Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Resultados 1 - 17 de 17
Filtrar
1.
Cerebellum ; 2023 Nov 27.
Artículo en Inglés | MEDLINE | ID: mdl-38008790

RESUMEN

The aim of our study is to define the most frequent etiology, clinical presentation, and predictive factors of outcome in children with acute ataxia (AA) and to determine "the red flags" in the diagnostic approach to children with AA. The retrospective study included the patients with AA treated in the institute from 2015 to 2021. The inclusion criteria were children aged 1-18 years, evolution time of ataxia within 72 h, and diagnosis made by a physician. The exclusion criteria were anamnestic data about ataxia without confirmation by any physician, chronic/persistent ataxia, and psychogenic or postictal ataxia. Clinical presentation was divided into two categories: (1) isolated cerebellar signs (CS): ataxic gait, dysmetria, dysdiadochokinesia, intention tremor, dysarthria, and nystagmus; (2) CS-plus symptoms which included CS associated with any of other symptoms such as encephalopathy (GCS < 15), awareness disturbances, vomiting, headache, a new onset limb or facial paresis, torticollis, hypotonia, and opsoclonus. The outcome was assessed at the end of hospitalization and was defined as complete or incomplete recovery. The study included 76 children, with a mean age of 5.7 years (IQR 2.1-8.3). The most frequent causes of AA were immune-mediated/infective cerebellar ataxia in 27 (35.5%), and intoxication in 24 (31.6%) cases, followed by vestibular ataxia, opsoclonus-myoclonus-ataxia syndrome, and intracranial expansive process. Forty-two (56%) cases experienced isolated CS, and 35 (46%) cases had CS-plus. Complete recovery was experienced by 62 (81.6%) patients. Analysis of some risk factors (sex, age, presence of previous infection, "cerebellar plus symptoms," and structural abnormalities/neuroimaging abnormalities) and their relation to outcome was performed. Analysis showed that presence of additional symptoms to ataxia, so called "cerebellar plus symptoms" (p = 0.002) and structural abnormalities (p < 0.001), had statistically higher frequency of poor outcome. Statistical significance remained in the univariate analysis. Significant data was included in multivariate logistic regression analysis which also showed that presence of "cerebellar plus symptoms" (p = 0.021) and structural abnormalities (p = 0.002) is related to a poor outcome. Most of the children with AA have "benign" etiology such as intoxication and post/parainfectious cerebellar ataxia with favorable outcomes. On the other hand, AA might be the first manifestation of CNS neoplasm or paraneoplastic phenomena. "The red flags" associated with cerebellar signs are limbs or facial palsy, hypotonia, GCS < 15, vomiting, opsoclonus, headache, myoclonus, visual impairment, torticollis, and vertigo. The presence of those signs and/or structural brain abnormalities was related to poor outcomes in children with AA.

2.
J Infect Chemother ; 29(8): 792-795, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-37061090

RESUMEN

Acute coronavirus disease 2019 (COVID-19)-associated cerebellar ataxia without multisystem inflammatory syndrome in children (MIS-C) or encephalopathy in children has been rarely reported. We reviewed medical records of hospitalized children who had developed cerebellar ataxia during the acute phase of COVID-19 infection, without MIS-C or encephalopathy, in our center. We also conducted a literature review and summarized the clinical characteristics, treatment, and outcomes. We found three cases in our center and additional three cases in the literature. All patients were male and five were preschool children. The cerebellar symptoms started between day 2 and day 10 during the acute phase of the COVID-19 infection. Two cases were complicated by mutism. One patient received therapy for acute cerebellar ataxia with corticosteroids, and others did not receive any specific therapy for acute cerebellar ataxia. The symptoms improved completely in all patients, with the recovery interval ranging from one week to two months. Further studies are warranted to elucidate the pathogenesis of acute cerebellar ataxia during acute COVID-19 in children.


