Detalles de la búsqueda
1.
Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and ß-amyloid inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem
; 88-89: 117333, 2023 06 06.
Artículo
Inglés
| MEDLINE | ID: mdl-37236021
2.
Naturally Inspired Molecules for Neuropathic Pain Inhibition-Effect of Mirogabalin and Cebranopadol on Mechanical and Thermal Nociceptive Threshold in Mice.
Molecules
; 28(23)2023 Nov 30.
Artículo
Inglés
| MEDLINE | ID: mdl-38067591
3.
Multitargeting Histamine H3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives.
Molecules
; 28(5)2023 Mar 03.
Artículo
Inglés
| MEDLINE | ID: mdl-36903593
4.
The Antiarrhythmic and Hypotensive Effects of S-61 and S-73, the Pyrrolidin-2-one Derivatives with α1-Adrenolytic Properties.
Int J Mol Sci
; 23(18)2022 Sep 08.
Artículo
Inglés
| MEDLINE | ID: mdl-36142287
5.
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease.
Molecules
; 28(1)2022 Dec 28.
Artículo
Inglés
| MEDLINE | ID: mdl-36615435
6.
Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease.
Bioorg Chem
; 114: 105129, 2021 09.
Artículo
Inglés
| MEDLINE | ID: mdl-34217977
7.
Biphenylalkoxyamine Derivatives-Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity.
Molecules
; 26(12)2021 Jun 11.
Artículo
Inglés
| MEDLINE | ID: mdl-34208297
8.
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.
J Enzyme Inhib Med Chem
; 35(1): 1944-1952, 2020 Dec.
Artículo
Inglés
| MEDLINE | ID: mdl-33092411
9.
Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives.
Bioorg Chem
; 90: 103084, 2019 09.
Artículo
Inglés
| MEDLINE | ID: mdl-31271942
10.
Metabolic benefits of 1-(3-(4-(o-tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one: a non-selective α-adrenoceptor antagonist.
J Endocrinol Invest
; 41(5): 609-619, 2018 May.
Artículo
Inglés
| MEDLINE | ID: mdl-29110282
11.
α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one.
Bioorg Med Chem
; 23(9): 2104-11, 2015 May 01.
Artículo
Inglés
| MEDLINE | ID: mdl-25813897
12.
Antiarrhythmic and α-Adrenoceptor Antagonistic Properties of Novel Arylpiperazine Derivatives of Pyrrolidin-2-one.
Arch Pharm (Weinheim)
; 348(12): 861-7, 2015 Dec.
Artículo
Inglés
| MEDLINE | ID: mdl-26523954
13.
Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.
Eur J Med Chem
; 249: 115135, 2023 Mar 05.
Artículo
Inglés
| MEDLINE | ID: mdl-36696766
14.
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, ß-secretase, and amyloid ß aggregation as potential treatment of Alzheimer's disease.
Eur J Med Chem
; 261: 115832, 2023 Dec 05.
Artículo
Inglés
| MEDLINE | ID: mdl-37837674
15.
Development, Recent Achievements and Current Directions of Research into GABA Uptake Inhibitors.
Curr Med Chem
; 28(4): 750-776, 2021.
Artículo
Inglés
| MEDLINE | ID: mdl-31612818
16.
The Antiarrhythmic Activity of Novel Pyrrolidin-2-one Derivative S-75 in Adrenaline-Induced Arrhythmia.
Pharmaceuticals (Basel)
; 14(11)2021 Oct 20.
Artículo
Inglés
| MEDLINE | ID: mdl-34832847
17.
Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity.
Eur J Med Chem
; 221: 113512, 2021 Oct 05.
Artículo
Inglés
| MEDLINE | ID: mdl-34015586
18.
Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity.
ACS Chem Neurosci
; 12(16): 3073-3100, 2021 08 18.
Artículo
Inglés
| MEDLINE | ID: mdl-34347423
19.
Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands.
Eur J Med Chem
; 185: 111785, 2020 Jan 01.
Artículo
Inglés
| MEDLINE | ID: mdl-31669851
20.
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.
Eur J Med Chem
; 188: 111920, 2020 Feb 15.
Artículo
Inglés
| MEDLINE | ID: mdl-31901745