1.
Bioorg Med Chem
; 20(16): 4995-5000, 2012 Aug 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22795899
RESUMEN
New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.