Asunto(s)
Encefalopatías , COVID-19 , Ataxia Cerebelosa , Preescolar , Humanos , Masculino , Femenino , Ataxia Cerebelosa/diagnóstico , COVID-19/complicaciones , COVID-19/patología , Cerebelo/patología , Síndrome de Respuesta Inflamatoria Sistémica/complicaciones , Síndrome de Respuesta Inflamatoria Sistémica/patología
3.
Brain Dev ; 46(2): 103-107, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38000948

RESUMEN

OBJECTIVE: To analyze etiologic factors of pediatric acute ataxia and to identify the severity of its underlying causes for urgent medical intervention. METHODS: Clinical data of children diagnosed with acute ataxia between December 2015 and December 2021 from one national medical center were analyzed retrospectively. RESULTS: A total of 99 children (59 boys, 40 girls), median age at disease onset 55 (range: 12-168) months, were enrolled. The median follow period was 46 (range 6-78) months. Eighty-six (86.9 %) children were diagnosed with immune-associated acute ataxia, among which acute post-infectious cerebellar ataxia (APCA) was the most common diagnosis (50.5 %), followed by demyelinating diseases of the central nervous system (18.2 %) and Guillain-Barré syndrome (9.1 %). On cerebrospinal fluid (CSF) examination, 35/73 (47.9 %) patients had pleocytosis (>5 cells/mm3), and 18/73 (24.7 %) had elevated protein levels. Thirty-one patients (31.3 %) had an abnormal cerebral MRI. Children with other immune-associated acute cerebellar ataxia had more extracerebellar symptoms, intracranial MRI lesions, abnormal CSF results, longer hospital stay, higher recurrence rates and incidence of neurological sequelae than children with APCA. CONCLUSION: Immune-associated acute ataxia is the main cause of pediatric acute ataxia, among which APCA is the most common phenotype. However, some immune-associated diseases, especially autoantibody-mediated disease, which has a higher recurrence rate and neurological sequelae account for an increasing proportion of pediatric acute ataxia. When children present with extracerebellar symptoms, abnormal cranial MRI or CSF results, and without prodromal infection, prudent differential diagnosis is recommended.


Asunto(s)
Ataxia Cerebelosa , Masculino , Femenino , Niño , Humanos , Ataxia Cerebelosa/diagnóstico , Ataxia Cerebelosa/epidemiología , Ataxia Cerebelosa/etiología , Estudios Retrospectivos , Ataxia/epidemiología , Ataxia/etiología , Hospitales , Imagen por Resonancia Magnética/efectos adversos , Enfermedad Aguda
4.
Medicina (B Aires) ; 73 Suppl 1: 30-7, 2013.
Artículo en Español | MEDLINE | ID: mdl-24072049

RESUMEN

Acute cerebellar ataxia of childhood is the most frequent neurological complication of chickenpox virus infection. Acute cerebellar ataxia is categorized within the group of acute postinfectious complications. The aims of this study were: (I) to evaluate the clinical presentation, management, and follow-up of children hospitalized due to acute cerebellar ataxia in a tertiary pediatric hospital, where immunization for chickenpox is not available, and (II) to describe the differential diagnosis of acute postinfectious cerebellitis. We evaluated 95 patients with acute cerebellar ataxia. The diagnostic criteria for acute ataxia were: Acute-onset loss of coordination or gait difficulties, with or without nystagmus, lasting less than 48 hours in a previously healthy child. All children met the inclusion criteria, except those with drug-induced ataxia in whom duration should be less than 24 hours for inclusion in the study. The data were recorded in a clinical pediatrics and neurological chart. Among immunosuppressed patients acute cerebellar ataxia was most frequently due to chickenpox. Most of the patients were male. Age at presentation ranged from preschool to 5 years of age. Time lapse between presentation of the rash and hospital admission ranged from 1 to 3 days. CSF study was performed in 59.5% of the cases. Brain magnetic resonance imaging and computed tomography scan showed edema in 33.3%. Intravenous acyclovir was used in 23 patients, however, no significant differences were found in clinical manifestations and follow-up between treated and untreated patients. Ataxia was the first clinical manifestation. Mean hospital stay ranged from 2 to 11 days with a mean of 4 days.


