[Headache in autonomic-vascular dystonia]. / Golovnye boli pri vegeto-sosudistoi distonii.

The clinical variants of headaches were observed in 83 patients with autonomic vascular dystonia. The diagnostic table was designed to differentiate between the latter and migraine. Bulbar conjunctiva and retinal microcirculation studies revealed multiple morphological and hemodynamic changes. These were especially marked during painful paroxysms. The substantial increase in red blood cell aggregation rates was observed within the entire headache exacerbation. The data provide grounds for using adrenergic blockers, antiaggregatory and venotonic drugs in these conditions.

[Pathogenetic aspects of ischemic strokes]. / Nekotorye aspekty patogeneza ishemicheskikh insul'tov.

The article presents data on total calibrometry of the vascular bed of the brain in 26 patients who had died of ischemic cerebral stroke. All patients with nonthrombotic ischemic cerebral stroke showed a considerable decrease in the total lumen of the cerebrovascular bed on the side of the ischemic focus with a significant increase in the coefficient of hemispherical asymmetry. In most cases impoverishment of the hemodynamics was related not to occlusive or gross stenosing process of one of the major vessels but rather to nonmanifest narrowing of several vessels in the hemisphere on the involved side. The coefficient of asymmetry in patients with thrombotic cerebral stroke was the minimal which is explained by the fact that even complete thrombosis of one vessel has no serious effect on the total lumen of the vascular bed of the brain. The findings obtained confirm the theory of the involvement of cerebrovascular insufficiency in the genesis of ischemic cerebral strokes as the main pathogenic component in acute disorders of the cerebral circulation.

[Clinical aspects and pathogenesis of the initial (precrisis) disorders of cerebral circulation]. / K klinike i patogeneze nachal'nykh (predkrizovykh) narushenii mozgovogo krovoobrashcheniia.

In 82 patients from 20--35 years of age with vegetative-vascular dystonia the authors studied clinical variants of the disease, the bioelectrical brain activity, the state of cerebral circulation, the visual analyzer, the cardiovascular system, histamine, protein, lipid, carbohydrate metabolism and the state of coagulative blood system. In the majority of the cases the studies demonstrated hystaminemia, some shifts in the biochemical blood content, an increased brain vascular tone, a drop of blood repletion and disturbances of regional hemodynamics. The studies also depicted a decreased functional lability of the main cortical bioelectrical processes, disturbances of electric activity and propulsive possibilities of the myocardium. It was also possible to demonstrate intercorrelation between the biochemical and electrophysiological indices with the type and form of the disease. It is assumed that the leading role in the pathogenesis of the disease belongs to the dysfunction of the limbico-reticular complex. Certain recommendations for normalization of the histamine metabolism are given as well as for the normalization of the reticulo-hypothalamic system functions. The authors also indicate a necessity of an early screening of the patients with vegetative-vascular dystonia.