnea related oxygen desaturation during sleep.

[Serum γ-glutamyltransferase in obstructive sleep apnea hypopnea syndrome and its role in predicting concomitant diabetes mellitus].

OBJECTIVE: To determine the association of obstructive sleep apnea hypopnea syndrome(OSAHS) with serum γ-glutamyltransferase(γ-GT) and whether serum γ-GT is an independent predictor for diabetes mellitus(DM) in OSAHS patients. METHODS: A total of 172 Han Chinese subjects were enrolled and divided into three groups based on full-night polysomnography(PSG): severe OSAHS group(AHI>30 events/h), mild to moderate OSAHS group (5