Asunto(s)
Ataxia Cerebelosa/diagnóstico , Ataxia Cerebelosa/etiología , Enfermedad Aguda , Aciclovir/uso terapéutico , Antivirales/uso terapéutico , Ataxia Cerebelosa/tratamiento farmacológico , Niño , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Estudios Retrospectivos , Factores de Tiempo
5.
Pediatr Neurol ; 139: 1-6, 2023 02.
Artículo en Inglés | MEDLINE | ID: mdl-36462247

RESUMEN

BACKGROUND: We aimed to evaluate patients with acute ataxia and to determine the warning clinical factors in the early prediction of neurological emergencies. METHOD: Patients with a history of balance and gait coordination disorder and clinically diagnosed as acute ataxia in pediatric emergency department were included in the study. As a result of final diagnosis, the characteristics of patients with and without clinically urgent neurological pathology (CUNP) were compared. CUNP was defined as any nervous system disorder requiring early diagnosis and prompt medical or surgical treatment and/or intensive care unit admission to prevent disabling or life-threatening evolution. RESULTS: Eighty-eight patients with a median age of 5 years were included in the study (37 [42%] patients with CUNP and 51 [58%] without CUNP). In the CUNP group, the median age of patients and symptom duration were significantly higher (P < 0.001 and P = 0.011, respectively). The most common etiologies were acute post/parainfectious cerebellar ataxias (n = 40 [45.4%]), acute cerebellitis (n = 9 [10.2%]), and Guillain-Barré syndrome (n = 8 [9%]). Hyporeflexia/areflexia and dysmetria were associated with a higher risk of CUNP. Headache, loss of consciousness, and visual dysfunction were the findings appearing exclusively in patients with CUNP. CONCLUSIONS: The most common etiologies in acute ataxia are benign and transient, whereas life-threatening conditions may occur rarely and may require urgent intervention. Older age; prolonged symptom duration; focal neurological deficits such as hemiparesis, hyporeflexia, and visual impairment; and nonspecific findings such as loss of consciousness and headache are the most striking "red flags" of a potential neurological emergency and should alert clinicians to CUNP.


Asunto(s)
Ataxia Cerebelosa , Niño , Preescolar , Humanos , Enfermedad Aguda , Ataxia/diagnóstico , Ataxia/etiología , Ataxia Cerebelosa/diagnóstico , Servicio de Urgencia en Hospital , Cefalea/diagnóstico , Cefalea/etiología , Reflejo Anormal , Inconsciencia
6.
Clin Park Relat Disord ; 3: 100053, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-34316636

RESUMEN

Cerebellar ataxic syndrome is a heterogenous class of disorders which can result from a miscellany of causes- genetic or acquired. There are a few metabolic, immune mediated, inflammatory and hereditary causes of ataxia which can be diagnosed from the gamut of possibilities, offering great relief to the ailing patient, their family and the treating physician. A pragmatic algorithm for diagnosing treatable causes of ataxia includes a thorough clinical history, meticulous examination for associated signs and an investigative mind to clinch the diagnosis. With novel diagnostic techniques and targeted therapies, early diagnosis and treatment can lead to favourable outcomes. In this review, diseases presenting predominantly as cerebellar ataxia and are treatable by targeted therapies are discussed.

