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1.
Phys Rev Lett ; 106(25): 252503, 2011 Jun 24.
Artículo en Inglés | MEDLINE | ID: mdl-21770637

RESUMEN

We report on the first direct measurement of the proton separation energy for the proton-unbound nucleus (69)Br. Bypassing the (68)Se waiting point in the rp process is directly related to the 2p-capture rate through (69)Br, which depends exponentially on the proton separation energy. We find a proton separation energy for (69)Br of Sp((69)Br )= -785(-40)(+34) keV; this is less bound compared to previous predictions which have relied on uncertain theoretical calculations. The influence of the extracted proton separation energy on the rp process occurring in type I x-ray bursts is examined within the context of a one-zone burst model.

2.
Phys Med ; 41: 141-146, 2017 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-28869137

RESUMEN

Proton radiography is a novel imaging modality that allows direct measurement of the proton energy loss in various tissues. Currently, due to the conversion of so-called Hounsfield units from X-ray Computed Tomography (CT) into relative proton stopping powers (RPSP), the uncertainties of RPSP are 3-5% or higher, which need to be minimized down to 1% to make the proton treatment plans more accurate. In this work, we simulated a proton radiography system, with position-sensitive detectors (PSDs) and a residual energy detector (RED). The simulations were built using Geant4, a Monte Carlo simulation toolkit. A phantom, consisting of several materials was placed between the PSDs of various Water Equivalent Thicknesses (WET), corresponding to an ideal detector, a gaseous detector, silicon and plastic scintillator detectors. The energy loss radiograph and the scattering angle distributions of the protons were studied for proton beam energies of 150MeV, 190MeV and 230MeV. To improve the image quality deteriorated by the multiple Coulomb scattering (MCS), protons with small angles were selected. Two ways of calculating a scattering angle were considered using the proton's direction and position. A scattering angle cut of 8.7mrad was applied giving an optimal balance between quality and efficiency of the radiographic image. For the three proton beam energies, the number of protons used in image reconstruction with the direction method was half the number of protons kept using the position method.


Asunto(s)
Procesamiento de Imagen Asistido por Computador , Protones , Radiografía/instrumentación , Método de Montecarlo , Fantasmas de Imagen , Tomografía Computarizada por Rayos X
3.
Med Phys ; 42(4): 1884-94, 2015 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25832078

RESUMEN

PURPOSE: Spectral information of the output of x-ray tubes in (dual source) computer tomography (CT) scanners can be used to improve the conversion of CT numbers to proton stopping power and can be used to advantage in CT scanner quality assurance. The purpose of this study is to design, validate, and apply a compact portable Compton spectrometer that was constructed to accurately measure x-ray spectra of CT scanners. METHODS: In the design of the Compton spectrometer, the shielding materials were carefully chosen and positioned to reduce background by x-ray fluorescence from the materials used. The spectrum of Compton scattered x-rays alters from the original source spectrum due to various physical processes. Reconstruction of the original x-ray spectrum from the Compton scattered spectrum is based on Monte Carlo simulations of the processes involved. This reconstruction is validated by comparing directly and indirectly measured spectra of a mobile x-ray tube. The Compton spectrometer is assessed in a clinical setting by measuring x-ray spectra at various tube voltages of three different medical CT scanner x-ray tubes. RESULTS: The directly and indirectly measured spectra are in good agreement (their ratio being 0.99) thereby validating the reconstruction method. The measured spectra of the medical CT scanners are consistent with theoretical spectra and spectra obtained from the x-ray tube manufacturer. CONCLUSIONS: A Compton spectrometer has been successfully designed, constructed, validated, and applied in the measurement of x-ray spectra of CT scanners. These measurements show that our compact Compton spectrometer can be rapidly set-up using the alignment lasers of the CT scanner, thereby enabling its use in commissioning, troubleshooting, and, e.g., annual performance check-ups of CT scanners.


Asunto(s)
Radiometría/instrumentación , Análisis Espectral/instrumentación , Tomógrafos Computarizados por Rayos X , Algoritmos , Simulación por Computador , Diseño de Equipo , Fluorescencia , Humanos , Método de Montecarlo , Protección Radiológica/instrumentación , Protección Radiológica/métodos , Radiometría/métodos , Análisis Espectral/métodos , Rayos X
4.
Phys Med Biol ; 60(23): 8923-47, 2015 Dec 07.
Artículo en Inglés | MEDLINE | ID: mdl-26539812

RESUMEN

The only method for in vivo dose delivery verification in proton beam radiotherapy in clinical use today is positron emission tomography (PET) of the positron emitters produced in the patient during irradiation. PET imaging while the beam is on (so called beam-on PET) is an attractive option, providing the largest number of counts, the least biological washout and the fastest feedback. In this implementation, all nuclides, independent of their half-life, will contribute. As a first step towards assessing the relevance of short-lived nuclides (half-life shorter than that of (10)C, T1/2 = 19 s) for in vivo dose delivery verification using beam-on PET, we measured their production in the stopping of 55 MeV protons in water, carbon, phosphorus and calcium The most copiously produced short-lived nuclides and their production rates relative to the relevant long-lived nuclides are: (12)N (T1/2 = 11 ms) on carbon (9% of (11)C), (29)P (T1/2 = 4.1 s) on phosphorus (20% of (30)P) and (38m)K (T1/2 = 0.92 s) on calcium (113% of (38g)K). No short-lived nuclides are produced on oxygen. The number of decays integrated from the start of an irradiation as a function of time during the irradiation of PMMA and 4 tissue materials has been determined. For (carbon-rich) adipose tissue, (12)N dominates up to 70 s. On bone tissue, (12)N dominates over (15)O during the first 8-15 s (depending on carbon-to-oxygen ratio). The short-lived nuclides created on phosphorus and calcium provide 2.5 times more beam-on PET counts than the long-lived ones produced on these elements during a 70 s irradiation. From the estimated number of (12)N PET counts, we conclude that, for any tissue, (12)N PET imaging potentially provides equal to superior proton range information compared to prompt gamma imaging with an optimized knife-edge slit camera. The practical implementation of (12)N PET imaging is discussed.


