1.
Chem Commun (Camb)
; 58(80): 11272-11275, 2022 Oct 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36112125
RESUMEN
Herein, we report a DMAP-catalysed Curtius rearrangement and intramolecular cyclisation cascade reaction of 2-substituted aryl carboxylic acids with organic azides for the first time. This protocol features simple operation, broad scope and metal-free conditions, furnishing a broad spectrum of biologically attractive heterocycles. The synthetic virtue of this reaction was demonstrated by gram-scale synthesis and applicability toward drug-like molecules.