7.
J Clin Neurosci ; 68: 146-150, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31327588

RESUMEN

We aimed to identify the most common causes of acute ataxia in children in the era of widespread varicella vaccination and the yield of commonly used diagnostic work-up. This retrospective study reviewed the medical records of children who presented with ataxia of less than 72 h duration, over the last 12 years. Associated signs and symptoms, laboratory, EEG and neuroimaging studies, final diagnosis and clinical findings at discharge and during follow-up were studied. A total of 58 patients (35 boys, 23 girls), mean age 4.9 ±â€¯3.8 years, were enrolled. The most common etiology of acute ataxia in our study was post-infectious acute cerebellar ataxia (50%). Children diagnosed with post-infectious acute cerebellar ataxia were significantly younger (3.48 ±â€¯2.23 vs. 6.5 ±â€¯3.1 years, p = 0.01), as compared with children diagnosed with infection and acute disseminated encephalomyelitis. 86% of children with post-infectious cerebellar ataxia were younger than 5 years of age. The abnormality yield of work-up studies performed in our cohort was 39% for lumbar puncture, 36% for EEG, 7% for CT scan. MRI was done in children who showed extra cerebellar signs, when vascular or demyelinating diseases were suspected and in children with prolonged symptoms and was abnormal in 8 (14%) children. We conclude that post-infectious acute cerebellar ataxia remains the most common cause of acute ataxia in children. Although lumbar puncture and neuroimaging should be considered in all children with acute cerebellar ataxia, younger children with a history of previous viral illness and no extra cerebellar signs and symptoms may benefit from watchful waiting.


Asunto(s)
Ataxia Cerebelosa/diagnóstico , Ataxia Cerebelosa/etiología , Adolescente , Varicela/complicaciones , Varicela/epidemiología , Varicela/prevención & control , Niño , Preescolar , Estudios de Cohortes , Femenino , Humanos , Lactante , Masculino , Estudios Retrospectivos , Vacunación
8.
Artículo en Inglés | MEDLINE | ID: mdl-30647991

RESUMEN

Background: Anti-GAD-related cerebellar ataxia has rarely been described as an acute cause of autoimmune ataxia. Phenomenology Shown: A young female who acutely developed anti-GAD-associated ataxia with magnetic resonance imaging (MRI) showing cerebellar edema and follow-up MRI 6 months later showing cerebellar atrophy. Educational Value: Recognizing that anti-GAD-associated cerebellar ataxia can present in a young adult as an acute and severe cause of ataxia, with cerebellar changes evident on MRI.


Asunto(s)
Autoanticuerpos/sangre , Ataxia Cerebelosa/sangre , Ataxia Cerebelosa/diagnóstico por imagen , Glutamato Descarboxilasa/sangre , Biomarcadores/sangre , Femenino , Humanos , Adulto Joven
9.
Artículo en Inglés | MEDLINE | ID: mdl-30783548

RESUMEN

Background: Arm levitation is an involuntary elevation of the upper limb, a manifestation of the alien-limb phenomenon. It has rarely been reported in Creutzfeldt-Jakob disease (CJD), less so as an initial manifestation. Case Report: We report a 56-year-old right-handed man with rapidly progressive gait ataxia and involuntary elevation of the left upper limb. During the next few weeks, the patient developed cognitive impairment, apraxia, visual hallucinations, and myoclonus. He met diagnostic criteria for CJD. We evaluated additional published cases of early-appearance of alien-limb phenomenon in the context of CJD; there were 22 such cases and alien-limb phenomenon was the first and exclusive manifestation in only five of them. Discussion: Arm levitation may be a distinct presentation of CJD, appearing earlier than other clinical features.


Asunto(s)
Fenómeno de la Extremidad Ajena/diagnóstico , Síndrome de Creutzfeldt-Jakob/diagnóstico , Fenómeno de la Extremidad Ajena/fisiopatología , Brazo , Encéfalo/diagnóstico por imagen , Encéfalo/fisiopatología , Síndrome de Creutzfeldt-Jakob/fisiopatología , Diagnóstico Diferencial , Humanos , Masculino , Persona de Mediana Edad
10.
Brain Dev ; 39(4): 349-351, 2017 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-27876395

RESUMEN

Lamotrigine (LTG) represents the most commonly prescribed of the so-called new generation antiepileptic drugs. We describe a child who was admitted to the emergency room because of generalized tonic-clonic status epilepticus followed by a complex neurological picture with hyperkinesia and acute ataxia as a result of a LTG intoxication. The experience on acute LTG intoxication is very limited in pediatrics. The present case provides information on the clinical picture related to LTG overdose and confirms that drug intoxications should be considered in the differential diagnosis strategy when severe and polymorphic neurological symptoms occur acutely.