Asunto(s)
Neoplasias/diagnóstico por imagen , Neoplasias/radioterapia , Fantasmas de Imagen , Tomografía de Emisión de Positrones/métodos , Terapia de Protones , Radiofármacos/farmacocinética , Radioterapia Asistida por Computador/métodos , Humanos , Neoplasias/metabolismo , Distribución Tisular
5.
Phys Med Biol ; 54(19): 5831-46, 2009 Oct 07.
Artículo en Inglés | MEDLINE | ID: mdl-19741273

RESUMEN

Monte Carlo simulations based on the Geant4 simulation toolkit were performed for the carbon wedge degrader used in the beam line at the Center of Proton Therapy of the Paul Scherrer Institute (PSI). The simulations are part of the beam line studies for the development and understanding of the GANTRY2 and OPTIS2 treatment facilities at PSI, but can also be applied to other beam lines. The simulated stopping power, momentum distributions at the degrader exit and beam line transmission have been compared to accurate benchmark measurements. Because the beam transport through magnetic elements is not easily modeled using Geant4a connection to the TURTLE beam line simulation program was made. After adjusting the mean ionization potential of the carbon degrader material from 78 eV to 95 eV, we found an accurate match between simulations and benchmark measurements, so that the simulation model could be validated. We found that the degrader does not completely erase the initial beam phase space even at low degraded beam energies. Using the validation results, we present a study of the usability of beryllium as a degrader material (mean ionization potential 63.7 eV). We found an improvement in the transmission of 30-45%, depending on the degraded beam energy, the higher value for the lower energies.


Asunto(s)
Berilio , Carbono , Protones , Programas Informáticos , Benchmarking , Método de Montecarlo , Terapia de Protones , Control de Calidad , Reproducibilidad de los Resultados , Dispersión de Radiación
6.
Phys Rev Lett ; 90(6): 062301, 2003 Feb 14.
Artículo en Inglés | MEDLINE | ID: mdl-12633288

RESUMEN

For the first time a high-precision proton-deuteron bremsstrahlung experiment has been performed in which all the different exit channels have been distinguished separately. High-precision cross sections and analyzing powers in one of the outgoing channels, namely, the coherent bremsstrahlung with a proton and a deuteron in the final state, are presented at 190 MeV incoming proton beam energy and are compared to calculations based on the low-energy theorem. The results of the calculations vary considerably calling for a fully microscopic calculation. However, using a recipe including the initial- and final-state interactions, the predictions come close to the data.

7.
Phys Rev Lett ; 92(20): 202301, 2004 May 21.
Artículo en Inglés | MEDLINE | ID: mdl-15169344

RESUMEN

Data on proton-neutron bremsstrahlung have been obtained from a measurement of the quasifree breakup channel in proton-deuteron bremsstrahlung. This high-precision measurement, with an incident proton energy of 190 MeV, is fully exclusive; i.e., the protons, the neutron, and the photon have been detected. The quasifree differential cross sections obtained are compared with microscopic calculations and calculations based on soft-photon models. There are sizable differences between the models and also between the models and the data obtained for this simple process.

8.
Phys Rev Lett ; 88(12): 122302, 2002 Mar 25.
Artículo en Inglés | MEDLINE | ID: mdl-11909450

RESUMEN

Photon energy spectra up to the kinematic limit have been measured in 190 MeV proton reactions with light and heavy nuclei to investigate the influence of the multiple-scattering process on the photon production. Relative to the predictions of models based on a quasifree production mechanism, a strong suppression of bremsstrahlung is observed in the low-energy region of the photon spectrum. We attribute this effect to the interference of photon amplitudes due to multiple scattering of nucleons in the nuclear medium.

9.
Phys Rev Lett ; 92(17): 172502, 2004 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-15169141

RESUMEN

A new experimental approach was developed that can reduce the uncertainties in astrophysical rapid proton capture (rp) process calculations due to nuclear data. This approach utilizes neutron removal from a radioactive ion beam to populate the nuclear states of interest. Excited states were deduced by the gamma-decay spectra measured in a semiconductor Ge-detector array. In the first case studied, 33Ar, excited states were measured with uncertainties of several keV. The 2 orders of magnitude improvement in the uncertainty of the level energies resulted in a 3 orders of magnitude improvement in the uncertainty of the calculated 32Cl(p,gamma)33Ar rate that is critical to the modeling of the rp process. This approach has the potential to measure key properties of almost all interesting nuclei on the rp-process path.

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