Asunto(s)
Anticonvulsivantes/envenenamiento , Sobredosis de Droga/diagnóstico , Triazinas/envenenamiento , Preescolar , Diagnóstico Diferencial , Discinesia Inducida por Medicamentos/diagnóstico , Servicios Médicos de Urgencia , Humanos , Lamotrigina , Masculino , Estado Epiléptico/inducido químicamente , Estado Epiléptico/diagnóstico
11.
J Clin Neurosci ; 41: 90-91, 2017 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-28460866

RESUMEN

We report a case of varicella-zoster virus (VZV) infection with acute cerebellitis and encephalitis with associated Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in an elderly man presenting with acute cerebellar ataxia without antecedent rash. Cerebrospinal fluid examination (CSF) revealed a mononuclear pleocytosis, high protein, normal glucose, positive for VZV polymerase chain reaction (PCR). Early acyclovir treatment is beneficial for acute VZV cerebellitis. Clinicians should consider infectious Central Nervous System (CNS) causes for presentations of acute cerebellar ataxia in adult patients, particularly if there is an accompanying clouded sensorium.


Asunto(s)
Encefalitis por Varicela Zóster/diagnóstico , Síndrome de Secreción Inadecuada de ADH/diagnóstico , Aciclovir/uso terapéutico , Anciano de 80 o más Años , Antivirales/uso terapéutico , Cerebelo/patología , Encefalitis por Varicela Zóster/tratamiento farmacológico , Exantema/diagnóstico , Humanos , Masculino
12.
Med. infant ; 29(3): 200-204, Septiembre 2022. tab, ilus
Artículo en Español | LILACS, UNISALUD, BINACIS | ID: biblio-1399589

RESUMEN

La ataxia es una alteración de la coordinación motora voluntaria y del control postural. Es una entidad poco frecuente en la infancia, siendo la principal causa de ataxia aguda descripta en la bibliografía, de origen inmunológico (post infecciosa), seguida de las intoxicaciones. Para el diagnóstico es fundamental una anamnesis detallada, cronología de los síntomas, antecedentes infecciosos o de contacto con sustancias tóxicas y un examen neurológico completo. El objetivo de nuestro estudio fue analizar retrospectivamente la causa de ataxia aguda como signo neurológico predominante en pacientes que consultaron en el Hospital Juan P. Garrahan. Diseño: Se trata de un estudio descriptivo, observacional, retrospectivo y de corte transversal. Población: niños de 1 a 18 años, con o sin patología previa conocida, que consultaron al servicio de emergencias del hospital por ataxia entre enero de 2013 y octubre de 2018. Método: recolección y análisis de historias clínicas comprendidas en esa fecha, con alteración en la marcha como síntoma de consulta. Resultados: de un total de 237 pacientes, la causa más frecuente de ataxia aguda fue la inmunológica (incluyendo en este grupo a las postinfecciosas y a las no asociadas a infección). Conclusión: En nuestro hospital con tercer nivel de atención, la causa más frecuente de ataxia aguda fue la inmunológica. En segundo lugar, las intoxicaciones y, en tercer lugar, las enfermedades neurológicas. (AU)


Ataxia is a disorder of voluntary motor coordination and postural control, which is rare in childhood. The main cause of acute ataxia described in the literature is immune-mediated inflammation (postinfectious), followed by intoxication. A detailed anamnesis, chronology of symptoms, history of infection or contact with toxic substances, and a complete neurological examination are essential in the diagnostic work-up. The aim of our study was to retrospectively analyze the cause of acute ataxia as a predominant neurological sign in patients who consulted at Hospital Juan P. Garrahan. Study design: A descriptive, observational, retrospective, cross-sectional study was conducted. Study population: children aged 1 to 18 years, with or without known previous disease, who presented to the hospital emergency department for ataxia between January 2013 and October 2018. Method: collection and analysis of medical records from that period of patients with gait disturbance as the reason for consultation. Results: out of a total of 237 patients, the most frequent cause of acute ataxia was immune-mediated inflammation (both post-infectious and noninfectious). Conclusion: In our tertiary care hospital, the most frequent cause of acute ataxia was immune-mediated inflammation. The second most frequent cause was intoxication and the third neurological diseases (AU)


Asunto(s)
Humanos , Lactante , Preescolar , Niño , Adolescente , Ataxia/diagnóstico , Ataxia/etiología , Ataxia/inducido químicamente , Examen Neurológico , Enfermedad Aguda , Estudios Transversales , Estudios Retrospectivos , Diagnóstico Diferencial
13.
Artículo en Zh | WPRIM | ID: wpr-930396

RESUMEN

Objective:To investigate the clinical application of the new classification criteria in children with Miller Fisher syndrome (MFS), and to analyze clinical characteristics of different types of MFS.Methods:Clinical data of MFS patients hospitalized in the Department of Neurology, Beijing Children′s Hospital, Capital Medical University from January 2015 to December 2019 were collected and analyzed retrospectively, including demographic characteristics, clinical symptoms, neurological examination findings, laboratory examination data, diagnosis and treatment, and prognosis.The counting data was described by percentage, and the measurement data was described by median.Results:A total of 23 patients were included in the research, including 14 males and 9 females, with a median age of 4 years and 8 months.There were 3 cases of pure MFS; 5 cases of incomplete MFS, including 1 case of acute ptosis and 4 cases of acute ataxia neuropathy; 15 cases of overlapping syndrome, including 13 cases of MFS/Guillain Barre syndrome (GBS), 1 case of MFS/pharyngocervical brachial variant GBS(PCB GBS)and 1 case of MFS/GBS/Bickertaff brainstem encephalitis (BBE). In addition to Ⅲ, Ⅳ and Ⅵ cranial nerve palsy, 11 cases had the involvement of other cra-nial nerves, including 2 cases in pure MFS, 8 cases in MFS/GBS and 1 case in MFS/GBS/BBE.Autonomic nervous dysfunction occurred in 6 cases.Respiratory muscle paralysis occurred in 6 cases, including 5 cases in MFS/GBS and 1 case in MFS/GBS/BBE.Graded by the Hughes scoring system (HG score), 3 cases with pure MFS were graded 4 points; 1 case with acute ptosis was graded 0; 3 cases with acute ataxia neuropathy were graded 2 points, and the other one was graded 3 points; 1 case with MFS/PCB GBS was graded 3 points; 10 cases with MFS/GBS were graded 4 points, 1 case was graded 3 points, and the other 2 cases were graded 2 points; 1 case with MFS/GBS/BBE was graded 4 points.Twenty-two patients were treated with intravenous immunoglobulin.The HG of all patients at discharge decreased at varying degree, which was graded 0 at 6 months of follow-up.Conclusions:The clinical application of the new diagnostic classification method is helpful to the accurate diagnosis of different types of MFS.More than half of MFS cases will develop into the overlapping syndrome.The overlapping of MFS and GBS or BBE is prone to the involvement of cranial nerves except for the external ophthalmic muscles, autonomic nerve dysfunction and respiratory muscle paralysis.The disease course of MFS varies, and its diagnosis should be comprehensively made.All cases of MFS in this study have a satisfactory prognosis.

14.
Eur J Paediatr Neurol ; 20(3): 435-8, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-26968729

RESUMEN

BACKGROUND: Subacute sclerosing panencephalitis is a devastating neurodegenerative disease with a characteristic clinical course. Atypical presentations may be seen in 10% of the cases. AIMS: To describe the atypical clinical and radiological features of SSPE in a child form endemic country. METHODS: A 5-year-old boy presented with acute-onset cerebellar ataxia without associated encephalopathy, focal motor deficits, seizures or cognitive decline. He had varicella-like illness with vesicular, itchy truncal rash erupting one month prior to the onset of these symptoms. He underwent detailed neurological assessment, relevant laboratory and radiological investigations. RESULTS: Neuroimaging revealed peculiar brain stem lesions involving the pons and cerebellum suggestive of demyelination. With a presumptive diagnosis of clinically isolated syndrome of demyelination, he was administered pulse methylprednisolone (30 mg/kg/day for 5 days). Four weeks later he developed myoclonic jerks. Electroencephalogram showed characteristic periodic complexes time-locked with myoclonus. CSF and serum anti-measles antibody titres were elevated (1:625). CONCLUSION: Our report highlights that subacute sclerosing panencephalitis can present atypically as isolated acute cerebellar ataxia and peculiar involvement of longitudinal and sparing of transverse pontine fibres. The predominant brainstem abnormalities in the clinical setting may mimick acute demyelinating syndrome. Hence, it is important to recognize these features of subacute sclerosing panencephalitis in children, especially in the endemic countries.


Asunto(s)
Ataxia Cerebelosa/etiología , Panencefalitis Esclerosante Subaguda/complicaciones , Panencefalitis Esclerosante Subaguda/diagnóstico , Enfermedad Aguda , Tronco Encefálico/diagnóstico por imagen , Tronco Encefálico/patología , Ataxia Cerebelosa/diagnóstico por imagen , Preescolar , Electroencefalografía , Humanos , Masculino , Mioclonía/etiología , Mioclonía/patología , Neuroimagen , Examen Neurológico , Convulsiones/epidemiología , Convulsiones/patología
15.
J Child Neurol ; 31(9): 1156-60, 2016 08.
Artículo en Inglés | MEDLINE | ID: mdl-27071467

RESUMEN

We categorized the causes of acute ataxia in the pediatric population-referred to the Division of Neurology-at a large, urban pediatric medical center. Of the 120 cases identified over the past 11 years, post-infectious cerebellar ataxia was the most commonly diagnosed (59%), followed by drug intoxication, opsoclonus-myoclonus ataxia syndrome, episodic ataxia, acute cerebellitis, cerebellar stroke, ADEM, meningitis, cerebral vein thrombosis, Leigh's disease, Miller-Fisher syndrome, and concussion. Among the patients with post-infectious cerebellar ataxia, 85% were 1-6 years old and all had a history of antecedent viral illness. CSF pleocytosis was present in 40% of patients; all had normal brain MRIs. The majority (91%) recovered within 30 days. We conclude that post-infectious cerebellar ataxia remains the most common cause of acute ataxia in childhood and that it carries a good prognosis. We also differentiate acute post-infectious cerebellar ataxia from other causes with similar presentations.


Asunto(s)
Ataxia/epidemiología , Ataxia/etiología , Enfermedad Aguda , Ataxia/diagnóstico por imagen , Ataxia/terapia , Encéfalo/diagnóstico por imagen , Enfermedades Cerebelosas/diagnóstico por imagen , Enfermedades Cerebelosas/epidemiología , Enfermedades Cerebelosas/etiología , Enfermedades Cerebelosas/terapia , Niño , Preescolar , Femenino , Humanos , Lactante , Infecciones/complicaciones , Infecciones/epidemiología , Infecciones/terapia , Imagen por Resonancia Magnética , Masculino , Estudios Retrospectivos
16.
Pediatr Neurol ; 65: 14-30, 2016 12.
Artículo en Inglés | MEDLINE | ID: mdl-27789117

RESUMEN

Acute ataxia in a pediatric patient poses a diagnostic dilemma for any physician. While the most common etiologies are benign, occasional individuals require urgent intervention. Children with stroke, toxic ingestion, infection, and neuro-inflammatory disorders frequently exhibit ataxia as an essential-if not the only-presenting feature. The available retrospective research utilize inconsistent definitions of acute ataxia, precluding the ability to pool data from these studies. No prospective data exist that report on patients presenting to the emergency department with ataxia. This review examines the reported causes of ataxia and attempts to group them into distinct categories: post-infectious and inflammatory central and peripheral phenomena, toxic ingestion, neurovascular, infectious and miscellaneous. From there, we synthesize the existing literature to understand which aspects of the history, physical exam, and ancillary testing might aid in narrowing the differential diagnosis. MRI is superior to CT in detecting inflammatory or vascular insults in the posterior fossa, though CT may be necessary in emergent situations. Lumbar puncture may be deferred until after admission in most instances, with suspicion for meningitis being the major exception. There is insufficient evidence to guide laboratory evaluation of serum, testing should be ordered based on clinical judgement-recommended studies include metabolic profiles and screening labs for metabolic disorders (lactate and ammonia). All patients should be reflexively screened for toxic ingestions.


Asunto(s)
Ataxia/diagnóstico , Ataxia/terapia , Servicios Médicos de Urgencia/métodos , Servicio de Urgencia en Hospital , Enfermedad Aguda , Ataxia/inducido químicamente , Ataxia Cerebelosa/inducido químicamente , Ataxia Cerebelosa/diagnóstico , Ataxia Cerebelosa/terapia , Niño , Diagnóstico Diferencial , Sobredosis de Droga/diagnóstico , Sobredosis de Droga/terapia , Humanos
17.
Acta neurol. colomb ; 30(3): 169-174, jul.-sep. 2014. ilus, tab
Artículo en Español | LILACS | ID: lil-731690

RESUMEN

La ataxia aguda (AA) en la población pediátrica generalmente es secundaria a disfunción cerebelosade origen inmunológico. En urgencias, la rápida detección de patologías de menor frecuencia y mayorgravedad que requieren tratamiento específico es prioridad.Objetivos: Describir la etiología de la AA en los pacientes valorados por Neuropediatría en la FundaciónHospital la Misericordia entre los años 2009 y 2013.Métodos y Materiales: Estudio descriptivo tipo serie de casos. Revisión retrospectiva de historias clínicas depacientes de 1 mes a 18 años con diagnóstico definitivo de AA. Análisis de datos mediante SPSS 21, medidasde tendencia central, Kaplan Meier y prueba de Log Rank.Resultados: Se recopilaron 48 casos, de los cuales el 91,67% fue de origen cerebeloso. El diagnóstico etiológicomás frecuente fue cerebelitis o romboencefalitis viral en 25%, seguido de intoxicación aguda y post infecciosa(20,5% cada una). En cuanto a pronóstico, el 60.4 % tuvo una recuperación completa, siendo esta más rápidaen la ataxia postinfecciosa, tóxica y post traumática.Discusión: La disfunción cerebelosa fue la causa más frecuente de ataxia, los diagnósticos etiológicos principalesfueron ataxia de origen infeccioso y post infeccioso, el antecedente de infección 1 a 30 días antes del iniciode los síntomas neurológicos fue positivo en 41.67 %, lo que sugiere un importante papel de la inmunidad.Conclusiones: La mayoría de las ataxias agudas son secundarias a disfunción cerebelosa infecciosa, inmunológicao tóxica; el pronóstico depende de la etiología y generalmente es benigno...


Asunto(s)
Humanos , Ataxia , Colombia , Urgencias Médicas
SELECCIÓN DE REFERENCIAS
Detalles de la búsqueda